iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-021925

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

AAKN02018183

Gene Name

UCHL5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000000667.3	ENSCPOT00000000672.2	ENSCPOP00000000589.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	6.60e-96	321.6	1	321

Active Site

Position(s)	Description	Evidence
88	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
164	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 1    mnsqvkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktif 89
           m++++ ew+ +esdPg+ft+l++ fg+++  qvee++sL+pen++++ +pv+gl++lFk+++ +e +          +vv+++ ++tif
   Q: 1    MTGNAGEWCLMESDPGVFTELIKGFGCRGA-QVEEIWSLEPENFEKL-KPVHGLIFLFKWQPGEEPAG---------SVVQDSRLDTIF 78
           788999************************.****************.********************.........899********* PP
   S: 90   fakqvigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeaf 178
           fakqvi+N+Cat+A++svllnc+++ ++lG+tls++ke+++++++ +k+lal+n++v++++hns+ar+++++ + +++++    +++af
   Q: 79   FAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDAKTSAK----EEDAF 163
           ****************************************************************************9887....79*** PP
   S: 179  hfvsyvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid........ 259
           hfvsyv++ngrlyeldgl++ P+dl++  +++++ +++k     ++   +++++eirfnl+aiv+dr++i+++++  l+ +        
   Q: 164  HFVSYVPVNGRLYELDGLREGPIDLAA-YQKNDWISAVKTSHRKMDT--KYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQlaeeepmd 249
           **************************9.5677899999999855555..89***********************976666577888888 PP
   S: 260  .keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefg 333
             +  ++l++i+se++k+++ +++e++k k++ki++irR++ny  fi++++k+la++++l  lve+    + +++
   Q: 250  tDQGNNMLSAIQSEVAKNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKA---KEKQN 321
           7444589*********************************************************993...33344 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MTGNAGEWCL MESDPGVFTE LIKGFGCRGA QVEEIWSLEP ENFEKLKPVH GLIFLFKWQP 60
GEEPAGSVVQ DSRLDTIFFA KQVINNACAT QAIVSVLLNC THQDVHLGET LSEFKEFSQS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACGGGCA ATGCCGGGGA GTGGTGCCTC ATGGAAAGCG ATCCCGGGGT CTTCACCGAG 60
CTCATTAAAG GATTCGGTGA GAACCAGGGG GACCGTTTTG GGCCGGGGGT CACGGGAGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005829--C:cytosol
GO:0031011--C:Ino80 complex
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0004866--F:endopeptidase inhibitor activity
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0048853--P:forebrain morphogenesis
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0016579--P:protein deubiquitination
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	45.48	1.00e-80	292.00
IUUC-Aml-001866	Ailuropoda melanoleuca	95.85	4.00e-180	623.00
IUUC-Atr-002966	Amborella trichopoda	44.25	2.00e-73	269.00
IUUC-Apl-003306	Anas platyrhynchos	82.40	3.00e-169	587.00
IUUC-Aca-004763	Anolis carolinensis	91.32	8.00e-171	592.00
IUUC-Aly-005581	Arabidopsis lyrata	45.90	1.00e-72	266.00
IUUC-Ath-007283	Arabidopsis thaliana	46.20	8.00e-76	276.00
IUUC-Ago-007999	Ashbya gossypii	32.90	2.00e-33	135.00
IUUC-Acl-008231	Aspergillus clavatus	40.66	7.00e-47	180.00
IUUC-Afl-008557	Aspergillus flavus	35.95	2.00e-49	188.00
IUUC-Afu-008988	Aspergillus fumigatus	42.50	1.00e-48	186.00
IUUC-Ani-009420	Aspergillus nidulans	36.25	1.00e-47	183.00
IUUC-Ang-009859	Aspergillus niger	39.18	6.00e-45	174.00
IUUC-Aor-010145	Aspergillus oryzae	35.95	2.00e-49	188.00
IUUC-Ate-010347	Aspergillus terreus	39.37	2.00e-47	182.00
IUUC-Ame-010791	Astyanax mexicanus	86.32	7.00e-173	599.00
IUUC-Bgr-012298	Blumeria graminis	35.86	6.00e-43	167.00
IUUC-Bta-013251	Bos taurus	94.89	3.00e-177	613.00
IUUC-Bci-013786	Botrytis cinerea	36.28	3.00e-52	198.00
IUUC-Bdi-014132	Brachypodium distachyon	47.99	2.00e-77	282.00
IUUC-Bol-015611	Brassica oleracea	47.26	1.00e-77	282.00
IUUC-Bra-017769	Brassica rapa	47.26	1.00e-77	283.00
IUUC-Cel-018604	Caenorhabditis elegans	46.82	5.00e-79	287.00
IUUC-Cja-019768	Callithrix jacchus	86.80	2.00e-173	601.00
IUUC-Cfa-020207	Canis familiaris	95.85	4.00e-180	623.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	43.71	4.00e-69	254.00
IUUC-Csa-023958	Chlorocebus sabaeus	94.89	8.00e-177	612.00
IUUC-Cho-024928	Choloepus hoffmanni	100.00	8.00e-43	167.00
IUUC-Cin-025771	Ciona intestinalis	51.70	2.00e-93	335.00
IUUC-Csv-026149	Ciona savignyi	55.17	2.00e-96	345.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	36.03	3.00e-46	178.00
IUUC-Cne-026955	Cryptococcus neoformans	36.39	9.00e-52	196.00
IUUC-Cme-027104	Cyanidioschyzon merolae	32.87	3.00e-47	182.00
IUUC-Dre-027409	Danio rerio	85.41	1.00e-169	588.00
IUUC-Dno-028921	Dasypus novemcinctus	95.53	1.00e-179	622.00
IUUC-Dse-031170	Dothistroma septosporum	37.46	3.00e-52	198.00
IUUC-Dme-031677	Drosophila melanogaster	57.36	9.00e-109	386.00
IUUC-Ete-032707	Echinops telfairi	65.20	1.00e-110	392.00
IUUC-Eca-033776	Equus caballus	95.14	6.00e-163	566.00
IUUC-Eeu-035305	Erinaceus europaeus	79.26	7.00e-84	303.00
IUUC-Fca-035846	Felis catus	88.24	2.00e-175	608.00
IUUC-Fal-037597	Ficedula albicollis	91.67	8.00e-151	525.00
IUUC-Fox-037670	Fusarium oxysporum	41.23	3.00e-50	192.00
IUUC-Fso-038243	Fusarium solani	40.91	2.00e-49	189.00
IUUC-Gmo-038499	Gadus morhua	79.87	3.00e-152	530.00
IUUC-Ggr-039975	Gaeumannomyces graminis	40.56	2.00e-43	169.00
IUUC-Gga-040904	Gallus gallus	91.10	5.00e-178	616.00
IUUC-Gac-042058	Gasterosteus aculeatus	84.98	5.00e-162	563.00
IUUC-Gma-043763	Glycine max	46.29	7.00e-79	286.00
IUUC-Ggo-044699	Gorilla gorilla	89.25	1.00e-161	562.00
IUUC-Hsa-046227	Homo sapiens	95.21	4.00e-179	620.00
IUUC-Hvu-047359	Hordeum vulgare	45.18	5.00e-79	287.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	86.63	4.00e-174	603.00
IUUC-Lch-049829	Latimeria chalumnae	89.14	1.00e-167	582.00
IUUC-Lpe-050899	Leersia perrieri	46.37	4.00e-72	264.00
IUUC-Loc-052264	Lepisosteus oculatus	86.62	2.00e-164	571.00
IUUC-Lma-053110	Leptosphaeria maculans	36.42	2.00e-42	166.00
IUUC-Laf-053639	Loxodonta africana	95.85	4.00e-180	623.00
IUUC-Mcc-055506	Macaca mulatta	94.89	8.00e-177	612.00
IUUC-Mor-057001	Magnaporthe oryzae	44.30	2.00e-49	189.00
IUUC-Mpo-057608	Magnaporthe poae	40.64	1.00e-32	132.00
IUUC-Mtr-057731	Medicago truncatula	47.46	6.00e-79	287.00
IUUC-Mla-059016	Melampsora laricipopulina	43.43	3.00e-43	167.00
IUUC-Mga-060178	Meleagris gallopavo	91.12	1.00e-164	572.00
IUUC-Mvi-060353	Microbotryum violaceum	37.31	9.00e-51	193.00
IUUC-Mmr-060738	Microcebus murinus	95.21	5.00e-179	619.00
IUUC-Mdo-062266	Monodelphis domestica	95.38	4.00e-112	396.00
IUUC-Mmu-063619	Mus musculus	92.33	2.00e-174	604.00
IUUC-Mac-065301	Musa acuminata	48.58	4.00e-82	297.00
IUUC-Mpu-066058	Mustela putorius furo	95.53	2.00e-179	621.00
IUUC-Mlu-067292	Myotis lucifugus	93.93	3.00e-175	607.00
IUUC-Nfi-068275	Neosartorya fischeri	35.90	4.00e-50	191.00
IUUC-Ncr-068713	Neurospora crassa	36.79	2.00e-52	199.00
IUUC-Nle-069013	Nomascus leucogenys	94.57	3.00e-176	610.00
IUUC-Opr-070628	Ochotona princeps	83.24	1.00e-162	565.00
IUUC-Ont-072688	Oreochromis niloticus	85.40	4.00e-162	563.00
IUUC-Oan-073004	Ornithorhynchus anatinus	92.18	3.00e-133	467.00
IUUC-Ocu-074303	Oryctolagus cuniculus	95.53	6.00e-180	624.00
IUUC-Oba-075002	Oryza barthii	46.39	2.00e-75	275.00
IUUC-Obr-076392	Oryza brachyantha	47.35	4.00e-73	267.00
IUUC-Ogl-077271	Oryza glaberrima	46.39	2.00e-75	275.00
IUUC-Ogu-078493	Oryza glumaepatula	46.39	5.00e-76	277.00
IUUC-Oin-080084	Oryza indica	46.39	5.00e-76	277.00
IUUC-Olo-080803	Oryza longistaminata	46.08	9.00e-76	276.00
IUUC-Ome-081146	Oryza meridionalis	45.48	2.00e-74	272.00
IUUC-Oni-082146	Oryza nivara	46.39	5.00e-76	277.00
IUUC-Opu-083633	Oryza punctata	46.37	4.00e-72	265.00
IUUC-Oru-084789	Oryza rufipogon	46.39	5.00e-76	277.00
IUUC-Osa-086196	Oryza sativa	46.39	5.00e-76	277.00
IUUC-Ola-087126	Oryzias latipes	85.30	7.00e-159	552.00
IUUC-Olu-087665	Ostreococcus lucimarinus	41.52	3.00e-66	244.00
IUUC-Oga-089140	Otolemur garnettii	86.76	4.00e-174	603.00
IUUC-Oar-090296	Ovis aries	94.57	2.00e-177	614.00
IUUC-Ptr-090566	Pan troglodytes	95.21	4.00e-179	620.00
IUUC-Pan-092052	Papio anubis	94.89	9.00e-177	612.00
IUUC-Psi-093723	Pelodiscus sinensis	90.97	2.00e-156	544.00
IUUC-Pma-094568	Petromyzon marinus	57.29	9.00e-98	349.00
IUUC-Pno-095120	Phaeosphaeria nodorum	37.05	2.00e-44	172.00
IUUC-Ppa-095761	Physcomitrella patens	45.61	8.00e-78	283.00
IUUC-Pfo-096210	Poecilia formosa	85.30	6.00e-163	566.00
IUUC-Pab-098463	Pongo abelii	95.21	5.00e-179	620.00
IUUC-Pop-099109	Populus trichocarpa	46.29	9.00e-79	286.00
IUUC-Pca-100108	Procavia capensis	92.68	1.00e-134	472.00
IUUC-Ppe-101176	Prunus persica	48.49	7.00e-80	290.00
IUUC-Pva-102629	Pteropus vampyrus	91.60	8.00e-141	493.00
IUUC-Pgr-103419	Puccinia graminis	37.98	2.00e-52	199.00
IUUC-Pte-104207	Pyrenophora teres	44.38	5.00e-33	133.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	37.38	1.00e-51	196.00
IUUC-Rno-105579	Rattus norvegicus	82.66	3.00e-153	534.00
IUUC-Sha-106894	Sarcophilus harrisii	89.86	2.00e-146	511.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	36.88	2.00e-53	202.00
IUUC-Spo-108371	Schizosaccharomyces pombe	39.93	7.00e-54	203.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	36.59	1.00e-42	166.00
IUUC-Smo-109396	Selaginella moellendorffii	49.23	5.00e-82	297.00
IUUC-Sit-110630	Setaria italica	47.40	6.00e-80	290.00
IUUC-Sly-110972	Solanum lycopersicum	47.60	3.00e-74	271.00
IUUC-Stu-112185	Solanum tuberosum	48.19	1.00e-82	299.00
IUUC-Sar-113294	Sorex araneus	82.91	1.00e-166	578.00
IUUC-Sbi-113951	Sorghum bicolor	47.71	2.00e-80	292.00
IUUC-Ssc-115501	Sus scrofa	93.94	4.00e-166	577.00
IUUC-Tgu-117152	Taeniopygia guttata	91.32	8.00e-151	525.00
IUUC-Tru-118388	Takifugu rubripes	84.35	1.00e-161	562.00
IUUC-Tsy-119109	Tarsius syrichta	95.53	2.00e-179	621.00
IUUC-Tni-120048	Tetraodon nigroviridis	84.35	3.00e-162	564.00
IUUC-Tca-121750	Theobroma cacao	46.75	4.00e-82	297.00
IUUC-Tre-122130	Trichoderma reesei	37.87	1.00e-50	193.00
IUUC-Tvi-122284	Trichoderma virens	37.87	7.00e-48	184.00
IUUC-Tae-124082	Triticum aestivum	45.78	3.00e-79	288.00
IUUC-Tur-126366	Triticum urartu	41.41	3.00e-60	226.00
IUUC-Tme-127187	Tuber melanosporum	39.27	4.00e-51	194.00
IUUC-Tbe-127619	Tupaia belangeri	86.06	3.00e-136	477.00
IUUC-Ttr-128867	Tursiops truncatus	82.86	2.00e-115	408.00
IUUC-Vda-129912	Verticillium dahliae	36.03	1.00e-47	183.00
IUUC-Vpa-130552	Vicugna pacos	97.01	3.00e-118	418.00
IUUC-Vvi-130881	Vitis vinifera	48.66	2.00e-80	291.00
IUUC-Xtr-131934	Xenopus tropicalis	82.67	5.00e-166	576.00
IUUC-Xma-133312	Xiphophorus maculatus	85.30	7.00e-163	566.00
IUUC-Zma-135462	Zea mays	41.85	3.00e-66	245.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence