iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
miRNAMap	RAID2
Protein-protein Interaction
IID	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.40e-39	132.7	205	238
UBD/Beta-Prp	5.70e-49	168.0	569	828

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf....sdtllvsGsdDgtikvWDl 30
           gH+d+++++++     d +l+s+s D+ i++W+l
   Q: 205  GHEDWIRGVEWatfgRDLFLASCSQDCLIRIWRL 238
           8************998799*************96 PP

UBD/Beta-Prp

   S: 12   vitcvkfspdksllatgsrdgt.....ikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvw.....dls........ 82
            i cv++ ++k+lla++++ +      i++w++ ++k ++sl  h+ +vt+++fspd+k+l+ +s+Drt  +w       s        
   Q: 569  EIVCVACNNSKTLLASACKASQkehaaIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLWkrqdaTSSefdpffsl 657
           46679999*********97543233339*********************************************7775433345555555 PP
   S: 83   .tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee................tlsghdgvvncvvvhpdg.nllv 153
            +++  +t   h++ ++s+++sp+++++ +Gs+d+ + vw    g+c ++                + s  ++v  c v++p +  +++
   Q: 658  fAFTNKITS-VHSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECKSShnpmehpirpcssildVGSSVTAVSVCPVLNPAQrYIVA 741
           433333333.48899999**********************....555544557789*******9999999999999********55566 PP
   S: 154  sGslDrtvrlWdl.ktgkllrtl.........tgghtdsvyslsfdsng....................kelvsgsldgtvklwdlqt 211
            G   +++ +++  kt++ + ++         ++ h   ++ l ++s +                     +++s+++d tvk++ + +
   Q: 742  IGLESGKICIYSWnKTNQEINDWtscvetnpsQS-HSLGIRRLCWKSCSddddddddddteqseegpewLHFASCGEDHTVKIYRVNR 828
           69999******99956666666655544447444.7777777775555566678888899999999*99***************9875 PP

Organism

Mus musculus

Functional Description
(View)

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4 (By similarity).

Protein Sequence
(Fasta)

MVSSVLEVSH VFCCPNRVRG ALSWNTGPGG LLAFGTSCSV VLYDPQKKVV ITNLNGHTAR 60
VNCLQWIRTE DGSPSNELVS GGSDNRVIHW ELENNQVLKS VRLQGHEGPV CAVHAIYQSG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGGAGGAG CTCGGCCATT GACCACCTAG CATCATGGTT TCTTCTGTGC TGGAGGTGTC 60
TCATGTGTTT TGCTGCCCGA ACCGGGTTCG AGGAGCTTTG AGTTGGAATA CCGGGCCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR027295--Quinoprotein_ADH-like_fam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0033588--C:Elongator holoenzyme complex
GO:0000123--C:histone acetyltransferase complex
GO:0000502--C:proteasome complex
GO:0008023--C:transcription elongation factor complex
GO:0061133--F:endopeptidase activator activity
GO:0019901--F:protein kinase binding
GO:0043248--P:proteasome assembly
GO:0046425--P:regulation of JAK-STAT cascade
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006368--P:transcription elongation from RNA polymerase II promoter

KEGG

mmu:58523

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000056	Aegilops tauschii	32.69	1.00e-114	407.00
IUUC-Aml-002049	Ailuropoda melanoleuca	66.40	0.00e+00	947.00
IUUC-Atr-002456	Amborella trichopoda	35.22	2.00e-122	433.00
IUUC-Apl-004053	Anas platyrhynchos	63.75	0.00e+00	1035.00
IUUC-Aca-004535	Anolis carolinensis	55.09	0.00e+00	927.00
IUUC-Aly-005746	Arabidopsis lyrata	34.33	2.00e-118	420.00
IUUC-Ath-006664	Arabidopsis thaliana	34.18	2.00e-114	407.00
IUUC-Ago-007971	Ashbya gossypii	32.36	6.00e-93	335.00
IUUC-Acl-008173	Aspergillus clavatus	32.76	1.00e-107	384.00
IUUC-Afl-008665	Aspergillus flavus	27.80	2.00e-35	144.00
IUUC-Afu-008976	Aspergillus fumigatus	32.22	7.00e-104	371.00
IUUC-Ani-009284	Aspergillus nidulans	31.70	1.00e-101	364.00
IUUC-Ang-009809	Aspergillus niger	32.25	3.00e-98	353.00
IUUC-Aor-009959	Aspergillus oryzae	31.99	6.00e-100	358.00
IUUC-Ate-010442	Aspergillus terreus	30.29	4.00e-96	346.00
IUUC-Ame-011409	Astyanax mexicanus	52.35	0.00e+00	865.00
IUUC-Bgr-012137	Blumeria graminis	32.56	6.00e-108	385.00
IUUC-Bta-012892	Bos taurus	77.57	0.00e+00	1355.00
IUUC-Bci-013944	Botrytis cinerea	30.80	2.00e-89	324.00
IUUC-Bdi-014512	Brachypodium distachyon	34.15	3.00e-119	422.00
IUUC-Bol-015741	Brassica oleracea	34.18	6.00e-121	428.00
IUUC-Bra-017367	Brassica rapa	34.22	2.00e-121	429.00
IUUC-Cel-018712	Caenorhabditis elegans	32.59	4.00e-89	322.00
IUUC-Cja-018865	Callithrix jacchus	62.47	0.00e+00	1094.00
IUUC-Cfa-021006	Canis familiaris	78.01	0.00e+00	1347.00
IUUC-Cpo-021370	Cavia porcellus	76.22	0.00e+00	1308.00
IUUC-Csa-023845	Chlorocebus sabaeus	78.14	0.00e+00	1367.00
IUUC-Cho-024640	Choloepus hoffmanni	79.63	0.00e+00	823.00
IUUC-Cin-025772	Ciona intestinalis	41.78	1.00e-156	546.00
IUUC-Csv-025891	Ciona savignyi	37.75	3.00e-151	529.00
IUUC-Cgl-026443	Colletotrichum gloeosporioides	32.02	4.00e-101	362.00
IUUC-Cne-027081	Cryptococcus neoformans	30.38	5.00e-97	348.00
IUUC-Cme-027225	Cyanidioschyzon merolae	27.84	1.00e-48	188.00
IUUC-Dre-028250	Danio rerio	53.79	0.00e+00	882.00
IUUC-Dno-028847	Dasypus novemcinctus	76.32	0.00e+00	1326.00
IUUC-Dor-030351	Dipodomys ordii	75.42	0.00e+00	1285.00
IUUC-Dse-031317	Dothistroma septosporum	31.99	2.00e-101	363.00
IUUC-Dme-032019	Drosophila melanogaster	41.30	8.00e-176	610.00
IUUC-Ete-033194	Echinops telfairi	71.11	0.00e+00	715.00
IUUC-Eca-033779	Equus caballus	77.54	0.00e+00	1350.00
IUUC-Eeu-034790	Erinaceus europaeus	62.80	0.00e+00	1023.00
IUUC-Fca-036090	Felis catus	79.05	0.00e+00	1268.00
IUUC-Fal-037663	Ficedula albicollis	56.68	0.00e+00	904.00
IUUC-Fox-037828	Fusarium oxysporum	29.54	3.00e-98	353.00
IUUC-Fso-038462	Fusarium solani	31.16	3.00e-99	356.00
IUUC-Gmo-039450	Gadus morhua	54.64	0.00e+00	919.00
IUUC-Ggr-040023	Gaeumannomyces graminis	30.02	8.00e-87	315.00
IUUC-Gga-040480	Gallus gallus	62.29	0.00e+00	1062.00
IUUC-Gac-041544	Gasterosteus aculeatus	56.24	0.00e+00	955.00
IUUC-Gma-044048	Glycine max	35.31	7.00e-129	454.00
IUUC-Ggo-045381	Gorilla gorilla	73.02	0.00e+00	1254.00
IUUC-Hsa-046096	Homo sapiens	65.97	0.00e+00	1171.00
IUUC-Hvu-047494	Hordeum vulgare	33.29	8.00e-122	431.00
IUUC-Itr-048823	Ictidomys tridecemlineatus	73.15	0.00e+00	980.00
IUUC-Kpa-049241	Komagataella pastoris	30.79	8.00e-98	351.00
IUUC-Lch-050512	Latimeria chalumnae	60.53	0.00e+00	845.00
IUUC-Lpe-051448	Leersia perrieri	33.80	9.00e-120	424.00
IUUC-Loc-051882	Lepisosteus oculatus	56.43	0.00e+00	966.00
IUUC-Lma-053023	Leptosphaeria maculans	34.18	2.00e-108	387.00
IUUC-Laf-054519	Loxodonta africana	76.46	0.00e+00	1332.00
IUUC-Mcc-055580	Macaca mulatta	72.24	0.00e+00	1298.00
IUUC-Meu-056606	Macropus eugenii	54.74	1.00e-128	453.00
IUUC-Mor-057109	Magnaporthe oryzae	32.00	5.00e-98	352.00
IUUC-Mpo-057297	Magnaporthe poae	27.61	3.00e-86	313.00
IUUC-Mtr-058348	Medicago truncatula	35.41	5.00e-129	455.00
IUUC-Mla-059159	Melampsora laricipopulina	29.20	4.00e-80	293.00
IUUC-Mga-059778	Meleagris gallopavo	54.57	0.00e+00	643.00
IUUC-Mvi-060447	Microbotryum violaceum	32.13	4.00e-111	395.00
IUUC-Mmr-061139	Microcebus murinus	65.93	0.00e+00	1159.00
IUUC-Mdo-061866	Monodelphis domestica	67.38	0.00e+00	1174.00
IUUC-Mac-064693	Musa acuminata	35.17	5.00e-126	445.00
IUUC-Mpu-066547	Mustela putorius furo	77.66	0.00e+00	1326.00
IUUC-Mlu-067156	Myotis lucifugus	76.91	0.00e+00	1363.00
IUUC-Nfi-068616	Neosartorya fischeri	33.18	9.00e-106	378.00
IUUC-Ncr-068915	Neurospora crassa	28.50	5.00e-87	315.00
IUUC-Nle-069958	Nomascus leucogenys	76.05	0.00e+00	1310.00
IUUC-Opr-071093	Ochotona princeps	72.61	7.00e-166	577.00
IUUC-Ont-072178	Oreochromis niloticus	55.62	0.00e+00	947.00
IUUC-Oan-073667	Ornithorhynchus anatinus	63.05	0.00e+00	1074.00
IUUC-Ocu-074662	Oryctolagus cuniculus	76.79	0.00e+00	1352.00
IUUC-Oba-075577	Oryza barthii	35.57	2.00e-127	449.00
IUUC-Obr-076566	Oryza brachyantha	34.52	9.00e-127	447.00
IUUC-Ogl-077054	Oryza glaberrima	35.52	2.00e-127	449.00
IUUC-Ogu-078846	Oryza glumaepatula	35.57	4.00e-127	449.00
IUUC-Oin-079084	Oryza indica	35.48	4.00e-127	449.00
IUUC-Olo-080933	Oryza longistaminata	32.25	1.00e-101	364.00
IUUC-Ome-081500	Oryza meridionalis	33.02	3.00e-109	389.00
IUUC-Oni-082352	Oryza nivara	35.19	2.00e-125	443.00
IUUC-Opu-084116	Oryza punctata	34.66	7.00e-121	428.00
IUUC-Oru-085249	Oryza rufipogon	35.48	4.00e-127	449.00
IUUC-Osa-086270	Oryza sativa	35.48	4.00e-127	449.00
IUUC-Ola-086625	Oryzias latipes	50.64	0.00e+00	821.00
IUUC-Olu-087638	Ostreococcus lucimarinus	33.24	6.00e-82	298.00
IUUC-Oga-088634	Otolemur garnettii	62.68	0.00e+00	1093.00
IUUC-Oar-089475	Ovis aries	77.09	0.00e+00	1323.00
IUUC-Ptr-091131	Pan troglodytes	78.26	0.00e+00	1367.00
IUUC-Pan-092869	Papio anubis	77.55	0.00e+00	1348.00
IUUC-Psi-093146	Pelodiscus sinensis	66.86	0.00e+00	949.00
IUUC-Pma-094479	Petromyzon marinus	52.20	0.00e+00	642.00
IUUC-Pno-095061	Phaeosphaeria nodorum	30.69	3.00e-69	256.00
IUUC-Ppa-095618	Physcomitrella patens	35.69	1.00e-130	461.00
IUUC-Pfo-096816	Poecilia formosa	55.91	0.00e+00	934.00
IUUC-Pab-097548	Pongo abelii	77.66	0.00e+00	1360.00
IUUC-Pop-099643	Populus trichocarpa	36.55	1.00e-134	474.00
IUUC-Pca-100983	Procavia capensis	77.54	0.00e+00	704.00
IUUC-Ppe-101301	Prunus persica	34.68	3.00e-127	449.00
IUUC-Pva-102460	Pteropus vampyrus	77.78	0.00e+00	1349.00
IUUC-Pgr-103507	Puccinia graminis	30.15	7.00e-82	298.00
IUUC-Ptt-103892	Puccinia triticina	28.59	4.00e-67	249.00
IUUC-Pte-104283	Pyrenophora teres	34.65	7.00e-104	371.00
IUUC-Pyt-104465	Pyrenophora triticirepentis	34.21	2.00e-101	363.00
IUUC-Rno-105842	Rattus norvegicus	88.70	0.00e+00	1494.00
IUUC-Sce-106459	Saccharomyces cerevisiae	31.12	4.00e-98	352.00
IUUC-Sha-106586	Sarcophilus harrisii	47.29	0.00e+00	765.00
IUUC-Sja-107868	Schizosaccharomyces japonicus	30.08	4.00e-85	309.00
IUUC-Spo-108302	Schizosaccharomyces pombe	32.70	3.00e-91	329.00
IUUC-Smo-108861	Selaginella moellendorffii	35.58	2.00e-129	456.00
IUUC-Sit-109915	Setaria italica	34.60	6.00e-126	445.00
IUUC-Sly-111714	Solanum lycopersicum	35.61	2.00e-131	463.00
IUUC-Stu-112631	Solanum tuberosum	35.31	4.00e-129	455.00
IUUC-Sar-113200	Sorex araneus	67.11	0.00e+00	1116.00
IUUC-Sbi-114582	Sorghum bicolor	34.97	5.00e-126	445.00
IUUC-Sre-115001	Sporisorium reilianum	28.37	6.00e-53	203.00
IUUC-Ssc-115519	Sus scrofa	77.54	0.00e+00	1351.00
IUUC-Tgu-116987	Taeniopygia guttata	61.76	0.00e+00	1029.00
IUUC-Tru-118476	Takifugu rubripes	53.42	0.00e+00	887.00
IUUC-Tsy-119230	Tarsius syrichta	64.42	3.00e-147	515.00
IUUC-Tni-120448	Tetraodon nigroviridis	38.47	9.00e-147	514.00
IUUC-Tca-121650	Theobroma cacao	34.73	2.00e-128	452.00
IUUC-Tre-122086	Trichoderma reesei	32.09	1.00e-97	351.00
IUUC-Tvi-122397	Trichoderma virens	32.70	9.00e-95	341.00
IUUC-Tae-125778	Triticum aestivum	33.69	3.00e-123	436.00
IUUC-Tur-126578	Triticum urartu	33.72	5.00e-122	432.00
IUUC-Tme-126927	Tuber melanosporum	31.53	1.00e-91	331.00
IUUC-Tbe-127922	Tupaia belangeri	64.58	8.00e-114	404.00
IUUC-Ttr-128918	Tursiops truncatus	78.61	0.00e+00	1364.00
IUUC-Uma-129474	Ustilago maydis	25.50	4.00e-42	167.00
IUUC-Vda-129944	Verticillium dahliae	31.62	3.00e-92	333.00
IUUC-Vpa-130693	Vicugna pacos	75.15	0.00e+00	1287.00
IUUC-Vvi-130949	Vitis vinifera	34.67	2.00e-124	439.00
IUUC-Xtr-132639	Xenopus tropicalis	51.11	0.00e+00	858.00
IUUC-Xma-134223	Xiphophorus maculatus	58.14	1.00e-171	596.00
IUUC-Yli-134601	Yarrowia lipolytica	33.60	3.00e-108	385.00
IUUC-Zma-135952	Zea mays	35.29	3.00e-127	449.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence