iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-027849

Ensembl Protein ID

ENSDARP00000127139.1

UniProt Accession

F1QCM5; F1QCM5_DANRE

Genbank Protein ID

ENSDARP00000062779

Protein Name

Intersectin 2a

Genbank Nucleotide ID

BX322665

Gene Name

itsn2a

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000000161.12	ENSDART00000153266.1	ENSDARP00000127139.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.10e-49	167.2	1075	1127

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           +v+++ydy+a+n+de++++kG  ++v+  ++ + +W+kg  e +g  GlfP n+v+ 
   Q: 1075 QVIAMYDYKAANKDEMSFQKGQLITVL--NKDNPDWWKG--EVAGVTGLFPTNYVKM 1127
           689************************..77899*****..9*************85 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MNGGFSIWAI TPEERGKHDK QFDSLAPTLG YLSGDQARKF FLQSGLPTSV LADIWALADI 60
GKDGKMDRLE FSIAMKLIKL QLQGQPLPSS LPIIMKQTPT PVMTSSSRFG MGSMPNLSAM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGACGTCAG CCCTATCACT TGTGGAGAGT GAAGCGACGC CGCAGTCCGC GATCTGCAGT 60
GAGAGAGCAG GTACAGCCGA TCCCTTACCT GGAAACCTCA ACCGCACGTC CTCCGTTATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1185--Reference proteome

Interpro

IPR000008--C2_dom
IPR000219--DH-domain
IPR011992--EF-hand-dom_pair
IPR002048--EF_hand_dom
IPR000261--EH_dom
IPR001331--GDS_CDC24_CS
IPR027029--Intersectin-2
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50004--C2
PS00741--DH_1
PS50010--DH_2
PS50222--EF_HAND_2
PS50031--EH
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF00168--C2
PF12763--EF-hand_4
PF16652--PH_13
PF00621--RhoGEF
PF00018--SH3_1
PF07653--SH3_2
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN

SMART

SM00239--C2
SM00054--EFh
SM00027--EH
SM00233--PH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005622--C:intracellular
GO:0005509--F:calcium ion binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0006897--P:endocytosis
GO:0035556--P:intracellular signal transduction
GO:0035023--P:regulation of Rho protein signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001455	Ailuropoda melanoleuca	65.06	0.00e+00	1245.00
IUUC-Apl-004205	Anas platyrhynchos	56.75	0.00e+00	1335.00
IUUC-Aca-004287	Anolis carolinensis	60.90	0.00e+00	1253.00
IUUC-Ame-011759	Astyanax mexicanus	80.98	0.00e+00	1536.00
IUUC-Bta-013248	Bos taurus	64.31	0.00e+00	1223.00
IUUC-Cel-018490	Caenorhabditis elegans	29.57	6.00e-44	173.00
IUUC-Cfa-020628	Canis familiaris	65.17	0.00e+00	1246.00
IUUC-Csa-023122	Chlorocebus sabaeus	64.86	0.00e+00	1244.00
IUUC-Cne-026918	Cryptococcus neoformans	36.39	1.00e-40	162.00
IUUC-Dno-029419	Dasypus novemcinctus	64.35	0.00e+00	1235.00
IUUC-Dme-032099	Drosophila melanogaster	30.37	6.00e-50	193.00
IUUC-Eca-034196	Equus caballus	62.61	0.00e+00	1181.00
IUUC-Fca-035757	Felis catus	65.06	0.00e+00	1240.00
IUUC-Fal-037531	Ficedula albicollis	65.38	0.00e+00	1246.00
IUUC-Gmo-039555	Gadus morhua	72.16	0.00e+00	1162.00
IUUC-Gac-041320	Gasterosteus aculeatus	56.03	0.00e+00	1299.00
IUUC-Ggo-045405	Gorilla gorilla	65.07	0.00e+00	1245.00
IUUC-Hsa-046833	Homo sapiens	65.07	0.00e+00	1245.00
IUUC-Kpa-049215	Komagataella pastoris	36.17	2.00e-15	77.80
IUUC-Lch-050094	Latimeria chalumnae	66.06	0.00e+00	1278.00
IUUC-Loc-052646	Lepisosteus oculatus	69.00	0.00e+00	1337.00
IUUC-Mcc-054709	Macaca mulatta	64.96	0.00e+00	1245.00
IUUC-Mmu-064226	Mus musculus	63.68	0.00e+00	1248.00
IUUC-Mpu-066431	Mustela putorius furo	65.28	0.00e+00	1252.00
IUUC-Opr-070815	Ochotona princeps	56.55	0.00e+00	1021.00
IUUC-Ont-072464	Oreochromis niloticus	67.55	0.00e+00	1278.00
IUUC-Ocu-073856	Oryctolagus cuniculus	54.84	0.00e+00	1206.00
IUUC-Ola-087489	Oryzias latipes	63.12	0.00e+00	1135.00
IUUC-Oga-088449	Otolemur garnettii	64.54	0.00e+00	1238.00
IUUC-Oar-090275	Ovis aries	64.84	0.00e+00	1238.00
IUUC-Ptr-091667	Pan troglodytes	64.86	0.00e+00	1240.00
IUUC-Pfo-096864	Poecilia formosa	63.54	0.00e+00	1212.00
IUUC-Pab-098755	Pongo abelii	62.19	0.00e+00	1176.00
IUUC-Pva-102433	Pteropus vampyrus	55.56	0.00e+00	1014.00
IUUC-Pgr-103473	Puccinia graminis	32.74	2.00e-40	162.00
IUUC-Ptt-103973	Puccinia triticina	25.40	7.00e-28	120.00
IUUC-Sar-112978	Sorex araneus	56.94	0.00e+00	639.00
IUUC-Sre-115028	Sporisorium reilianum	35.27	2.00e-33	139.00
IUUC-Ssc-115562	Sus scrofa	59.94	0.00e+00	1118.00
IUUC-Tgu-116758	Taeniopygia guttata	65.20	0.00e+00	1240.00
IUUC-Tru-117714	Takifugu rubripes	64.32	0.00e+00	1186.00
IUUC-Tni-119958	Tetraodon nigroviridis	66.99	0.00e+00	1242.00
IUUC-Ttr-129196	Tursiops truncatus	62.98	0.00e+00	1192.00
IUUC-Uma-129456	Ustilago maydis	31.52	3.00e-33	139.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence