iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-048111

Ensembl Protein ID

ENSSTOP00000021163.1

UniProt Accession

I3N9W6; I3N9W6_ICTTR

Genbank Protein ID

ENSSTOP00000021163

Protein Name

Ubiquitin-related modifier 1

Genbank Nucleotide ID

AGTP01020095

Gene Name

URM1; Urm1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000025351.1	ENSSTOT00000020118.1	ENSSTOP00000021163.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UBQ/UBQ_Other	63.04	2.00e-12	64.70	IUUC-Sce-106366

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ictidomys tridecemlineatus

Functional Description
(View)

Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.

Protein Sequence
(Fasta)

GGAELLFDGV KKHQVTLPGQ EEPWDIRNLL IWIKKNLLKE RPELFLQGDS VRPGILVLIN 60
DADWELLGEL DYQLQDQDSV LFISTLHGG 89

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Nucleotide Sequence
(Fasta)

AGGTGGTGCT GAGCTCCTAT TTGATGGTGT AAAAAAACAT CAAGTCACCT TGCCTGGGCA 60
GGAGGAGCCC TGTGAGTATT GGCTTTTTAA GCTGGGGTGG GGGAGTGGAT ATTGGGCAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway

Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1

Pfam

PF09138--Urm1

Gene Ontology

GO:0005829--C:cytosol
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002254	Ailuropoda melanoleuca	95.51	3.00e-46	176.00
IUUC-Atr-003089	Amborella trichopoda	58.24	1.00e-27	113.00
IUUC-Apl-003382	Anas platyrhynchos	89.89	8.00e-43	164.00
IUUC-Aca-004981	Anolis carolinensis	85.39	3.00e-42	162.00
IUUC-Aly-005517	Arabidopsis lyrata	54.95	2.00e-27	113.00
IUUC-Ath-006718	Arabidopsis thaliana	54.76	5.00e-24	102.00
IUUC-Ago-007917	Ashbya gossypii	43.96	2.00e-18	83.60
IUUC-Acl-008054	Aspergillus clavatus	64.00	7.00e-15	71.20
IUUC-Afl-008704	Aspergillus flavus	55.06	1.00e-20	90.50
IUUC-Aor-009890	Aspergillus oryzae	55.91	2.00e-22	96.70
IUUC-Bta-012448	Bos taurus	95.51	5.00e-46	174.00
IUUC-Bci-013865	Botrytis cinerea	45.16	1.00e-18	84.30
IUUC-Bdi-014980	Brachypodium distachyon	62.34	5.00e-24	101.00
IUUC-Bol-016055	Brassica oleracea	52.50	2.00e-23	99.80
IUUC-Bra-016845	Brassica rapa	52.50	2.00e-23	99.80
IUUC-Cel-018485	Caenorhabditis elegans	36.56	3.00e-10	55.80
IUUC-Cja-019587	Callithrix jacchus	97.75	1.00e-46	176.00
IUUC-Cfa-020653	Canis familiaris	94.38	8.00e-46	174.00
IUUC-Cpo-021622	Cavia porcellus	97.75	1.00e-46	176.00
IUUC-Cre-023015	Chlamydomonas reinhardtii	54.44	5.00e-23	98.60
IUUC-Csa-023756	Chlorocebus sabaeus	95.52	1.00e-33	134.00
IUUC-Cgl-026518	Colletotrichum gloeosporioides	45.16	2.00e-18	84.00
IUUC-Cne-026953	Cryptococcus neoformans	56.84	3.00e-25	107.00
IUUC-Cme-027314	Cyanidioschyzon merolae	50.77	3.00e-16	75.90
IUUC-Dre-027884	Danio rerio	79.78	3.00e-39	152.00
IUUC-Dno-029262	Dasypus novemcinctus	91.18	3.00e-32	130.00
IUUC-Dor-030601	Dipodomys ordii	86.15	3.00e-24	102.00
IUUC-Dme-031893	Drosophila melanogaster	68.54	1.00e-30	123.00
IUUC-Ete-032773	Echinops telfairi	93.18	4.00e-44	168.00
IUUC-Eca-034187	Equus caballus	96.63	2.00e-46	176.00
IUUC-Eeu-034808	Erinaceus europaeus	91.01	9.00e-45	170.00
IUUC-Fca-036107	Felis catus	93.26	1.00e-45	173.00
IUUC-Fal-036607	Ficedula albicollis	88.76	2.00e-42	162.00
IUUC-Fox-037698	Fusarium oxysporum	47.31	1.00e-19	87.80
IUUC-Gmo-039492	Gadus morhua	78.65	7.00e-39	150.00
IUUC-Ggr-039965	Gaeumannomyces graminis	48.39	8.00e-18	82.40
IUUC-Gga-041268	Gallus gallus	89.89	4.00e-43	165.00
IUUC-Gac-042111	Gasterosteus aculeatus	82.02	9.00e-41	157.00
IUUC-Gma-043240	Glycine max	53.57	7.00e-23	98.20
IUUC-Ggo-045176	Gorilla gorilla	95.52	4.00e-25	106.00
IUUC-Hsa-046077	Homo sapiens	96.63	5.00e-38	148.00
IUUC-Kpa-049157	Komagataella pastoris	47.25	2.00e-17	79.70
IUUC-Lch-049889	Latimeria chalumnae	78.65	1.00e-39	153.00
IUUC-Lpe-050783	Leersia perrieri	59.04	3.00e-23	99.00
IUUC-Loc-052400	Lepisosteus oculatus	79.78	2.00e-39	152.00
IUUC-Lma-053259	Leptosphaeria maculans	47.31	1.00e-18	84.00
IUUC-Laf-053596	Loxodonta africana	94.51	1.00e-44	170.00
IUUC-Mcc-054845	Macaca mulatta	95.51	7.00e-46	174.00
IUUC-Meu-055968	Macropus eugenii	93.26	1.00e-44	170.00
IUUC-Mor-057126	Magnaporthe oryzae	46.24	2.00e-16	77.80
IUUC-Mpo-057311	Magnaporthe poae	48.39	1.00e-18	85.10
IUUC-Mtr-058266	Medicago truncatula	51.16	1.00e-22	97.10
IUUC-Mla-058847	Melampsora laricipopulina	41.05	2.00e-10	57.40
IUUC-Mga-059468	Meleagris gallopavo	89.89	7.00e-43	164.00
IUUC-Mvi-060235	Microbotryum violaceum	56.16	4.00e-17	80.10
IUUC-Mdo-061948	Monodelphis domestica	92.13	2.00e-44	169.00
IUUC-Mmu-063946	Mus musculus	95.51	6.00e-46	174.00
IUUC-Mac-064812	Musa acuminata	58.33	8.00e-25	104.00
IUUC-Mpu-066763	Mustela putorius furo	94.38	6.00e-45	171.00
IUUC-Mlu-066970	Myotis lucifugus	97.01	8.00e-34	134.00
IUUC-Ncr-068824	Neurospora crassa	46.24	1.00e-17	80.90
IUUC-Nle-069849	Nomascus leucogenys	94.03	3.00e-33	133.00
IUUC-Opr-070227	Ochotona princeps	97.75	1.00e-46	176.00
IUUC-Ont-072530	Oreochromis niloticus	84.27	1.00e-41	160.00
IUUC-Oan-073191	Ornithorhynchus anatinus	85.39	3.00e-41	159.00
IUUC-Ocu-074460	Oryctolagus cuniculus	94.38	1.00e-45	173.00
IUUC-Oba-075499	Oryza barthii	68.75	8.00e-23	99.00
IUUC-Obr-076896	Oryza brachyantha	58.75	3.00e-22	97.80
IUUC-Ogl-077834	Oryza glaberrima	68.75	2.00e-23	99.80
IUUC-Ogu-078622	Oryza glumaepatula	68.75	2.00e-23	99.80
IUUC-Oin-079358	Oryza indica	68.75	8.00e-23	99.80
IUUC-Olo-081035	Oryza longistaminata	56.25	1.00e-23	102.00
IUUC-Oni-082425	Oryza nivara	68.75	2.00e-23	99.80
IUUC-Opu-083461	Oryza punctata	68.25	1.00e-22	98.20
IUUC-Oru-084875	Oryza rufipogon	61.97	3.00e-21	92.40
IUUC-Oga-089128	Otolemur garnettii	95.51	4.00e-46	175.00
IUUC-Oar-089896	Ovis aries	95.51	5.00e-46	174.00
IUUC-Ptr-091618	Pan troglodytes	95.52	4.00e-25	106.00
IUUC-Pan-092238	Papio anubis	95.52	1.00e-33	134.00
IUUC-Psi-093879	Pelodiscus sinensis	86.52	3.00e-42	162.00
IUUC-Pma-094484	Petromyzon marinus	78.48	1.00e-33	133.00
IUUC-Ppa-095801	Physcomitrella patens	58.02	2.00e-22	96.30
IUUC-Pfo-097192	Poecilia formosa	80.90	2.00e-40	155.00
IUUC-Pab-098203	Pongo abelii	96.63	5.00e-38	148.00
IUUC-Pop-099614	Populus trichocarpa	55.95	5.00e-24	101.00
IUUC-Pca-100507	Procavia capensis	95.52	1.00e-33	133.00
IUUC-Ppe-101174	Prunus persica	56.04	5.00e-26	108.00
IUUC-Pva-102735	Pteropus vampyrus	95.51	8.00e-43	164.00
IUUC-Pgr-103510	Puccinia graminis	38.95	2.00e-09	53.90
IUUC-Ptt-103918	Puccinia triticina	34.74	1.00e-07	48.10
IUUC-Pte-104173	Pyrenophora teres	49.46	2.00e-20	90.10
IUUC-Pyt-104806	Pyrenophora triticirepentis	49.46	2.00e-20	89.70
IUUC-Rno-105820	Rattus norvegicus	95.51	7.00e-46	174.00
IUUC-Sce-106366	Saccharomyces cerevisiae	40.66	3.00e-15	72.40
IUUC-Sja-107727	Schizosaccharomyces japonicus	42.05	3.00e-14	69.70
IUUC-Spo-108074	Schizosaccharomyces pombe	40.00	7.00e-08	48.10
IUUC-Smo-108944	Selaginella moellendorffii	61.80	1.00e-26	110.00
IUUC-Sit-110277	Setaria italica	57.14	1.00e-23	100.00
IUUC-Sly-111505	Solanum lycopersicum	54.76	2.00e-24	103.00
IUUC-Stu-112076	Solanum tuberosum	55.95	6.00e-25	104.00
IUUC-Sbi-114274	Sorghum bicolor	58.44	1.00e-23	100.00
IUUC-Sre-114953	Sporisorium reilianum	59.57	2.00e-24	103.00
IUUC-Ssc-115418	Sus scrofa	94.38	7.00e-46	174.00
IUUC-Tgu-117311	Taeniopygia guttata	89.89	2.00e-42	162.00
IUUC-Tru-118598	Takifugu rubripes	82.02	2.00e-40	155.00
IUUC-Tni-120109	Tetraodon nigroviridis	78.89	2.00e-37	146.00
IUUC-Tca-120942	Theobroma cacao	55.42	3.00e-23	99.40
IUUC-Tre-122099	Trichoderma reesei	48.39	1.00e-15	73.60
IUUC-Tvi-122285	Trichoderma virens	50.54	1.00e-16	77.40
IUUC-Tae-125193	Triticum aestivum	56.63	5.00e-23	98.60
IUUC-Tur-126677	Triticum urartu	49.47	2.00e-20	90.50
IUUC-Tme-127120	Tuber melanosporum	49.46	2.00e-20	90.10
IUUC-Tbe-128050	Tupaia belangeri	68.54	4.00e-27	112.00
IUUC-Ttr-129019	Tursiops truncatus	93.26	4.00e-43	165.00
IUUC-Uma-129483	Ustilago maydis	58.51	2.00e-22	97.10
IUUC-Vda-129690	Verticillium dahliae	41.07	2.00e-16	77.00
IUUC-Vvi-131174	Vitis vinifera	56.63	3.00e-24	102.00
IUUC-Xma-133862	Xiphophorus maculatus	80.90	2.00e-40	155.00
IUUC-Yli-134398	Yarrowia lipolytica	48.35	3.00e-17	79.30
IUUC-Zma-134964	Zea mays	60.98	5.00e-23	98.60

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence