iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	2.70e-41	140.6	6	141

Active Site

Position(s)	Description	Evidence
86	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWspalsv 98
           Rl+kel++l+ +  ++++    d+++l +w  li+ p++ pY++g+F++ei+fp +YPfkPPk++f t+i+hPn++e+G+vCl i+ ++e+W+pa+  
   Q: 6    RLRKELSDLQGNALKSFRDIKADDDNLLRWTGLIV-PDNPPYNKGAFRIEINFPAEYPFKPPKINFKTRIYHPNIDEKGQVCLPII-STENWKPATRT 101
           99****************9999999**********.**************************************************.5********** PP
   S: 99   esvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
            +v+ +++ l+++p+pe+pl++e ae++ k+r+++ k+++
   Q: 102  DQVVQALVDLINDPEPEHPLRAELAEEFLKDRKKFVKNAE 141
           ***********************************99985 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MTAPRRLRKE LSDLQGNALK SFRDIKADDD NLLRWTGLIV PDNPPYNKGA FRIEINFPAE 60
YPFKPPKINF KTRIYHPNID EKGQVCLPII STENWKPATR TDQVVQALVD LINDPEPEHP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAATTGGAAG ATTCTTCAAC GAACCATTTT CAGCGAAATT CGCAGACTTA CGTGCGGATT 60
TTTTTGGGCC AGTGCGAAAA CCAAAGGTGA CACCCCGCAA CTGGAGCACT AGGAGCTCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005524--F:ATP binding
GO:0016874--F:ligase activity
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0022008--P:neurogenesis
GO:0097039--P:protein linear polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0019233--P:sensory perception of pain

KEGG

dme:Dmel_CG5788

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001446	Ailuropoda melanoleuca	81.42	3.00e-44	169.00
IUUC-Apl-003318	Anas platyrhynchos	73.97	5.00e-55	205.00
IUUC-Aca-005234	Anolis carolinensis	73.65	2.00e-55	206.00
IUUC-Ame-011452	Astyanax mexicanus	72.97	2.00e-55	206.00
IUUC-Bta-012693	Bos taurus	73.97	5.00e-55	205.00
IUUC-Cel-018332	Caenorhabditis elegans	59.87	1.00e-58	217.00
IUUC-Cja-019062	Callithrix jacchus	74.03	2.00e-58	216.00
IUUC-Cfa-020027	Canis familiaris	74.03	2.00e-58	216.00
IUUC-Cpo-022341	Cavia porcellus	74.03	2.00e-58	216.00
IUUC-Csa-023794	Chlorocebus sabaeus	50.33	2.00e-41	160.00
IUUC-Cho-024821	Choloepus hoffmanni	52.78	9.00e-42	161.00
IUUC-Cin-025130	Ciona intestinalis	68.18	6.00e-48	182.00
IUUC-Csv-026183	Ciona savignyi	66.23	2.00e-49	186.00
IUUC-Dre-027710	Danio rerio	73.38	1.00e-58	218.00
IUUC-Dno-029371	Dasypus novemcinctus	82.05	3.00e-46	175.00
IUUC-Dor-031017	Dipodomys ordii	71.43	8.00e-54	201.00
IUUC-Ete-032754	Echinops telfairi	74.03	2.00e-58	216.00
IUUC-Eca-034056	Equus caballus	71.43	5.00e-56	208.00
IUUC-Eeu-034942	Erinaceus europaeus	74.03	2.00e-58	216.00
IUUC-Fca-036173	Felis catus	74.03	2.00e-58	216.00
IUUC-Fal-036820	Ficedula albicollis	74.48	4.00e-55	205.00
IUUC-Gmo-038480	Gadus morhua	73.10	2.00e-54	203.00
IUUC-Gga-041039	Gallus gallus	74.03	2.00e-58	216.00
IUUC-Gac-041571	Gasterosteus aculeatus	66.67	9.00e-50	187.00
IUUC-Ggo-044482	Gorilla gorilla	74.66	2.00e-55	206.00
IUUC-Hsa-046287	Homo sapiens	74.03	2.00e-58	216.00
IUUC-Itr-049057	Ictidomys tridecemlineatus	77.94	1.00e-53	200.00
IUUC-Lch-049699	Latimeria chalumnae	79.31	7.00e-43	165.00
IUUC-Loc-052000	Lepisosteus oculatus	73.08	2.00e-57	214.00
IUUC-Laf-053833	Loxodonta africana	73.47	5.00e-55	205.00
IUUC-Mcc-054978	Macaca mulatta	73.38	1.00e-68	251.00
IUUC-Meu-056738	Macropus eugenii	75.73	2.00e-35	139.00
IUUC-Mga-060134	Meleagris gallopavo	74.00	1.00e-54	204.00
IUUC-Mmr-061002	Microcebus murinus	73.47	9.00e-55	205.00
IUUC-Mdo-062043	Monodelphis domestica	60.96	3.00e-53	200.00
IUUC-Mmu-063615	Mus musculus	74.03	2.00e-58	216.00
IUUC-Mpu-066122	Mustela putorius furo	46.62	3.00e-38	149.00
IUUC-Mlu-067987	Myotis lucifugus	72.08	4.00e-67	245.00
IUUC-Nle-069967	Nomascus leucogenys	74.03	3.00e-69	253.00
IUUC-Opr-070315	Ochotona princeps	74.03	2.00e-58	216.00
IUUC-Ont-072036	Oreochromis niloticus	72.73	1.00e-57	214.00
IUUC-Oan-073297	Ornithorhynchus anatinus	56.36	3.00e-34	135.00
IUUC-Ocu-074565	Oryctolagus cuniculus	73.47	3.00e-55	206.00
IUUC-Ola-086994	Oryzias latipes	72.30	3.00e-64	236.00
IUUC-Oga-088173	Otolemur garnettii	72.55	5.00e-54	202.00
IUUC-Oar-089520	Ovis aries	73.47	3.00e-55	206.00
IUUC-Ptr-090890	Pan troglodytes	73.38	7.00e-68	248.00
IUUC-Pan-092445	Papio anubis	74.66	2.00e-55	206.00
IUUC-Psi-093376	Pelodiscus sinensis	73.97	5.00e-55	205.00
IUUC-Pma-094445	Petromyzon marinus	72.66	1.00e-49	187.00
IUUC-Pfo-096258	Poecilia formosa	72.73	2.00e-57	213.00
IUUC-Pab-097654	Pongo abelii	74.03	2.00e-58	216.00
IUUC-Pca-100712	Procavia capensis	59.09	2.00e-39	153.00
IUUC-Pva-103113	Pteropus vampyrus	74.48	7.00e-55	204.00
IUUC-Pgr-103630	Puccinia graminis	42.28	1.00e-33	134.00
IUUC-Ptt-103816	Puccinia triticina	42.95	3.00e-33	133.00
IUUC-Rno-104863	Rattus norvegicus	48.37	6.00e-39	152.00
IUUC-Sha-106823	Sarcophilus harrisii	77.37	1.00e-53	200.00
IUUC-Sar-113240	Sorex araneus	74.48	7.00e-55	204.00
IUUC-Ssc-115442	Sus scrofa	74.03	2.00e-58	216.00
IUUC-Tgu-117352	Taeniopygia guttata	73.97	5.00e-55	205.00
IUUC-Tru-117653	Takifugu rubripes	72.73	5.00e-58	215.00
IUUC-Tsy-119345	Tarsius syrichta	81.42	3.00e-44	169.00
IUUC-Tni-119709	Tetraodon nigroviridis	72.73	5.00e-58	215.00
IUUC-Tbe-127294	Tupaia belangeri	73.97	2.00e-54	203.00
IUUC-Ttr-128840	Tursiops truncatus	74.03	2.00e-58	216.00
IUUC-Vpa-130649	Vicugna pacos	54.55	1.00e-30	123.00
IUUC-Xtr-132650	Xenopus tropicalis	74.03	9.00e-59	218.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence