iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-050279

Ensembl Protein ID

ENSLACP00000021274.1

UniProt Accession

H3BHA3; H3BHA3_LATCH

Genbank Protein ID

ENSLACP00000021274

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

AFYH01001579

Gene Name

PAN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000018694.1	ENSLACT00000021415.1	ENSLACP00000021274.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.70e-11	42.7	655	930

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 136  kknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke....slqdcLesftkeeelegenkyycekckkkqeaekk 220
           ++++s+i +lF+ ++++  +c +c+++++r ++ l ++l+ ++ ++++k     ++ d+L+       le++ + +ce+c+k+q ++++
   Q: 655  SSGDSVIGQLFGCEVENCSTC-RCGKETVRLSSTLLFTLHYHDMTSSDKIikevNFADVLKRSIC---LEQNTQAWCENCEKYQPTVQT 739
           67899**************99.8*******************88866544333355555554444...5666679************** PP
   S: 221  lklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfcts......................................... 267
             ++ lP+vL ++    s++e++    k + ++ f +  L+ +   ++                                         
   Q: 740  RNIRCLPDVLAINCEVNSMKEAEFW--KAQAEYAFRKAmLKEKA--EKmknkffpfaredlcnaeglhfytsieelkntwipysikmrl 824
           ***************9988776444..78888888765454443..2233578888888888889999999988888888888888888 PP
   S: 268  ...................................peekqkekkkYeLiavvvHsG.slssGHYvayvkn...........ekgkWllf 309
                                              p e+++ +++Y+L+  v H   s  +G  va+++            ++++W+lf
   Q: 825  sktkelevtrcseseeaisivitlnlgygvtlqlnPMEEEEGTYIYDLMVTVAHILdSRTGGNLVAHIRVgetyhqrkegvTHQQWYLF 913
           888888888777777777777777777777777775555555**************9*************999988877777888**** PP
   S: 310  dDskVtevkeeevleet 326
           +D  +++v++ e  ++ 
   Q: 914  NDFLIEPVDKCEAMQFD 930
           **999999876666644 PP

Organism

Latimeria chalumnae

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Protein Sequence
(Fasta)

MNFEALDPEL TDYSPAIHVS LDPALDTSLD PGLDPHLNPT LLQNVELDPD GVPLEAMPVP 60
DPMHLMEGVY SELHTVVSEV GVPVSVSHFD LQEELLWVGN HGGHATSFFG PTMDRYSSFQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAATTTTG AAGCTCTTGA CCCTGAGCTT ACTGATTACT CCCCGGCGAT CCATGTCAGC 60
CTCGACCCCG CTCTGGATAC TTCCTTGGAT CCGGGACTCG ATCCGCATCT CAACCCGACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	72.51	0.00e+00	1723.00
IUUC-Apl-003500	Anas platyrhynchos	73.73	0.00e+00	1626.00
IUUC-Aca-004930	Anolis carolinensis	76.03	0.00e+00	1829.00
IUUC-Acl-008214	Aspergillus clavatus	39.48	6.00e-67	249.00
IUUC-Afu-009112	Aspergillus fumigatus	40.57	2.00e-66	247.00
IUUC-Ang-009531	Aspergillus niger	28.58	1.00e-119	424.00
IUUC-Ame-011259	Astyanax mexicanus	71.69	0.00e+00	1737.00
IUUC-Bta-012371	Bos taurus	72.75	0.00e+00	1721.00
IUUC-Bci-013684	Botrytis cinerea	41.96	3.00e-71	263.00
IUUC-Cja-019297	Callithrix jacchus	70.53	0.00e+00	1669.00
IUUC-Cfa-020489	Canis familiaris	72.59	0.00e+00	1717.00
IUUC-Cpo-022392	Cavia porcellus	72.38	0.00e+00	1739.00
IUUC-Csa-023220	Chlorocebus sabaeus	72.34	0.00e+00	1717.00
IUUC-Csv-025841	Ciona savignyi	51.85	2.00e-132	467.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	29.96	6.00e-139	488.00
IUUC-Cne-026932	Cryptococcus neoformans	42.65	2.00e-71	264.00
IUUC-Dre-028482	Danio rerio	68.23	0.00e+00	1649.00
IUUC-Dno-029398	Dasypus novemcinctus	72.06	0.00e+00	1702.00
IUUC-Dor-030307	Dipodomys ordii	66.42	0.00e+00	888.00
IUUC-Dme-032111	Drosophila melanogaster	39.03	0.00e+00	768.00
IUUC-Eca-033985	Equus caballus	72.75	0.00e+00	1721.00
IUUC-Eeu-034928	Erinaceus europaeus	80.75	0.00e+00	645.00
IUUC-Fca-035587	Felis catus	72.51	0.00e+00	1740.00
IUUC-Fal-037587	Ficedula albicollis	75.47	0.00e+00	1770.00
IUUC-Fso-038133	Fusarium solani	32.92	7.00e-82	298.00
IUUC-Gmo-039076	Gadus morhua	68.87	0.00e+00	1645.00
IUUC-Ggr-039957	Gaeumannomyces graminis	29.94	9.00e-119	421.00
IUUC-Gga-040948	Gallus gallus	75.71	0.00e+00	1810.00
IUUC-Gac-042396	Gasterosteus aculeatus	68.73	0.00e+00	1689.00
IUUC-Ggo-045412	Gorilla gorilla	72.26	0.00e+00	1715.00
IUUC-Hsa-046076	Homo sapiens	72.34	0.00e+00	1719.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	67.40	0.00e+00	1537.00
IUUC-Kpa-049178	Komagataella pastoris	40.48	1.00e-67	251.00
IUUC-Loc-052872	Lepisosteus oculatus	73.10	0.00e+00	1748.00
IUUC-Lma-052986	Leptosphaeria maculans	41.37	3.00e-67	250.00
IUUC-Laf-054181	Loxodonta africana	70.78	0.00e+00	1689.00
IUUC-Mcc-054812	Macaca mulatta	72.34	0.00e+00	1707.00
IUUC-Meu-056325	Macropus eugenii	74.27	0.00e+00	1749.00
IUUC-Mor-057246	Magnaporthe oryzae	38.82	2.00e-54	207.00
IUUC-Mpo-057464	Magnaporthe poae	30.26	2.00e-121	430.00
IUUC-Mla-058911	Melampsora laricipopulina	40.77	1.00e-68	254.00
IUUC-Mga-059335	Meleagris gallopavo	75.25	0.00e+00	1751.00
IUUC-Mvi-060461	Microbotryum violaceum	30.85	2.00e-113	404.00
IUUC-Mmr-060636	Microcebus murinus	72.42	0.00e+00	1708.00
IUUC-Mmu-063503	Mus musculus	72.43	0.00e+00	1717.00
IUUC-Mpu-066670	Mustela putorius furo	72.59	0.00e+00	1716.00
IUUC-Mlu-068119	Myotis lucifugus	71.78	0.00e+00	1753.00
IUUC-Nfi-068398	Neosartorya fischeri	40.17	3.00e-66	247.00
IUUC-Ncr-068927	Neurospora crassa	26.92	1.00e-109	391.00
IUUC-Nle-069651	Nomascus leucogenys	70.56	0.00e+00	1666.00
IUUC-Opr-070614	Ochotona princeps	71.52	0.00e+00	1673.00
IUUC-Ont-072433	Oreochromis niloticus	70.82	0.00e+00	1761.00
IUUC-Oan-073283	Ornithorhynchus anatinus	62.23	0.00e+00	1132.00
IUUC-Ocu-074401	Oryctolagus cuniculus	72.40	0.00e+00	1722.00
IUUC-Ola-087522	Oryzias latipes	69.05	0.00e+00	1699.00
IUUC-Oga-088226	Otolemur garnettii	72.32	0.00e+00	1733.00
IUUC-Oar-089241	Ovis aries	72.91	0.00e+00	1756.00
IUUC-Pan-092297	Papio anubis	72.47	0.00e+00	1515.00
IUUC-Psi-094043	Pelodiscus sinensis	71.04	0.00e+00	1668.00
IUUC-Pma-094394	Petromyzon marinus	62.49	0.00e+00	1383.00
IUUC-Pno-095053	Phaeosphaeria nodorum	40.64	9.00e-68	251.00
IUUC-Ppa-095188	Physcomitrella patens	32.04	8.00e-78	285.00
IUUC-Pfo-097517	Poecilia formosa	69.43	0.00e+00	1729.00
IUUC-Pca-100471	Procavia capensis	72.78	0.00e+00	1618.00
IUUC-Pva-102805	Pteropus vampyrus	71.33	0.00e+00	1387.00
IUUC-Pte-104021	Pyrenophora teres	29.51	2.00e-131	463.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	29.43	2.00e-130	460.00
IUUC-Rno-105471	Rattus norvegicus	72.01	0.00e+00	1721.00
IUUC-Sce-106235	Saccharomyces cerevisiae	37.64	1.00e-60	228.00
IUUC-Sha-106883	Sarcophilus harrisii	74.78	0.00e+00	1631.00
IUUC-Spo-108169	Schizosaccharomyces pombe	30.01	6.00e-121	428.00
IUUC-Sar-113323	Sorex araneus	70.09	0.00e+00	1214.00
IUUC-Sre-115075	Sporisorium reilianum	37.32	7.00e-59	223.00
IUUC-Ssc-116363	Sus scrofa	72.16	0.00e+00	1739.00
IUUC-Tru-118427	Takifugu rubripes	69.59	0.00e+00	1721.00
IUUC-Tni-120218	Tetraodon nigroviridis	69.19	0.00e+00	1720.00
IUUC-Tre-122177	Trichoderma reesei	29.32	8.00e-126	444.00
IUUC-Tme-127176	Tuber melanosporum	29.16	4.00e-112	399.00
IUUC-Tbe-127641	Tupaia belangeri	69.52	0.00e+00	656.00
IUUC-Ttr-128888	Tursiops truncatus	68.14	0.00e+00	994.00
IUUC-Uma-129361	Ustilago maydis	38.12	7.00e-62	233.00
IUUC-Xtr-132811	Xenopus tropicalis	70.89	0.00e+00	1695.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence