iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033700

UUCD1 version

UUC-EqC-00769

Ensembl Protein ID

ENSECAP00000012166.1

UniProt Accession

F7C741; F7C741_HORSE

Protein Name

Probable cytosolic iron-sulfur protein assembly protein CIAO1; WD repeat-containing protein 39

Gene Name

CIAO1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000014428.1	ENSECAT00000015163.1	ENSECAP00000012166.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.50e-45	148.8	192	222
UBD/Beta-Prp	2.50e-54	184.7	13	179

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gH++ v++laf ++  +l+s+sdD t+++W+
   Q: 192  GHESTVWSLAFdPSgQRLASCSDDRTVRIWR 222
           8***********6669**************8 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkl..lrsl.sgheaevtavkfspdgkilvtgseDrtikvw..dlstgkcvhtl 90
           +h++s++  +++ p ++lla+ + d+++++w ++  +    + l +gh+ +v+ v +sp g++l+++s D+t ++w  + ++++cv tl
   Q: 13   AHPDSRCWFLAWNPAGTLLASCGGDRRVRIWGTEGDSWicKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWkkNQDDFECVTTL 101
           688999999999*********************9877654566689******************************99999******** PP
   S: 91   kghedsvlslsfspsgdklvsGshdrtirvwdletgqclee..tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl 166
           +ghe++v s+++ psg+ l++ s+d+ + vw+++++ ++e   +l+ h++ v +vv+hp++ ll+s+s+D tv+l++ 
   Q: 102  EGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECvsVLNSHTQDVKHVVWHPNQELLASASYDDTVKLYRE 179
           *********************************9987776566********************************975 PP

Organism

Equus caballus

Functional Description
(View)

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

Protein Sequence
(Fasta)

MKDSLVLLGR VPAHPDSRCW FLAWNPAGTL LASCGGDRRV RIWGTEGDSW ICKSVLSEGH 60
QRTVRKVAWS PCGNYLASAS FDATTCIWKK NQDDFECVTT LEGHENEVKS VAWAPSGNLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAGGCCGGA GGGGCGTCGC GGGGGTCTGC GTGGGGGCAC CCGCGGTCGG CGCGGCTGAC 60
TCTGCCTGGC TCCTCCACAC CCTGCGCCAG GCCGCCATGA AGGACTCGCT GGTGCTGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR028608--CIAO1/Cia1
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0097361--C:CIA complex
GO:0071817--C:MMXD complex
GO:0007059--P:chromosome segregation
GO:0016226--P:iron-sulfur cluster assembly

KEGG

ecb:100062424

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000874	Aegilops tauschii	49.08	4.00e-67	249.00
IUUC-Aml-001317	Ailuropoda melanoleuca	97.64	0.00e+00	637.00
IUUC-Atr-003029	Amborella trichopoda	52.20	6.00e-94	337.00
IUUC-Apl-004042	Anas platyrhynchos	78.79	2.00e-57	213.00
IUUC-Aly-006458	Arabidopsis lyrata	48.70	1.00e-85	309.00
IUUC-Ath-006671	Arabidopsis thaliana	48.70	2.00e-85	309.00
IUUC-Ago-007820	Ashbya gossypii	40.29	8.00e-60	223.00
IUUC-Acl-008042	Aspergillus clavatus	32.49	7.00e-52	197.00
IUUC-Afl-008639	Aspergillus flavus	33.89	1.00e-55	210.00
IUUC-Afu-008899	Aspergillus fumigatus	36.65	1.00e-50	194.00
IUUC-Ani-009453	Aspergillus nidulans	33.10	4.00e-52	198.00
IUUC-Ang-009758	Aspergillus niger	35.91	4.00e-54	204.00
IUUC-Aor-010212	Aspergillus oryzae	33.89	1.00e-55	210.00
IUUC-Ate-010314	Aspergillus terreus	33.33	7.00e-54	204.00
IUUC-Ame-010676	Astyanax mexicanus	78.14	1.00e-158	552.00
IUUC-Bgr-012095	Blumeria graminis	30.92	1.00e-38	153.00
IUUC-Bta-012884	Bos taurus	94.10	2.00e-177	614.00
IUUC-Bci-013622	Botrytis cinerea	33.43	3.00e-39	155.00
IUUC-Bdi-014614	Brachypodium distachyon	49.41	6.00e-86	310.00
IUUC-Bol-016439	Brassica oleracea	47.94	5.00e-83	300.00
IUUC-Bra-016830	Brassica rapa	46.90	1.00e-81	296.00
IUUC-Cel-018709	Caenorhabditis elegans	40.67	5.00e-64	237.00
IUUC-Cja-019822	Callithrix jacchus	97.05	0.00e+00	636.00
IUUC-Cfa-020823	Canis familiaris	98.23	0.00e+00	640.00
IUUC-Cre-022811	Chlamydomonas reinhardtii	47.99	3.00e-81	295.00
IUUC-Csa-023754	Chlorocebus sabaeus	97.94	0.00e+00	641.00
IUUC-Cin-025395	Ciona intestinalis	57.61	1.00e-116	412.00
IUUC-Csv-025943	Ciona savignyi	55.86	1.00e-113	402.00
IUUC-Cgl-026435	Colletotrichum gloeosporioides	30.61	4.00e-37	149.00
IUUC-Cne-026939	Cryptococcus neoformans	32.14	4.00e-49	188.00
IUUC-Cme-027239	Cyanidioschyzon merolae	40.91	9.00e-45	174.00
IUUC-Dre-028172	Danio rerio	76.65	2.00e-156	544.00
IUUC-Dno-029472	Dasypus novemcinctus	95.90	5.00e-154	536.00
IUUC-Dor-031134	Dipodomys ordii	85.55	2.00e-153	534.00
IUUC-Dse-031535	Dothistroma septosporum	30.81	3.00e-48	186.00
IUUC-Dme-032020	Drosophila melanogaster	59.09	1.00e-117	415.00
IUUC-Eeu-035010	Erinaceus europaeus	95.28	1.00e-178	618.00
IUUC-Fca-036309	Felis catus	89.71	4.00e-173	600.00
IUUC-Fal-037243	Ficedula albicollis	73.95	3.00e-86	310.00
IUUC-Fox-038058	Fusarium oxysporum	33.33	9.00e-45	174.00
IUUC-Fso-038459	Fusarium solani	32.73	2.00e-39	156.00
IUUC-Gmo-039375	Gadus morhua	75.15	4.00e-140	490.00
IUUC-Ggr-040002	Gaeumannomyces graminis	35.96	3.00e-41	162.00
IUUC-Gga-040294	Gallus gallus	80.63	1.00e-131	462.00
IUUC-Gac-042499	Gasterosteus aculeatus	74.48	1.00e-139	489.00
IUUC-Gma-043543	Glycine max	49.56	1.00e-87	315.00
IUUC-Ggo-045181	Gorilla gorilla	97.94	0.00e+00	641.00
IUUC-Hsa-046528	Homo sapiens	97.94	0.00e+00	641.00
IUUC-Hvu-047341	Hordeum vulgare	57.98	7.00e-56	209.00
IUUC-Itr-048790	Ictidomys tridecemlineatus	97.94	0.00e+00	639.00
IUUC-Kpa-049353	Komagataella pastoris	37.01	7.00e-58	217.00
IUUC-Lch-049763	Latimeria chalumnae	80.54	2.00e-162	565.00
IUUC-Lpe-051500	Leersia perrieri	45.28	5.00e-82	298.00
IUUC-Loc-052021	Lepisosteus oculatus	80.54	6.00e-154	536.00
IUUC-Lma-053331	Leptosphaeria maculans	36.00	3.00e-57	216.00
IUUC-Laf-054558	Loxodonta africana	95.28	1.00e-180	624.00
IUUC-Mcc-055374	Macaca mulatta	97.64	0.00e+00	639.00
IUUC-Meu-056042	Macropus eugenii	77.59	3.00e-112	397.00
IUUC-Mor-057187	Magnaporthe oryzae	35.48	5.00e-39	155.00
IUUC-Mtr-058072	Medicago truncatula	49.11	6.00e-87	313.00
IUUC-Mla-059108	Melampsora laricipopulina	31.07	5.00e-51	195.00
IUUC-Mga-059370	Meleagris gallopavo	64.81	1.00e-102	365.00
IUUC-Mvi-060495	Microbotryum violaceum	36.29	3.00e-57	215.00
IUUC-Mmr-060902	Microcebus murinus	97.35	0.00e+00	634.00
IUUC-Mdo-062510	Monodelphis domestica	93.22	3.00e-171	593.00
IUUC-Mmu-063575	Mus musculus	94.69	2.00e-179	621.00
IUUC-Mac-065322	Musa acuminata	51.34	1.00e-91	329.00
IUUC-Mpu-065925	Mustela putorius furo	97.64	0.00e+00	635.00
IUUC-Mlu-067755	Myotis lucifugus	96.76	0.00e+00	633.00
IUUC-Nfi-068327	Neosartorya fischeri	32.13	3.00e-49	189.00
IUUC-Ncr-068845	Neurospora crassa	33.23	1.00e-32	134.00
IUUC-Nle-069406	Nomascus leucogenys	95.58	1.00e-179	621.00
IUUC-Opr-070416	Ochotona princeps	75.52	9.00e-133	466.00
IUUC-Ont-071936	Oreochromis niloticus	75.96	7.00e-144	503.00
IUUC-Oan-073452	Ornithorhynchus anatinus	92.73	1.00e-75	274.00
IUUC-Ocu-074791	Oryctolagus cuniculus	95.28	0.00e+00	625.00
IUUC-Oba-075636	Oryza barthii	50.15	2.00e-89	322.00
IUUC-Obr-076742	Oryza brachyantha	49.30	2.00e-78	285.00
IUUC-Ogl-077766	Oryza glaberrima	50.15	2.00e-89	322.00
IUUC-Ogu-079039	Oryza glumaepatula	50.15	6.00e-90	323.00
IUUC-Oin-079315	Oryza indica	49.66	1.00e-78	286.00
IUUC-Olo-080669	Oryza longistaminata	44.53	1.00e-81	296.00
IUUC-Ome-081490	Oryza meridionalis	50.15	1.00e-89	323.00
IUUC-Oni-082572	Oryza nivara	50.15	2.00e-89	322.00
IUUC-Opu-083732	Oryza punctata	50.30	1.00e-89	323.00
IUUC-Oru-084763	Oryza rufipogon	50.15	2.00e-89	322.00
IUUC-Osa-085372	Oryza sativa	50.15	2.00e-89	322.00
IUUC-Ola-087379	Oryzias latipes	72.57	3.00e-139	488.00
IUUC-Olu-087801	Ostreococcus lucimarinus	36.31	1.00e-44	172.00
IUUC-Oga-089076	Otolemur garnettii	96.46	0.00e+00	629.00
IUUC-Oar-090022	Ovis aries	94.10	7.00e-177	612.00
IUUC-Ptr-090809	Pan troglodytes	97.94	0.00e+00	641.00
IUUC-Pan-091685	Papio anubis	97.94	0.00e+00	647.00
IUUC-Psi-093046	Pelodiscus sinensis	89.02	7.00e-171	592.00
IUUC-Pma-094181	Petromyzon marinus	64.99	7.00e-133	466.00
IUUC-Pno-094882	Phaeosphaeria nodorum	35.44	2.00e-56	213.00
IUUC-Ppa-095172	Physcomitrella patens	47.97	8.00e-86	310.00
IUUC-Pfo-096396	Poecilia formosa	72.40	3.00e-140	491.00
IUUC-Pab-098427	Pongo abelii	97.35	0.00e+00	634.00
IUUC-Pop-100016	Populus trichocarpa	52.23	3.00e-90	325.00
IUUC-Pca-101048	Procavia capensis	96.17	0.00e+00	627.00
IUUC-Ppe-102050	Prunus persica	48.00	3.00e-86	311.00
IUUC-Pva-103117	Pteropus vampyrus	96.76	0.00e+00	632.00
IUUC-Pgr-103307	Puccinia graminis	33.79	9.00e-56	211.00
IUUC-Ptt-103938	Puccinia triticina	38.06	1.00e-48	186.00
IUUC-Pte-104315	Pyrenophora teres	33.81	9.00e-56	210.00
IUUC-Pyt-104825	Pyrenophora triticirepentis	33.33	2.00e-55	209.00
IUUC-Rno-105523	Rattus norvegicus	94.10	7.00e-179	619.00
IUUC-Sce-106297	Saccharomyces cerevisiae	41.96	7.00e-64	237.00
IUUC-Sha-106981	Sarcophilus harrisii	93.52	4.00e-144	503.00
IUUC-Sja-107715	Schizosaccharomyces japonicus	38.73	2.00e-55	210.00
IUUC-Spo-108214	Schizosaccharomyces pombe	41.18	9.00e-57	214.00
IUUC-Smo-109034	Selaginella moellendorffii	47.04	2.00e-82	298.00
IUUC-Sit-110663	Setaria italica	51.03	1.00e-90	326.00
IUUC-Sly-110898	Solanum lycopersicum	47.67	6.00e-82	297.00
IUUC-Stu-112647	Solanum tuberosum	50.75	2.00e-69	255.00
IUUC-Sbi-114288	Sorghum bicolor	48.68	3.00e-86	311.00
IUUC-Sre-115065	Sporisorium reilianum	43.80	2.00e-75	276.00
IUUC-Ssc-115960	Sus scrofa	90.21	2.00e-179	620.00
IUUC-Tru-118382	Takifugu rubripes	72.40	2.00e-149	521.00
IUUC-Tsy-119585	Tarsius syrichta	88.79	1.00e-162	565.00
IUUC-Tni-120133	Tetraodon nigroviridis	75.15	2.00e-144	504.00
IUUC-Tca-121167	Theobroma cacao	49.85	3.00e-81	295.00
IUUC-Tre-122119	Trichoderma reesei	29.84	2.00e-40	160.00
IUUC-Tvi-122407	Trichoderma virens	30.07	1.00e-40	160.00
IUUC-Tae-125748	Triticum aestivum	49.26	7.00e-83	300.00
IUUC-Tur-126682	Triticum urartu	48.89	2.00e-67	248.00
IUUC-Tme-127095	Tuber melanosporum	36.19	2.00e-62	232.00
IUUC-Tbe-128004	Tupaia belangeri	97.94	0.00e+00	637.00
IUUC-Ttr-129284	Tursiops truncatus	92.11	3.00e-171	594.00
IUUC-Uma-129527	Ustilago maydis	43.97	5.00e-76	278.00
IUUC-Vda-129854	Verticillium dahliae	31.91	2.00e-38	153.00
IUUC-Vpa-130681	Vicugna pacos	96.55	2.00e-49	189.00
IUUC-Vvi-131004	Vitis vinifera	53.75	7.00e-88	317.00
IUUC-Xtr-131928	Xenopus tropicalis	82.20	2.00e-157	548.00
IUUC-Xma-134290	Xiphophorus maculatus	71.81	5.00e-137	480.00
IUUC-Yli-134364	Yarrowia lipolytica	44.02	3.00e-67	248.00
IUUC-Zma-135658	Zea mays	50.15	6.00e-87	313.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence