iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000048205.2	ENSRNOT00000074649.2	ENSRNOP00000064341.2
ENSRNOG00000048205.2	ENSRNOT00000078961.1	ENSRNOP00000069133.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
RAID2
Post-translational Modifications (PTMs)
CPLM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.10e-33	116.3	31	143

Active Site

Position(s)	Description	Evidence
87	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 27   ltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsilkeeekWspalsvesvlls.iqsllaepn 113
           l+e+ v++ Gp++tpYeggv+k+++++p++YPfk+P++ f++kifhPn++   G+vCl++++  ++W++ +++++++ s + +lla pn
   Q: 31   LNEFVVKFYGPQGTPYEGGVWKVRVDLPDKYPFKSPSIGFMNKIFHPNIDGVsGTVCLDVIN--QTWTALYDLTNIFESfLPQLLAYPN 117
           7899**********************************************999********9..*************66378999**** PP
   S: 114  pesplneeaaellkknreeykkkvre 139
           p +pln +aa ++ +++eeyk+k++e
   Q: 118  PIDPLNGDAAAMYLHRPEEYKQKIKE 143
           ***********************985 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MSSPSPGKRR MDTDVVKLIE SKHEVTILGG LNEFVVKFYG PQGTPYEGGV WKVRVDLPDK 60
YPFKSPSIGF MNKIFHPNID GVSGTVCLDV INQTWTALYD LTNIFESFLP QLLAYPNPID 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACGGGACCGC GCGGGTGTTG CCACCTCGGC CGAGGAGCCG GCGAGGCCGC GGGGCCCTGC 60
GAGCTGGGCC CGGGGCCCGT GACAGACGGG CCAAGGAGGG GAGAGAGGCG GCGGCGGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000745	Aegilops tauschii	59.48	4.00e-52	196.00
IUUC-Aml-001260	Ailuropoda melanoleuca	98.91	4.00e-85	306.00
IUUC-Atr-002681	Amborella trichopoda	58.17	4.00e-52	196.00
IUUC-Apl-003547	Anas platyrhynchos	98.18	6.00e-72	262.00
IUUC-Aca-005224	Anolis carolinensis	98.79	9.00e-74	269.00
IUUC-Aly-005836	Arabidopsis lyrata	57.14	2.00e-51	194.00
IUUC-Ath-007534	Arabidopsis thaliana	57.14	1.00e-51	195.00
IUUC-Ago-007727	Ashbya gossypii	59.74	4.00e-52	197.00
IUUC-Acl-008119	Aspergillus clavatus	58.24	1.00e-56	212.00
IUUC-Afl-008412	Aspergillus flavus	61.11	3.00e-46	177.00
IUUC-Afu-008925	Aspergillus fumigatus	56.42	1.00e-53	202.00
IUUC-Ani-009294	Aspergillus nidulans	57.14	9.00e-52	196.00
IUUC-Ang-009805	Aspergillus niger	61.73	1.00e-56	211.00
IUUC-Aor-010201	Aspergillus oryzae	53.75	8.00e-48	182.00
IUUC-Ate-010441	Aspergillus terreus	65.55	4.00e-47	180.00
IUUC-Ame-010807	Astyanax mexicanus	74.32	3.00e-61	226.00
IUUC-Bta-012802	Bos taurus	98.91	4.00e-85	306.00
IUUC-Bdi-014415	Brachypodium distachyon	60.13	5.00e-52	196.00
IUUC-Bol-016385	Brassica oleracea	58.67	1.00e-50	192.00
IUUC-Bra-016989	Brassica rapa	58.67	3.00e-50	191.00
IUUC-Cel-018412	Caenorhabditis elegans	66.45	7.00e-65	239.00
IUUC-Cja-019571	Callithrix jacchus	73.94	5.00e-62	229.00
IUUC-Cfa-020811	Canis familiaris	98.91	4.00e-85	306.00
IUUC-Cpo-021889	Cavia porcellus	91.26	2.00e-75	274.00
IUUC-Cre-022956	Chlamydomonas reinhardtii	56.86	1.00e-50	192.00
IUUC-Csa-023289	Chlorocebus sabaeus	98.91	4.00e-85	306.00
IUUC-Cho-024517	Choloepus hoffmanni	78.14	5.00e-56	209.00
IUUC-Cin-025571	Ciona intestinalis	62.89	5.00e-54	202.00
IUUC-Cgl-026627	Colletotrichum gloeosporioides	64.34	1.00e-51	195.00
IUUC-Cne-027006	Cryptococcus neoformans	57.46	6.00e-47	180.00
IUUC-Cme-027171	Cyanidioschyzon merolae	60.00	3.00e-53	201.00
IUUC-Dre-027450	Danio rerio	97.27	1.00e-84	305.00
IUUC-Dno-029838	Dasypus novemcinctus	98.91	4.00e-85	306.00
IUUC-Dor-031119	Dipodomys ordii	98.91	4.00e-85	306.00
IUUC-Dse-031243	Dothistroma septosporum	61.15	1.00e-56	212.00
IUUC-Dme-031807	Drosophila melanogaster	78.14	8.00e-77	279.00
IUUC-Ete-032437	Echinops telfairi	74.86	2.00e-62	231.00
IUUC-Eca-034123	Equus caballus	98.84	9.00e-79	285.00
IUUC-Eeu-034543	Erinaceus europaeus	95.59	7.00e-35	139.00
IUUC-Fca-035502	Felis catus	98.91	4.00e-85	306.00
IUUC-Fal-037054	Ficedula albicollis	98.79	2.00e-74	271.00
IUUC-Fox-037912	Fusarium oxysporum	68.69	8.00e-41	159.00
IUUC-Fso-038148	Fusarium solani	60.26	6.00e-51	192.00
IUUC-Gmo-038858	Gadus morhua	94.54	7.00e-90	322.00
IUUC-Ggr-039749	Gaeumannomyces graminis	63.78	5.00e-48	183.00
IUUC-Gga-040942	Gallus gallus	98.91	4.00e-85	306.00
IUUC-Gac-042079	Gasterosteus aculeatus	93.99	6.00e-89	319.00
IUUC-Gma-042856	Glycine max	62.75	2.00e-54	204.00
IUUC-Hsa-046545	Homo sapiens	98.91	4.00e-85	306.00
IUUC-Hvu-047746	Hordeum vulgare	59.44	7.00e-49	186.00
IUUC-Itr-048474	Ictidomys tridecemlineatus	98.91	4.00e-85	306.00
IUUC-Kpa-049144	Komagataella pastoris	65.91	2.00e-49	188.00
IUUC-Lch-050589	Latimeria chalumnae	91.80	2.00e-75	274.00
IUUC-Lpe-051335	Leersia perrieri	59.48	1.00e-51	195.00
IUUC-Loc-052829	Lepisosteus oculatus	97.81	1.00e-79	288.00
IUUC-Lma-052971	Leptosphaeria maculans	59.54	1.00e-45	176.00
IUUC-Laf-053526	Loxodonta africana	97.27	4.00e-83	300.00
IUUC-Mcc-055611	Macaca mulatta	98.91	4.00e-85	306.00
IUUC-Meu-056722	Macropus eugenii	58.79	1.00e-35	142.00
IUUC-Mor-057278	Magnaporthe oryzae	64.34	2.00e-51	194.00
IUUC-Mpo-057484	Magnaporthe poae	64.35	5.00e-46	176.00
IUUC-Mtr-058579	Medicago truncatula	58.71	7.00e-53	199.00
IUUC-Mla-058926	Melampsora laricipopulina	63.58	9.00e-57	212.00
IUUC-Mga-059801	Meleagris gallopavo	98.91	4.00e-85	306.00
IUUC-Mvi-060244	Microbotryum violaceum	61.94	2.00e-55	208.00
IUUC-Mmr-061205	Microcebus murinus	98.91	4.00e-85	306.00
IUUC-Mdo-062038	Monodelphis domestica	98.23	4.00e-42	162.00
IUUC-Mmu-063974	Mus musculus	98.91	4.00e-85	306.00
IUUC-Mac-065158	Musa acuminata	63.23	4.00e-56	210.00
IUUC-Mpu-066759	Mustela putorius furo	98.91	4.00e-85	306.00
IUUC-Mlu-067674	Myotis lucifugus	93.33	1.00e-74	271.00
IUUC-Nfi-068618	Neosartorya fischeri	61.54	2.00e-51	194.00
IUUC-Ncr-068712	Neurospora crassa	68.33	3.00e-50	190.00
IUUC-Nle-069926	Nomascus leucogenys	98.91	4.00e-85	306.00
IUUC-Opr-070598	Ochotona princeps	98.91	4.00e-85	306.00
IUUC-Ont-071893	Oreochromis niloticus	95.63	3.00e-87	313.00
IUUC-Oan-073273	Ornithorhynchus anatinus	98.79	2.00e-74	271.00
IUUC-Ocu-074357	Oryctolagus cuniculus	98.51	3.00e-77	280.00
IUUC-Oba-075055	Oryza barthii	59.48	1.00e-51	195.00
IUUC-Obr-076538	Oryza brachyantha	58.82	2.00e-51	194.00
IUUC-Ogl-077784	Oryza glaberrima	59.48	1.00e-51	195.00
IUUC-Ogu-078045	Oryza glumaepatula	59.48	1.00e-51	195.00
IUUC-Oin-079163	Oryza indica	59.48	1.00e-51	195.00
IUUC-Olo-080847	Oryza longistaminata	54.11	4.00e-43	167.00
IUUC-Ome-081586	Oryza meridionalis	55.15	4.00e-49	187.00
IUUC-Oni-082913	Oryza nivara	59.48	1.00e-51	195.00
IUUC-Opu-083651	Oryza punctata	59.48	1.00e-51	195.00
IUUC-Oru-084980	Oryza rufipogon	59.48	1.00e-51	195.00
IUUC-Osa-085334	Oryza sativa	59.44	3.00e-48	183.00
IUUC-Ola-087423	Oryzias latipes	95.63	3.00e-91	327.00
IUUC-Oga-088412	Otolemur garnettii	98.91	4.00e-85	306.00
IUUC-Oar-090282	Ovis aries	96.49	8.00e-75	272.00
IUUC-Ptr-090470	Pan troglodytes	98.91	4.00e-85	306.00
IUUC-Pan-092552	Papio anubis	98.91	4.00e-85	306.00
IUUC-Psi-093516	Pelodiscus sinensis	91.85	1.00e-75	275.00
IUUC-Pno-094800	Phaeosphaeria nodorum	67.31	2.00e-43	167.00
IUUC-Ppa-095962	Physcomitrella patens	58.06	3.00e-53	201.00
IUUC-Pfo-097374	Poecilia formosa	98.36	1.00e-84	305.00
IUUC-Pab-098112	Pongo abelii	98.91	4.00e-85	306.00
IUUC-Pop-099923	Populus trichocarpa	60.65	8.00e-54	202.00
IUUC-Pca-100436	Procavia capensis	80.99	9.00e-63	231.00
IUUC-Ppe-101144	Prunus persica	61.29	8.00e-54	202.00
IUUC-Pva-102776	Pteropus vampyrus	98.36	3.00e-83	300.00
IUUC-Pgr-103325	Puccinia graminis	63.24	8.00e-52	196.00
IUUC-Ptt-104010	Puccinia triticina	61.65	3.00e-47	181.00
IUUC-Pte-104024	Pyrenophora teres	55.81	4.00e-53	200.00
IUUC-Pyt-104715	Pyrenophora triticirepentis	63.64	1.00e-50	191.00
IUUC-Sce-106165	Saccharomyces cerevisiae	58.17	7.00e-43	166.00
IUUC-Sha-106524	Sarcophilus harrisii	98.79	4.00e-74	270.00
IUUC-Sja-107813	Schizosaccharomyces japonicus	60.93	5.00e-53	199.00
IUUC-Spo-108105	Schizosaccharomyces pombe	60.13	8.00e-54	202.00
IUUC-Ssl-108543	Sclerotinia sclerotiorum	54.84	8.00e-47	179.00
IUUC-Smo-108971	Selaginella moellendorffii	62.67	9.00e-55	206.00
IUUC-Sit-110211	Setaria italica	59.48	3.00e-51	195.00
IUUC-Sly-111324	Solanum lycopersicum	60.65	3.00e-54	204.00
IUUC-Stu-112525	Solanum tuberosum	59.48	7.00e-53	199.00
IUUC-Sar-113572	Sorex araneus	80.61	2.00e-50	191.00
IUUC-Sbi-113911	Sorghum bicolor	59.48	6.00e-52	196.00
IUUC-Sre-115027	Sporisorium reilianum	61.69	8.00e-58	216.00
IUUC-Ssc-116221	Sus scrofa	98.27	1.00e-76	278.00
IUUC-Tgu-116965	Taeniopygia guttata	98.79	4.00e-74	269.00
IUUC-Tru-117574	Takifugu rubripes	95.63	9.00e-79	285.00
IUUC-Tni-120422	Tetraodon nigroviridis	95.63	5.00e-79	286.00
IUUC-Tca-121140	Theobroma cacao	62.58	3.00e-55	207.00
IUUC-Tre-122110	Trichoderma reesei	64.12	4.00e-50	190.00
IUUC-Tvi-122592	Trichoderma virens	57.62	1.00e-48	184.00
IUUC-Tae-123045	Triticum aestivum	59.48	4.00e-52	196.00
IUUC-Tur-126414	Triticum urartu	58.82	1.00e-51	195.00
IUUC-Tme-127020	Tuber melanosporum	54.14	1.00e-39	155.00
IUUC-Tbe-128053	Tupaia belangeri	83.03	2.00e-54	204.00
IUUC-Ttr-128734	Tursiops truncatus	98.91	4.00e-85	306.00
IUUC-Uma-129334	Ustilago maydis	61.69	7.00e-58	216.00
IUUC-Vda-129953	Verticillium dahliae	57.14	8.00e-53	199.00
IUUC-Vpa-130729	Vicugna pacos	98.79	4.00e-74	269.00
IUUC-Vvi-131055	Vitis vinifera	59.49	2.00e-54	204.00
IUUC-Xtr-132368	Xenopus tropicalis	97.81	4.00e-84	303.00
IUUC-Xma-133864	Xiphophorus maculatus	98.36	1.00e-84	305.00
IUUC-Yli-134339	Yarrowia lipolytica	56.77	6.00e-56	209.00
IUUC-Zma-135728	Zea mays	58.50	5.00e-49	186.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence