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Tag Content
iUUCD ID IUUC-Apl-003500
Ensembl Protein ID ENSAPLP00000004800.1
UniProt Accession U3IC28; U3IC28_ANAPL
Genbank Protein ID ENSAPLP00000004800
Protein Name PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2
Genbank Nucleotide ID ADON01147514
Gene Name PAN2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSAPLG00000005195.1 ENSAPLT00000005420.1 ENSAPLP00000004800.1
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.30e-16 60.5 525 915
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.gyeqqDaqEfl 96
             Y+N+++Q L++++++r+l+ +   + +++      + +l ++l  lf+ l  s+    + +++l+a++++ e    g    D+ E +
   Q: 525  NAYCNCMIQ-LYFLEPVRCLVQN---HLCQK------EFCLGCELGLLFHMLDLSRGDPCQGSNFLRAFRTIPEASAlGLILADSDEAT 603
           56******9.999*********9...55654......57*******************************9999844599999999998 PP
   S: 97   afl.ldqleeelkk....eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgke 180
             + l +l ++ ++    + +++++e+e+ +  +     +++  ++ +s+i +lF  ++++  +c +c+++++r ++ l ++l+ p+++
   Q: 604  GKVnLGRLIQSWNRfiltQLHQETQEQEGPQ--AYRGAGSSSFGSSRDSVIGQLFSCEMENCSMC-RCGKETVRVSSTLLFTLSYPEST 689
           6544899999998875533333333333333..445557889999****************9999.8********************99 PP
   S: 181  etkkeslqdc.Lesftkeee.legenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfct 266
           e+    ++d  ++++ k+   le++ + +ce+c+k+q ++++  ++ lP+vL+++    s +e+     k + ++ f +  +    f +
   Q: 690  EK---PVKDYeFAQILKRSIcLEQNTQAWCENCEKYQPTVQTRNIRCLPDVLVINCEVNSSKEA--DFWKTQAEYAFQRAmMRRGGFEI 773
           87...4444325666555542677778****************************999955444..33478888888755333333444 PP
   S: 267  s...........................................................peekqke.....kkkYeLiavvvHsG.sl 290
           +                                                           p     +      + Y+L+a vvH   s 
   Q: 774  TkgkeislgewkelgnpdtghsypsveelknvwiphaikmsltknkeldvcnwsesdelsP-----SddpdsVYVYDLMATVVHILdSR 857
           4556666666666666666666666666666666666666666555555555555555553.....0555559*************9** PP
   S: 291  ssGHYvayvkn...........ekgkWllfdDskVtevkeeevleetg..staYvlfY 335
            +G  v ++k            ++++W+lf+D  +++v++ e +++    + + +l+Y
   Q: 858  TGGSLVGHIKVgetyhqrkegvTHQQWYLFNDFLIEPVDKCEAVQFDMswKVPAILYY 915
           ***********999988877777888*********99998776665444555555555 PP
   
Organism Anas platyrhynchos
Functional Description
(View)

Functional Description


     Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.
 Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.
Protein Sequence
(Fasta)
MNFEGLDPSL AEYAPALHPA LDPVLDPHLN PSLLQNVELD AEGVPLEGIA VPDSVHIVEG 60
MYSELHTAVS EVGVPVSVSH FDLHEEMLWV GNHGGHATSF FGPTLERYSS FQVNSSDDIR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Apl-003500|DUB,USP|Anas platyrhynchos
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAATTTTG AAGGGCTCGA CCCCTCCCTC GCCGAGTATG CTCCCGCTCT CCACCCCGCG 60
CTCGACCCCG TCCTGGACCC GCACCTGAAC CCCAGCTTGC TGCAGAACGT GGAGCTGGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Apl-003500|DUB,USP|Anas platyrhynchos
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome
Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom
PROSITE

PS50235--USP_3
Pfam

PF00929--RNase_T
PF13423--UCH_1
SMART

SM00479--EXOIII
Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001273 Ailuropoda melanoleuca 85.70 0.00e+00 1900.00
IUUC-Aca-004930 Anolis carolinensis 90.00 0.00e+00 1986.00
IUUC-Acl-008214 Aspergillus clavatus 32.06 2.00e-143 503.00
IUUC-Afu-009112 Aspergillus fumigatus 31.95 2.00e-133 470.00
IUUC-Ang-009531 Aspergillus niger 31.53 7.00e-136 478.00
IUUC-Ame-011259 Astyanax mexicanus 77.89 0.00e+00 1751.00
IUUC-Bta-012371 Bos taurus 86.21 0.00e+00 1907.00
IUUC-Bci-013684 Botrytis cinerea 30.46 2.00e-122 433.00
IUUC-Cja-019297 Callithrix jacchus 82.58 0.00e+00 1838.00
IUUC-Cfa-020489 Canis familiaris 85.77 0.00e+00 1889.00
IUUC-Cpo-022392 Cavia porcellus 85.08 0.00e+00 1907.00
IUUC-Csa-023220 Chlorocebus sabaeus 85.44 0.00e+00 1901.00
IUUC-Csv-025841 Ciona savignyi 46.55 2.00e-133 470.00
IUUC-Cgl-026534 Colletotrichum gloeosporioides 30.51 4.00e-89 323.00
IUUC-Cne-026932 Cryptococcus neoformans 45.52 6.00e-62 232.00
IUUC-Dre-028482 Danio rerio 75.18 0.00e+00 1702.00
IUUC-Dno-029398 Dasypus novemcinctus 85.92 0.00e+00 1900.00
IUUC-Dor-030307 Dipodomys ordii 79.52 0.00e+00 987.00
IUUC-Dme-032111 Drosophila melanogaster 39.92 0.00e+00 810.00
IUUC-Eca-033985 Equus caballus 86.21 0.00e+00 1907.00
IUUC-Eeu-034928 Erinaceus europaeus 75.81 0.00e+00 703.00
IUUC-Fca-035587 Felis catus 85.61 0.00e+00 1898.00
IUUC-Fal-037587 Ficedula albicollis 94.64 0.00e+00 2095.00
IUUC-Fso-038133 Fusarium solani 30.81 2.00e-78 287.00
IUUC-Gmo-039076 Gadus morhua 75.49 0.00e+00 1679.00
IUUC-Ggr-039957 Gaeumannomyces graminis 31.31 1.00e-125 444.00
IUUC-Gga-040948 Gallus gallus 97.59 0.00e+00 2147.00
IUUC-Gac-042396 Gasterosteus aculeatus 76.19 0.00e+00 1734.00
IUUC-Ggo-045412 Gorilla gorilla 85.44 0.00e+00 1896.00
IUUC-Hsa-046076 Homo sapiens 85.52 0.00e+00 1900.00
IUUC-Itr-048143 Ictidomys tridecemlineatus 80.67 0.00e+00 1721.00
IUUC-Kpa-049178 Komagataella pastoris 39.04 3.00e-52 200.00
IUUC-Lch-050279 Latimeria chalumnae 77.30 0.00e+00 921.00
IUUC-Loc-052872 Lepisosteus oculatus 78.98 0.00e+00 1736.00
IUUC-Lma-052986 Leptosphaeria maculans 31.75 9.00e-132 464.00
IUUC-Laf-054181 Loxodonta africana 83.45 0.00e+00 1871.00
IUUC-Mcc-054812 Macaca mulatta 85.68 0.00e+00 1895.00
IUUC-Meu-056325 Macropus eugenii 88.00 0.00e+00 1944.00
IUUC-Mor-057246 Magnaporthe oryzae 28.44 2.00e-107 383.00
IUUC-Mpo-057464 Magnaporthe poae 31.43 2.00e-130 459.00
IUUC-Mla-058911 Melampsora laricipopulina 32.26 2.00e-91 330.00
IUUC-Mga-059335 Meleagris gallopavo 97.41 0.00e+00 2141.00
IUUC-Mvi-060461 Microbotryum violaceum 32.87 2.00e-127 450.00
IUUC-Mmr-060636 Microcebus murinus 85.59 0.00e+00 1895.00
IUUC-Mmu-063503 Mus musculus 83.91 0.00e+00 1859.00
IUUC-Mpu-066670 Mustela putorius furo 85.94 0.00e+00 1898.00
IUUC-Mlu-068119 Myotis lucifugus 85.41 0.00e+00 1948.00
IUUC-Nfi-068398 Neosartorya fischeri 32.39 2.00e-142 500.00
IUUC-Ncr-068927 Neurospora crassa 28.30 2.00e-109 390.00
IUUC-Nle-069651 Nomascus leucogenys 81.54 0.00e+00 1803.00
IUUC-Opr-070614 Ochotona princeps 84.49 0.00e+00 1856.00
IUUC-Ont-072433 Oreochromis niloticus 76.33 0.00e+00 1755.00
IUUC-Oan-073283 Ornithorhynchus anatinus 73.03 0.00e+00 1278.00
IUUC-Ocu-074401 Oryctolagus cuniculus 84.36 0.00e+00 1887.00
IUUC-Ola-087522 Oryzias latipes 76.63 0.00e+00 1711.00
IUUC-Oga-088226 Otolemur garnettii 84.13 0.00e+00 1887.00
IUUC-Oar-089241 Ovis aries 85.88 0.00e+00 1929.00
IUUC-Pan-092297 Papio anubis 85.89 0.00e+00 1681.00
IUUC-Psi-094043 Pelodiscus sinensis 89.20 0.00e+00 1922.00
IUUC-Pma-094394 Petromyzon marinus 69.53 0.00e+00 1478.00
IUUC-Pno-095053 Phaeosphaeria nodorum 31.85 6.00e-133 468.00
IUUC-Ppa-095188 Physcomitrella patens 30.59 3.00e-84 306.00
IUUC-Pfo-097517 Poecilia formosa 77.32 0.00e+00 1770.00
IUUC-Pca-100471 Procavia capensis 85.66 0.00e+00 1783.00
IUUC-Pva-102805 Pteropus vampyrus 81.19 0.00e+00 1451.00
IUUC-Pte-104021 Pyrenophora teres 31.69 5.00e-147 515.00
IUUC-Pyt-104682 Pyrenophora triticirepentis 31.69 1.00e-146 514.00
IUUC-Rno-105471 Rattus norvegicus 84.22 0.00e+00 1860.00
IUUC-Sce-106235 Saccharomyces cerevisiae 33.74 2.00e-45 177.00
IUUC-Sha-106883 Sarcophilus harrisii 87.31 0.00e+00 1789.00
IUUC-Spo-108169 Schizosaccharomyces pombe 31.48 9.00e-128 451.00
IUUC-Sar-113323 Sorex araneus 85.26 0.00e+00 1371.00
IUUC-Sre-115075 Sporisorium reilianum 48.65 8.00e-59 222.00
IUUC-Ssc-116363 Sus scrofa 84.45 0.00e+00 1909.00
IUUC-Tru-118427 Takifugu rubripes 77.15 0.00e+00 1802.00
IUUC-Tni-120218 Tetraodon nigroviridis 77.30 0.00e+00 1792.00
IUUC-Tre-122177 Trichoderma reesei 30.68 1.00e-134 474.00
IUUC-Tme-127176 Tuber melanosporum 32.27 2.00e-130 459.00
IUUC-Tbe-127641 Tupaia belangeri 78.09 0.00e+00 722.00
IUUC-Ttr-128888 Tursiops truncatus 83.80 0.00e+00 1117.00
IUUC-Uma-129361 Ustilago maydis 50.00 2.00e-61 231.00
IUUC-Xtr-132811 Xenopus tropicalis 81.72 0.00e+00 1828.00
Created Date 25-Jun-2017

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