iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088625

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAQR03127827

Gene Name

USP5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000010847.2	ENSOGAT00000010852.2	ENSOGAP00000009712.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-63	215.1	325	855
UBD/Alpha-Helix/UBA	1.00e-22	79.6	725	762

Active Site

Position(s)	Description	Evidence
334	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
818	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel....................wkskkkavs 69
           tG++NlgN+CY+NSv+Q+L++ip++++ + + k ek+ +++p++p+++++++++kl + l                    +k+ +  ++
   Q: 325  TGIRNLGNSCYLNSVVQVLFSIPDFQRKYVD-KLEKIFQNAPTDPTQDFSTQVAKLGHGLlsgeyskpapesgdgeqvpeQKEVQDGIA 412
           7******************************.99999999********************66666666666666655443366666*** PP
   S: 70   prellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikcle 158
           pr++++ ++k ++efs+++qqDaqEf+ +l++ +e+++                             ++++  +++F++ ++++ikcl+
   Q: 413  PRMFKALIGKGHPEFSTNRQQDAQEFFLHLINMVERNC-----------------------------RSSENPNEVFRFLVEEKIKCLA 472
           **************************************.............................6788899*************** PP
   S: 159  cdnvssreepfldlslpvpgkeetkke............................slqdcLesftkeeelegenkyycekckkkqeaek 219
            ++v+ ++   + ++lpvp++   +k                              +++cLe++ ++e++++   ++++  ++k+ a+k
   Q: 473  TEKVKYTQRVDYIMQLPVPMDAALNKAeelleyeekkrqaeeekmplpelvraqvPFSSCLEAYGAPEQVDD---FWSTALQAKSVAVK 558
           ********************998887799*****************************************97...************** PP
   S: 220  klklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts......................................... 267
           ++++ ++P++L++++k+f+f  + ++++k++ ++e+p+eLd+s+   +                                         
   Q: 559  TTRFASFPDYLVIQIKKFTFGLD-WVPKKLDVSIEMPEELDISQLRGTglqpgeeelpdiapplvtpdepkgslgfygnededsfcsph 646
           ********************997.*******************9888878888888888888888888888888888888888777777 PP
   S: 268  .............................................................................peekqke..... 274
                                                                                        p     e     
   Q: 647  fssptspmldesviiqlvemgfpmdacrkavyytgnsgaeaamnwvmshmddpdfanplilpgssgpgstsaaaeppP-----Edcvtt 730
           777777777777777777777777777777777776666666666666666666666666666666665555555550.....055555 PP
   S: 275  ...................................................................kkkYeLiavvvHsG.slssGHY 295
                                                                              + kY+L+a ++H+G s+ +GHY
   Q: 731  ivsmgfsrdqalkalratnnsleravdwifshiddldaeaamdisegrsaadsisesvpvgpkvrdgPGKYQLFAFISHMGtSTMCGHY 819
           5555555555555566666666667777777777777777777777777778888888888888888********************** PP
   S: 296  vayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           v+++k+ +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 820  VCHIKK-EGRWVIYNDQKVCAS--EKPPK---DLGYIYFYQR 855
           ******.9***********999..78888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ed +  +v+MGF+r++al+aLra+nn+le+Av++++++
   Q: 725  EDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIFSH 762
           889999******************************97 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MAELSEEALL SVLPTIRVPK AGDRVHKDEC AFSFDTPESE GGLYICMNTF LGFGKQYVER 60
HFNKTGQRVY LHLRRTRRLK EDTTTGTGDP PRKKPTRLAI GVEGGFDLNE EKFEYDEDVK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGAGGGCT GGGAACAGTG GGAGTCGCTG TGTGTGCTGG AGCTGCTGCC GGTGTCATGG 60
CGGAGCTGAG CGAGGAGGCG CTGCTGTCAG TGTTACCGAC GATCCGGGTC CCTAAGGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	44.00	0.00e+00	650.00
IUUC-Aml-002104	Ailuropoda melanoleuca	97.65	0.00e+00	1639.00
IUUC-Apl-003774	Anas platyrhynchos	89.61	0.00e+00	1519.00
IUUC-Aca-005368	Anolis carolinensis	84.75	0.00e+00	1505.00
IUUC-Aly-005727	Arabidopsis lyrata	47.22	0.00e+00	736.00
IUUC-Ath-006974	Arabidopsis thaliana	47.20	0.00e+00	736.00
IUUC-Ago-007890	Ashbya gossypii	29.24	6.00e-82	298.00
IUUC-Acl-008057	Aspergillus clavatus	33.29	3.00e-123	436.00
IUUC-Afl-008547	Aspergillus flavus	35.85	3.00e-116	412.00
IUUC-Afu-008805	Aspergillus fumigatus	34.03	4.00e-114	405.00
IUUC-Ani-009441	Aspergillus nidulans	32.18	8.00e-98	351.00
IUUC-Ang-009720	Aspergillus niger	33.76	3.00e-118	419.00
IUUC-Aor-010111	Aspergillus oryzae	33.53	1.00e-125	443.00
IUUC-Ate-010531	Aspergillus terreus	31.76	4.00e-103	369.00
IUUC-Ame-011893	Astyanax mexicanus	64.01	0.00e+00	991.00
IUUC-Bgr-012183	Blumeria graminis	33.22	1.00e-120	427.00
IUUC-Bta-013179	Bos taurus	97.88	0.00e+00	1645.00
IUUC-Bci-013858	Botrytis cinerea	34.38	5.00e-130	458.00
IUUC-Bdi-014904	Brachypodium distachyon	46.52	0.00e+00	711.00
IUUC-Bol-015296	Brassica oleracea	47.61	0.00e+00	748.00
IUUC-Bra-017939	Brassica rapa	47.61	0.00e+00	751.00
IUUC-Cel-018625	Caenorhabditis elegans	34.58	2.00e-135	476.00
IUUC-Cja-019063	Callithrix jacchus	97.65	0.00e+00	1628.00
IUUC-Cfa-020976	Canis familiaris	95.28	0.00e+00	1588.00
IUUC-Cpo-022265	Cavia porcellus	95.17	0.00e+00	1586.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	39.19	4.00e-112	398.00
IUUC-Csa-024177	Chlorocebus sabaeus	94.93	0.00e+00	1455.00
IUUC-Cho-024702	Choloepus hoffmanni	88.79	0.00e+00	993.00
IUUC-Cin-025411	Ciona intestinalis	49.70	0.00e+00	838.00
IUUC-Csv-026347	Ciona savignyi	46.12	0.00e+00	798.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	34.10	4.00e-114	405.00
IUUC-Cne-026831	Cryptococcus neoformans	35.45	2.00e-129	456.00
IUUC-Dre-027982	Danio rerio	66.94	0.00e+00	1099.00
IUUC-Dno-029034	Dasypus novemcinctus	97.64	0.00e+00	1653.00
IUUC-Dor-030479	Dipodomys ordii	92.66	0.00e+00	709.00
IUUC-Dse-031467	Dothistroma septosporum	36.11	1.00e-130	460.00
IUUC-Dme-032075	Drosophila melanogaster	49.14	0.00e+00	802.00
IUUC-Ete-032865	Echinops telfairi	86.38	0.00e+00	1455.00
IUUC-Eca-034059	Equus caballus	98.02	0.00e+00	1657.00
IUUC-Eeu-035304	Erinaceus europaeus	92.22	0.00e+00	1497.00
IUUC-Fca-035515	Felis catus	98.23	0.00e+00	1651.00
IUUC-Fal-037271	Ficedula albicollis	86.22	0.00e+00	1420.00
IUUC-Fox-037745	Fusarium oxysporum	34.66	6.00e-128	451.00
IUUC-Fso-038158	Fusarium solani	35.34	1.00e-127	450.00
IUUC-Gmo-039071	Gadus morhua	64.30	0.00e+00	1078.00
IUUC-Ggr-040098	Gaeumannomyces graminis	34.22	1.00e-118	421.00
IUUC-Gga-040635	Gallus gallus	89.41	0.00e+00	1590.00
IUUC-Gac-042528	Gasterosteus aculeatus	63.88	0.00e+00	1093.00
IUUC-Gma-043614	Glycine max	46.67	0.00e+00	711.00
IUUC-Ggo-044602	Gorilla gorilla	97.88	0.00e+00	1640.00
IUUC-Hsa-045959	Homo sapiens	97.88	0.00e+00	1640.00
IUUC-Hvu-047563	Hordeum vulgare	46.79	4.00e-170	591.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	98.82	0.00e+00	1650.00
IUUC-Kpa-049156	Komagataella pastoris	33.06	1.00e-113	404.00
IUUC-Lch-049648	Latimeria chalumnae	81.56	0.00e+00	1370.00
IUUC-Lpe-051523	Leersia perrieri	46.37	0.00e+00	714.00
IUUC-Loc-052520	Lepisosteus oculatus	61.74	0.00e+00	1015.00
IUUC-Lma-053216	Leptosphaeria maculans	34.32	2.00e-113	404.00
IUUC-Laf-054327	Loxodonta africana	97.05	0.00e+00	1631.00
IUUC-Mcc-055443	Macaca mulatta	98.00	0.00e+00	1644.00
IUUC-Meu-056298	Macropus eugenii	91.68	0.00e+00	1059.00
IUUC-Mor-057106	Magnaporthe oryzae	34.71	3.00e-129	455.00
IUUC-Mpo-057589	Magnaporthe poae	34.44	2.00e-123	436.00
IUUC-Mtr-058680	Medicago truncatula	48.14	0.00e+00	734.00
IUUC-Mla-058903	Melampsora laricipopulina	32.12	2.00e-119	423.00
IUUC-Mga-059669	Meleagris gallopavo	88.50	0.00e+00	1507.00
IUUC-Mvi-060476	Microbotryum violaceum	34.35	1.00e-120	427.00
IUUC-Mmr-060575	Microcebus murinus	98.47	0.00e+00	1651.00
IUUC-Mdo-062183	Monodelphis domestica	91.75	0.00e+00	1533.00
IUUC-Mmu-063592	Mus musculus	97.76	0.00e+00	1641.00
IUUC-Mac-065634	Musa acuminata	42.69	0.00e+00	689.00
IUUC-Mpu-066082	Mustela putorius furo	94.69	0.00e+00	1580.00
IUUC-Mlu-067345	Myotis lucifugus	96.82	0.00e+00	1620.00
IUUC-Nfi-068558	Neosartorya fischeri	34.93	4.00e-123	435.00
IUUC-Ncr-068960	Neurospora crassa	34.77	5.00e-116	412.00
IUUC-Nle-070173	Nomascus leucogenys	95.17	0.00e+00	1580.00
IUUC-Opr-070556	Ochotona princeps	97.17	0.00e+00	1635.00
IUUC-Ont-071502	Oreochromis niloticus	64.54	0.00e+00	1090.00
IUUC-Ocu-074861	Oryctolagus cuniculus	95.52	0.00e+00	1588.00
IUUC-Oba-075109	Oryza barthii	45.96	0.00e+00	718.00
IUUC-Obr-076292	Oryza brachyantha	47.37	0.00e+00	715.00
IUUC-Ogl-077065	Oryza glaberrima	47.25	0.00e+00	748.00
IUUC-Ogu-078776	Oryza glumaepatula	45.96	0.00e+00	730.00
IUUC-Oin-080048	Oryza indica	46.78	0.00e+00	741.00
IUUC-Olo-080711	Oryza longistaminata	44.11	0.00e+00	661.00
IUUC-Ome-081506	Oryza meridionalis	45.15	0.00e+00	672.00
IUUC-Oni-082320	Oryza nivara	45.41	0.00e+00	716.00
IUUC-Opu-083801	Oryza punctata	46.14	0.00e+00	711.00
IUUC-Oru-085139	Oryza rufipogon	45.41	0.00e+00	718.00
IUUC-Osa-085713	Oryza sativa	47.37	0.00e+00	751.00
IUUC-Ola-086951	Oryzias latipes	65.23	0.00e+00	1080.00
IUUC-Olu-087822	Ostreococcus lucimarinus	41.53	0.00e+00	632.00
IUUC-Oar-089995	Ovis aries	96.94	0.00e+00	1627.00
IUUC-Ptr-090640	Pan troglodytes	95.52	0.00e+00	1629.00
IUUC-Pan-091974	Papio anubis	98.12	0.00e+00	1636.00
IUUC-Psi-093957	Pelodiscus sinensis	89.66	0.00e+00	1598.00
IUUC-Pma-094242	Petromyzon marinus	71.47	2.00e-165	574.00
IUUC-Pno-094835	Phaeosphaeria nodorum	34.86	1.00e-106	380.00
IUUC-Ppa-095901	Physcomitrella patens	48.62	0.00e+00	786.00
IUUC-Pfo-097148	Poecilia formosa	65.77	0.00e+00	1098.00
IUUC-Pab-098068	Pongo abelii	90.21	0.00e+00	1462.00
IUUC-Pop-098943	Populus trichocarpa	46.91	0.00e+00	724.00
IUUC-Pca-100738	Procavia capensis	97.51	0.00e+00	1139.00
IUUC-Ppe-101315	Prunus persica	47.26	0.00e+00	731.00
IUUC-Pva-102154	Pteropus vampyrus	96.11	0.00e+00	1617.00
IUUC-Pgr-103343	Puccinia graminis	33.10	2.00e-108	386.00
IUUC-Ptt-103928	Puccinia triticina	30.43	2.00e-106	380.00
IUUC-Pte-104306	Pyrenophora teres	32.64	2.00e-104	374.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	33.76	2.00e-107	383.00
IUUC-Rno-105801	Rattus norvegicus	97.41	0.00e+00	1637.00
IUUC-Sce-106304	Saccharomyces cerevisiae	27.96	5.00e-73	269.00
IUUC-Sha-107635	Sarcophilus harrisii	90.92	0.00e+00	1541.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	31.90	9.00e-108	384.00
IUUC-Spo-108144	Schizosaccharomyces pombe	32.07	5.00e-113	402.00
IUUC-Smo-108848	Selaginella moellendorffii	47.89	0.00e+00	738.00
IUUC-Sit-110728	Setaria italica	47.96	0.00e+00	774.00
IUUC-Sly-111523	Solanum lycopersicum	47.10	0.00e+00	761.00
IUUC-Sbi-114419	Sorghum bicolor	47.09	0.00e+00	755.00
IUUC-Sre-115225	Sporisorium reilianum	34.66	3.00e-126	446.00
IUUC-Ssc-115686	Sus scrofa	97.76	0.00e+00	1640.00
IUUC-Tgu-117346	Taeniopygia guttata	89.07	0.00e+00	1560.00
IUUC-Tru-118350	Takifugu rubripes	64.89	0.00e+00	1104.00
IUUC-Tni-120658	Tetraodon nigroviridis	66.20	0.00e+00	1096.00
IUUC-Tca-121585	Theobroma cacao	47.33	0.00e+00	731.00
IUUC-Tre-122043	Trichoderma reesei	34.34	2.00e-118	419.00
IUUC-Tvi-122303	Trichoderma virens	34.15	5.00e-125	441.00
IUUC-Tae-125686	Triticum aestivum	46.89	0.00e+00	733.00
IUUC-Tur-126732	Triticum urartu	44.42	0.00e+00	687.00
IUUC-Tme-126909	Tuber melanosporum	34.49	4.00e-118	419.00
IUUC-Tbe-127261	Tupaia belangeri	90.70	0.00e+00	1039.00
IUUC-Uma-129599	Ustilago maydis	33.62	4.00e-128	452.00
IUUC-Vda-129688	Verticillium dahliae	33.60	6.00e-120	425.00
IUUC-Vvi-131116	Vitis vinifera	47.33	0.00e+00	710.00
IUUC-Xtr-131953	Xenopus tropicalis	78.60	0.00e+00	1352.00
IUUC-Xma-133837	Xiphophorus maculatus	65.78	0.00e+00	1102.00
IUUC-Yli-134510	Yarrowia lipolytica	35.34	7.00e-130	457.00
IUUC-Zma-135786	Zea mays	47.20	0.00e+00	723.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence