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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064343
Ensembl Protein ID ENSMUSP00000002305.8
UniProt Accession Q3UWM4; A6H6E5; Q3UWN8; Q6ZPJ5; Q8C969; Q8C9E0; Q91VX8; KDM7A_MOUSE
Genbank Protein ID BAC31226.2; BAC31377.1; BAE22876.1; BAE22890.1; AAH07161.1; AAI45849.1; BAC98239.1
Protein Name Lysine-specific demethylase 7A; JmjC domain-containing histone demethylation protein 1D; Lysine-specific demethylase 7
Genbank Nucleotide ID AK042327; AK042834; AK136209; AK136238; BC007161; BC145848; AK129429
Gene Name Kdm7a; Jhdm1d; Kdm7; Kiaa1718
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000042599.8 ENSMUST00000002305.8 ENSMUSP00000002305.8
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 1.30e-08 36.0 38 86
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           ++C vC+++++ ++ ++eC+ C++wfH  C++ + e    + + + Cp+C 
   Q: 38   VYC-VCRQPYDVNRFMIECDVCKDWFHGSCVGVE-EHHAVDIDLYHCPDCA 86
           69*.******************************.999999999******7 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate (By similarity).
 Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate (By similarity).
Protein Sequence
(Fasta)
MAGAAAAVAA GAAAGAAAAA GSVSAPGRAS APPPPPPVYC VCRQPYDVNR FMIECDVCKD 60
WFHGSCVGVE EHHAVDIDLY HCPDCAALHG SSLMKKRRNW HRHDYTEVDD GSKPVQAGTR 120
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Protein Fasta Sequence


>IUUC-Mmu-064343|E3,PHD|Mus musculus
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Nucleotide Sequence
(Fasta)
AAGACGCCGC CGCCGCAGCC GCCGCCGCTG CTGCTGCCGC CGCCGCCGCC GCCGGGGCTG 60
CTGCTCCGGC TGCTGCAGGA GGCGGCGCTG GCTGGCGGCT GCGCTCGCTC CAGTCAGCGA 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064343|E3,PHD|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003347--JmjC_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51184--JMJC
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF02373--JmjC
PF00628--PHD
SMART

SM00558--JmjC
SM00249--PHD
Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0071558--F:histone demethylase activity (H3-K27 specific)
GO:0051864--F:histone demethylase activity (H3-K36 specific)
GO:0032454--F:histone demethylase activity (H3-K9 specific)
GO:0035575--F:histone demethylase activity (H4-K20 specific)
GO:0005506--F:iron ion binding
GO:0035064--F:methylated histone binding
GO:0016706--F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0008270--F:zinc ion binding
GO:0071557--P:histone H3-K27 demethylation
GO:0070544--P:histone H3-K36 demethylation
GO:0033169--P:histone H3-K9 demethylation
GO:0035574--P:histone H4-K20 demethylation
GO:0030901--P:midbrain development
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG mmu:338523
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ame-011675 Astyanax mexicanus 58.38 0.00e+00 767.00
IUUC-Cja-018757 Callithrix jacchus 89.82 0.00e+00 1611.00
IUUC-Csa-023888 Chlorocebus sabaeus 89.82 0.00e+00 1638.00
IUUC-Cme-027118 Cyanidioschyzon merolae 30.79 3.00e-52 199.00
IUUC-Dre-027922 Danio rerio 65.91 0.00e+00 764.00
IUUC-Dno-030062 Dasypus novemcinctus 88.23 0.00e+00 1585.00
IUUC-Gga-040633 Gallus gallus 93.92 0.00e+00 712.00
IUUC-Gac-041447 Gasterosteus aculeatus 60.74 0.00e+00 801.00
IUUC-Hsa-046706 Homo sapiens 89.93 0.00e+00 1622.00
IUUC-Loc-052781 Lepisosteus oculatus 60.45 0.00e+00 1010.00
IUUC-Mmr-061767 Microcebus murinus 86.95 0.00e+00 1555.00
IUUC-Mdo-062778 Monodelphis domestica 83.66 0.00e+00 1514.00
IUUC-Ola-087006 Oryzias latipes 60.58 0.00e+00 808.00
IUUC-Ptr-090549 Pan troglodytes 89.93 0.00e+00 1620.00
IUUC-Pan-091786 Papio anubis 89.83 0.00e+00 1640.00
IUUC-Smo-109024 Selaginella moellendorffii 36.61 7.00e-59 221.00
IUUC-Ssc-116137 Sus scrofa 88.44 0.00e+00 1548.00
IUUC-Tru-118331 Takifugu rubripes 54.52 0.00e+00 876.00
IUUC-Tni-119870 Tetraodon nigroviridis 78.59 0.00e+00 752.00
IUUC-Ttr-129014 Tursiops truncatus 87.50 0.00e+00 1566.00
Created Date 25-Jun-2017

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