iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Nfi-068275

Ensembl Protein ID

CADNFIAP00001896

UniProt Accession

A1D1G7; A1D1G7_NEOFI

Genbank Protein ID

EAW22260.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

DS027688

Gene Name

NFIA_009400

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADNFIAG00001935	CADNFIAT00001935	CADNFIAP00001896

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	2.80e-59	200.2	4	245

Active Site

Position(s)	Description	Evidence
93	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
176	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 5    vkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvigN 97
           + +w ++esd g+ft l+e++gvk++ q+eel sLd ++++++  pv+g+++lFk++ +  s +++q +     +   +  +++ffa q+i+N
   Q: 4    GGGWSTIESDEGVFTSLIENLGVKDV-QFEELISLDADTIRSL-SPVYGVIFLFKWIREPPSTNTTQPLD---GTYITSLPENLFFAAQTIQN 91
           579***********************.****************.********************888764...35556788999********* PP
   S: 98   sCatyAllsvllnc....edkl.ldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyvn 185
           +C+t+A+lsv+ln     +    +++G++l  +k++t ++ p+ +++al+n++ ++ +hn++ar  ++  ++ + +++   + +++hf++y++
   Q: 92   ACGTQAILSVILNQdspaSTPYpINIGPELRSFKDFTTGFPPDLRGEALSNSETIRTAHNAFARASPFVDETVRTAQD--EEADVYHFIAYTP 182
           *************955543344689******************************************99888776655..4889********* PP
   S: 186  ingrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktl 251
           +ng lyeldgl+p+P+ +g++  ++  ++ ++v++    ri  + ++e rfnl+a+v d rv    
   Q: 183  VNGVLYELDGLQPYPISHGECDAETFPEKVIEVLQ---RRIARYPEGETRFNLMAVVRDLRVRARE 245
           ********************766666666666666...9********************9997655 PP

Organism

Neosartorya fischeri

Protein Sequence
(Fasta)

MADGGGWSTI ESDEGVFTSL IENLGVKDVQ FEELISLDAD TIRSLSPVYG VIFLFKWIRE 60
PPSTNTTQPL DGTYITSLPE NLFFAAQTIQ NACGTQAILS VILNQDSPAS TPYPINIGPE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCGACG GCGGAGGCTG GAGCACGATC GAGTCGGATG AGGTATGTTC AACTCCTTTC 60
TCCCCCAACA TAAACCTCAT CCTAACGCGT CCAGGGCGTC TTCACCTCCC TGATCGAGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0034399--C:nuclear periphery
GO:0031595--C:nuclear proteasome complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

nfi:NFIA_009400

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	39.31	6.00e-61	225.00
IUUC-Aml-001866	Ailuropoda melanoleuca	37.50	2.00e-55	207.00
IUUC-Atr-002966	Amborella trichopoda	48.84	3.00e-55	207.00
IUUC-Apl-003306	Anas platyrhynchos	34.88	2.00e-47	180.00
IUUC-Aca-004763	Anolis carolinensis	39.31	7.00e-56	208.00
IUUC-Aly-005581	Arabidopsis lyrata	51.48	1.00e-55	208.00
IUUC-Ath-007283	Arabidopsis thaliana	51.05	6.00e-57	212.00
IUUC-Ago-007999	Ashbya gossypii	37.17	9.00e-46	175.00
IUUC-Acl-008231	Aspergillus clavatus	87.03	2.00e-154	536.00
IUUC-Afl-008557	Aspergillus flavus	84.89	3.00e-145	505.00
IUUC-Afu-008988	Aspergillus fumigatus	98.10	2.00e-174	602.00
IUUC-Ani-009420	Aspergillus nidulans	74.43	9.00e-128	447.00
IUUC-Ang-009859	Aspergillus niger	79.25	1.00e-134	471.00
IUUC-Aor-010145	Aspergillus oryzae	84.89	3.00e-145	505.00
IUUC-Ate-010347	Aspergillus terreus	78.38	7.00e-139	484.00
IUUC-Ame-010791	Astyanax mexicanus	38.59	5.00e-57	213.00
IUUC-Bgr-012298	Blumeria graminis	60.13	2.00e-101	360.00
IUUC-Bta-013251	Bos taurus	39.55	1.00e-55	208.00
IUUC-Bci-013786	Botrytis cinerea	66.78	1.00e-118	417.00
IUUC-Bdi-014132	Brachypodium distachyon	46.39	7.00e-60	222.00
IUUC-Bol-015611	Brassica oleracea	41.69	3.00e-57	213.00
IUUC-Bra-017769	Brassica rapa	41.98	2.00e-57	214.00
IUUC-Cel-018604	Caenorhabditis elegans	37.05	5.00e-52	196.00
IUUC-Cja-019768	Callithrix jacchus	34.31	4.00e-50	190.00
IUUC-Cfa-020207	Canis familiaris	37.50	2.00e-55	207.00
IUUC-Cpo-021925	Cavia porcellus	35.90	3.00e-50	190.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	47.84	9.00e-56	208.00
IUUC-Csa-023958	Chlorocebus sabaeus	39.23	7.00e-56	209.00
IUUC-Cho-024928	Choloepus hoffmanni	41.86	4.00e-12	63.50
IUUC-Cin-025771	Ciona intestinalis	35.34	4.00e-53	199.00
IUUC-Csv-026149	Ciona savignyi	37.13	5.00e-56	209.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	51.31	4.00e-85	306.00
IUUC-Cne-026955	Cryptococcus neoformans	37.17	1.00e-51	195.00
IUUC-Cme-027104	Cyanidioschyzon merolae	34.31	9.00e-41	159.00
IUUC-Dre-027409	Danio rerio	39.42	1.00e-55	207.00
IUUC-Dno-028921	Dasypus novemcinctus	37.50	6.00e-55	206.00
IUUC-Dor-030891	Dipodomys ordii	32.79	9.00e-31	127.00
IUUC-Dse-031170	Dothistroma septosporum	59.12	8.00e-100	355.00
IUUC-Dme-031677	Drosophila melanogaster	38.71	2.00e-55	207.00
IUUC-Ete-032646	Echinops telfairi	40.78	2.00e-34	139.00
IUUC-Eca-033776	Equus caballus	37.24	2.00e-48	184.00
IUUC-Eeu-035305	Erinaceus europaeus	36.55	4.00e-29	120.00
IUUC-Fca-035846	Felis catus	34.41	6.00e-51	192.00
IUUC-Fal-037597	Ficedula albicollis	36.90	5.00e-48	182.00
IUUC-Fox-037670	Fusarium oxysporum	61.67	3.00e-93	332.00
IUUC-Fso-038243	Fusarium solani	61.00	7.00e-92	328.00
IUUC-Gmo-038499	Gadus morhua	35.69	7.00e-48	182.00
IUUC-Ggr-039975	Gaeumannomyces graminis	56.97	2.00e-88	317.00
IUUC-Gga-040904	Gallus gallus	38.34	6.00e-56	209.00
IUUC-Gac-042058	Gasterosteus aculeatus	37.94	1.00e-54	205.00
IUUC-Gma-043030	Glycine max	51.54	1.00e-59	221.00
IUUC-Ggo-044699	Gorilla gorilla	43.98	4.00e-54	203.00
IUUC-Hsa-046227	Homo sapiens	37.82	7.00e-56	209.00
IUUC-Hvu-047359	Hordeum vulgare	39.31	6.00e-61	225.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	34.30	1.00e-50	191.00
IUUC-Lch-049829	Latimeria chalumnae	39.55	3.00e-56	210.00
IUUC-Lpe-050899	Leersia perrieri	49.79	3.00e-61	226.00
IUUC-Loc-052264	Lepisosteus oculatus	38.78	2.00e-54	204.00
IUUC-Lma-053110	Leptosphaeria maculans	62.50	7.00e-93	332.00
IUUC-Laf-053639	Loxodonta africana	37.50	2.00e-55	207.00
IUUC-Mcc-055506	Macaca mulatta	38.91	7.00e-56	209.00
IUUC-Meu-056267	Macropus eugenii	37.69	8.00e-40	157.00
IUUC-Mor-057001	Magnaporthe oryzae	56.96	8.00e-90	321.00
IUUC-Mpo-057608	Magnaporthe poae	59.56	6.00e-56	208.00
IUUC-Mtr-057731	Medicago truncatula	50.38	1.00e-62	231.00
IUUC-Mla-059016	Melampsora laricipopulina	42.79	5.00e-43	165.00
IUUC-Mga-060178	Meleagris gallopavo	37.33	4.00e-49	186.00
IUUC-Mvi-060353	Microbotryum violaceum	36.91	9.00e-51	191.00
IUUC-Mmr-060738	Microcebus murinus	37.50	2.00e-55	207.00
IUUC-Mdo-062266	Monodelphis domestica	42.86	4.00e-45	172.00
IUUC-Mmu-063619	Mus musculus	38.66	5.00e-56	209.00
IUUC-Mac-065301	Musa acuminata	43.64	2.00e-64	237.00
IUUC-Mpu-066058	Mustela putorius furo	37.50	2.00e-55	207.00
IUUC-Mlu-067292	Myotis lucifugus	37.82	1.00e-54	204.00
IUUC-Ncr-068713	Neurospora crassa	60.00	6.00e-111	392.00
IUUC-Nle-069013	Nomascus leucogenys	39.10	5.00e-56	209.00
IUUC-Opr-070628	Ochotona princeps	32.84	3.00e-47	180.00
IUUC-Ont-072688	Oreochromis niloticus	37.70	3.00e-54	203.00
IUUC-Oan-073004	Ornithorhynchus anatinus	42.86	2.00e-46	177.00
IUUC-Ocu-074303	Oryctolagus cuniculus	37.30	1.00e-54	206.00
IUUC-Oba-075002	Oryza barthii	39.54	3.00e-61	226.00
IUUC-Obr-076392	Oryza brachyantha	48.85	3.00e-62	230.00
IUUC-Ogl-077271	Oryza glaberrima	39.54	3.00e-61	226.00
IUUC-Ogu-078493	Oryza glumaepatula	39.83	4.00e-62	229.00
IUUC-Oin-080084	Oryza indica	39.83	4.00e-62	229.00
IUUC-Olo-080803	Oryza longistaminata	40.11	1.00e-62	231.00
IUUC-Ome-081146	Oryza meridionalis	40.11	1.00e-62	231.00
IUUC-Oni-082146	Oryza nivara	39.83	4.00e-62	229.00
IUUC-Opu-083633	Oryza punctata	48.28	4.00e-62	229.00
IUUC-Oru-084789	Oryza rufipogon	39.83	4.00e-62	229.00
IUUC-Osa-086196	Oryza sativa	39.83	4.00e-62	229.00
IUUC-Ola-087126	Oryzias latipes	38.59	3.00e-55	207.00
IUUC-Olu-087665	Ostreococcus lucimarinus	40.14	1.00e-52	197.00
IUUC-Oga-089140	Otolemur garnettii	34.81	5.00e-51	192.00
IUUC-Oar-090296	Ovis aries	37.82	4.00e-54	202.00
IUUC-Ptr-090566	Pan troglodytes	37.82	7.00e-56	209.00
IUUC-Pan-092052	Papio anubis	39.23	7.00e-56	209.00
IUUC-Psi-093723	Pelodiscus sinensis	37.33	1.00e-48	184.00
IUUC-Pma-094568	Petromyzon marinus	45.87	1.00e-49	188.00
IUUC-Pno-095120	Phaeosphaeria nodorum	62.75	2.00e-99	353.00
IUUC-Ppa-095761	Physcomitrella patens	48.47	4.00e-60	223.00
IUUC-Pfo-096210	Poecilia formosa	38.26	1.00e-55	208.00
IUUC-Pab-098463	Pongo abelii	37.70	1.00e-55	208.00
IUUC-Pop-099423	Populus trichocarpa	39.71	5.00e-57	212.00
IUUC-Pca-100108	Procavia capensis	42.80	5.00e-51	192.00
IUUC-Ppe-101176	Prunus persica	48.08	4.00e-56	209.00
IUUC-Pva-102629	Pteropus vampyrus	43.98	2.00e-52	197.00
IUUC-Pgr-103419	Puccinia graminis	36.47	8.00e-46	175.00
IUUC-Pte-104207	Pyrenophora teres	60.80	2.00e-49	186.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	61.24	2.00e-99	353.00
IUUC-Rno-105579	Rattus norvegicus	35.42	9.00e-46	175.00
IUUC-Sha-106894	Sarcophilus harrisii	38.10	3.00e-46	176.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	45.60	4.00e-75	272.00
IUUC-Spo-108371	Schizosaccharomyces pombe	48.56	4.00e-79	285.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	66.17	8.00e-100	354.00
IUUC-Smo-109396	Selaginella moellendorffii	40.58	2.00e-57	214.00
IUUC-Sit-110630	Setaria italica	49.80	7.00e-63	232.00
IUUC-Sly-110972	Solanum lycopersicum	41.44	5.00e-57	212.00
IUUC-Stu-112185	Solanum tuberosum	42.74	3.00e-64	236.00
IUUC-Sar-113294	Sorex araneus	33.14	3.00e-45	174.00
IUUC-Sbi-113951	Sorghum bicolor	49.81	4.00e-63	233.00
IUUC-Ssc-115501	Sus scrofa	36.45	3.00e-50	190.00
IUUC-Tgu-117152	Taeniopygia guttata	36.90	5.00e-48	182.00
IUUC-Tru-118388	Takifugu rubripes	37.94	6.00e-55	206.00
IUUC-Tsy-119109	Tarsius syrichta	37.38	2.00e-55	207.00
IUUC-Tni-120048	Tetraodon nigroviridis	37.94	2.00e-55	207.00
IUUC-Tca-121750	Theobroma cacao	41.48	1.00e-62	231.00
IUUC-Tre-122130	Trichoderma reesei	63.14	3.00e-101	359.00
IUUC-Tvi-122284	Trichoderma virens	59.00	4.00e-96	342.00
IUUC-Tae-124082	Triticum aestivum	39.31	9.00e-61	225.00
IUUC-Tur-126366	Triticum urartu	39.91	5.00e-41	160.00
IUUC-Tme-127187	Tuber melanosporum	59.16	1.00e-106	377.00
IUUC-Tbe-127705	Tupaia belangeri	38.37	1.00e-38	152.00
IUUC-Ttr-128225	Tursiops truncatus	40.08	4.00e-43	167.00
IUUC-Vda-129912	Verticillium dahliae	55.23	1.00e-84	304.00
IUUC-Vpa-130552	Vicugna pacos	42.27	3.00e-45	173.00
IUUC-Vvi-130881	Vitis vinifera	40.29	7.00e-58	215.00
IUUC-Xtr-131934	Xenopus tropicalis	37.62	8.00e-55	205.00
IUUC-Xma-133312	Xiphophorus maculatus	38.26	1.00e-55	208.00
IUUC-Yli-134487	Yarrowia lipolytica	43.63	2.00e-68	250.00
IUUC-Zma-135639	Zea mays	42.37	8.00e-54	202.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence