iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	PINA	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	2.00e-10	40.6	3	57
E3 adaptor/Cullin RING/DCX/DWD	3.00e-25	87.3	390	423
UBD/Beta-Prp	1.40e-47	162.4	222	432

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 6    flCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlvPnlt 60
           ++C++++e+++ Pvv+p sG +++++ Iek+l ++g  +P+ +++l++e+l+  +t
   Q: 3    LVCALTNEVPETPVVSPhSGAVFEKRVIEKYLLENGC-DPISGKELKPEELIEIKT 57
           79**********************************9.*************98765 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrt 32
           gHt+++++++f  ++ +l++++dD  +k+WDlr+
   Q: 390  GHTGPISAISFseNGYYLATAADDACVKLWDLRK 423
           8**********976699**************986 PP

UBD/Beta-Prp

   S: 52   eaevtavkfspdgk.ilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpd 148
            +++ a+++++ +   ++tg++D+++ v++ +t ++v +lkgh+++++ + ++p+ d++++Gs d  ir+w+++t q    +l+ h+g v+++++hp+
   Q: 222  VPGILALDINSADHsKILTGGNDKNATVFNKDTEQMVAILKGHTKKITKVIYHPNEDTVITGSPDMNIRIWHVPTSQTQL-LLRCHEGPVTGLSLHPT 318
           45577888877655588888888888888888888888888888888888888888888888888888888888888888.88888888888888888 PP
   S: 149  gnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsi 246
           g++l s s D+   + d++tg+ll++     +   +  +f+++g  + +g  d++vk+wdl++++ v  + ght +++ + fs+n+ +l+++++D  +
   Q: 319  GDYLLSTSSDKHWAFSDIRTGRLLTKVIDTAEVGLTTAQFHPDGLIFGTGTVDSQVKIWDLKEQSNVANFPGHTGPISAISFSENGYYLATAADDACV 416
           88888888888888888888888888865556666666688888888888888888888888888888888888888888888888888888888888 PP
   S: 247  riWdlrsgdllktlql 262
           ++Wdlr+ ++ kt+ql
   Q: 417  KLWDLRKLKNFKTIQL 432
           8888888888888886 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MALVCALTNE VPETPVVSPH SGAVFEKRVI EKYLLENGCD PISGKELKPE ELIEIKTPAV 60
VKPKPPSATS IPATLKTMQD EWDALMIHSF TQRQQLQTTR QELSHALYQH DAACRVIARL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCGTCGCCG AGTAACTGGC ATAATAAGAA GAAGCGGCTT TGCCGACAAT TTTGCGCTTG 60
GCTCGGGAAA AACGTGTAAA ACATTTAATT TACCAACAAG ACTACGCGAA AAGCGACATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR013915--Pre-mRNA_splic_Prp19
IPR003613--Ubox_domain
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51698--U_BOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08606--Prp19
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00504--Ubox
SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0005875--C:microtubule associated complex
GO:0071011--C:precatalytic spliceosome
GO:0000974--C:Prp19 complex
GO:0005681--C:spliceosomal complex
GO:0071006--C:U2-type catalytic step 1 spliceosome
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006325--P:chromatin organization
GO:0000349--P:generation of catalytic spliceosome for first transesterification step
GO:0000398--P:mRNA splicing, via spliceosome
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0046579--P:positive regulation of Ras protein signal transduction
GO:0016567--P:protein ubiquitination
GO:0000381--P:regulation of alternative mRNA splicing, via spliceosome
GO:0019233--P:sensory perception of pain

KEGG

dme:Dmel_CG5519

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000488	Aegilops tauschii	40.39	9.00e-94	338.00
IUUC-Aml-001230	Ailuropoda melanoleuca	65.74	0.00e+00	657.00
IUUC-Atr-002594	Amborella trichopoda	42.91	1.00e-111	396.00
IUUC-Apl-003686	Anas platyrhynchos	60.84	2.00e-144	504.00
IUUC-Aca-005272	Anolis carolinensis	66.14	0.00e+00	682.00
IUUC-Aly-005586	Arabidopsis lyrata	44.79	6.00e-115	407.00
IUUC-Ath-007696	Arabidopsis thaliana	44.36	2.00e-112	399.00
IUUC-Acl-008335	Aspergillus clavatus	35.70	3.00e-65	241.00
IUUC-Afl-008527	Aspergillus flavus	35.73	7.00e-71	260.00
IUUC-Afu-008957	Aspergillus fumigatus	37.21	6.00e-75	273.00
IUUC-Ani-009280	Aspergillus nidulans	37.04	2.00e-59	222.00
IUUC-Ang-009746	Aspergillus niger	35.24	9.00e-63	233.00
IUUC-Aor-009905	Aspergillus oryzae	36.13	2.00e-73	268.00
IUUC-Ate-010412	Aspergillus terreus	37.53	1.00e-60	226.00
IUUC-Ame-011561	Astyanax mexicanus	65.56	1.00e-80	291.00
IUUC-Bgr-012283	Blumeria graminis	32.52	2.00e-51	196.00
IUUC-Bta-013242	Bos taurus	65.69	0.00e+00	682.00
IUUC-Bci-013901	Botrytis cinerea	33.40	1.00e-62	233.00
IUUC-Bdi-014277	Brachypodium distachyon	43.76	6.00e-115	406.00
IUUC-Bol-016207	Brassica oleracea	45.75	3.00e-114	404.00
IUUC-Bra-017650	Brassica rapa	45.66	3.00e-115	407.00
IUUC-Cel-018271	Caenorhabditis elegans	46.15	2.00e-132	465.00
IUUC-Cja-019879	Callithrix jacchus	65.95	0.00e+00	681.00
IUUC-Cfa-020175	Canis familiaris	66.08	0.00e+00	685.00
IUUC-Cpo-022379	Cavia porcellus	65.88	0.00e+00	683.00
IUUC-Cre-022993	Chlamydomonas reinhardtii	38.90	4.00e-89	321.00
IUUC-Csa-023500	Chlorocebus sabaeus	65.88	0.00e+00	684.00
IUUC-Cho-025065	Choloepus hoffmanni	55.52	4.00e-86	310.00
IUUC-Cin-025699	Ciona intestinalis	63.16	2.00e-150	524.00
IUUC-Csv-026128	Ciona savignyi	61.19	1.00e-178	618.00
IUUC-Cgl-026507	Colletotrichum gloeosporioides	33.72	7.00e-65	240.00
IUUC-Cne-026860	Cryptococcus neoformans	36.65	2.00e-89	322.00
IUUC-Dre-028187	Danio rerio	66.73	0.00e+00	676.00
IUUC-Dno-029453	Dasypus novemcinctus	65.88	0.00e+00	684.00
IUUC-Dor-030150	Dipodomys ordii	63.93	4.00e-79	287.00
IUUC-Dse-031220	Dothistroma septosporum	32.81	2.00e-59	222.00
IUUC-Ete-033035	Echinops telfairi	58.02	2.00e-165	575.00
IUUC-Eca-033478	Equus caballus	65.69	0.00e+00	682.00
IUUC-Eeu-034974	Erinaceus europaeus	66.57	1.00e-136	479.00
IUUC-Fca-036194	Felis catus	65.94	0.00e+00	676.00
IUUC-Fal-037417	Ficedula albicollis	66.27	0.00e+00	686.00
IUUC-Fox-037922	Fusarium oxysporum	31.83	4.00e-58	218.00
IUUC-Fso-038256	Fusarium solani	34.06	4.00e-64	237.00
IUUC-Gmo-038713	Gadus morhua	66.14	0.00e+00	679.00
IUUC-Ggr-039854	Gaeumannomyces graminis	32.75	1.00e-48	186.00
IUUC-Gga-041143	Gallus gallus	66.07	0.00e+00	687.00
IUUC-Gac-042129	Gasterosteus aculeatus	66.67	0.00e+00	682.00
IUUC-Gma-044273	Glycine max	44.11	2.00e-114	404.00
IUUC-Ggo-045262	Gorilla gorilla	65.88	0.00e+00	684.00
IUUC-Hsa-046036	Homo sapiens	65.88	0.00e+00	684.00
IUUC-Hvu-047442	Hordeum vulgare	42.52	3.00e-59	221.00
IUUC-Itr-048169	Ictidomys tridecemlineatus	65.35	0.00e+00	671.00
IUUC-Lch-050105	Latimeria chalumnae	66.53	0.00e+00	691.00
IUUC-Lpe-050976	Leersia perrieri	44.34	7.00e-113	400.00
IUUC-Loc-052042	Lepisosteus oculatus	59.83	2.00e-145	508.00
IUUC-Lma-053143	Leptosphaeria maculans	36.08	2.00e-63	236.00
IUUC-Laf-053451	Loxodonta africana	64.14	0.00e+00	677.00
IUUC-Mcc-055786	Macaca mulatta	65.88	0.00e+00	684.00
IUUC-Meu-056161	Macropus eugenii	64.73	6.00e-91	327.00
IUUC-Mor-057215	Magnaporthe oryzae	32.43	3.00e-52	198.00
IUUC-Mpo-057419	Magnaporthe poae	32.55	5.00e-47	181.00
IUUC-Mtr-057756	Medicago truncatula	44.68	4.00e-113	400.00
IUUC-Mla-059085	Melampsora laricipopulina	39.07	7.00e-87	313.00
IUUC-Mga-060158	Meleagris gallopavo	62.80	4.00e-177	613.00
IUUC-Mvi-060441	Microbotryum violaceum	36.53	1.00e-76	279.00
IUUC-Mmr-061085	Microcebus murinus	65.88	0.00e+00	684.00
IUUC-Mdo-061804	Monodelphis domestica	65.69	0.00e+00	682.00
IUUC-Mmu-063608	Mus musculus	63.52	0.00e+00	672.00
IUUC-Mac-064972	Musa acuminata	44.98	4.00e-115	407.00
IUUC-Mpu-065700	Mustela putorius furo	66.08	0.00e+00	685.00
IUUC-Mlu-068223	Myotis lucifugus	63.24	0.00e+00	671.00
IUUC-Nfi-068504	Neosartorya fischeri	37.08	7.00e-75	273.00
IUUC-Ncr-068729	Neurospora crassa	36.22	9.00e-60	223.00
IUUC-Nle-069754	Nomascus leucogenys	65.88	0.00e+00	684.00
IUUC-Opr-070621	Ochotona princeps	63.82	0.00e+00	638.00
IUUC-Ont-071377	Oreochromis niloticus	66.14	0.00e+00	677.00
IUUC-Oan-073498	Ornithorhynchus anatinus	46.32	3.00e-69	254.00
IUUC-Ocu-074182	Oryctolagus cuniculus	63.28	0.00e+00	671.00
IUUC-Oba-075509	Oryza barthii	44.15	4.00e-114	404.00
IUUC-Obr-076480	Oryza brachyantha	45.11	6.00e-116	410.00
IUUC-Ogl-077052	Oryza glaberrima	44.15	4.00e-114	404.00
IUUC-Ogu-078919	Oryza glumaepatula	44.15	5.00e-114	404.00
IUUC-Oin-079357	Oryza indica	43.63	2.00e-110	391.00
IUUC-Olo-080376	Oryza longistaminata	44.06	5.00e-102	363.00
IUUC-Ome-081973	Oryza meridionalis	43.85	7.00e-102	363.00
IUUC-Oni-082849	Oryza nivara	44.15	2.00e-114	405.00
IUUC-Opu-083243	Oryza punctata	44.15	3.00e-114	404.00
IUUC-Oru-084613	Oryza rufipogon	44.15	8.00e-114	403.00
IUUC-Osa-085407	Oryza sativa	44.23	9.00e-114	403.00
IUUC-Ola-086566	Oryzias latipes	64.90	0.00e+00	669.00
IUUC-Olu-087757	Ostreococcus lucimarinus	38.72	1.00e-86	312.00
IUUC-Oga-089010	Otolemur garnettii	64.64	0.00e+00	653.00
IUUC-Oar-089638	Ovis aries	65.69	0.00e+00	682.00
IUUC-Ptr-091141	Pan troglodytes	65.88	0.00e+00	684.00
IUUC-Pan-092662	Papio anubis	65.88	0.00e+00	684.00
IUUC-Psi-093777	Pelodiscus sinensis	66.35	4.00e-163	566.00
IUUC-Pno-095115	Phaeosphaeria nodorum	34.82	2.00e-63	235.00
IUUC-Ppa-095841	Physcomitrella patens	43.95	1.00e-116	412.00
IUUC-Pfo-096390	Poecilia formosa	65.15	0.00e+00	673.00
IUUC-Pab-098250	Pongo abelii	66.39	0.00e+00	640.00
IUUC-Pop-099854	Populus trichocarpa	44.42	1.00e-114	405.00
IUUC-Pca-100553	Procavia capensis	65.88	0.00e+00	677.00
IUUC-Ppe-101383	Prunus persica	44.12	1.00e-107	382.00
IUUC-Pva-102189	Pteropus vampyrus	65.69	0.00e+00	682.00
IUUC-Pgr-103304	Puccinia graminis	35.61	8.00e-78	283.00
IUUC-Ptt-103984	Puccinia triticina	35.42	4.00e-83	301.00
IUUC-Pte-104385	Pyrenophora teres	33.19	2.00e-62	232.00
IUUC-Pyt-104697	Pyrenophora triticirepentis	33.40	4.00e-63	234.00
IUUC-Rno-105581	Rattus norvegicus	65.88	0.00e+00	684.00
IUUC-Sha-107071	Sarcophilus harrisii	62.97	0.00e+00	670.00
IUUC-Sja-107697	Schizosaccharomyces japonicus	32.51	3.00e-36	145.00
IUUC-Spo-108315	Schizosaccharomyces pombe	31.72	3.00e-38	151.00
IUUC-Ssl-108628	Sclerotinia sclerotiorum	33.20	6.00e-61	227.00
IUUC-Smo-109648	Selaginella moellendorffii	44.81	8.00e-116	409.00
IUUC-Sit-109873	Setaria italica	44.25	4.00e-112	398.00
IUUC-Sly-111673	Solanum lycopersicum	44.77	8.00e-108	383.00
IUUC-Stu-112125	Solanum tuberosum	44.10	4.00e-106	377.00
IUUC-Sbi-114696	Sorghum bicolor	41.67	3.00e-101	361.00
IUUC-Sre-115134	Sporisorium reilianum	33.70	3.00e-75	275.00
IUUC-Ssc-116260	Sus scrofa	65.49	0.00e+00	681.00
IUUC-Tgu-116533	Taeniopygia guttata	66.47	0.00e+00	689.00
IUUC-Tru-117800	Takifugu rubripes	66.86	0.00e+00	683.00
IUUC-Tsy-118980	Tarsius syrichta	63.31	3.00e-179	620.00
IUUC-Tni-120334	Tetraodon nigroviridis	64.99	1.00e-135	475.00
IUUC-Tca-121807	Theobroma cacao	43.55	5.00e-114	404.00
IUUC-Tre-121920	Trichoderma reesei	35.33	5.00e-64	237.00
IUUC-Tvi-122294	Trichoderma virens	31.61	4.00e-51	194.00
IUUC-Tae-125713	Triticum aestivum	44.17	1.00e-115	409.00
IUUC-Tur-126664	Triticum urartu	39.75	4.00e-105	374.00
IUUC-Tme-127026	Tuber melanosporum	35.73	5.00e-68	251.00
IUUC-Tbe-127582	Tupaia belangeri	66.87	6.00e-137	479.00
IUUC-Ttr-128313	Tursiops truncatus	65.35	0.00e+00	676.00
IUUC-Uma-129626	Ustilago maydis	33.21	2.00e-72	265.00
IUUC-Vda-129699	Verticillium dahliae	35.06	6.00e-64	237.00
IUUC-Vpa-130593	Vicugna pacos	66.52	4.00e-176	610.00
IUUC-Vvi-131668	Vitis vinifera	45.21	3.00e-116	411.00
IUUC-Xtr-132186	Xenopus tropicalis	66.67	5.00e-169	586.00
IUUC-Xma-133212	Xiphophorus maculatus	65.15	0.00e+00	674.00
IUUC-Zma-135662	Zea mays	44.53	4.00e-114	404.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence