iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-106677

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

AEFK01130875

Gene Name

UCHL3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000000154.1	ENSSHAT00000000187.1	ENSSHAP00000000184.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	6.40e-65	219.8	12	227

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 17   lftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvigNsCatyAll 105
           + +++++++g++ ++q+ ++y+++pe l+++++pv+++lllF+i+ek+e +r ++   +++++ ++d++++++f+kq+i+N+C+t++l+
   Q: 12   VTNQFLKQLGLHPNWQFVDVYGMEPELLSMVPRPVCAVLLLFPITEKYEVFRIEE--EEKIKSEGQDVTESVYFMKQTISNACGTIGLI 98
           789*************************************************554..5689**************************** PP
   S: 106  svllncedkl.ldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyvningrlyel 193
           ++++n++dk+ ++ G+tl++++e++ ++spe++a+ l++ ++++++h+s a+++++++p+ +       +k  +hf+++v+++g+lyel
   Q: 99   HAIANNKDKMnFESGSTLKKFLEESLSMSPEERARYLEKYEAIRVTHESSAHEGQTEAPSID-------EKVDLHFIALVHVDGHLYEL 180
           ***********************************************************888.......8899**************** PP
   S: 194  dglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivad 244
           dg+kpfP+++gk+++++ l+d+++v+++f+er    + +e+rfn++a++a+
   Q: 181  DGRKPFPINHGKTSDDTLLEDAIEVCKKFMER----DPEELRFNAIALSAA 227
           ********************************....9**********9875 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MPEPRFLFPF QVTNQFLKQL GLHPNWQFVD VYGMEPELLS MVPRPVCAVL LLFPITEKYE 60
VFRIEEEEKI KSEGQDVTES VYFMKQTISN ACGTIGLIHA IANNKDKMNF ESGSTLKKFL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGGGTCGG GCGGGGGCCC AGGAGCCCGA GCAATGGATG CCTGAACCAC GTTTTCTTTT 60
TCCGTTTCAG GTCACCAACC AGGTGAGTGA GTTGTAGCCA GGGAGCCTCG AGTGCTTCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH

PROSITE

PS00140--UCH_1

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000360	Aegilops tauschii	40.18	1.00e-43	169.00
IUUC-Aml-001344	Ailuropoda melanoleuca	94.01	2.00e-116	410.00
IUUC-Atr-002931	Amborella trichopoda	47.25	4.00e-48	184.00
IUUC-Apl-003949	Anas platyrhynchos	89.20	3.00e-104	370.00
IUUC-Aca-004924	Anolis carolinensis	79.57	1.00e-102	365.00
IUUC-Aly-005721	Arabidopsis lyrata	48.37	5.00e-49	187.00
IUUC-Ath-006827	Arabidopsis thaliana	49.30	3.00e-49	187.00
IUUC-Ago-007950	Ashbya gossypii	32.87	1.00e-22	99.40
IUUC-Acl-008305	Aspergillus clavatus	39.73	7.00e-39	153.00
IUUC-Afl-008611	Aspergillus flavus	40.00	2.00e-39	155.00
IUUC-Afu-008945	Aspergillus fumigatus	39.56	2.00e-38	152.00
IUUC-Ani-009339	Aspergillus nidulans	39.38	7.00e-39	153.00
IUUC-Ang-009691	Aspergillus niger	37.33	1.00e-37	149.00
IUUC-Aor-009961	Aspergillus oryzae	40.44	2.00e-39	155.00
IUUC-Ate-010316	Aspergillus terreus	39.38	2.00e-39	155.00
IUUC-Ame-011157	Astyanax mexicanus	73.61	1.00e-89	322.00
IUUC-Bgr-012125	Blumeria graminis	35.68	1.00e-34	139.00
IUUC-Bta-012673	Bos taurus	93.55	9.00e-116	408.00
IUUC-Bci-013734	Botrytis cinerea	37.05	2.00e-36	145.00
IUUC-Bdi-014330	Brachypodium distachyon	42.79	4.00e-47	181.00
IUUC-Bol-015214	Brassica oleracea	50.00	2.00e-51	194.00
IUUC-Bra-017491	Brassica rapa	50.46	9.00e-52	196.00
IUUC-Cel-018302	Caenorhabditis elegans	37.38	3.00e-28	117.00
IUUC-Cfa-020371	Canis familiaris	91.05	7.00e-96	342.00
IUUC-Cpo-022036	Cavia porcellus	91.24	2.00e-111	394.00
IUUC-Cre-022599	Chlamydomonas reinhardtii	43.63	1.00e-30	125.00
IUUC-Csa-023854	Chlorocebus sabaeus	93.09	1.00e-114	405.00
IUUC-Cin-025545	Ciona intestinalis	47.69	3.00e-59	221.00
IUUC-Cgl-026659	Colletotrichum gloeosporioides	32.29	1.00e-25	109.00
IUUC-Cne-026914	Cryptococcus neoformans	35.19	1.00e-27	116.00
IUUC-Cme-027216	Cyanidioschyzon merolae	36.19	1.00e-20	92.80
IUUC-Dre-028356	Danio rerio	74.19	3.00e-91	327.00
IUUC-Dse-031461	Dothistroma septosporum	38.33	7.00e-32	130.00
IUUC-Dme-032146	Drosophila melanogaster	50.69	9.00e-56	209.00
IUUC-Eca-033220	Equus caballus	93.55	3.00e-115	407.00
IUUC-Fca-036421	Felis catus	94.01	2.00e-116	410.00
IUUC-Fal-036773	Ficedula albicollis	89.40	1.00e-106	378.00
IUUC-Fox-037830	Fusarium oxysporum	35.43	4.00e-36	144.00
IUUC-Fso-038259	Fusarium solani	35.68	6.00e-34	139.00
IUUC-Gmo-039468	Gadus morhua	67.40	2.00e-75	275.00
IUUC-Ggr-039832	Gaeumannomyces graminis	36.20	2.00e-32	132.00
IUUC-Gga-041205	Gallus gallus	84.28	3.00e-104	370.00
IUUC-Gac-041629	Gasterosteus aculeatus	67.25	2.00e-82	297.00
IUUC-Gma-043057	Glycine max	46.30	7.00e-43	166.00
IUUC-Ggo-044533	Gorilla gorilla	93.58	4.00e-115	406.00
IUUC-Hsa-046754	Homo sapiens	94.01	2.00e-116	410.00
IUUC-Hvu-047176	Hordeum vulgare	38.99	6.00e-36	143.00
IUUC-Itr-047992	Ictidomys tridecemlineatus	90.34	3.00e-71	259.00
IUUC-Kpa-049123	Komagataella pastoris	33.03	2.00e-26	111.00
IUUC-Lch-049685	Latimeria chalumnae	78.04	1.00e-96	345.00
IUUC-Lpe-051377	Leersia perrieri	42.93	4.00e-39	153.00
IUUC-Loc-051988	Lepisosteus oculatus	77.31	4.00e-94	337.00
IUUC-Lma-053316	Leptosphaeria maculans	39.65	1.00e-39	156.00
IUUC-Laf-053985	Loxodonta africana	93.12	1.00e-114	404.00
IUUC-Mcc-055888	Macaca mulatta	93.40	3.00e-112	397.00
IUUC-Mor-057271	Magnaporthe oryzae	35.75	1.00e-35	142.00
IUUC-Mpo-057343	Magnaporthe poae	31.25	2.00e-16	79.00
IUUC-Mtr-057713	Medicago truncatula	43.26	3.00e-43	167.00
IUUC-Mla-058942	Melampsora laricipopulina	43.12	2.00e-38	152.00
IUUC-Mga-059702	Meleagris gallopavo	88.73	8.00e-104	369.00
IUUC-Mvi-060249	Microbotryum violaceum	42.25	2.00e-34	138.00
IUUC-Mmr-061284	Microcebus murinus	66.43	4.00e-91	327.00
IUUC-Mdo-062639	Monodelphis domestica	84.25	4.00e-114	403.00
IUUC-Mmu-063299	Mus musculus	94.01	2.00e-116	410.00
IUUC-Mac-065075	Musa acuminata	44.44	3.00e-45	174.00
IUUC-Mpu-066769	Mustela putorius furo	94.01	2.00e-116	410.00
IUUC-Mlu-066937	Myotis lucifugus	91.71	3.00e-113	400.00
IUUC-Nfi-068320	Neosartorya fischeri	40.00	2.00e-39	155.00
IUUC-Ncr-068673	Neurospora crassa	37.67	2.00e-39	155.00
IUUC-Nle-069175	Nomascus leucogenys	87.61	2.00e-113	400.00
IUUC-Opr-070652	Ochotona princeps	64.00	6.00e-74	270.00
IUUC-Ont-072170	Oreochromis niloticus	69.43	4.00e-83	300.00
IUUC-Oan-073247	Ornithorhynchus anatinus	92.00	3.00e-46	176.00
IUUC-Ocu-074422	Oryctolagus cuniculus	93.09	6.00e-116	409.00
IUUC-Oba-075098	Oryza barthii	40.00	3.00e-42	164.00
IUUC-Obr-076041	Oryza brachyantha	42.59	2.00e-46	178.00
IUUC-Ogl-076980	Oryza glaberrima	42.59	9.00e-46	176.00
IUUC-Ogu-078978	Oryza glumaepatula	36.36	8.00e-39	153.00
IUUC-Oin-079285	Oryza indica	39.53	1.00e-41	162.00
IUUC-Olo-080671	Oryza longistaminata	40.47	2.00e-42	164.00
IUUC-Ome-081428	Oryza meridionalis	39.53	5.00e-41	160.00
IUUC-Oni-082406	Oryza nivara	40.00	3.00e-42	164.00
IUUC-Opu-083305	Oryza punctata	40.47	1.00e-41	162.00
IUUC-Oru-084969	Oryza rufipogon	40.00	3.00e-42	164.00
IUUC-Osa-085830	Oryza sativa	42.59	9.00e-46	176.00
IUUC-Ola-086893	Oryzias latipes	67.25	2.00e-80	291.00
IUUC-Olu-087858	Ostreococcus lucimarinus	41.47	8.00e-43	166.00
IUUC-Oga-088055	Otolemur garnettii	93.58	4.00e-115	406.00
IUUC-Oar-090319	Ovis aries	93.55	1.00e-115	408.00
IUUC-Pan-092714	Papio anubis	92.66	1.00e-113	402.00
IUUC-Psi-094036	Pelodiscus sinensis	87.39	8.00e-107	379.00
IUUC-Pma-094412	Petromyzon marinus	60.26	3.00e-48	183.00
IUUC-Pno-094997	Phaeosphaeria nodorum	35.25	5.00e-27	114.00
IUUC-Ppa-095519	Physcomitrella patens	49.53	2.00e-55	208.00
IUUC-Pfo-096182	Poecilia formosa	66.67	8.00e-81	292.00
IUUC-Pab-098216	Pongo abelii	94.44	7.00e-79	285.00
IUUC-Pop-099282	Populus trichocarpa	45.58	9.00e-44	169.00
IUUC-Ppe-101332	Prunus persica	43.67	9.00e-48	182.00
IUUC-Pgr-103430	Puccinia graminis	44.10	2.00e-41	162.00
IUUC-Ptt-103955	Puccinia triticina	46.19	8.00e-43	166.00
IUUC-Pte-104414	Pyrenophora teres	38.12	1.00e-32	132.00
IUUC-Pyt-104753	Pyrenophora triticirepentis	33.33	9.00e-30	123.00
IUUC-Rno-105096	Rattus norvegicus	93.09	2.00e-115	407.00
IUUC-Sce-106412	Saccharomyces cerevisiae	33.62	2.00e-24	105.00
IUUC-Sja-107753	Schizosaccharomyces japonicus	28.71	3.00e-20	91.70
IUUC-Spo-108322	Schizosaccharomyces pombe	29.61	2.00e-22	98.60
IUUC-Ssl-108641	Sclerotinia sclerotiorum	36.73	7.00e-35	140.00
IUUC-Smo-108914	Selaginella moellendorffii	47.51	5.00e-45	173.00
IUUC-Sit-110163	Setaria italica	43.98	4.00e-46	177.00
IUUC-Sly-111613	Solanum lycopersicum	47.44	2.00e-51	195.00
IUUC-Stu-112526	Solanum tuberosum	47.44	3.00e-47	181.00
IUUC-Sbi-114545	Sorghum bicolor	43.78	4.00e-44	171.00
IUUC-Sre-114961	Sporisorium reilianum	42.51	2.00e-33	135.00
IUUC-Ssc-115255	Sus scrofa	93.40	2.00e-112	397.00
IUUC-Tgu-117003	Taeniopygia guttata	84.65	2.00e-104	371.00
IUUC-Tru-118330	Takifugu rubripes	60.33	1.00e-58	220.00
IUUC-Tsy-119488	Tarsius syrichta	91.23	2.00e-53	202.00
IUUC-Tni-120042	Tetraodon nigroviridis	61.62	2.00e-60	226.00
IUUC-Tca-120976	Theobroma cacao	46.29	3.00e-50	191.00
IUUC-Tre-122149	Trichoderma reesei	39.64	1.00e-40	159.00
IUUC-Tvi-122450	Trichoderma virens	39.19	1.00e-39	155.00
IUUC-Tae-122693	Triticum aestivum	42.66	2.00e-45	175.00
IUUC-Tur-126250	Triticum urartu	40.18	5.00e-43	167.00
IUUC-Tme-126961	Tuber melanosporum	36.61	9.00e-31	126.00
IUUC-Uma-129382	Ustilago maydis	40.00	7.00e-36	143.00
IUUC-Vda-129850	Verticillium dahliae	29.79	1.00e-25	109.00
IUUC-Vpa-130783	Vicugna pacos	93.04	4.00e-54	204.00
IUUC-Vvi-131661	Vitis vinifera	45.12	7.00e-48	183.00
IUUC-Xtr-132428	Xenopus tropicalis	73.15	4.00e-93	333.00
IUUC-Xma-134245	Xiphophorus maculatus	65.94	2.00e-80	291.00
IUUC-Yli-134570	Yarrowia lipolytica	37.44	7.00e-34	137.00
IUUC-Zma-134740	Zea mays	42.86	6.00e-46	176.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence