iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tme-127176

Ensembl Protein ID

CAZ85679

UniProt Accession

D5GMD6; D5GMD6_TUBMM

Genbank Protein ID

CAZ85679.1

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

FN430354

Gene Name

PAN2; GSTUM_00010661001

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
GSTUM_00010661001	CAZ85679	CAZ85679

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.40e-12	45.3	445	764

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaee.fsgyeqqDaq..Eflafl 99
           Gl+ +    YmN +LQ+  ++p lr+l l+++  ++ +      + ++l+++  lf  l k + ++ + +++lk+++++     +g  ++D++  E+l+ +
   Q: 445  GLETHISNSYMNPLLQMYKFTPLLRNLALHHTATACTK------DDCMLCQMGFLFDMLDKANGQNCQATNFLKTFSSLPTAdRHGVLEEDSSsgELLSSM 539
           777777888*********************66666654......579************9******************99885679999997555999999 PP
   S: 100  ldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeeel 200
           +++l++ l              d++++++  ++++ +     +++   +  +++ +c+ c+++s    + +   +  p k+++  +s++ + ++  + +++
   Q: 540  IQSLNRFL-------------LDQISMDQRTWQNDSRA----LEEAITIGATKSQRCNICGKESRPLGDTNVTDMIYPPKHSKPVQSFSALVKQSIQMDTV 623
           99999999.............45555666666655555....4555567777888*********9998888888888888888788888888999999888 PP
   S: 201  egenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts............peekqkekkkYeLiavvvHsG. 288
           +   k +c+kc+++q+   +  +++lP++++++    + s  +++re+ ++   +p+e+ +   + +            + e  ++ ++++L++ v     
   Q: 624  Q---KGWCDKCQRYQQQAMRKLVRRLPKIMVFNATTNEKSL-TYVREHWSTPGWLPDEIGVLVTNGQlsvyqgedliimR-ERCENLVTFDLVGFVAEITp 719
           8...69**********99999***********999886655.47888888888888887776444445555555555532.223339*********99998 PP
   S: 289  .slssGHYvayvkn........ekgkWllfdDskVtevkeeevle 324
            + ++ H +++v+         e+  W  f+D  Vt+v++e+ l 
   Q: 720  eEKRNTHLISFVNVafsstdrtEESTWHIFNDFLVTPVRKEDALD 764
           88999*********999888766777*************999886 PP

Organism

Tuber melanosporum

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.

Protein Sequence
(Fasta)

MLLFRLHWHL TPTKNFYGLG ASKVGLLLTL VPIFENIPVT VVNDRGVISL AARSLHFSIR 60
RGLAQWNIKH AGFQNLSGFA YTNRGTSEIL VGGSQSSMFT VNVDRGTVIG EYSTEDDIKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTGCTGT TCCGCCTACA TTGGCATTTG ACACCAACCA AGAACTTTTA TGGGTTGGGA 60
GCGAGCAAGT ATGCTCAAAT CTTTCGTCCC GGGTCTCGGT AGATTGAATC TTAGCTTACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening

KEGG

tml:GSTUM_00010661001

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	32.76	9.00e-139	486.00
IUUC-Apl-003500	Anas platyrhynchos	32.07	3.00e-126	444.00
IUUC-Aca-004930	Anolis carolinensis	31.81	5.00e-140	490.00
IUUC-Acl-008214	Aspergillus clavatus	47.01	0.00e+00	952.00
IUUC-Afu-009112	Aspergillus fumigatus	46.34	0.00e+00	917.00
IUUC-Ang-009531	Aspergillus niger	46.41	0.00e+00	916.00
IUUC-Ame-011259	Astyanax mexicanus	30.45	1.00e-69	256.00
IUUC-Bta-012371	Bos taurus	32.98	1.00e-140	492.00
IUUC-Bci-013684	Botrytis cinerea	44.65	0.00e+00	850.00
IUUC-Cja-019297	Callithrix jacchus	33.17	3.00e-137	481.00
IUUC-Cfa-020489	Canis familiaris	32.63	1.00e-138	485.00
IUUC-Cpo-022392	Cavia porcellus	32.85	1.00e-137	482.00
IUUC-Csa-023220	Chlorocebus sabaeus	32.20	4.00e-139	487.00
IUUC-Csv-025841	Ciona savignyi	35.62	1.00e-62	233.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	47.75	0.00e+00	945.00
IUUC-Cne-026932	Cryptococcus neoformans	35.91	8.00e-169	586.00
IUUC-Dre-028482	Danio rerio	41.32	7.00e-68	250.00
IUUC-Dno-029398	Dasypus novemcinctus	32.76	8.00e-140	489.00
IUUC-Dor-030307	Dipodomys ordii	33.29	8.00e-93	333.00
IUUC-Dme-032111	Drosophila melanogaster	27.16	1.00e-64	240.00
IUUC-Eca-033985	Equus caballus	32.89	4.00e-140	490.00
IUUC-Eeu-034928	Erinaceus europaeus	31.05	4.00e-29	122.00
IUUC-Fca-035587	Felis catus	32.08	2.00e-140	491.00
IUUC-Fal-037587	Ficedula albicollis	32.07	7.00e-141	493.00
IUUC-Fso-038133	Fusarium solani	41.67	0.00e+00	789.00
IUUC-Gmo-039076	Gadus morhua	41.96	1.00e-66	246.00
IUUC-Ggr-039957	Gaeumannomyces graminis	42.67	0.00e+00	828.00
IUUC-Gga-040948	Gallus gallus	32.66	9.00e-139	486.00
IUUC-Gac-042396	Gasterosteus aculeatus	44.23	2.00e-67	249.00
IUUC-Ggo-045412	Gorilla gorilla	32.30	3.00e-139	488.00
IUUC-Hsa-046076	Homo sapiens	32.30	4.00e-139	487.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	32.10	3.00e-122	431.00
IUUC-Kpa-049178	Komagataella pastoris	35.11	6.00e-176	609.00
IUUC-Lch-050279	Latimeria chalumnae	28.83	8.00e-106	377.00
IUUC-Loc-052872	Lepisosteus oculatus	29.60	2.00e-66	246.00
IUUC-Lma-052986	Leptosphaeria maculans	44.68	0.00e+00	894.00
IUUC-Laf-054181	Loxodonta africana	32.70	1.00e-137	482.00
IUUC-Mcc-054812	Macaca mulatta	32.35	1.00e-141	495.00
IUUC-Meu-056325	Macropus eugenii	32.81	4.00e-139	487.00
IUUC-Mor-057246	Magnaporthe oryzae	39.44	0.00e+00	709.00
IUUC-Mpo-057464	Magnaporthe poae	42.82	0.00e+00	827.00
IUUC-Mla-058911	Melampsora laricipopulina	39.43	2.00e-117	415.00
IUUC-Mga-059335	Meleagris gallopavo	32.71	5.00e-140	490.00
IUUC-Mvi-060461	Microbotryum violaceum	37.08	1.00e-177	615.00
IUUC-Mmr-060636	Microcebus murinus	31.96	3.00e-137	481.00
IUUC-Mmu-063503	Mus musculus	32.23	1.00e-140	492.00
IUUC-Mpu-066670	Mustela putorius furo	32.89	4.00e-140	490.00
IUUC-Mlu-068119	Myotis lucifugus	32.48	2.00e-145	508.00
IUUC-Nfi-068398	Neosartorya fischeri	46.91	0.00e+00	947.00
IUUC-Ncr-068927	Neurospora crassa	39.83	0.00e+00	702.00
IUUC-Nle-069651	Nomascus leucogenys	31.31	4.00e-131	460.00
IUUC-Opr-070614	Ochotona princeps	32.92	1.00e-138	485.00
IUUC-Ont-072433	Oreochromis niloticus	44.52	1.00e-69	256.00
IUUC-Oan-073283	Ornithorhynchus anatinus	38.12	4.00e-59	221.00
IUUC-Ocu-074401	Oryctolagus cuniculus	32.57	7.00e-139	486.00
IUUC-Ola-087522	Oryzias latipes	31.35	8.00e-131	459.00
IUUC-Oga-088226	Otolemur garnettii	31.85	3.00e-141	494.00
IUUC-Oar-089241	Ovis aries	32.76	2.00e-141	495.00
IUUC-Pan-092297	Papio anubis	32.92	7.00e-141	493.00
IUUC-Psi-094043	Pelodiscus sinensis	31.01	1.00e-121	429.00
IUUC-Pma-094394	Petromyzon marinus	32.20	1.00e-138	486.00
IUUC-Pno-095053	Phaeosphaeria nodorum	46.51	0.00e+00	892.00
IUUC-Ppa-095188	Physcomitrella patens	43.30	5.00e-60	224.00
IUUC-Pfo-097517	Poecilia formosa	32.80	2.00e-139	488.00
IUUC-Pca-100471	Procavia capensis	32.05	1.00e-141	495.00
IUUC-Pva-102805	Pteropus vampyrus	33.64	5.00e-91	327.00
IUUC-Pte-104021	Pyrenophora teres	46.59	0.00e+00	923.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	46.73	0.00e+00	926.00
IUUC-Rno-105471	Rattus norvegicus	32.28	2.00e-141	495.00
IUUC-Sce-106235	Saccharomyces cerevisiae	31.27	9.00e-138	482.00
IUUC-Sha-106883	Sarcophilus harrisii	33.37	3.00e-137	480.00
IUUC-Spo-108169	Schizosaccharomyces pombe	38.81	0.00e+00	688.00
IUUC-Sar-113323	Sorex araneus	33.07	2.00e-115	409.00
IUUC-Sre-115075	Sporisorium reilianum	52.49	1.00e-63	236.00
IUUC-Ssc-116363	Sus scrofa	32.29	2.00e-140	491.00
IUUC-Tru-118427	Takifugu rubripes	43.87	2.00e-68	252.00
IUUC-Tni-120218	Tetraodon nigroviridis	43.55	5.00e-68	251.00
IUUC-Tre-122177	Trichoderma reesei	45.59	0.00e+00	912.00
IUUC-Tbe-127641	Tupaia belangeri	33.04	1.00e-24	107.00
IUUC-Ttr-128888	Tursiops truncatus	34.69	3.00e-103	368.00
IUUC-Uma-129361	Ustilago maydis	54.75	2.00e-66	245.00
IUUC-Xtr-132811	Xenopus tropicalis	31.04	4.00e-134	470.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence