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Tag Content
iUUCD ID IUUC-Mdo-061948
Ensembl Protein ID ENSMODP00000029600.1
UniProt Accession F6QJ94; F6QJ94_MONDO
Protein Name Ubiquitin-related modifier 1
Gene Name URM1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMODG00000023353.1 ENSMODT00000031174.1 ENSMODP00000029600.1
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 45.45 2.00e-18 84.70 IUUC-Sce-106366
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Monodelphis domestica
Functional Description
(View)

Functional Description


     Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
 Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Protein Sequence
(Fasta)
MAAPVSVQVE FGGGAELLFD GVKKHQVTLP SQDEPWDVRN LLIWIRKNLL KERPELFIQG 60
DSVRPGILVL INDADWELQG ELDYQLQDQD SILFISTLHG G 101
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Protein Fasta Sequence


>IUUC-Mdo-061948|ULD,UBQ_Other|Monodelphis domestica
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Nucleotide Sequence
(Fasta)
ATGGCGGCCC CCGTGTCAGT GCAGGTGGAG TTCGGGTGAG TTGGGGGTCT GGAGCCCAAG 60
GGAGGGGAGG ACCAGTAGCT CTATACAGAA GGGTGGTGTA TCGGGATGGC AGTTCCTTCT 120
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Nucleotide Fasta Sequence


>IUUC-Mdo-061948|ULD,UBQ_Other|Monodelphis domestica
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway
Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1
Pfam

PF09138--Urm1
Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016783--F:sulfurtransferase activity
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification
KEGG mdo:100011672
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002254 Ailuropoda melanoleuca 89.11 7.00e-51 191.00
IUUC-Atr-003089 Amborella trichopoda 58.59 9.00e-31 124.00
IUUC-Apl-003382 Anas platyrhynchos 86.81 4.00e-43 165.00
IUUC-Aca-004981 Anolis carolinensis 85.15 9.00e-49 184.00
IUUC-Aly-005517 Arabidopsis lyrata 56.52 2.00e-28 116.00
IUUC-Ath-006718 Arabidopsis thaliana 57.14 6.00e-25 105.00
IUUC-Ago-007917 Ashbya gossypii 44.44 7.00e-21 91.70
IUUC-Acl-008054 Aspergillus clavatus 68.00 6.00e-16 75.10
IUUC-Afl-008704 Aspergillus flavus 55.56 2.00e-21 92.80
IUUC-Aor-009890 Aspergillus oryzae 56.86 1.00e-25 108.00
IUUC-Bta-012448 Bos taurus 89.11 2.00e-50 190.00
IUUC-Bci-013865 Botrytis cinerea 48.51 1.00e-22 97.80
IUUC-Bdi-014980 Brachypodium distachyon 67.19 1.00e-23 101.00
IUUC-Bol-016055 Brassica oleracea 56.25 1.00e-24 103.00
IUUC-Bra-016845 Brassica rapa 56.25 1.00e-24 103.00
IUUC-Cel-018485 Caenorhabditis elegans 34.95 1.00e-11 60.80
IUUC-Cja-019587 Callithrix jacchus 91.09 3.00e-51 192.00
IUUC-Cfa-020653 Canis familiaris 90.10 1.00e-50 190.00
IUUC-Cpo-021622 Cavia porcellus 91.09 3.00e-51 192.00
IUUC-Cre-023015 Chlamydomonas reinhardtii 53.06 2.00e-26 110.00
IUUC-Csa-023756 Chlorocebus sabaeus 89.74 2.00e-38 150.00
IUUC-Cgl-026518 Colletotrichum gloeosporioides 45.54 4.00e-22 96.30
IUUC-Cne-026953 Cryptococcus neoformans 56.31 1.00e-28 118.00
IUUC-Cme-027314 Cyanidioschyzon merolae 45.45 6.00e-20 88.20
IUUC-Dre-027884 Danio rerio 77.23 2.00e-44 169.00
IUUC-Dno-029262 Dasypus novemcinctus 86.25 9.00e-38 149.00
IUUC-Dor-030601 Dipodomys ordii 60.40 3.00e-26 109.00
IUUC-Dme-031893 Drosophila melanogaster 58.82 8.00e-31 124.00
IUUC-Ete-032773 Echinops telfairi 84.16 1.00e-45 173.00
IUUC-Eca-034187 Equus caballus 92.08 3.00e-51 192.00
IUUC-Eeu-034808 Erinaceus europaeus 87.13 2.00e-49 186.00
IUUC-Fca-036107 Felis catus 89.11 1.00e-50 190.00
IUUC-Fal-036607 Ficedula albicollis 84.62 2.00e-42 162.00
IUUC-Fox-037698 Fusarium oxysporum 47.12 1.00e-23 100.00
IUUC-Gmo-039492 Gadus morhua 75.25 5.00e-44 168.00
IUUC-Ggr-039965 Gaeumannomyces graminis 47.12 2.00e-21 94.40
IUUC-Gga-041268 Gallus gallus 88.12 2.00e-49 186.00
IUUC-Gac-042111 Gasterosteus aculeatus 80.20 1.00e-46 177.00
IUUC-Gma-043240 Glycine max 51.19 1.00e-22 97.40
IUUC-Ggo-045176 Gorilla gorilla 89.74 6.00e-30 122.00
IUUC-Hsa-046077 Homo sapiens 90.10 1.00e-42 163.00
IUUC-Itr-048111 Ictidomys tridecemlineatus 92.13 2.00e-36 143.00
IUUC-Kpa-049157 Komagataella pastoris 47.47 6.00e-20 88.20
IUUC-Lch-049889 Latimeria chalumnae 77.23 8.00e-46 174.00
IUUC-Lpe-050783 Leersia perrieri 54.88 2.00e-22 96.70
IUUC-Loc-052400 Lepisosteus oculatus 78.22 2.00e-45 173.00
IUUC-Lma-053259 Leptosphaeria maculans 46.53 7.00e-23 98.60
IUUC-Laf-053596 Loxodonta africana 89.32 5.00e-50 188.00
IUUC-Mcc-054845 Macaca mulatta 84.69 6.00e-45 171.00
IUUC-Meu-055968 Macropus eugenii 97.03 1.00e-53 200.00
IUUC-Mor-057126 Magnaporthe oryzae 44.23 5.00e-20 89.70
IUUC-Mpo-057311 Magnaporthe poae 49.50 6.00e-23 99.40
IUUC-Mtr-058266 Medicago truncatula 50.00 8.00e-23 98.20
IUUC-Mla-058847 Melampsora laricipopulina 38.83 6.00e-12 62.80
IUUC-Mga-059468 Meleagris gallopavo 86.81 3.00e-43 165.00
IUUC-Mvi-060235 Microbotryum violaceum 62.69 4.00e-18 83.60
IUUC-Mmu-063946 Mus musculus 90.10 2.00e-50 189.00
IUUC-Mac-064812 Musa acuminata 65.62 4.00e-24 102.00
IUUC-Mpu-066763 Mustela putorius furo 90.10 8.00e-50 187.00
IUUC-Mlu-066970 Myotis lucifugus 91.03 1.00e-38 150.00
IUUC-Ncr-068824 Neurospora crassa 47.52 2.00e-21 93.20
IUUC-Nle-069849 Nomascus leucogenys 88.46 6.00e-38 149.00
IUUC-Opr-070227 Ochotona princeps 91.09 3.00e-51 192.00
IUUC-Ont-072530 Oreochromis niloticus 80.20 2.00e-46 176.00
IUUC-Oan-073191 Ornithorhynchus anatinus 86.52 1.00e-41 160.00
IUUC-Ocu-074460 Oryctolagus cuniculus 89.80 9.00e-49 184.00
IUUC-Oba-075499 Oryza barthii 57.32 2.00e-22 98.20
IUUC-Obr-076896 Oryza brachyantha 60.94 3.00e-21 95.10
IUUC-Ogl-077834 Oryza glaberrima 57.32 3.00e-23 99.40
IUUC-Ogu-078622 Oryza glumaepatula 57.32 3.00e-23 99.40
IUUC-Oin-079358 Oryza indica 57.32 2.00e-22 99.00
IUUC-Olo-081035 Oryza longistaminata 52.53 2.00e-24 104.00
IUUC-Oni-082425 Oryza nivara 57.32 3.00e-23 99.40
IUUC-Opu-083461 Oryza punctata 55.56 4.00e-22 97.10
IUUC-Oru-084875 Oryza rufipogon 57.75 1.00e-20 90.50
IUUC-Oga-089128 Otolemur garnettii 91.09 5.00e-51 191.00
IUUC-Oar-089896 Ovis aries 89.11 2.00e-50 190.00
IUUC-Ptr-091618 Pan troglodytes 89.74 6.00e-30 122.00
IUUC-Pan-092238 Papio anubis 89.74 2.00e-38 150.00
IUUC-Psi-093879 Pelodiscus sinensis 83.17 1.00e-47 180.00
IUUC-Pma-094484 Petromyzon marinus 79.21 3.00e-35 139.00
IUUC-Ppa-095801 Physcomitrella patens 56.79 1.00e-22 97.40
IUUC-Pfo-097192 Poecilia formosa 82.18 6.00e-47 177.00
IUUC-Pab-098203 Pongo abelii 90.10 3.00e-42 162.00
IUUC-Pop-099614 Populus trichocarpa 54.76 1.00e-24 103.00
IUUC-Pca-100507 Procavia capensis 89.74 2.00e-38 149.00
IUUC-Ppe-101174 Prunus persica 56.57 1.00e-29 120.00
IUUC-Pva-102735 Pteropus vampyrus 89.11 3.00e-47 179.00
IUUC-Pgr-103510 Puccinia graminis 36.89 2.00e-11 60.80
IUUC-Ptt-103918 Puccinia triticina 33.98 1.00e-09 54.70
IUUC-Pte-104173 Pyrenophora teres 50.49 6.00e-25 105.00
IUUC-Pyt-104806 Pyrenophora triticirepentis 50.49 6.00e-25 105.00
IUUC-Rno-105820 Rattus norvegicus 90.10 2.00e-50 189.00
IUUC-Sce-106366 Saccharomyces cerevisiae 45.45 8.00e-19 84.70
IUUC-Sja-107727 Schizosaccharomyces japonicus 40.62 7.00e-16 75.50
IUUC-Spo-108074 Schizosaccharomyces pombe 37.76 1.00e-09 53.90
IUUC-Smo-108944 Selaginella moellendorffii 61.80 5.00e-27 111.00
IUUC-Sit-110277 Setaria italica 55.95 4.00e-24 102.00
IUUC-Sly-111505 Solanum lycopersicum 54.76 4.00e-25 105.00
IUUC-Stu-112076 Solanum tuberosum 55.95 1.00e-25 107.00
IUUC-Sbi-114274 Sorghum bicolor 55.84 3.00e-23 99.80
IUUC-Sre-114953 Sporisorium reilianum 62.75 4.00e-30 122.00
IUUC-Ssc-115418 Sus scrofa 94.06 6.00e-52 194.00
IUUC-Tgu-117311 Taeniopygia guttata 84.62 2.00e-42 162.00
IUUC-Tru-118598 Takifugu rubripes 79.78 1.00e-39 153.00
IUUC-Tni-120109 Tetraodon nigroviridis 76.47 2.00e-42 163.00
IUUC-Tca-120942 Theobroma cacao 55.42 1.00e-23 100.00
IUUC-Tre-122099 Trichoderma reesei 49.46 2.00e-16 76.60
IUUC-Tvi-122285 Trichoderma virens 51.92 8.00e-21 91.70
IUUC-Tae-125193 Triticum aestivum 56.10 7.00e-23 98.20
IUUC-Tur-126677 Triticum urartu 48.42 3.00e-20 90.10
IUUC-Tme-127120 Tuber melanosporum 49.04 7.00e-25 105.00
IUUC-Tbe-128050 Tupaia belangeri 66.34 1.00e-31 127.00
IUUC-Ttr-129019 Tursiops truncatus 90.10 3.00e-48 182.00
IUUC-Uma-129483 Ustilago maydis 59.80 6.00e-28 115.00
IUUC-Vda-129690 Verticillium dahliae 41.96 1.00e-17 81.30
IUUC-Vvi-131174 Vitis vinifera 57.83 1.00e-24 104.00
IUUC-Xma-133862 Xiphophorus maculatus 82.18 6.00e-47 177.00
IUUC-Yli-134398 Yarrowia lipolytica 49.02 3.00e-19 86.30
IUUC-Zma-134964 Zea mays 55.56 2.00e-22 97.10
Created Date 25-Jun-2017

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