iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCING00000005509.3	ENSCINT00000011382.3	ENSCINP00000011382.3
ENSCING00000005509.3	ENSCINT00000028743.2	ENSCINP00000028497.2
ENSCING00000005509.3	ENSCINT00000011378.2	ENSCINP00000011378.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.70e-35	119.3	452	487
UBD/Beta-Prp	2.10e-75	253.4	230	551

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 4    dsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           +++tcl+f ++ ++l +G++DgtikvW++  g++l+
   Q: 452  EEITCLSFdDTcRRLFTGARDGTIKVWSFQNGNCLH 487
           46******755799*******************997 PP

UBD/Beta-Prp

   S: 6    kghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrsl.sgheaevtavkfspdgkilvtgseDrtikvw.dlstgkcvhtlkg 92
            + h +v++ + + p++++++++s+++++ v  ++ + + r +  + +++  + ++s++ +il+tgs D+++++w ++    ++++l+g
   Q: 230  GSIHNDVMRRILYVPQSDVIISSSMSSSTSVVLMDVKRKNRPYiFKVNKGAECFDYSKSLNILATGSLDHLVRIWnPYVVARPIVILQG 318
           566999********************9997765555555444446666699************************6666999******* PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqclee............................................tlsghd 137
           h+  ++++ +++    +v+ s+d +i+vwd+++++cl++                                            +   h+
   Q: 319  HSTGICDVVINEAYGQIVTYSKDAIIKVWDIKEQTCLQTispkfpslrevplslygsphnimiltcndsiallkmgklepkaeLPVTHE 407
           ************99********************************************************************99999** PP
   S: 138  gvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgght.dsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlng.htdn 224
           ++ ++++++p    +v++s+D+tv +Wd++tg+   t++ +h  + +++lsfd++ ++l +g++dgt+k+w++q+g+c+++l+   ++ 
   Q: 408  AALCGAAYNPLFHQIVTASDDSTVSVWDIETGSKSLTFSNAHGqEEITCLSFDDTCRRLFTGARDGTIKVWSFQNGNCLHELEPlEEAE 496
           **********99**************************88886268*************************************967789 PP
   S: 225  vksvrfspnderlvsgssDgsiriW........dlrsgdllktlqlhnssvisvav 272
           v+ v  +++ ++l++g   + i i+        +++  + +k+ qlh++ + +va+
   Q: 497  VTGVLSFQDRTILAVG-WNRRIVIYddsdpdtvNIKPTTSWKAGQLHQDDILAVAH 551
           9999999666666655.7999****999999999999999********99999987 PP

Organism

Ciona intestinalis

Protein Sequence
(Fasta)

EQMEMLFYKV DTACDGYVDW NEFCTYMLLQ MREWEHIQNL KLIPSSCNQR IIYLLQQETT 60
TRTLVVENPT RIVSISKVGT ICVWDFELKL LKKMLFSCTS SRRRFHTWVT DAIYMRNTQN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACGAAGAAA CTGGGCAAGT GAAGCAAGGT CCAGGAATGA TGTCTTTACA GGAATTTAAA 60
GCAACTATAT CAAGTATGCT TGGTACATCC AGATGGAACG AACAAATGGA GATGTTATTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0853--WD repeat

Interpro

IPR011992--EF-hand-dom_pair
IPR002048--EF_hand_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50222--EF_HAND_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF13833--EF-hand_8
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0005509--F:calcium ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003630	Anas platyrhynchos	28.99	3.00e-21	95.10
IUUC-Dre-027920	Danio rerio	35.39	7.00e-126	443.00
IUUC-Gmo-039225	Gadus morhua	34.57	2.00e-82	298.00
IUUC-Lch-050151	Latimeria chalumnae	43.81	1.00e-171	595.00
IUUC-Loc-052558	Lepisosteus oculatus	44.53	0.00e+00	630.00
IUUC-Mdo-062601	Monodelphis domestica	37.72	4.00e-147	514.00
IUUC-Ont-072106	Oreochromis niloticus	35.38	1.00e-134	473.00
IUUC-Ppa-095538	Physcomitrella patens	36.05	2.00e-21	96.30
IUUC-Smo-109247	Selaginella moellendorffii	26.07	6.00e-54	204.00
IUUC-Tru-117878	Takifugu rubripes	33.01	4.00e-76	277.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence