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Tag Content
iUUCD ID IUUC-Ame-011154
Ensembl Protein ID ENSAMXP00000008989.1
UniProt Accession W5KN27; W5KN27_ASTMX
Genbank Protein ID ENSAMXP00000008989
Protein Name Lissencephaly-1 homolog
Genbank Nucleotide ID APWO01079115
Gene Name pafah1b1a; PAFAH1B1; LIS1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSAMXG00000008734.1 ENSAMXT00000008989.1 ENSAMXP00000008989.1
ENSAMXG00000008734.1 ENSAMXT00000008990.1 ENSAMXP00000008990.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.60e-58 191.1 336 374
UBD/Beta-Prp 8.20e-92 307.8 107 410
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
    gH ++v+++ f ++ ++++s++dD+t+++WD++ ++ k
   Q: 336 GHDNWVRGMMFhPGgKFIISCADDKTLRIWDYKNKRCKK 374
    8***********999****************99999887 PP
   


   UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
    h s++t+v f+p s+++++s+d+tikvwd++tg++ r+l+gh++ v++++f+++gk+l+++s D+tik+wd++ ++c++t++gh+++v
   Q: 107 HRSPVTKVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNV 195
    6679999********************************************************************************** PP
   S: 98 lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
    s++++p+gd+++s+s+d+t ++w++ tg+c + t++gh+++v++v+ ++dg+l++s+s+D+tvr+W ++t+++ +l++ h++ v+++
   Q: 196 SSVAIMPNGDHIISASRDKTMKMWEVATGYCTK-TFTGHREWVRMVRPNQDGSLIASCSNDQTVRVWVVATKECKAELRE-HEHVVECI 282
    *********************************.*********************************************9.******** PP
   S: 187 sfdsng....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
    s+ +++ ++l+sgs+d+t+k+wd++ g c++tl gh+++v+ + f+p +++++s+++D+++riWd++++
   Q: 283 SWAPESahqtimdatgsetkksgkpgPFLLSGSRDKTIKMWDVSIGMCLMTLVGHDNWVRGMMFHPGGKFIISCADDKTLRIWDYKNKR 371
    ***************************************************************************************** PP
   S: 256 llktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
    + ktl+ h++ v+s ++ + +++v+gs d++v++w+++
   Q: 372 CKKTLSAHEHFVTSLDF-HKAAPYVVTGSVDQTVKVWECR 410
    *****************.999****************985 PP
   

Organism Astyanax mexicanus
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
Protein Sequence
(Fasta)
MVLSQRQRDE LNRAIADYLR SNGYEEAYSV FKKEAELDMN EELDKKYAGL LEKKWTSVIR 60
LQKKVMELES KLNEAQEEIT LGGPIAQKRD PKEWIPRPPE RYSLSGHRSP VTKVIFHPVF 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Ame-011154|E3,WD_repeat;UBD,Beta-Prp|Astyanax mexicanus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGCAGTGAC AGTCTGGCCA GTGAATGTCT TCAGACTGTC TGTTTGTGGT GTTCCTGCAG 60
CGAGTCTATC AAGGGAACGG TACGTTTTGA GTGGTAGACC TCCCTGTGAG CCGGAGCCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Ame-011154|E3,WD_repeat;UBD,Beta-Prp|Astyanax mexicanus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0493--Microtubule
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0005815--C:microtubule organizing center
GO:0048854--P:brain morphogenesis
GO:0030154--P:cell differentiation
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007067--P:mitotic nuclear division
GO:0006810--P:transport

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Afl-008502 Aspergillus flavus 45.69 7.00e-95 340.00
IUUC-Ani-009173 Aspergillus nidulans 43.28 3.00e-91 328.00
IUUC-Ang-009873 Aspergillus niger 45.06 1.00e-94 340.00
IUUC-Aor-009973 Aspergillus oryzae 44.44 9.00e-93 333.00
IUUC-Ate-010523 Aspergillus terreus 41.56 5.00e-90 324.00
IUUC-Bgr-011972 Blumeria graminis 46.78 1.00e-105 376.00
IUUC-Cin-025753 Ciona intestinalis 71.78 0.00e+00 630.00
IUUC-Dse-031164 Dothistroma septosporum 43.83 4.00e-102 365.00
IUUC-Fox-037996 Fusarium oxysporum 45.43 3.00e-103 368.00
IUUC-Fso-038160 Fusarium solani 43.84 1.00e-98 353.00
IUUC-Ggr-040051 Gaeumannomyces graminis 45.35 4.00e-98 351.00
IUUC-Gac-041613 Gasterosteus aculeatus 95.12 0.00e+00 825.00
IUUC-Mor-056962 Magnaporthe oryzae 44.60 2.00e-97 349.00
IUUC-Mpo-057583 Magnaporthe poae 45.52 4.00e-95 342.00
IUUC-Mvi-060403 Microbotryum violaceum 50.56 5.00e-130 457.00
IUUC-Ncr-068895 Neurospora crassa 48.66 2.00e-106 379.00
IUUC-Pno-094815 Phaeosphaeria nodorum 46.30 2.00e-103 369.00
IUUC-Pte-104261 Pyrenophora teres 46.30 2.00e-103 369.00
IUUC-Sre-115003 Sporisorium reilianum 50.00 5.00e-126 444.00
IUUC-Tre-121977 Trichoderma reesei 43.43 2.00e-102 365.00
IUUC-Tvi-122661 Trichoderma virens 44.09 4.00e-102 364.00
IUUC-Tbe-127492 Tupaia belangeri 60.05 1.00e-119 422.00
IUUC-Uma-129347 Ustilago maydis 48.40 1.00e-124 439.00
IUUC-Vda-129837 Verticillium dahliae 46.39 3.00e-101 361.00
Created Date 25-Jun-2017

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