iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052872

Ensembl Protein ID

ENSLOCP00000005186.1

UniProt Accession

W5M9X7; W5M9X7_LEPOC

Genbank Protein ID

ENSLOCP00000005186

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

AHAT01018666

Gene Name

pan2; PAN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000004333.1	ENSLOCT00000005194.1	ENSLOCP00000005186.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.10e-19	68.5	537	929

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.gyeqqDaqEfl 96
             Y+N+++Q+L++++++r+l+ +   + +++      + +l+++l  lf+ l  s+    + +++l+a++++ e    g    D+ E +
   Q: 537  NAYCNCMIQVLYFLEPVRCLVQN---HLCQK------EFCLACELGFLFHMLDLSRGDPCQASNFLRAFRTIPEASAlGLILADSDEQT 616
           56*********************...55654......57*******************************9999855655556666554 PP
   S: 97   .aflldqleeelkk....eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgke 180
            +  l +l ++ ++    + +++++e+e+ +  +     ++   + ++s++ +lF+ +++++ +c +c+++++r    l ++++ p+++
   Q: 617  gKSKLGRLIQSWNRfiltQLHQETQEQEGPQ--AYRGAGNSAFGSTGESVVGRLFGCEVENSSMC-RCGKETVRSALTLLFTMHYPENS 702
           2334555555555543323333333333333..44444677889999******************.8********************99 PP
   S: 181  etkkeslqdcLesftkeeele......genkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
                sl++ ++++  +e l+      ++ + +ce+c+k+q ++++  ++ lP+vL+++    s +e++    k + ++ f++ ++ ++
   Q: 703  -----SLDKTIKEYDFTEILKrsvclgQSTQAWCENCEKYQPTVQTRNIRCLPDVLVINCEVNSAKEAE--FWKAQAEYAFNKAVKKEE 784
           .....67777777766666552111215678*****************************999776654..448888888887777776 PP
   S: 264  fcts...........................................................peekqke.....kkkYeLiavvvHsG 288
           +                                                              +     e      ++Y+L+  v+H  
   Q: 785  MEPPkppepspteweelcsaegltfdssledlrrvwiplsikmtisktkglevhswseneelsS-----EeeaegAVIYDLMVTVSHIL 868
           5554666666777777777777777777777777777777777777777776666666655553.....044555************** PP
   S: 289  .slssGHYvayvkn...........ekgkWllfdDskVtevkeeevleetg..staYvlfY 335
               +G  va++k            ++++W+lf+D  +++++++e  ++    + + +l+Y
   Q: 869  dARTGGNLVAHIKVgetyhqrkegvTHQQWYLFNDFLIEPINKAEAAQFDMnwKVPAILYY 929
           99999*********999988877777888************99998886555555555555 PP

Organism

Lepisosteus oculatus

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Protein Sequence
(Fasta)

LAAPMMNFDG LDPSLADFPP ALHGGLEAGL EPPLDPRLDP ALLQSVELDP EGLAVPVPDS 60
VHLLEGMYSE LHSVAAEVGV PVTATHFDLQ EELLWMGNHR GHATSFFGPT MGRYSSFQAH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACGGAGCTG CCCCGGAAGT GATTTTGTGT TATTGTTTGG GAGGGAGGCA TGCAGGTTTT 60
CGAAATTCAA CGTAAATTTG TAAACGGTAA GAGAAGGTTA TGTTCTTGTT TTTTTTTTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	77.04	0.00e+00	1845.00
IUUC-Apl-003500	Anas platyrhynchos	79.24	0.00e+00	1732.00
IUUC-Aca-004930	Anolis carolinensis	78.48	0.00e+00	1893.00
IUUC-Acl-008214	Aspergillus clavatus	30.01	3.00e-83	303.00
IUUC-Afu-009112	Aspergillus fumigatus	28.89	8.00e-74	272.00
IUUC-Ang-009531	Aspergillus niger	28.76	4.00e-75	276.00
IUUC-Ame-011259	Astyanax mexicanus	87.94	0.00e+00	2111.00
IUUC-Bta-012371	Bos taurus	76.79	0.00e+00	1833.00
IUUC-Bci-013684	Botrytis cinerea	46.64	6.00e-69	256.00
IUUC-Cja-019297	Callithrix jacchus	74.94	0.00e+00	1793.00
IUUC-Cfa-020489	Canis familiaris	76.54	0.00e+00	1825.00
IUUC-Cpo-022392	Cavia porcellus	76.79	0.00e+00	1857.00
IUUC-Csa-023220	Chlorocebus sabaeus	76.54	0.00e+00	1836.00
IUUC-Csv-025841	Ciona savignyi	47.14	3.00e-136	479.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	28.42	1.00e-82	301.00
IUUC-Cne-026932	Cryptococcus neoformans	43.33	9.00e-73	268.00
IUUC-Dre-028482	Danio rerio	85.41	0.00e+00	2054.00
IUUC-Dno-029398	Dasypus novemcinctus	77.08	0.00e+00	1843.00
IUUC-Dor-030307	Dipodomys ordii	72.75	0.00e+00	1034.00
IUUC-Dme-032111	Drosophila melanogaster	41.24	0.00e+00	874.00
IUUC-Eca-033985	Equus caballus	76.87	0.00e+00	1835.00
IUUC-Eeu-034928	Erinaceus europaeus	77.04	6.00e-178	618.00
IUUC-Fca-035587	Felis catus	76.95	0.00e+00	1860.00
IUUC-Fal-037587	Ficedula albicollis	79.45	0.00e+00	1835.00
IUUC-Fso-038133	Fusarium solani	42.40	2.00e-73	270.00
IUUC-Gmo-039076	Gadus morhua	84.39	0.00e+00	2015.00
IUUC-Ggr-039957	Gaeumannomyces graminis	29.34	4.00e-75	276.00
IUUC-Gga-040948	Gallus gallus	79.37	0.00e+00	1886.00
IUUC-Gac-042396	Gasterosteus aculeatus	85.00	0.00e+00	2069.00
IUUC-Ggo-045412	Gorilla gorilla	76.63	0.00e+00	1836.00
IUUC-Hsa-046076	Homo sapiens	76.63	0.00e+00	1837.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	71.60	0.00e+00	1644.00
IUUC-Kpa-049178	Komagataella pastoris	40.72	1.00e-65	245.00
IUUC-Lch-050279	Latimeria chalumnae	72.94	0.00e+00	1724.00
IUUC-Lma-052986	Leptosphaeria maculans	30.96	8.00e-88	318.00
IUUC-Laf-054181	Loxodonta africana	74.86	0.00e+00	1797.00
IUUC-Mcc-054812	Macaca mulatta	76.63	0.00e+00	1828.00
IUUC-Meu-056325	Macropus eugenii	77.84	0.00e+00	1853.00
IUUC-Mor-057246	Magnaporthe oryzae	26.54	2.00e-62	234.00
IUUC-Mpo-057464	Magnaporthe poae	29.44	3.00e-74	273.00
IUUC-Mla-058911	Melampsora laricipopulina	40.95	8.00e-67	249.00
IUUC-Mga-059335	Meleagris gallopavo	79.85	0.00e+00	1852.00
IUUC-Mvi-060461	Microbotryum violaceum	34.09	1.00e-139	491.00
IUUC-Mmr-060636	Microcebus murinus	76.46	0.00e+00	1826.00
IUUC-Mmu-063503	Mus musculus	76.02	0.00e+00	1816.00
IUUC-Mpu-066670	Mustela putorius furo	76.95	0.00e+00	1836.00
IUUC-Mlu-068119	Myotis lucifugus	76.38	0.00e+00	1879.00
IUUC-Nfi-068398	Neosartorya fischeri	29.99	5.00e-83	303.00
IUUC-Ncr-068927	Neurospora crassa	40.52	3.00e-69	257.00
IUUC-Nle-069651	Nomascus leucogenys	73.52	0.00e+00	1753.00
IUUC-Opr-070614	Ochotona princeps	75.53	0.00e+00	1790.00
IUUC-Ont-072433	Oreochromis niloticus	84.23	0.00e+00	2085.00
IUUC-Oan-073283	Ornithorhynchus anatinus	68.30	0.00e+00	1301.00
IUUC-Ocu-074401	Oryctolagus cuniculus	75.96	0.00e+00	1817.00
IUUC-Ola-087522	Oryzias latipes	84.55	0.00e+00	2028.00
IUUC-Oga-088226	Otolemur garnettii	75.84	0.00e+00	1835.00
IUUC-Oar-089241	Ovis aries	76.95	0.00e+00	1865.00
IUUC-Pan-092297	Papio anubis	78.36	0.00e+00	1668.00
IUUC-Psi-094043	Pelodiscus sinensis	75.83	0.00e+00	1761.00
IUUC-Pma-094394	Petromyzon marinus	68.70	0.00e+00	1533.00
IUUC-Pno-095053	Phaeosphaeria nodorum	29.73	9.00e-75	275.00
IUUC-Ppa-095188	Physcomitrella patens	31.10	9.00e-89	322.00
IUUC-Pfo-097517	Poecilia formosa	85.60	0.00e+00	2083.00
IUUC-Pca-100471	Procavia capensis	78.19	0.00e+00	1764.00
IUUC-Pva-102805	Pteropus vampyrus	74.55	0.00e+00	1448.00
IUUC-Pte-104021	Pyrenophora teres	30.80	3.00e-91	330.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	30.51	6.00e-90	325.00
IUUC-Rno-105471	Rattus norvegicus	76.59	0.00e+00	1833.00
IUUC-Sce-106235	Saccharomyces cerevisiae	38.17	2.00e-58	221.00
IUUC-Sha-106883	Sarcophilus harrisii	78.31	0.00e+00	1735.00
IUUC-Spo-108169	Schizosaccharomyces pombe	49.66	1.00e-74	275.00
IUUC-Sar-113323	Sorex araneus	77.68	0.00e+00	1375.00
IUUC-Sre-115075	Sporisorium reilianum	49.10	9.00e-58	219.00
IUUC-Ssc-116363	Sus scrofa	75.96	0.00e+00	1838.00
IUUC-Tru-118427	Takifugu rubripes	85.31	0.00e+00	2109.00
IUUC-Tni-120218	Tetraodon nigroviridis	85.07	0.00e+00	2116.00
IUUC-Tre-122177	Trichoderma reesei	28.81	3.00e-77	283.00
IUUC-Tme-127176	Tuber melanosporum	41.49	4.00e-67	249.00
IUUC-Tbe-127641	Tupaia belangeri	66.60	3.00e-177	616.00
IUUC-Ttr-128888	Tursiops truncatus	77.53	0.00e+00	1157.00
IUUC-Uma-129361	Ustilago maydis	38.71	1.00e-60	228.00
IUUC-Xtr-132811	Xenopus tropicalis	75.82	0.00e+00	1793.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence