iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012864

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin thioesterase OTU1

Genbank Nucleotide ID

BC122788

Gene Name

YOD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000020273.4	ENSBTAT00000027017.4	ENSBTAP00000027017.4

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
DUB/OTU	30.93	8.00e-34	139.00	IUUC-Sce-106323
ULD/UDP/UFD/UBX	30.93	8.00e-34	139.00	IUUC-Sce-106323

Active Site

Position(s)	Description	Evidence
157	N/A	{ECO:0000250\|UniProtKB:Q96FW1}
160	Nucleophile	{ECO:0000250\|UniProtKB:Q5VVQ6}
267		{ECO:0000250\|UniProtKB:Q5VVQ6}
342		{ECO:0000250\|UniProtKB:Q96FW1}

Organism

Bos taurus

Functional Description
(View)

Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin (By similarity).

Protein Sequence
(Fasta)

MFGPAKGGHF GVHPAAGCPG GVSQPAAGTK AGPAGVCPVG GRTNAMWRLR CKAKEGTHVL 60
QGLSSRTRVR ELQGQIAAIT GISPGCQRIL VGYPPECLDL SNGDTILEDL PIQSGDMLIV 120

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Nucleotide Sequence
(Fasta)

GACTTCTCGC GATGTTTGGA CCGGCAAAGG GTGGCCATTT TGGAGTCCAC CCGGCGGCTG 60
GTTGCCCCGG CGGCGTTAGC CAGCCTGCTG CCGGGACCAA AGCTGGCCCC GCCGGTGTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0834--Unfolded protein response
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003323--OTU_dom
IPR029071--Ubiquitin-rel_dom
IPR013087--Znf_C2H2_type

PROSITE

PS50802--OTU
PS00028--ZINC_FINGER_C2H2_1

Pfam

PF02338--OTU

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904265--F:ubiquitin-specific protease activity involved in negative regulation of retrograde protein transport, ER to cytosol
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0016579--P:protein deubiquitination
GO:0035871--P:protein K11-linked deubiquitination
GO:1990167--P:protein K27-linked deubiquitination
GO:0035523--P:protein K29-linked deubiquitination
GO:1990168--P:protein K33-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

bta:539931

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000271	Aegilops tauschii	47.62	2.00e-43	168.00
IUUC-Aml-001860	Ailuropoda melanoleuca	92.82	0.00e+00	667.00
IUUC-Atr-002548	Amborella trichopoda	49.03	4.00e-50	190.00
IUUC-Apl-004025	Anas platyrhynchos	78.33	3.00e-102	364.00
IUUC-Aca-004505	Anolis carolinensis	72.52	1.00e-134	472.00
IUUC-Aly-005999	Arabidopsis lyrata	45.63	6.00e-47	180.00
IUUC-Ath-006774	Arabidopsis thaliana	46.60	1.00e-47	182.00
IUUC-Ago-007741	Ashbya gossypii	39.39	3.00e-37	148.00
IUUC-Acl-008278	Aspergillus clavatus	41.46	6.00e-42	164.00
IUUC-Afl-008710	Aspergillus flavus	35.03	3.00e-42	165.00
IUUC-Afu-009009	Aspergillus fumigatus	42.44	2.00e-43	169.00
IUUC-Ani-009430	Aspergillus nidulans	32.23	2.00e-40	159.00
IUUC-Ang-009508	Aspergillus niger	40.21	1.00e-36	146.00
IUUC-Aor-009992	Aspergillus oryzae	35.33	4.00e-43	168.00
IUUC-Ate-010440	Aspergillus terreus	35.50	2.00e-45	176.00
IUUC-Ame-011038	Astyanax mexicanus	70.49	2.00e-126	444.00
IUUC-Bgr-012262	Blumeria graminis	34.95	3.00e-33	135.00
IUUC-Bci-013986	Botrytis cinerea	34.45	1.00e-34	140.00
IUUC-Bdi-014194	Brachypodium distachyon	49.76	1.00e-49	189.00
IUUC-Bol-016166	Brassica oleracea	47.09	3.00e-48	184.00
IUUC-Bra-017783	Brassica rapa	47.57	1.00e-48	186.00
IUUC-Cja-019488	Callithrix jacchus	91.95	0.00e+00	661.00
IUUC-Cpo-021728	Cavia porcellus	88.22	0.00e+00	639.00
IUUC-Cre-022819	Chlamydomonas reinhardtii	46.08	5.00e-42	163.00
IUUC-Csa-024237	Chlorocebus sabaeus	93.40	2.00e-167	581.00
IUUC-Cho-024544	Choloepus hoffmanni	91.38	0.00e+00	657.00
IUUC-Cin-025549	Ciona intestinalis	44.92	4.00e-74	271.00
IUUC-Cgl-026552	Colletotrichum gloeosporioides	31.14	1.00e-33	137.00
IUUC-Cne-027022	Cryptococcus neoformans	44.06	2.00e-43	169.00
IUUC-Cme-027196	Cyanidioschyzon merolae	37.32	1.00e-45	176.00
IUUC-Dre-027799	Danio rerio	70.63	1.00e-120	426.00
IUUC-Dno-029863	Dasypus novemcinctus	89.94	0.00e+00	651.00
IUUC-Dor-030804	Dipodomys ordii	83.95	1.00e-169	588.00
IUUC-Dse-031494	Dothistroma septosporum	31.90	3.00e-41	162.00
IUUC-Dme-032065	Drosophila melanogaster	41.16	1.00e-67	249.00
IUUC-Ete-033193	Echinops telfairi	89.94	0.00e+00	630.00
IUUC-Eca-033993	Equus caballus	92.53	0.00e+00	665.00
IUUC-Fca-035949	Felis catus	93.68	0.00e+00	676.00
IUUC-Fal-037473	Ficedula albicollis	76.27	6.00e-99	353.00
IUUC-Fox-037779	Fusarium oxysporum	31.06	4.00e-30	125.00
IUUC-Fso-038370	Fusarium solani	36.11	1.00e-27	117.00
IUUC-Gmo-038778	Gadus morhua	57.89	2.00e-90	325.00
IUUC-Ggr-039940	Gaeumannomyces graminis	33.33	3.00e-35	142.00
IUUC-Gga-041102	Gallus gallus	68.61	3.00e-122	431.00
IUUC-Gac-041954	Gasterosteus aculeatus	69.48	2.00e-123	435.00
IUUC-Gma-043608	Glycine max	46.60	1.00e-47	182.00
IUUC-Ggo-044753	Gorilla gorilla	91.09	0.00e+00	649.00
IUUC-Hsa-045714	Homo sapiens	90.20	6.00e-158	549.00
IUUC-Hvu-047600	Hordeum vulgare	47.89	2.00e-50	191.00
IUUC-Itr-048026	Ictidomys tridecemlineatus	91.38	0.00e+00	661.00
IUUC-Kpa-049360	Komagataella pastoris	31.25	3.00e-40	158.00
IUUC-Lch-049900	Latimeria chalumnae	72.37	2.00e-122	431.00
IUUC-Lpe-050984	Leersia perrieri	40.20	2.00e-31	128.00
IUUC-Loc-052567	Lepisosteus oculatus	71.48	2.00e-129	455.00
IUUC-Lma-053247	Leptosphaeria maculans	31.50	2.00e-40	159.00
IUUC-Laf-053361	Loxodonta africana	90.23	5.00e-175	606.00
IUUC-Meu-056137	Macropus eugenii	75.14	2.00e-149	521.00
IUUC-Mor-057191	Magnaporthe oryzae	30.68	4.00e-26	112.00
IUUC-Mpo-057565	Magnaporthe poae	39.59	6.00e-32	131.00
IUUC-Mtr-058196	Medicago truncatula	47.57	5.00e-48	183.00
IUUC-Mla-059096	Melampsora laricipopulina	43.15	7.00e-39	154.00
IUUC-Mga-059489	Meleagris gallopavo	78.81	7.00e-109	385.00
IUUC-Mvi-060300	Microbotryum violaceum	38.05	2.00e-42	166.00
IUUC-Mmr-061618	Microcebus murinus	92.59	1.00e-163	568.00
IUUC-Mdo-061909	Monodelphis domestica	84.84	2.00e-157	548.00
IUUC-Mmu-063434	Mus musculus	86.49	2.00e-176	611.00
IUUC-Mac-064676	Musa acuminata	49.03	3.00e-50	191.00
IUUC-Mpu-066733	Mustela putorius furo	92.53	0.00e+00	664.00
IUUC-Mlu-066990	Myotis lucifugus	86.04	3.00e-180	624.00
IUUC-Nfi-068249	Neosartorya fischeri	42.44	5.00e-43	167.00
IUUC-Ncr-068764	Neurospora crassa	33.23	7.00e-34	137.00
IUUC-Nle-069094	Nomascus leucogenys	91.38	0.00e+00	652.00
IUUC-Oan-073585	Ornithorhynchus anatinus	84.21	1.00e-153	535.00
IUUC-Oba-075949	Oryza barthii	49.03	2.00e-48	185.00
IUUC-Obr-076096	Oryza brachyantha	49.03	8.00e-49	186.00
IUUC-Ogl-077106	Oryza glaberrima	48.54	5.00e-48	183.00
IUUC-Ogu-078024	Oryza glumaepatula	49.03	3.00e-48	184.00
IUUC-Oin-079635	Oryza indica	48.06	6.00e-48	183.00
IUUC-Olo-080299	Oryza longistaminata	49.03	4.00e-48	184.00
IUUC-Ome-081359	Oryza meridionalis	49.03	2.00e-48	185.00
IUUC-Oni-082459	Oryza nivara	48.54	5.00e-48	183.00
IUUC-Opu-083167	Oryza punctata	50.00	1.00e-49	189.00
IUUC-Oru-084577	Oryza rufipogon	48.06	6.00e-48	183.00
IUUC-Osa-085746	Oryza sativa	52.94	7.00e-12	61.60
IUUC-Ola-086890	Oryzias latipes	70.16	1.00e-125	442.00
IUUC-Olu-087585	Ostreococcus lucimarinus	43.78	3.00e-43	167.00
IUUC-Oga-088190	Otolemur garnettii	89.07	1.00e-164	572.00
IUUC-Oar-089631	Ovis aries	97.13	0.00e+00	699.00
IUUC-Pan-091892	Papio anubis	91.95	0.00e+00	657.00
IUUC-Pma-094491	Petromyzon marinus	56.69	2.00e-88	318.00
IUUC-Pno-094993	Phaeosphaeria nodorum	33.23	3.00e-43	169.00
IUUC-Ppa-095791	Physcomitrella patens	51.94	3.00e-52	197.00
IUUC-Pfo-096301	Poecilia formosa	71.29	1.00e-126	445.00
IUUC-Pab-097873	Pongo abelii	91.09	0.00e+00	647.00
IUUC-Pop-099482	Populus trichocarpa	47.09	2.00e-49	188.00
IUUC-Pca-100817	Procavia capensis	89.18	4.00e-158	550.00
IUUC-Ppe-101624	Prunus persica	49.76	4.00e-51	194.00
IUUC-Pva-102120	Pteropus vampyrus	89.08	1.00e-180	625.00
IUUC-Pgr-103368	Puccinia graminis	30.48	1.00e-42	166.00
IUUC-Ptt-103923	Puccinia triticina	31.82	4.00e-41	161.00
IUUC-Pte-104199	Pyrenophora teres	39.70	6.00e-41	160.00
IUUC-Pyt-104502	Pyrenophora triticirepentis	32.84	7.00e-42	164.00
IUUC-Rno-105605	Rattus norvegicus	87.93	4.00e-173	600.00
IUUC-Sce-106323	Saccharomyces cerevisiae	30.93	5.00e-30	124.00
IUUC-Sha-107176	Sarcophilus harrisii	85.17	6.00e-133	466.00
IUUC-Sja-107812	Schizosaccharomyces japonicus	38.57	3.00e-36	145.00
IUUC-Spo-108085	Schizosaccharomyces pombe	31.44	1.00e-39	156.00
IUUC-Smo-109050	Selaginella moellendorffii	48.54	5.00e-50	190.00
IUUC-Sit-110056	Setaria italica	47.32	4.00e-48	184.00
IUUC-Sly-111869	Solanum lycopersicum	50.29	6.00e-44	169.00
IUUC-Stu-112452	Solanum tuberosum	48.78	3.00e-50	191.00
IUUC-Sar-113629	Sorex araneus	80.33	1.00e-53	203.00
IUUC-Sbi-114422	Sorghum bicolor	48.06	2.00e-49	187.00
IUUC-Sre-115105	Sporisorium reilianum	42.50	1.00e-32	134.00
IUUC-Ssc-115553	Sus scrofa	91.38	0.00e+00	654.00
IUUC-Tgu-116921	Taeniopygia guttata	76.79	2.00e-98	351.00
IUUC-Tru-117830	Takifugu rubripes	68.87	5.00e-125	440.00
IUUC-Tsy-119320	Tarsius syrichta	90.52	0.00e+00	648.00
IUUC-Tni-119706	Tetraodon nigroviridis	66.78	9.00e-118	416.00
IUUC-Tca-121238	Theobroma cacao	48.06	3.00e-49	187.00
IUUC-Tae-124711	Triticum aestivum	48.54	8.00e-50	190.00
IUUC-Tme-126966	Tuber melanosporum	34.94	2.00e-50	192.00
IUUC-Tbe-127712	Tupaia belangeri	92.42	6.00e-106	375.00
IUUC-Ttr-129168	Tursiops truncatus	90.52	0.00e+00	657.00
IUUC-Uma-129461	Ustilago maydis	40.98	6.00e-38	151.00
IUUC-Vda-129890	Verticillium dahliae	36.11	2.00e-25	108.00
IUUC-Vpa-130616	Vicugna pacos	90.52	0.00e+00	648.00
IUUC-Vvi-131250	Vitis vinifera	48.54	4.00e-49	187.00
IUUC-Xtr-132126	Xenopus tropicalis	70.39	2.00e-129	455.00
IUUC-Xma-133596	Xiphophorus maculatus	70.82	5.00e-126	443.00
IUUC-Yli-134562	Yarrowia lipolytica	32.88	1.00e-34	140.00
IUUC-Zma-135205	Zea mays	47.57	1.00e-48	185.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence