iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Nfi-068558

Ensembl Protein ID

CADNFIAP00006983

UniProt Accession

A1DG53; A1DG53_NEOFI

Genbank Protein ID

EAW18360.1

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

DS027696

Gene Name

NFIA_083110

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADNFIAG00007150	CADNFIAT00007150	CADNFIAP00006983

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.80e-54	183.6	246	729
UBD/Alpha-Helix/UBA	7.60e-22	75.9	595	633

Active Site

Position(s)	Description	Evidence
255	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
684	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel...................wkskkkavsprell 74
           tGl+NlgN+CY+ Sv+QcL++ pe+++ + +  +e+ + +  ++p +++ ++++kl   +                      ++k  sp +++
   Q: 246  TGLTNLGNSCYLSSVVQCLFSSPEFQQRYYH-SSEEPPLS--QQPAEDFETQMRKLADGIlsgryskpnadviaspdspEVPHQKGLSPAMFK 335
           7****************************99.55555554..5678888888888888884444444444444433332255666******** PP
   S: 75   kalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           + +++ +eefs+++qqDa Efl +l++ ++++                              +++    d+F++ ++++++cl+c+ v  r +
   Q: 336  HLIGRGHEEFSTMRQQDAFEFLLHLFKLIQRTQ---------------------------CPEGRGNPIDNFRFAVEQRLQCLSCKGVRYRID 401
           ******************************988...........................5666777789*********************** PP
   S: 168  pfldlslpvpgkeetkke.............slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           +   +s+pvp +++  ++             +l++cL+ ft++e +e    ++c++c ++   +k+ +++++P+ L+l+  Rf  +  +++++
   Q: 402  EQDNVSIPVPVRRQLGTNstdpsadsefesvTLSECLDVFTANEIVE----LSCPSCGSSNGFSKRSSFRTMPQELVLNARRF--EVVNWVPR 488
           **********777665557888899999999***************9....9*******************************..5577**** PP
   S: 248  kinkkvefple.Ldlspfctspeekqke................................................................. 274
           k++  v++ +  Ld sp++ s +e+ ++                                                                 
   Q: 489  KLDIPVDVSDDpLDFSPYVGSMKEEGEKllpeddpsdsgfspdqnilnqllamgfprircekalhatgnsdteaamnwlfshmddpdidmplv 581
           *********************554444456666666666666666666666666666666667777777777777777777777777777777 PP
   S: 275  ..................................................................................kkkYeLiavvv 285
                                                                                             + +Y+L a+v+
   Q: 582  gskvtdpanmalqdpskvgqlsemgidedrakralaatggdvdraldwvfshpdempeyesgnrdsgsrlpgngkipgfhetPARYQLRAIVC 674
           7777777777777777888888888888888888888888888888888888888888899999999999999999999999*********** PP
   S: 286  HsG.slssGHYvayvkn.....ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           H+G s++ GHYva+v++     ++ +W+ f+D+kV  v+  +  +   + aY++f+ r
   Q: 675  HKGtSVHAGHYVAFVRKmlpgqDNPSWVMFNDEKVVGVDDIQDMK---KFAYLYFFSR 729
           *****************988744555************7544444...79*****987 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           d +k+ ql eMG+d+++a++aL+a+++++++A+++++++
   Q: 595  DPSKVGQLSEMGIDEDRAKRALAATGGDVDRALDWVFSH 633
           7899*********************************97 PP

Organism

Neosartorya fischeri

Protein Sequence
(Fasta)

MLHYKRFCHP LALNIKRSRK KIQRGEPPQK ISKLAIAAET DEDRYDTAIR VICYECRLDD 60
IDASSGSLAV VVDGVMKAMT FSKKEEIKAW EQEFVPCEHT LCLVQQTPKQ TESQELSQCT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTTCATT ACAAGCGCTT TTGCCATCCT TTAGCACTGA ACATCAAGAG GTCGCGAAAG 60
AAGATACAGG TGCGTGGAGG CCATATCTAC TCGCAATGCG TACAATGTTC GGTGTCATGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

nfi:NFIA_083110

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	32.12	1.00e-95	342.00
IUUC-Aml-002104	Ailuropoda melanoleuca	34.60	1.00e-120	426.00
IUUC-Atr-002580	Amborella trichopoda	33.50	4.00e-108	384.00
IUUC-Apl-003774	Anas platyrhynchos	35.43	7.00e-127	446.00
IUUC-Aca-005368	Anolis carolinensis	35.20	1.00e-128	452.00
IUUC-Aly-005727	Arabidopsis lyrata	34.72	1.00e-115	408.00
IUUC-Ath-006974	Arabidopsis thaliana	35.16	2.00e-117	414.00
IUUC-Ago-007890	Ashbya gossypii	32.81	4.00e-100	357.00
IUUC-Acl-008057	Aspergillus clavatus	75.86	0.00e+00	1167.00
IUUC-Afl-008547	Aspergillus flavus	70.95	0.00e+00	999.00
IUUC-Afu-008805	Aspergillus fumigatus	91.53	0.00e+00	1377.00
IUUC-Ani-009441	Aspergillus nidulans	63.40	0.00e+00	908.00
IUUC-Ang-009720	Aspergillus niger	68.54	0.00e+00	1021.00
IUUC-Aor-010111	Aspergillus oryzae	71.33	0.00e+00	1105.00
IUUC-Ate-010531	Aspergillus terreus	64.36	0.00e+00	938.00
IUUC-Ame-011893	Astyanax mexicanus	34.69	2.00e-102	365.00
IUUC-Bgr-012183	Blumeria graminis	52.30	0.00e+00	793.00
IUUC-Bta-013179	Bos taurus	34.56	2.00e-119	422.00
IUUC-Bci-013858	Botrytis cinerea	58.78	0.00e+00	900.00
IUUC-Bdi-014904	Brachypodium distachyon	35.61	1.00e-102	365.00
IUUC-Bol-015296	Brassica oleracea	34.94	4.00e-116	410.00
IUUC-Bra-017619	Brassica rapa	35.33	3.00e-118	417.00
IUUC-Cel-018625	Caenorhabditis elegans	30.82	2.00e-79	288.00
IUUC-Cja-019063	Callithrix jacchus	34.31	9.00e-117	412.00
IUUC-Cfa-020976	Canis familiaris	35.32	1.00e-123	435.00
IUUC-Cpo-022265	Cavia porcellus	35.27	3.00e-123	434.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	31.50	1.00e-66	245.00
IUUC-Csa-024177	Chlorocebus sabaeus	36.13	3.00e-110	391.00
IUUC-Cho-024702	Choloepus hoffmanni	33.91	4.00e-81	294.00
IUUC-Cin-025411	Ciona intestinalis	32.78	2.00e-100	358.00
IUUC-Csv-026347	Ciona savignyi	31.66	1.00e-95	342.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	55.95	0.00e+00	793.00
IUUC-Cne-026831	Cryptococcus neoformans	43.95	7.00e-160	555.00
IUUC-Cme-027335	Cyanidioschyzon merolae	40.79	7.00e-56	210.00
IUUC-Dre-027982	Danio rerio	32.11	3.00e-102	364.00
IUUC-Dno-029034	Dasypus novemcinctus	35.18	1.00e-122	432.00
IUUC-Dor-030479	Dipodomys ordii	36.22	7.00e-57	214.00
IUUC-Dse-031467	Dothistroma septosporum	52.27	0.00e+00	772.00
IUUC-Dme-032075	Drosophila melanogaster	37.54	1.00e-111	395.00
IUUC-Ete-032865	Echinops telfairi	33.24	2.00e-99	355.00
IUUC-Eca-034059	Equus caballus	34.69	5.00e-120	423.00
IUUC-Eeu-035304	Erinaceus europaeus	35.54	1.00e-118	419.00
IUUC-Fca-035515	Felis catus	34.69	2.00e-121	428.00
IUUC-Fal-037271	Ficedula albicollis	35.95	1.00e-126	445.00
IUUC-Fox-037745	Fusarium oxysporum	57.36	0.00e+00	845.00
IUUC-Fso-038158	Fusarium solani	57.67	0.00e+00	841.00
IUUC-Gmo-039071	Gadus morhua	33.21	2.00e-107	381.00
IUUC-Ggr-040098	Gaeumannomyces graminis	54.79	0.00e+00	787.00
IUUC-Gga-040635	Gallus gallus	35.42	4.00e-127	447.00
IUUC-Gac-042528	Gasterosteus aculeatus	34.47	4.00e-110	390.00
IUUC-Gma-043614	Glycine max	33.46	7.00e-107	380.00
IUUC-Ggo-044602	Gorilla gorilla	34.69	3.00e-120	424.00
IUUC-Hsa-045959	Homo sapiens	34.69	3.00e-120	424.00
IUUC-Hvu-047563	Hordeum vulgare	37.48	2.00e-102	364.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	34.77	1.00e-121	428.00
IUUC-Kpa-049156	Komagataella pastoris	39.66	1.00e-151	528.00
IUUC-Lch-049648	Latimeria chalumnae	35.21	7.00e-117	413.00
IUUC-Lpe-051523	Leersia perrieri	34.02	6.00e-104	370.00
IUUC-Loc-052072	Lepisosteus oculatus	33.46	6.00e-109	387.00
IUUC-Lma-053216	Leptosphaeria maculans	59.27	0.00e+00	869.00
IUUC-Laf-054327	Loxodonta africana	34.81	6.00e-121	426.00
IUUC-Mcc-055443	Macaca mulatta	34.81	1.00e-120	426.00
IUUC-Meu-056298	Macropus eugenii	34.08	1.00e-78	285.00
IUUC-Mor-057106	Magnaporthe oryzae	57.71	0.00e+00	855.00
IUUC-Mpo-057589	Magnaporthe poae	56.22	0.00e+00	798.00
IUUC-Mtr-058680	Medicago truncatula	33.93	4.00e-112	397.00
IUUC-Mla-058903	Melampsora laricipopulina	43.18	2.00e-167	580.00
IUUC-Mga-059669	Meleagris gallopavo	35.26	7.00e-123	432.00
IUUC-Mvi-060476	Microbotryum violaceum	43.54	3.00e-156	543.00
IUUC-Mmr-060575	Microcebus murinus	34.81	2.00e-121	428.00
IUUC-Mdo-062183	Monodelphis domestica	34.79	2.00e-123	434.00
IUUC-Mmu-063592	Mus musculus	34.68	1.00e-121	428.00
IUUC-Mac-065634	Musa acuminata	34.71	5.00e-55	207.00
IUUC-Mpu-066082	Mustela putorius furo	35.15	4.00e-123	434.00
IUUC-Mlu-067345	Myotis lucifugus	34.44	2.00e-118	417.00
IUUC-Ncr-068960	Neurospora crassa	57.47	0.00e+00	823.00
IUUC-Nle-070173	Nomascus leucogenys	35.19	5.00e-122	430.00
IUUC-Opr-070556	Ochotona princeps	34.73	2.00e-121	428.00
IUUC-Ont-071502	Oreochromis niloticus	34.44	2.00e-110	391.00
IUUC-Oan-072959	Ornithorhynchus anatinus	44.05	6.00e-47	178.00
IUUC-Ocu-074861	Oryctolagus cuniculus	35.23	7.00e-123	433.00
IUUC-Oba-075109	Oryza barthii	34.60	7.00e-108	383.00
IUUC-Obr-076292	Oryza brachyantha	33.42	2.00e-104	371.00
IUUC-Ogl-077065	Oryza glaberrima	35.84	3.00e-115	407.00
IUUC-Ogu-078776	Oryza glumaepatula	34.86	5.00e-112	397.00
IUUC-Oin-080048	Oryza indica	36.23	1.00e-114	405.00
IUUC-Olo-080711	Oryza longistaminata	34.10	1.00e-104	372.00
IUUC-Ome-081506	Oryza meridionalis	34.86	3.00e-107	380.00
IUUC-Oni-082320	Oryza nivara	33.63	2.00e-106	378.00
IUUC-Opu-083801	Oryza punctata	33.42	2.00e-100	358.00
IUUC-Oru-085139	Oryza rufipogon	33.63	5.00e-107	380.00
IUUC-Osa-085713	Oryza sativa	35.97	2.00e-116	411.00
IUUC-Ola-086951	Oryzias latipes	33.13	3.00e-104	371.00
IUUC-Olu-087822	Ostreococcus lucimarinus	32.86	2.00e-92	332.00
IUUC-Oga-088625	Otolemur garnettii	34.56	1.00e-120	425.00
IUUC-Oar-089995	Ovis aries	34.32	2.00e-119	421.00
IUUC-Ptr-090640	Pan troglodytes	35.67	4.00e-124	437.00
IUUC-Pan-091974	Papio anubis	34.80	1.00e-120	425.00
IUUC-Psi-093957	Pelodiscus sinensis	35.30	4.00e-127	447.00
IUUC-Pma-094242	Petromyzon marinus	40.52	9.00e-72	262.00
IUUC-Pno-094835	Phaeosphaeria nodorum	59.57	0.00e+00	858.00
IUUC-Ppa-095901	Physcomitrella patens	36.55	3.00e-126	444.00
IUUC-Pfo-097148	Poecilia formosa	34.57	1.00e-109	389.00
IUUC-Pab-098068	Pongo abelii	32.67	5.00e-101	360.00
IUUC-Pop-098943	Populus trichocarpa	34.63	1.00e-109	389.00
IUUC-Pca-100738	Procavia capensis	35.77	3.00e-96	344.00
IUUC-Ppe-101315	Prunus persica	33.38	9.00e-107	379.00
IUUC-Pva-102154	Pteropus vampyrus	34.07	2.00e-117	414.00
IUUC-Pgr-103343	Puccinia graminis	41.44	2.00e-129	454.00
IUUC-Ptt-103928	Puccinia triticina	35.38	7.00e-123	432.00
IUUC-Pte-104306	Pyrenophora teres	58.04	0.00e+00	823.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	58.10	0.00e+00	835.00
IUUC-Rno-105801	Rattus norvegicus	34.69	1.00e-121	428.00
IUUC-Sce-106304	Saccharomyces cerevisiae	35.50	3.00e-110	390.00
IUUC-Sha-107635	Sarcophilus harrisii	34.68	2.00e-121	427.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	43.03	1.00e-161	561.00
IUUC-Spo-108144	Schizosaccharomyces pombe	39.01	4.00e-156	543.00
IUUC-Smo-108703	Selaginella moellendorffii	36.92	3.00e-114	404.00
IUUC-Sit-110728	Setaria italica	34.11	4.00e-111	394.00
IUUC-Sly-111523	Solanum lycopersicum	34.63	2.00e-119	421.00
IUUC-Sar-113733	Sorex araneus	40.44	3.00e-62	231.00
IUUC-Sbi-114419	Sorghum bicolor	34.64	1.00e-110	392.00
IUUC-Sre-115225	Sporisorium reilianum	41.04	3.00e-160	556.00
IUUC-Ssc-115686	Sus scrofa	34.64	3.00e-120	424.00
IUUC-Tgu-117346	Taeniopygia guttata	35.18	1.00e-122	432.00
IUUC-Tru-118350	Takifugu rubripes	32.47	9.00e-108	382.00
IUUC-Tsy-119278	Tarsius syrichta	34.31	1.00e-92	332.00
IUUC-Tni-120658	Tetraodon nigroviridis	33.05	6.00e-104	370.00
IUUC-Tca-121585	Theobroma cacao	34.16	1.00e-106	379.00
IUUC-Tre-122043	Trichoderma reesei	55.54	0.00e+00	803.00
IUUC-Tvi-122303	Trichoderma virens	56.73	0.00e+00	827.00
IUUC-Tae-123798	Triticum aestivum	34.45	2.00e-107	382.00
IUUC-Tur-126732	Triticum urartu	31.68	1.00e-94	338.00
IUUC-Tme-126909	Tuber melanosporum	56.89	0.00e+00	843.00
IUUC-Tbe-127261	Tupaia belangeri	31.48	6.00e-75	273.00
IUUC-Ttr-128295	Tursiops truncatus	29.45	1.00e-82	299.00
IUUC-Uma-129599	Ustilago maydis	41.50	1.00e-162	565.00
IUUC-Vda-129688	Verticillium dahliae	55.21	0.00e+00	800.00
IUUC-Vpa-130170	Vicugna pacos	40.23	1.00e-49	189.00
IUUC-Vvi-131116	Vitis vinifera	34.72	4.00e-109	387.00
IUUC-Xtr-131953	Xenopus tropicalis	34.24	9.00e-112	396.00
IUUC-Xma-133837	Xiphophorus maculatus	34.57	1.00e-109	389.00
IUUC-Yli-134510	Yarrowia lipolytica	43.13	5.00e-163	566.00
IUUC-Zma-135786	Zea mays	34.50	2.00e-106	378.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence