iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012615

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

U4/U6 small nuclear ribonucleoprotein Prp4; U4/U6 snRNP 60 kDa protein; WD splicing factor Prp4

Genbank Nucleotide ID

BC105270

Gene Name

PRPF4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000004571.5	ENSBTAT00000006004.5	ENSBTAP00000006004.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.10e-38	128.8	404	442
UBD/Beta-Prp	1.70e-62	211.4	229	476

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH  ++++++f ++  ++++Gs+D+t+kvWDlr+ +++ 
   Q: 404  GHLKEIYGINFsPNgYHIATGSGDNTCKVWDLRQRRCVY 442
           7999********77799*****************99985 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk........ilvtgseDrtikvwdlstgkcvht 89
           ++ +i+  +fsp++++lat++++g  k+w+v + +ll++l gh+  v a+ f+p++          l++++ D+ +k+w+l++ ++v  
   Q: 229  DDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTvsldqkdvNLASCAADGSVKLWSLDSDEPVAD 317
           67899999********************************************99988888888999*********************** PP
   S: 90   lkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgg 178
           ++gh+ +v  ++++psg +l ++  dr  r+wdle ++++   ++gh+  v  +++h+dg+l  +G+lD + r+Wdl+tg+++  l+g 
   Q: 318  IEGHTVRVARVTWHPSGRFLGTTCYDRSWRLWDLEAQEEIL-HQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEG- 404
           *****************************************.********************************************99. PP
   S: 179  htdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs.pnderlvsgssDgsiriW 249
           h + +y ++f++ng ++++gs d+t k+wdl++ +cv+t  +h++ v+ v+f   ++++l++g+ D++ +iW
   Q: 405  HLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEpIHGNFLLTGAYDNTAKIW 476
           *****************************************************88***************** PP

Organism

Bos taurus

Functional Description
(View)

Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (By similarity).

Protein Sequence
(Fasta)

MASTRPSSTA TKTKAPDDLV APVVKKPHIY YGSLEEKERE RLAKGESGLL GKEGLKAGIE 60
AGNINITSGE VFEIEEHISE RQAEVLAEFE RRKRARQINV STDDSEVKAC LRALGEPITL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACGTAGAGC GCGGCTTTCG CTGGGGCTTC GCGTCTCCGG AGCCCAGCAT GGCTTCCACA 60
CGACCCTCCT CCACGGTACA GGTCTCATTC TGGCAGGGAG CTCTGAGGGG GTGGGGGTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0747--Spliceosome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR014906--PRP4-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08799--PRP4
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00500--SFM
SM00320--WD40

Gene Ontology

GO:0015030--C:Cajal body
GO:0016607--C:nuclear speck
GO:0005681--C:spliceosomal complex
GO:0097525--C:spliceosomal snRNP complex
GO:0071001--C:U4/U6 snRNP
GO:0046540--C:U4/U6 x U5 tri-snRNP complex
GO:0030621--F:U4 snRNA binding
GO:0017070--F:U6 snRNA binding
GO:0000398--P:mRNA splicing, via spliceosome

KEGG

bta:508735

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000771	Aegilops tauschii	44.39	8.00e-100	357.00
IUUC-Aml-001737	Ailuropoda melanoleuca	99.41	0.00e+00	1011.00
IUUC-Atr-002828	Amborella trichopoda	43.33	2.00e-103	369.00
IUUC-Apl-003723	Anas platyrhynchos	89.44	0.00e+00	951.00
IUUC-Aca-004972	Anolis carolinensis	89.67	0.00e+00	895.00
IUUC-Aly-006531	Arabidopsis lyrata	43.15	1.00e-94	340.00
IUUC-Ath-007367	Arabidopsis thaliana	44.03	2.00e-108	385.00
IUUC-Ago-007893	Ashbya gossypii	32.89	3.00e-55	209.00
IUUC-Acl-008236	Aspergillus clavatus	38.45	3.00e-90	325.00
IUUC-Afl-008522	Aspergillus flavus	40.21	5.00e-99	354.00
IUUC-Afu-008904	Aspergillus fumigatus	38.92	3.00e-95	342.00
IUUC-Ani-009198	Aspergillus nidulans	39.58	4.00e-98	352.00
IUUC-Ang-009662	Aspergillus niger	42.29	5.00e-99	354.00
IUUC-Aor-009881	Aspergillus oryzae	40.21	4.00e-99	355.00
IUUC-Ate-010333	Aspergillus terreus	38.02	3.00e-88	318.00
IUUC-Ame-011697	Astyanax mexicanus	80.40	0.00e+00	816.00
IUUC-Bgr-012254	Blumeria graminis	38.76	2.00e-97	349.00
IUUC-Bci-013720	Botrytis cinerea	38.63	2.00e-98	352.00
IUUC-Bdi-014302	Brachypodium distachyon	45.43	6.00e-109	387.00
IUUC-Bol-015594	Brassica oleracea	43.10	2.00e-98	353.00
IUUC-Bra-017465	Brassica rapa	42.89	8.00e-99	354.00
IUUC-Cel-018632	Caenorhabditis elegans	44.30	1.00e-108	386.00
IUUC-Cja-019747	Callithrix jacchus	98.85	0.00e+00	1033.00
IUUC-Cfa-020288	Canis familiaris	99.41	0.00e+00	1013.00
IUUC-Cpo-021440	Cavia porcellus	97.24	0.00e+00	993.00
IUUC-Cre-022716	Chlamydomonas reinhardtii	47.75	4.00e-86	311.00
IUUC-Csa-023139	Chlorocebus sabaeus	99.70	0.00e+00	705.00
IUUC-Cho-024481	Choloepus hoffmanni	95.35	0.00e+00	861.00
IUUC-Cin-025106	Ciona intestinalis	59.31	1.00e-176	612.00
IUUC-Csv-026087	Ciona savignyi	57.54	6.00e-175	607.00
IUUC-Cgl-026538	Colletotrichum gloeosporioides	37.72	2.00e-92	333.00
IUUC-Cne-026793	Cryptococcus neoformans	41.29	2.00e-105	375.00
IUUC-Dre-028723	Danio rerio	80.00	0.00e+00	793.00
IUUC-Dno-029299	Dasypus novemcinctus	98.81	0.00e+00	1008.00
IUUC-Dor-030345	Dipodomys ordii	74.81	4.00e-98	351.00
IUUC-Dse-031562	Dothistroma septosporum	37.16	1.00e-89	323.00
IUUC-Dme-031783	Drosophila melanogaster	56.89	1.00e-140	493.00
IUUC-Ete-032669	Echinops telfairi	97.32	0.00e+00	1019.00
IUUC-Eca-033566	Equus caballus	99.41	0.00e+00	1007.00
IUUC-Eeu-034524	Erinaceus europaeus	98.74	6.00e-146	510.00
IUUC-Fca-036215	Felis catus	99.41	0.00e+00	1011.00
IUUC-Fal-037018	Ficedula albicollis	90.44	0.00e+00	795.00
IUUC-Fox-037936	Fusarium oxysporum	37.21	2.00e-85	310.00
IUUC-Fso-038366	Fusarium solani	38.22	4.00e-91	328.00
IUUC-Gmo-038966	Gadus morhua	66.95	3.00e-140	491.00
IUUC-Ggr-039942	Gaeumannomyces graminis	36.33	2.00e-84	306.00
IUUC-Gga-040797	Gallus gallus	91.42	0.00e+00	936.00
IUUC-Gac-042598	Gasterosteus aculeatus	68.79	0.00e+00	662.00
IUUC-Gma-044220	Glycine max	44.75	3.00e-103	369.00
IUUC-Ggo-044682	Gorilla gorilla	98.81	0.00e+00	998.00
IUUC-Hsa-045804	Homo sapiens	98.47	0.00e+00	1028.00
IUUC-Hvu-047567	Hordeum vulgare	44.19	3.00e-94	338.00
IUUC-Itr-047882	Ictidomys tridecemlineatus	98.46	0.00e+00	1032.00
IUUC-Kpa-049369	Komagataella pastoris	33.24	6.00e-62	231.00
IUUC-Lch-050074	Latimeria chalumnae	80.54	0.00e+00	826.00
IUUC-Lpe-051333	Leersia perrieri	44.26	1.00e-99	356.00
IUUC-Loc-052164	Lepisosteus oculatus	81.78	0.00e+00	840.00
IUUC-Lma-053088	Leptosphaeria maculans	37.17	7.00e-85	308.00
IUUC-Laf-053460	Loxodonta africana	98.47	0.00e+00	1030.00
IUUC-Mcc-055859	Macaca mulatta	99.41	0.00e+00	1011.00
IUUC-Meu-056134	Macropus eugenii	94.75	0.00e+00	989.00
IUUC-Mor-057251	Magnaporthe oryzae	37.23	8.00e-86	311.00
IUUC-Mpo-057375	Magnaporthe poae	40.40	4.00e-54	204.00
IUUC-Mtr-057656	Medicago truncatula	44.19	2.00e-93	336.00
IUUC-Mla-059145	Melampsora laricipopulina	40.53	1.00e-101	363.00
IUUC-Mga-059855	Meleagris gallopavo	88.27	0.00e+00	934.00
IUUC-Mvi-060372	Microbotryum violaceum	41.98	9.00e-94	337.00
IUUC-Mmr-060826	Microcebus murinus	98.62	0.00e+00	1008.00
IUUC-Mdo-062748	Monodelphis domestica	95.64	0.00e+00	982.00
IUUC-Mmu-063351	Mus musculus	99.01	0.00e+00	1007.00
IUUC-Mac-064846	Musa acuminata	44.70	1.00e-95	343.00
IUUC-Mpu-066006	Mustela putorius furo	99.41	0.00e+00	1011.00
IUUC-Mlu-067398	Myotis lucifugus	99.01	0.00e+00	1007.00
IUUC-Nfi-068399	Neosartorya fischeri	38.72	8.00e-101	360.00
IUUC-Ncr-068711	Neurospora crassa	37.71	1.00e-92	333.00
IUUC-Nle-069982	Nomascus leucogenys	98.85	0.00e+00	1033.00
IUUC-Opr-070596	Ochotona princeps	98.08	0.00e+00	1028.00
IUUC-Ont-072374	Oreochromis niloticus	76.98	0.00e+00	756.00
IUUC-Oan-073166	Ornithorhynchus anatinus	93.86	0.00e+00	745.00
IUUC-Ocu-074371	Oryctolagus cuniculus	99.21	0.00e+00	1010.00
IUUC-Oba-075083	Oryza barthii	44.06	1.00e-102	366.00
IUUC-Obr-076405	Oryza brachyantha	44.03	5.00e-99	354.00
IUUC-Ogl-077683	Oryza glaberrima	43.86	1.00e-102	366.00
IUUC-Ogu-078486	Oryza glumaepatula	44.09	3.00e-102	365.00
IUUC-Oin-079679	Oryza indica	44.06	2.00e-105	376.00
IUUC-Olo-080243	Oryza longistaminata	46.22	1.00e-90	326.00
IUUC-Ome-081230	Oryza meridionalis	43.86	3.00e-105	375.00
IUUC-Oni-082961	Oryza nivara	43.86	3.00e-105	375.00
IUUC-Opu-083189	Oryza punctata	42.98	5.00e-102	364.00
IUUC-Oru-084353	Oryza rufipogon	44.16	5.00e-103	367.00
IUUC-Osa-085458	Oryza sativa	43.86	3.00e-105	375.00
IUUC-Ola-086940	Oryzias latipes	74.90	0.00e+00	753.00
IUUC-Olu-087580	Ostreococcus lucimarinus	35.68	6.00e-64	238.00
IUUC-Oga-088703	Otolemur garnettii	93.86	0.00e+00	980.00
IUUC-Oar-089829	Ovis aries	99.23	0.00e+00	1000.00
IUUC-Ptr-090838	Pan troglodytes	98.47	0.00e+00	1028.00
IUUC-Pan-092261	Papio anubis	98.28	0.00e+00	1024.00
IUUC-Psi-093020	Pelodiscus sinensis	91.02	0.00e+00	950.00
IUUC-Pno-094858	Phaeosphaeria nodorum	37.72	2.00e-80	293.00
IUUC-Ppa-095531	Physcomitrella patens	45.14	1.00e-117	417.00
IUUC-Pfo-096812	Poecilia formosa	70.02	0.00e+00	670.00
IUUC-Pab-097805	Pongo abelii	89.06	0.00e+00	887.00
IUUC-Pop-100051	Populus trichocarpa	44.37	4.00e-105	375.00
IUUC-Pca-100152	Procavia capensis	98.83	0.00e+00	1017.00
IUUC-Ppe-101244	Prunus persica	46.00	4.00e-106	378.00
IUUC-Pva-102529	Pteropus vampyrus	94.83	0.00e+00	981.00
IUUC-Pgr-103550	Puccinia graminis	36.88	1.00e-102	367.00
IUUC-Ptt-103951	Puccinia triticina	33.53	7.00e-81	294.00
IUUC-Pte-104151	Pyrenophora teres	37.58	3.00e-80	292.00
IUUC-Pyt-104571	Pyrenophora triticirepentis	38.23	5.00e-82	298.00
IUUC-Rno-105747	Rattus norvegicus	98.81	0.00e+00	1005.00
IUUC-Sce-106418	Saccharomyces cerevisiae	33.63	1.00e-67	250.00
IUUC-Sha-107334	Sarcophilus harrisii	96.04	0.00e+00	983.00
IUUC-Sja-107794	Schizosaccharomyces japonicus	35.25	3.00e-71	262.00
IUUC-Spo-108189	Schizosaccharomyces pombe	38.34	1.00e-82	300.00
IUUC-Ssl-108550	Sclerotinia sclerotiorum	37.77	3.00e-96	345.00
IUUC-Smo-108924	Selaginella moellendorffii	46.57	6.00e-111	394.00
IUUC-Sit-110102	Setaria italica	44.34	2.00e-103	369.00
IUUC-Sly-111668	Solanum lycopersicum	46.50	5.00e-107	381.00
IUUC-Stu-111928	Solanum tuberosum	45.60	2.00e-106	379.00
IUUC-Sar-113266	Sorex araneus	85.97	0.00e+00	821.00
IUUC-Sbi-114134	Sorghum bicolor	44.12	6.00e-104	371.00
IUUC-Sre-115114	Sporisorium reilianum	41.31	2.00e-104	372.00
IUUC-Ssc-115443	Sus scrofa	99.41	0.00e+00	1011.00
IUUC-Tgu-117157	Taeniopygia guttata	90.47	0.00e+00	885.00
IUUC-Tru-118587	Takifugu rubripes	74.66	0.00e+00	735.00
IUUC-Tsy-119157	Tarsius syrichta	99.23	0.00e+00	778.00
IUUC-Tni-120427	Tetraodon nigroviridis	75.05	0.00e+00	743.00
IUUC-Tca-121368	Theobroma cacao	44.35	1.00e-106	380.00
IUUC-Tre-122074	Trichoderma reesei	37.45	6.00e-88	318.00
IUUC-Tvi-122349	Trichoderma virens	36.65	1.00e-86	313.00
IUUC-Tae-125651	Triticum aestivum	44.09	2.00e-102	365.00
IUUC-Tur-126532	Triticum urartu	43.60	3.00e-88	318.00
IUUC-Tme-126951	Tuber melanosporum	40.84	2.00e-101	363.00
IUUC-Tbe-128136	Tupaia belangeri	89.85	0.00e+00	916.00
IUUC-Ttr-129169	Tursiops truncatus	98.66	2.00e-165	575.00
IUUC-Uma-129399	Ustilago maydis	42.39	2.00e-102	366.00
IUUC-Vda-129842	Verticillium dahliae	37.77	2.00e-93	336.00
IUUC-Vpa-130440	Vicugna pacos	98.28	0.00e+00	1028.00
IUUC-Vvi-131075	Vitis vinifera	47.17	2.00e-107	383.00
IUUC-Xtr-132713	Xenopus tropicalis	48.92	1.00e-108	387.00
IUUC-Xma-133002	Xiphophorus maculatus	79.67	5.00e-172	596.00
IUUC-Yli-134569	Yarrowia lipolytica	36.04	2.00e-76	280.00
IUUC-Zma-135799	Zea mays	42.40	8.00e-101	360.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence