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Tag Content
iUUCD ID IUUC-Lch-050473
Ensembl Protein ID ENSLACP00000010280.1
UniProt Accession H3AKV9; H3AKV9_LATCH
Genbank Protein ID ENSLACP00000010280
Protein Name Coatomer subunit beta'
Genbank Nucleotide ID AFYH01119275
Gene Name COPB2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSLACG00000009056.1 ENSLACT00000010358.1 ENSLACP00000010280.1
ENSLACG00000009056.1 ENSLACT00000010359.1 ENSLACP00000010281.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.00e-34 115.8 183 224
UBD/Beta-Prp 7.50e-73 245.5 13 290
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf...sd.tllvsGsdDgtikvWDlrtgvllks 38
           gH+ +v+c+++    d ++l+sG+dD  +k+WD+   +++++
   Q: 183  GHEKGVNCIDYysgGDkPYLISGADDRLVKIWDYQNKTCVQT 224
           8*********9999778****************999988875 PP
   

   UBD/Beta-Prp
   S: 8    hhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkgheds 96
           ++++++++v+ +p +++++++ ++g++ vw+ +t++l+++++ ++ +v+a kf  ++++ +tg++D+ i+v++++t + vh++++h+d+
   Q: 13   ARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVITGADDMQIRVFNYNTLERVHIFEAHSDY 101
           67899************************************************************************************ PP
   S: 97   vlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltgghtdsvy 184
           +++++++p++ ++++ s+d  i++wd+++++  +++++gh++ v+ +v++p++ n ++s+slDrt+++W+l + +   tl g h++ v+
   Q: 102  IRCIAVHPTQPYILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDnNQFASASLDRTIKVWQLGSSSPNFTLDG-HEKGVN 189
           *******************************9999**********************************************9.****** PP
   S: 185  slsfdsng..kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisva 271
           ++++ s g  ++l+sg++d+ vk+wd+q+++cv+tl+gh +nv++v f+p+  ++++gs+Dg++riW + +  l +tl++  ++v++va
   Q: 190  CIDYYSGGdkPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCVSFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVA 278
           ***8887777******************************************************************************* PP
   S: 272  vlsfgdnvlvlg 283
            l+ ++nv +  
   Q: 279  SLRGSNNVALGY 290
           *99998887544 PP
   
Organism Latimeria chalumnae
Functional Description
(View)

Functional Description


     The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
 The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Protein Sequence
(Fasta)
MPLRLDIKRK LTARSDRVKS VDLHPTEPWM LASLYNGSVC VWNHETQTLV KTFEVCDLPV 60
RAAKFVARKN WVITGADDMQ IRVFNYNTLE RVHIFEAHSD YIRCIAVHPT QPYILTSSDD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Lch-050473|E3,WD_repeat;UBD,Beta-Prp|Latimeria chalumnae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAGTTCCACG TCAGACAGCC CAGCGAAGCG TCTCCCTGTA TCCCGGAGAG AGAGAGAGAG 60
GAGGAGGAGG AGGAGGATAA CAACTCAGCT TTACCTTCAG GCAGAGCCGC TTCTCTGTCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Lch-050473|E3,WD_repeat;UBD,Beta-Prp|Latimeria chalumnae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR006692--Coatomer_WD-assoc_reg
IPR016453--COPB2
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF04053--Coatomer_WDAD
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0030663--C:COPI-coated vesicle membrane
GO:0000139--C:Golgi membrane
GO:0030117--C:membrane coat
GO:0005198--F:structural molecule activity
GO:0006886--P:intracellular protein transport
GO:0030903--P:notochord development
GO:0061053--P:somite development
GO:0016192--P:vesicle-mediated transport
KEGG lcm:102358509
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000654 Aegilops tauschii 54.09 0.00e+00 949.00
IUUC-Aml-002154 Ailuropoda melanoleuca 90.52 0.00e+00 1710.00
IUUC-Atr-003090 Amborella trichopoda 59.19 0.00e+00 1077.00
IUUC-Apl-003976 Anas platyrhynchos 93.49 0.00e+00 1722.00
IUUC-Aca-004301 Anolis carolinensis 93.29 0.00e+00 1711.00
IUUC-Aly-006508 Arabidopsis lyrata 58.71 0.00e+00 1093.00
IUUC-Ath-007630 Arabidopsis thaliana 62.33 0.00e+00 1105.00
IUUC-Ago-007914 Ashbya gossypii 46.42 0.00e+00 760.00
IUUC-Acl-008237 Aspergillus clavatus 55.99 0.00e+00 961.00
IUUC-Afl-008535 Aspergillus flavus 55.29 0.00e+00 908.00
IUUC-Afu-008845 Aspergillus fumigatus 55.70 0.00e+00 932.00
IUUC-Ani-009135 Aspergillus nidulans 55.44 0.00e+00 911.00
IUUC-Ang-009654 Aspergillus niger 55.75 0.00e+00 860.00
IUUC-Aor-009939 Aspergillus oryzae 54.58 0.00e+00 963.00
IUUC-Ate-010355 Aspergillus terreus 54.14 0.00e+00 911.00
IUUC-Ame-010922 Astyanax mexicanus 86.20 0.00e+00 1516.00
IUUC-Bgr-012249 Blumeria graminis 52.71 0.00e+00 922.00
IUUC-Bta-013579 Bos taurus 96.91 0.00e+00 1464.00
IUUC-Bci-013866 Botrytis cinerea 55.30 0.00e+00 920.00
IUUC-Bdi-015046 Brachypodium distachyon 61.14 0.00e+00 1108.00
IUUC-Bol-016271 Brassica oleracea 60.59 0.00e+00 1109.00
IUUC-Bra-017758 Brassica rapa 61.43 0.00e+00 1108.00
IUUC-Cel-018387 Caenorhabditis elegans 63.91 0.00e+00 1181.00
IUUC-Cja-019145 Callithrix jacchus 91.08 0.00e+00 1712.00
IUUC-Cfa-020564 Canis familiaris 92.51 0.00e+00 1708.00
IUUC-Cpo-022201 Cavia porcellus 92.73 0.00e+00 1709.00
IUUC-Cre-022938 Chlamydomonas reinhardtii 59.32 0.00e+00 996.00
IUUC-Csa-023383 Chlorocebus sabaeus 96.30 0.00e+00 1166.00
IUUC-Cho-024454 Choloepus hoffmanni 90.34 0.00e+00 1390.00
IUUC-Cin-025681 Ciona intestinalis 77.23 0.00e+00 1379.00
IUUC-Csv-026012 Ciona savignyi 72.65 0.00e+00 1353.00
IUUC-Cgl-026649 Colletotrichum gloeosporioides 52.00 0.00e+00 839.00
IUUC-Cne-026986 Cryptococcus neoformans 51.45 0.00e+00 913.00
IUUC-Cme-027219 Cyanidioschyzon merolae 47.92 0.00e+00 846.00
IUUC-Dre-027846 Danio rerio 94.58 0.00e+00 1701.00
IUUC-Dor-030462 Dipodomys ordii 91.13 0.00e+00 1257.00
IUUC-Dse-031268 Dothistroma septosporum 54.94 0.00e+00 946.00
IUUC-Dme-031791 Drosophila melanogaster 72.15 0.00e+00 1271.00
IUUC-Ete-033166 Echinops telfairi 86.56 0.00e+00 1001.00
IUUC-Eca-034180 Equus caballus 90.14 0.00e+00 1650.00
IUUC-Eeu-035086 Erinaceus europaeus 77.82 0.00e+00 815.00
IUUC-Fca-036265 Felis catus 90.53 0.00e+00 1714.00
IUUC-Fal-037202 Ficedula albicollis 92.55 0.00e+00 1667.00
IUUC-Fox-037711 Fusarium oxysporum 55.27 0.00e+00 877.00
IUUC-Fso-038268 Fusarium solani 54.64 0.00e+00 874.00
IUUC-Gmo-039046 Gadus morhua 93.72 0.00e+00 1676.00
IUUC-Ggr-039863 Gaeumannomyces graminis 55.04 0.00e+00 897.00
IUUC-Gga-041112 Gallus gallus 94.68 0.00e+00 1728.00
IUUC-Gac-041733 Gasterosteus aculeatus 93.04 0.00e+00 1632.00
IUUC-Gma-042910 Glycine max 62.64 0.00e+00 1118.00
IUUC-Ggo-044984 Gorilla gorilla 90.53 0.00e+00 1704.00
IUUC-Hsa-046698 Homo sapiens 90.64 0.00e+00 1706.00
IUUC-Hvu-047669 Hordeum vulgare 71.75 2.00e-170 591.00
IUUC-Itr-048212 Ictidomys tridecemlineatus 90.63 0.00e+00 1700.00
IUUC-Kpa-049265 Komagataella pastoris 49.44 0.00e+00 866.00
IUUC-Lpe-051579 Leersia perrieri 60.69 0.00e+00 1095.00
IUUC-Loc-052675 Lepisosteus oculatus 94.57 0.00e+00 1728.00
IUUC-Lma-053218 Leptosphaeria maculans 54.59 0.00e+00 917.00
IUUC-Laf-053757 Loxodonta africana 91.09 0.00e+00 1705.00
IUUC-Mcc-054859 Macaca mulatta 91.08 0.00e+00 1712.00
IUUC-Meu-056174 Macropus eugenii 91.88 0.00e+00 730.00
IUUC-Mor-057264 Magnaporthe oryzae 56.14 0.00e+00 880.00
IUUC-Mpo-057538 Magnaporthe poae 55.42 0.00e+00 910.00
IUUC-Mtr-058310 Medicago truncatula 62.76 0.00e+00 1128.00
IUUC-Mla-058937 Melampsora laricipopulina 54.09 0.00e+00 916.00
IUUC-Mga-059875 Meleagris gallopavo 94.12 0.00e+00 1719.00
IUUC-Mvi-060240 Microbotryum violaceum 49.25 0.00e+00 913.00
IUUC-Mmr-061261 Microcebus murinus 91.08 0.00e+00 1713.00
IUUC-Mdo-062076 Monodelphis domestica 92.54 0.00e+00 1725.00
IUUC-Mmu-063324 Mus musculus 90.78 0.00e+00 1708.00
IUUC-Mac-064636 Musa acuminata 60.12 0.00e+00 1085.00
IUUC-Mpu-065961 Mustela putorius furo 90.75 0.00e+00 1707.00
IUUC-Mlu-067059 Myotis lucifugus 94.44 0.00e+00 1649.00
IUUC-Nfi-068277 Neosartorya fischeri 55.40 0.00e+00 921.00
IUUC-Ncr-068659 Neurospora crassa 52.58 0.00e+00 905.00
IUUC-Nle-069034 Nomascus leucogenys 90.97 0.00e+00 1712.00
IUUC-Opr-070334 Ochotona princeps 96.46 0.00e+00 1503.00
IUUC-Ont-071563 Oreochromis niloticus 94.22 0.00e+00 1693.00
IUUC-Oan-073416 Ornithorhynchus anatinus 95.49 0.00e+00 1637.00
IUUC-Ocu-074522 Oryctolagus cuniculus 90.53 0.00e+00 1702.00
IUUC-Oba-075760 Oryza barthii 59.11 0.00e+00 1081.00
IUUC-Obr-076163 Oryza brachyantha 63.50 0.00e+00 1101.00
IUUC-Ogl-077450 Oryza glaberrima 60.28 0.00e+00 1110.00
IUUC-Ogu-078994 Oryza glumaepatula 59.11 0.00e+00 1080.00
IUUC-Oin-079856 Oryza indica 59.69 0.00e+00 1077.00
IUUC-Olo-080731 Oryza longistaminata 58.40 0.00e+00 1064.00
IUUC-Ome-081762 Oryza meridionalis 55.42 0.00e+00 1000.00
IUUC-Oni-082324 Oryza nivara 59.11 0.00e+00 1080.00
IUUC-Opu-083400 Oryza punctata 58.03 0.00e+00 1067.00
IUUC-Oru-084829 Oryza rufipogon 59.11 0.00e+00 1081.00
IUUC-Osa-086026 Oryza sativa 60.28 0.00e+00 1112.00
IUUC-Ola-087245 Oryzias latipes 93.86 0.00e+00 1688.00
IUUC-Olu-087655 Ostreococcus lucimarinus 59.36 0.00e+00 1050.00
IUUC-Oga-088163 Otolemur garnettii 87.93 0.00e+00 1640.00
IUUC-Oar-089842 Ovis aries 92.28 0.00e+00 1704.00
IUUC-Ptr-090501 Pan troglodytes 90.86 0.00e+00 1707.00
IUUC-Pan-092011 Papio anubis 91.08 0.00e+00 1713.00
IUUC-Psi-093308 Pelodiscus sinensis 95.88 0.00e+00 1718.00
IUUC-Pma-094695 Petromyzon marinus 79.35 0.00e+00 1436.00
IUUC-Pno-094785 Phaeosphaeria nodorum 62.41 3.00e-112 399.00
IUUC-Ppa-095911 Physcomitrella patens 61.96 0.00e+00 1129.00
IUUC-Pfo-096587 Poecilia formosa 90.78 0.00e+00 1697.00
IUUC-Pab-097926 Pongo abelii 88.53 0.00e+00 1618.00
IUUC-Pop-099634 Populus trichocarpa 62.47 0.00e+00 1100.00
IUUC-Pca-100965 Procavia capensis 89.32 0.00e+00 1660.00
IUUC-Ppe-101470 Prunus persica 62.88 0.00e+00 1120.00
IUUC-Pva-102451 Pteropus vampyrus 90.38 0.00e+00 1252.00
IUUC-Pgr-103453 Puccinia graminis 54.11 0.00e+00 929.00
IUUC-Ptt-103868 Puccinia triticina 54.55 0.00e+00 928.00
IUUC-Pte-104274 Pyrenophora teres 55.39 0.00e+00 949.00
IUUC-Pyt-104794 Pyrenophora triticirepentis 54.72 0.00e+00 897.00
IUUC-Rno-105979 Rattus norvegicus 82.90 0.00e+00 1248.00
IUUC-Sce-106269 Saccharomyces cerevisiae 47.30 0.00e+00 786.00
IUUC-Sha-106905 Sarcophilus harrisii 94.42 0.00e+00 1716.00
IUUC-Sja-107838 Schizosaccharomyces japonicus 47.72 0.00e+00 830.00
IUUC-Spo-108299 Schizosaccharomyces pombe 47.16 0.00e+00 831.00
IUUC-Smo-108695 Selaginella moellendorffii 62.10 0.00e+00 1080.00
IUUC-Sit-110239 Setaria italica 58.22 0.00e+00 1108.00
IUUC-Sly-111525 Solanum lycopersicum 62.15 0.00e+00 1118.00
IUUC-Stu-112906 Solanum tuberosum 61.84 0.00e+00 993.00
IUUC-Sar-113472 Sorex araneus 89.16 0.00e+00 1142.00
IUUC-Sbi-114052 Sorghum bicolor 63.54 0.00e+00 1118.00
IUUC-Sre-115040 Sporisorium reilianum 52.50 0.00e+00 918.00
IUUC-Ssc-115593 Sus scrofa 90.89 0.00e+00 1714.00
IUUC-Tgu-117239 Taeniopygia guttata 93.01 0.00e+00 1728.00
IUUC-Tru-118025 Takifugu rubripes 93.53 0.00e+00 1681.00
IUUC-Tsy-118824 Tarsius syrichta 88.85 0.00e+00 1156.00
IUUC-Tni-120142 Tetraodon nigroviridis 92.13 0.00e+00 1677.00
IUUC-Tca-121613 Theobroma cacao 60.02 0.00e+00 1113.00
IUUC-Tre-122072 Trichoderma reesei 55.11 0.00e+00 926.00
IUUC-Tvi-122546 Trichoderma virens 54.61 0.00e+00 912.00
IUUC-Tae-125292 Triticum aestivum 62.64 0.00e+00 1108.00
IUUC-Tur-126283 Triticum urartu 54.96 0.00e+00 947.00
IUUC-Tme-127041 Tuber melanosporum 55.92 0.00e+00 969.00
IUUC-Tbe-127770 Tupaia belangeri 90.51 0.00e+00 1254.00
IUUC-Ttr-129294 Tursiops truncatus 90.78 0.00e+00 1710.00
IUUC-Uma-129351 Ustilago maydis 51.16 0.00e+00 909.00
IUUC-Vda-129716 Verticillium dahliae 54.99 0.00e+00 944.00
IUUC-Vpa-130037 Vicugna pacos 79.71 0.00e+00 848.00
IUUC-Vvi-131689 Vitis vinifera 62.59 0.00e+00 1111.00
IUUC-Xtr-132633 Xenopus tropicalis 91.21 0.00e+00 1690.00
IUUC-Xma-133347 Xiphophorus maculatus 91.26 0.00e+00 1697.00
IUUC-Yli-134455 Yarrowia lipolytica 50.89 0.00e+00 842.00
IUUC-Zma-135867 Zea mays 62.01 0.00e+00 1120.00
Created Date 25-Jun-2017

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