iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062079

UUCD1 version

UUC-MoD-01145

Ensembl Protein ID

ENSMODP00000007075.2

UniProt Accession

F6U4F9; F6U4F9_MONDO

Protein Name

Uncharacterized protein

Gene Name

USP7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000005702.2	ENSMODT00000007216.2	ENSMODP00000007075.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.70e-65	220.9	181	480

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           +GlkN+g+tCYmNS+LQ+L+++++lr+++    + +      +++++++  +lq++f el ++++k v +++l+k+++        ++q
   Q: 181  VGLKNQGATCYMNSLLQTLFFTNQLRKAVYM-MPTEG-----DDSSKSVPLALQRVFYEL-QHSDKPVGTKKLTKSFG--------FMQ 254
           6******************************.44433.....466889************.88888999*99999995........8** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           +D+qE++++lld++e+++                          k +  + +i +lF+g++ s i+c++ d +s r+e+ +d++l+++g
   Q: 255  HDVQELCRVLLDNVENKM--------------------------KGTCVEGTIPKLFRGKMVSYIQCKDVDYRSDRREDYYDIQLSIKG 317
           ******************..........................789****************************************** PP
   S: 179  keetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts 267
           k+     ++ +++ ++++ e+l+g+nky   +  ++qeaek +k+ +lP+vL+l+L+Rf ++ ++++++kin+++efp++L l++f+++
   Q: 318  KK-----NIFESFIDYVAVEQLDGDNKYDAGEH-GLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQK 400
           **.....9*********************9996.7****************************************************** PP
   S: 268  peekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetg...........staYvlfYkr 337
           ++ k+  + +Y L+av+vHsG  ++GHYv+y +   +gkW++fdD+ V+ +kee ++ + g           ++aY+l+Y r
   Q: 401  TDPKD--PANYILHAVLVHSGDNHGGHYVVYLNPrGDGKWCKFDDDVVRCTKEEAIEHNYGghdddlsvrhcTNAYMLVYIR 480
           88777..*************************9845666*******************888*******************87 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

LKAGDTDDPP RITQNPVING NVAMADGHNN TEEDMEDGNT NWNNMGLSIS TIFFPCACKL 60
LPIKFLHQEF PIPMKSHIQC FFFFLLIHML FKNRSWSCHA QAVLKIINYK DDEKSFSRRI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTAAAAGCTG GAGATACAGA TGATCCACCA AGAATTACAC AAAATCCTGT CATCAATGGA 60
AATGTAGCAA TGGCCGATGG ACATAATAAC ACAGAGGAAG ATATGGAGGA TGGTAAGTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR008974--TRAF-like
IPR024729--USP7_ICP0-binding_dom
IPR029346--USP_C
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF14533--USP7_C2
PF12436--USP7_ICP0_bdg

Gene Ontology

GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0010216--P:maintenance of DNA methylation
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0050821--P:protein stabilization
GO:0006283--P:transcription-coupled nucleotide-excision repair
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000761	Aegilops tauschii	33.07	1.00e-126	447.00
IUUC-Aml-002408	Ailuropoda melanoleuca	90.75	0.00e+00	1981.00
IUUC-Atr-003067	Amborella trichopoda	36.57	6.00e-118	418.00
IUUC-Apl-003558	Anas platyrhynchos	90.76	0.00e+00	2003.00
IUUC-Aca-004518	Anolis carolinensis	86.51	0.00e+00	1913.00
IUUC-Aly-006453	Arabidopsis lyrata	37.17	3.00e-145	509.00
IUUC-Ath-006591	Arabidopsis thaliana	36.56	1.00e-141	497.00
IUUC-Ago-007849	Ashbya gossypii	33.85	4.00e-126	446.00
IUUC-Acl-008327	Aspergillus clavatus	35.60	1.00e-159	557.00
IUUC-Afl-008491	Aspergillus flavus	36.16	3.00e-152	532.00
IUUC-Afu-008804	Aspergillus fumigatus	36.55	7.00e-150	525.00
IUUC-Ang-009776	Aspergillus niger	36.82	2.00e-150	527.00
IUUC-Aor-009998	Aspergillus oryzae	35.32	5.00e-144	505.00
IUUC-Ate-010428	Aspergillus terreus	36.20	3.00e-151	529.00
IUUC-Ame-010903	Astyanax mexicanus	86.96	0.00e+00	1930.00
IUUC-Bgr-012132	Blumeria graminis	33.84	3.00e-135	476.00
IUUC-Bta-013192	Bos taurus	90.48	0.00e+00	1976.00
IUUC-Bci-013924	Botrytis cinerea	35.04	2.00e-142	500.00
IUUC-Bdi-014920	Brachypodium distachyon	35.94	2.00e-142	499.00
IUUC-Bol-016114	Brassica oleracea	36.98	6.00e-141	495.00
IUUC-Bra-017853	Brassica rapa	36.83	7.00e-141	494.00
IUUC-Cel-018219	Caenorhabditis elegans	33.24	4.00e-136	479.00
IUUC-Cja-019006	Callithrix jacchus	89.65	0.00e+00	1961.00
IUUC-Cfa-020361	Canis familiaris	90.84	0.00e+00	1982.00
IUUC-Cpo-022320	Cavia porcellus	90.48	0.00e+00	1973.00
IUUC-Cre-022708	Chlamydomonas reinhardtii	44.10	1.00e-79	290.00
IUUC-Csa-024050	Chlorocebus sabaeus	90.57	0.00e+00	1980.00
IUUC-Cho-024434	Choloepus hoffmanni	88.69	0.00e+00	1399.00
IUUC-Cin-025689	Ciona intestinalis	50.69	0.00e+00	1063.00
IUUC-Csv-025963	Ciona savignyi	50.60	0.00e+00	1028.00
IUUC-Cgl-026650	Colletotrichum gloeosporioides	33.71	2.00e-139	490.00
IUUC-Cne-026968	Cryptococcus neoformans	37.45	1.00e-166	580.00
IUUC-Cme-027103	Cyanidioschyzon merolae	35.47	2.00e-101	364.00
IUUC-Dre-028510	Danio rerio	87.14	0.00e+00	1931.00
IUUC-Dno-029696	Dasypus novemcinctus	90.38	0.00e+00	1968.00
IUUC-Dor-030611	Dipodomys ordii	73.22	0.00e+00	793.00
IUUC-Dse-031433	Dothistroma septosporum	33.94	4.00e-136	479.00
IUUC-Dme-031583	Drosophila melanogaster	46.60	0.00e+00	911.00
IUUC-Ete-033191	Echinops telfairi	88.44	0.00e+00	1927.00
IUUC-Eca-034122	Equus caballus	90.47	0.00e+00	1976.00
IUUC-Eeu-035292	Erinaceus europaeus	97.28	1.00e-150	527.00
IUUC-Fca-036377	Felis catus	90.75	0.00e+00	1980.00
IUUC-Fal-036964	Ficedula albicollis	90.84	0.00e+00	1965.00
IUUC-Fox-037695	Fusarium oxysporum	34.70	4.00e-146	512.00
IUUC-Fso-038084	Fusarium solani	34.35	2.00e-145	510.00
IUUC-Gmo-038644	Gadus morhua	86.69	0.00e+00	1925.00
IUUC-Ggr-040029	Gaeumannomyces graminis	33.90	1.00e-145	511.00
IUUC-Gga-040944	Gallus gallus	90.96	0.00e+00	1996.00
IUUC-Gac-041740	Gasterosteus aculeatus	87.15	0.00e+00	1930.00
IUUC-Gma-043300	Glycine max	37.05	1.00e-152	534.00
IUUC-Ggo-044947	Gorilla gorilla	90.57	0.00e+00	1979.00
IUUC-Hsa-046278	Homo sapiens	90.39	0.00e+00	1976.00
IUUC-Hvu-047749	Hordeum vulgare	37.00	3.00e-125	442.00
IUUC-Itr-047904	Ictidomys tridecemlineatus	96.99	0.00e+00	1847.00
IUUC-Kpa-049121	Komagataella pastoris	31.93	5.00e-115	409.00
IUUC-Lch-049847	Latimeria chalumnae	89.65	0.00e+00	1974.00
IUUC-Lpe-051505	Leersia perrieri	36.02	2.00e-128	453.00
IUUC-Loc-052234	Lepisosteus oculatus	83.96	0.00e+00	1221.00
IUUC-Lma-053169	Leptosphaeria maculans	36.61	4.00e-157	549.00
IUUC-Laf-053566	Loxodonta africana	90.85	0.00e+00	1982.00
IUUC-Mcc-055549	Macaca mulatta	90.48	0.00e+00	1973.00
IUUC-Meu-056887	Macropus eugenii	88.95	0.00e+00	1284.00
IUUC-Mor-057149	Magnaporthe oryzae	34.60	2.00e-144	507.00
IUUC-Mpo-057536	Magnaporthe poae	34.19	2.00e-147	516.00
IUUC-Mtr-058583	Medicago truncatula	38.27	7.00e-149	521.00
IUUC-Mla-058899	Melampsora laricipopulina	38.46	2.00e-159	556.00
IUUC-Mga-060148	Meleagris gallopavo	90.93	0.00e+00	2008.00
IUUC-Mvi-060207	Microbotryum violaceum	39.41	2.00e-167	583.00
IUUC-Mmr-060946	Microcebus murinus	90.67	0.00e+00	1982.00
IUUC-Mmu-063678	Mus musculus	90.19	0.00e+00	1966.00
IUUC-Mac-065416	Musa acuminata	37.71	5.00e-140	492.00
IUUC-Mpu-066744	Mustela putorius furo	90.46	0.00e+00	1932.00
IUUC-Mlu-067949	Myotis lucifugus	90.01	0.00e+00	1956.00
IUUC-Nfi-068342	Neosartorya fischeri	36.45	9.00e-150	524.00
IUUC-Ncr-068818	Neurospora crassa	35.75	2.00e-149	523.00
IUUC-Nle-070064	Nomascus leucogenys	90.48	0.00e+00	1978.00
IUUC-Opr-071001	Ochotona princeps	87.81	0.00e+00	1598.00
IUUC-Ont-072095	Oreochromis niloticus	86.87	0.00e+00	1927.00
IUUC-Oan-073483	Ornithorhynchus anatinus	91.78	0.00e+00	1946.00
IUUC-Ocu-073967	Oryctolagus cuniculus	89.62	0.00e+00	1889.00
IUUC-Oba-075312	Oryza barthii	34.80	4.00e-125	442.00
IUUC-Obr-076514	Oryza brachyantha	37.16	3.00e-139	489.00
IUUC-Ogl-077038	Oryza glaberrima	35.71	5.00e-135	475.00
IUUC-Ogu-078265	Oryza glumaepatula	33.92	3.00e-120	426.00
IUUC-Oin-079988	Oryza indica	33.53	7.00e-114	405.00
IUUC-Olo-080297	Oryza longistaminata	32.62	2.00e-108	387.00
IUUC-Ome-081879	Oryza meridionalis	36.98	1.00e-135	478.00
IUUC-Oni-082409	Oryza nivara	33.63	1.00e-124	441.00
IUUC-Opu-083199	Oryza punctata	35.80	2.00e-130	460.00
IUUC-Oru-085109	Oryza rufipogon	36.42	2.00e-131	464.00
IUUC-Osa-085418	Oryza sativa	39.18	4.00e-116	412.00
IUUC-Ola-086640	Oryzias latipes	87.06	0.00e+00	1922.00
IUUC-Olu-087874	Ostreococcus lucimarinus	32.96	9.00e-131	461.00
IUUC-Oga-089059	Otolemur garnettii	83.78	0.00e+00	1795.00
IUUC-Oar-089710	Ovis aries	90.47	0.00e+00	1974.00
IUUC-Ptr-091334	Pan troglodytes	90.57	0.00e+00	1979.00
IUUC-Pan-091717	Papio anubis	92.20	0.00e+00	1913.00
IUUC-Psi-093933	Pelodiscus sinensis	90.62	0.00e+00	2009.00
IUUC-Pma-094648	Petromyzon marinus	77.85	0.00e+00	1553.00
IUUC-Pno-095020	Phaeosphaeria nodorum	35.72	8.00e-143	501.00
IUUC-Ppa-095922	Physcomitrella patens	36.41	4.00e-144	506.00
IUUC-Pfo-096181	Poecilia formosa	86.59	0.00e+00	1925.00
IUUC-Pab-098231	Pongo abelii	88.08	0.00e+00	1905.00
IUUC-Pop-100083	Populus trichocarpa	36.84	3.00e-144	506.00
IUUC-Pca-100543	Procavia capensis	68.85	0.00e+00	795.00
IUUC-Ppe-101523	Prunus persica	36.00	2.00e-139	489.00
IUUC-Pva-102472	Pteropus vampyrus	89.55	0.00e+00	1930.00
IUUC-Pgr-103463	Puccinia graminis	38.73	2.00e-158	553.00
IUUC-Ptt-103716	Puccinia triticina	38.48	6.00e-157	548.00
IUUC-Pte-104360	Pyrenophora teres	37.60	3.00e-144	506.00
IUUC-Pyt-104581	Pyrenophora triticirepentis	37.19	2.00e-142	500.00
IUUC-Rno-105816	Rattus norvegicus	90.02	0.00e+00	1971.00
IUUC-Sce-106230	Saccharomyces cerevisiae	30.33	5.00e-109	389.00
IUUC-Sha-107439	Sarcophilus harrisii	92.59	0.00e+00	2004.00
IUUC-Sja-107690	Schizosaccharomyces japonicus	33.63	3.00e-127	450.00
IUUC-Spo-108019	Schizosaccharomyces pombe	35.93	2.00e-132	466.00
IUUC-Smo-109308	Selaginella moellendorffii	36.84	2.00e-139	490.00
IUUC-Sit-110404	Setaria italica	36.98	1.00e-143	504.00
IUUC-Sly-111774	Solanum lycopersicum	36.65	3.00e-147	516.00
IUUC-Stu-112387	Solanum tuberosum	36.56	1.00e-146	514.00
IUUC-Sar-113685	Sorex araneus	89.82	0.00e+00	1953.00
IUUC-Sbi-114037	Sorghum bicolor	37.11	5.00e-143	502.00
IUUC-Sre-115156	Sporisorium reilianum	38.45	2.00e-170	593.00
IUUC-Ssc-116297	Sus scrofa	90.57	0.00e+00	1980.00
IUUC-Tgu-116767	Taeniopygia guttata	90.68	0.00e+00	2006.00
IUUC-Tru-118208	Takifugu rubripes	86.51	0.00e+00	1894.00
IUUC-Tsy-119277	Tarsius syrichta	70.72	3.00e-145	509.00
IUUC-Tni-119890	Tetraodon nigroviridis	86.51	0.00e+00	1897.00
IUUC-Tca-121501	Theobroma cacao	36.52	3.00e-142	499.00
IUUC-Tre-122169	Trichoderma reesei	34.21	2.00e-140	493.00
IUUC-Tvi-122600	Trichoderma virens	34.85	2.00e-147	517.00
IUUC-Tae-125264	Triticum aestivum	36.62	7.00e-140	492.00
IUUC-Tur-126287	Triticum urartu	35.35	6.00e-134	472.00
IUUC-Tme-127045	Tuber melanosporum	36.56	3.00e-153	536.00
IUUC-Tbe-127696	Tupaia belangeri	86.97	2.00e-158	553.00
IUUC-Ttr-129161	Tursiops truncatus	90.66	0.00e+00	1973.00
IUUC-Uma-129535	Ustilago maydis	38.19	6.00e-174	605.00
IUUC-Vda-129708	Verticillium dahliae	32.63	2.00e-148	520.00
IUUC-Vvi-130882	Vitis vinifera	37.62	1.00e-139	490.00
IUUC-Xtr-132073	Xenopus tropicalis	85.79	0.00e+00	1872.00
IUUC-Xma-133949	Xiphophorus maculatus	86.32	0.00e+00	1917.00
IUUC-Yli-134527	Yarrowia lipolytica	34.56	1.00e-130	461.00
IUUC-Zma-135550	Zea mays	35.39	1.00e-131	464.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence