iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sly-111211

Ensembl Protein ID

Solyc12g043000.1.1

UniProt Accession

K4DF88; K4DF88_SOLLC

Protein Name

Coatomer subunit beta'

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Solyc12g043000.1	Solyc12g043000.1.1	Solyc12g043000.1.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.40e-35	120.5	184	224
UBD/Beta-Prp	1.20e-67	229.0	14	288

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf...sd.tllvsGsdDgtikvWDlrtgvllks 38
           H  +v+c+++    d ++l++GsdD+t kvWD+ t  ++++
   Q: 184  HLKGVNCVDYftgGDkPYLITGSDDHTAKVWDYQTKSCVQT 224
           8889****966*9778*******************999986 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvls 99
           +++++++v+ +p++++++++ ++gt+ +w+++t+++ +s++  e +v++ kf+p++++ v g++D++i+v++++t + v ++++h+d++++
   Q: 14   RSERVKSVDLHPSEPWILASLYSGTVCIWNYQTQTMAKSFEVTELPVRSAKFIPRKQWVVAGADDMFIRVYNYNTMDKVKVFEAHTDYIRC 104
           5678999************************************************************************************ PP
   S: 100  lsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltgghtdsvysls.. 187
           ++++p+  +++s s+d  i++wd+e+g+   ++++gh++ v+ v+++p++ n ++s+slDrt+++W+l + +   tl   h + v++++  
   Q: 105  VAVHPTLPYVLSSSDDMLIKLWDWEKGWLCTQIFEGHSHYVMQVTFNPKDtNTFASASLDRTIKIWNLGSPDPNFTLDA-HLKGVNCVDyf 194
           ****************************9999*********************************************98.*********64 PP
   S: 188  fdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdn 278
              ++++l++gs+d t k+wd+qt++cv+tl+ght nv+ v f+p+  ++++gs+Dg++riW +++  l +tl++  ++v+++ +++ +++
   Q: 195  TGGDKPYLITGSDDHTAKVWDYQTKSCVQTLEGHTHNVSAVCFHPELPIIITGSEDGTVRIWHSTTYRLENTLNYGLERVWAIGYMRSSRR 285
           44555******************************************************************************99777777 PP
   S: 279  vlv 281
           v++
   Q: 286  VVI 288
           664 PP

Organism

Solanum lycopersicum

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

Protein Sequence
(Fasta)

MPLRLEIKRK LAQRSERVKS VDLHPSEPWI LASLYSGTVC IWNYQTQTMA KSFEVTELPV 60
RSAKFIPRKQ WVVAGADDMF IRVYNYNTMD KVKVFEAHTD YIRCVAVHPT LPYVLSSSDD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTGAGTT TTCTAGTTTC AACCAATTTT ATAATGACTT TTGCGTTGTC GGATCTGAAT 60
CATTCCGATC CGGTTATGTC TTCCTCTCGA AGTTTTGCAT ATTGTTCGAG TATTTTTAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR006692--Coatomer_WD-assoc_reg
IPR016453--COPB2
IPR020472--G-protein_beta_WD-40_rep
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF04053--Coatomer_WDAD
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0006891--P:intra-Golgi vesicle-mediated transport
GO:0006886--P:intracellular protein transport
GO:0006890--P:retrograde vesicle-mediated transport, Golgi to ER

KEGG

sly:101264409

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000654	Aegilops tauschii	71.41	0.00e+00	1367.00
IUUC-Cne-026986	Cryptococcus neoformans	49.64	0.00e+00	872.00
IUUC-Gma-042910	Glycine max	85.87	0.00e+00	1628.00
IUUC-Hvu-047669	Hordeum vulgare	90.68	0.00e+00	696.00
IUUC-Mac-064636	Musa acuminata	81.41	0.00e+00	1552.00
IUUC-Ome-081762	Oryza meridionalis	78.34	0.00e+00	1394.00
IUUC-Osa-086026	Oryza sativa	81.97	0.00e+00	1537.00
IUUC-Smo-108695	Selaginella moellendorffii	81.37	0.00e+00	1404.00
IUUC-Stu-112906	Solanum tuberosum	98.97	0.00e+00	1634.00
IUUC-Sbi-113801	Sorghum bicolor	81.53	0.00e+00	1536.00
IUUC-Tur-126283	Triticum urartu	72.47	0.00e+00	1370.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence