iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPTM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	19617556

Classification

Family	E-value	Score	Start	End
E2/UBC	2.30e-34	116.6	31	169

Active Site

Position(s)	Description	Evidence
115	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    Rlkkelkelekdppegisakpvdesd......ltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWspal 96
           Rlk++l +l+  p+ ++ + ++   d        ++ev  + p++ +Y+ g  +++++f+e YP++PPkv +l+kifhPn++ +G+vCl+il+  e+Wspal
   Q: 31   RLKRDLDSLDLPPTVTLNVITSP--DsadrsqSPKLEVI-VRPDEGYYNYGSINFNLDFNEVYPIEPPKVVCLKKIFHPNIDLKGNVCLNILR--EDWSPAL 127
           77788888755555444333322..21123325556655.55**************************************************9..******* PP
   S: 97   svesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           +++s+++++  l+ epnp++pln++aa+ll++ ++e+ + vr
   Q: 128  DLQSIITGLLFLFLEPNPNDPLNKDAAKLLCEGEKEFAEAVR 169
           **************************************9997 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Accepts the ubiquitin-like protein NEDD8/RUB1 from the UBA3-ULA1 E1 complex and catalyzes its covalent attachment to other proteins. The major substrate is CDC53/Cullin.

Protein Sequence
(Fasta)

MLKLRQLQKK KQKENENSSS IQPNLSAARI RLKRDLDSLD LPPTVTLNVI TSPDSADRSQ 60
SPKLEVIVRP DEGYYNYGSI NFNLDFNEVY PIEPPKVVCL KKIFHPNIDL KGNVCLNILR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTACGTA GATGCAACTA TATCTTTCCG TTTCTCATTG GCGGTTTTTA GCGATCGAAA 60
ATACTAACAT AATCTTTTTG GGGGGTGAGA ATGTATATGT GTACTGGATA TGTATATTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0016874--F:ligase activity
GO:0019788--F:NEDD8 transferase activity
GO:0045116--P:protein neddylation

KEGG

sce:YLR306W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000196	Aegilops tauschii	45.64	1.00e-34	137.00
IUUC-Aml-002007	Ailuropoda melanoleuca	44.97	2.00e-34	135.00
IUUC-Atr-003170	Amborella trichopoda	43.48	3.00e-40	155.00
IUUC-Aca-005037	Anolis carolinensis	41.80	2.00e-40	155.00
IUUC-Aly-005638	Arabidopsis lyrata	42.22	2.00e-39	153.00
IUUC-Ath-006876	Arabidopsis thaliana	42.22	2.00e-39	153.00
IUUC-Ago-007910	Ashbya gossypii	46.79	2.00e-40	156.00
IUUC-Acl-008364	Aspergillus clavatus	45.86	3.00e-38	149.00
IUUC-Afl-008463	Aspergillus flavus	45.22	2.00e-39	152.00
IUUC-Afu-008803	Aspergillus fumigatus	47.13	6.00e-40	154.00
IUUC-Ani-009422	Aspergillus nidulans	45.86	2.00e-37	146.00
IUUC-Ang-009728	Aspergillus niger	51.22	1.00e-37	146.00
IUUC-Aor-009962	Aspergillus oryzae	45.22	2.00e-39	152.00
IUUC-Ate-010430	Aspergillus terreus	42.17	1.00e-32	130.00
IUUC-Ame-011382	Astyanax mexicanus	41.71	2.00e-39	152.00
IUUC-Bgr-012306	Blumeria graminis	41.80	1.00e-40	157.00
IUUC-Bta-012818	Bos taurus	41.49	1.00e-39	153.00
IUUC-Bci-013626	Botrytis cinerea	41.27	2.00e-40	156.00
IUUC-Bdi-014528	Brachypodium distachyon	48.03	1.00e-38	150.00
IUUC-Bol-016135	Brassica oleracea	43.17	5.00e-40	154.00
IUUC-Bra-016704	Brassica rapa	43.41	6.00e-40	154.00
IUUC-Cja-019213	Callithrix jacchus	40.41	1.00e-37	147.00
IUUC-Cfa-020242	Canis familiaris	41.05	5.00e-38	148.00
IUUC-Cpo-022405	Cavia porcellus	40.74	2.00e-39	152.00
IUUC-Cre-022865	Chlamydomonas reinhardtii	44.74	1.00e-37	146.00
IUUC-Csa-023269	Chlorocebus sabaeus	41.49	1.00e-39	153.00
IUUC-Cin-025333	Ciona intestinalis	42.70	3.00e-40	155.00
IUUC-Csv-025898	Ciona savignyi	37.56	3.00e-36	142.00
IUUC-Cgl-026477	Colletotrichum gloeosporioides	42.55	7.00e-39	150.00
IUUC-Cne-027097	Cryptococcus neoformans	44.62	4.00e-42	161.00
IUUC-Cme-027287	Cyanidioschyzon merolae	46.58	3.00e-15	72.80
IUUC-Dre-028514	Danio rerio	40.11	1.00e-36	143.00
IUUC-Dno-029678	Dasypus novemcinctus	39.68	4.00e-35	138.00
IUUC-Dse-031265	Dothistroma septosporum	42.78	2.00e-41	159.00
IUUC-Dme-032076	Drosophila melanogaster	44.81	2.00e-42	163.00
IUUC-Eca-034075	Equus caballus	40.96	1.00e-38	150.00
IUUC-Fca-035654	Felis catus	44.97	2.00e-34	135.00
IUUC-Fox-037877	Fusarium oxysporum	42.41	6.00e-37	144.00
IUUC-Fso-038428	Fusarium solani	43.98	8.00e-40	154.00
IUUC-Gmo-039402	Gadus morhua	41.71	2.00e-39	153.00
IUUC-Ggr-039731	Gaeumannomyces graminis	41.80	7.00e-38	147.00
IUUC-Gga-041122	Gallus gallus	40.45	2.00e-36	143.00
IUUC-Gma-043805	Glycine max	45.25	2.00e-40	156.00
IUUC-Ggo-044436	Gorilla gorilla	41.49	1.00e-39	153.00
IUUC-Hsa-046026	Homo sapiens	41.49	1.00e-39	153.00
IUUC-Hvu-047056	Hordeum vulgare	42.39	1.00e-38	150.00
IUUC-Itr-047889	Ictidomys tridecemlineatus	41.49	1.00e-39	153.00
IUUC-Kpa-049315	Komagataella pastoris	51.34	2.00e-50	189.00
IUUC-Lch-050360	Latimeria chalumnae	41.01	2.00e-24	103.00
IUUC-Lpe-050743	Leersia perrieri	44.07	8.00e-39	150.00
IUUC-Lma-053001	Leptosphaeria maculans	42.59	8.00e-37	144.00
IUUC-Laf-053463	Loxodonta africana	45.64	6.00e-35	137.00
IUUC-Meu-056085	Macropus eugenii	44.59	1.00e-34	136.00
IUUC-Mor-057250	Magnaporthe oryzae	46.50	5.00e-38	148.00
IUUC-Mpo-057481	Magnaporthe poae	46.50	6.00e-37	144.00
IUUC-Mtr-058251	Medicago truncatula	45.25	2.00e-41	159.00
IUUC-Mla-059119	Melampsora laricipopulina	45.16	2.00e-41	159.00
IUUC-Mga-059881	Meleagris gallopavo	44.64	7.00e-25	103.00
IUUC-Mvi-060449	Microbotryum violaceum	48.41	1.00e-40	156.00
IUUC-Mmu-063962	Mus musculus	41.49	1.00e-39	153.00
IUUC-Mac-064435	Musa acuminata	44.57	3.00e-42	162.00
IUUC-Mlu-066955	Myotis lucifugus	44.44	2.00e-34	136.00
IUUC-Nfi-068300	Neosartorya fischeri	47.13	6.00e-40	154.00
IUUC-Ncr-068944	Neurospora crassa	41.88	6.00e-38	148.00
IUUC-Nle-069051	Nomascus leucogenys	44.97	2.00e-34	135.00
IUUC-Opr-070635	Ochotona princeps	44.59	1.00e-33	133.00
IUUC-Ont-072348	Oreochromis niloticus	41.71	2.00e-39	152.00
IUUC-Ocu-074905	Oryctolagus cuniculus	41.49	1.00e-39	153.00
IUUC-Oba-075203	Oryza barthii	43.48	5.00e-40	154.00
IUUC-Obr-076067	Oryza brachyantha	43.58	5.00e-39	151.00
IUUC-Ogl-077594	Oryza glaberrima	43.58	4.00e-39	151.00
IUUC-Ogu-078347	Oryza glumaepatula	43.48	5.00e-40	154.00
IUUC-Oin-079115	Oryza indica	43.48	5.00e-40	154.00
IUUC-Olo-080697	Oryza longistaminata	43.48	6.00e-40	154.00
IUUC-Ome-081713	Oryza meridionalis	43.58	6.00e-39	151.00
IUUC-Oni-082123	Oryza nivara	43.48	5.00e-40	154.00
IUUC-Opu-083937	Oryza punctata	43.48	5.00e-40	154.00
IUUC-Oru-084723	Oryza rufipogon	43.48	5.00e-40	154.00
IUUC-Osa-086013	Oryza sativa	43.48	5.00e-40	154.00
IUUC-Olu-087854	Ostreococcus lucimarinus	43.60	8.00e-38	147.00
IUUC-Oga-088580	Otolemur garnettii	41.49	1.00e-39	153.00
IUUC-Oar-089623	Ovis aries	39.22	5.00e-28	114.00
IUUC-Ptr-091020	Pan troglodytes	44.59	1.00e-33	133.00
IUUC-Pan-092119	Papio anubis	44.97	2.00e-34	135.00
IUUC-Psi-093494	Pelodiscus sinensis	44.97	3.00e-35	138.00
IUUC-Pno-094972	Phaeosphaeria nodorum	40.00	6.00e-35	138.00
IUUC-Ppa-095266	Physcomitrella patens	45.20	9.00e-44	167.00
IUUC-Pfo-097205	Poecilia formosa	40.21	2.00e-35	139.00
IUUC-Pab-098434	Pongo abelii	41.49	1.00e-39	153.00
IUUC-Pop-099789	Populus trichocarpa	45.81	1.00e-41	160.00
IUUC-Pca-100300	Procavia capensis	45.27	3.00e-34	135.00
IUUC-Ppe-101216	Prunus persica	44.13	2.00e-35	139.00
IUUC-Pva-102143	Pteropus vampyrus	41.49	1.00e-39	153.00
IUUC-Pgr-103675	Puccinia graminis	45.45	7.00e-42	161.00
IUUC-Ptt-103997	Puccinia triticina	44.92	5.00e-42	161.00
IUUC-Pte-104042	Pyrenophora teres	42.59	1.00e-37	146.00
IUUC-Pyt-104616	Pyrenophora triticirepentis	49.59	2.00e-35	139.00
IUUC-Rno-105107	Rattus norvegicus	41.49	1.00e-39	153.00
IUUC-Sha-106899	Sarcophilus harrisii	44.08	3.00e-35	139.00
IUUC-Sja-107789	Schizosaccharomyces japonicus	46.52	2.00e-41	159.00
IUUC-Spo-108143	Schizosaccharomyces pombe	44.92	3.00e-44	169.00
IUUC-Ssl-108427	Sclerotinia sclerotiorum	41.49	5.00e-39	151.00
IUUC-Smo-109440	Selaginella moellendorffii	42.11	7.00e-39	150.00
IUUC-Sit-109702	Setaria italica	47.37	1.00e-37	146.00
IUUC-Sly-111045	Solanum lycopersicum	45.25	2.00e-41	159.00
IUUC-Stu-112655	Solanum tuberosum	42.93	2.00e-40	156.00
IUUC-Sar-113632	Sorex araneus	40.96	2.00e-38	149.00
IUUC-Sbi-114410	Sorghum bicolor	42.86	7.00e-39	150.00
IUUC-Sre-114912	Sporisorium reilianum	47.80	9.00e-41	157.00
IUUC-Tsy-119639	Tarsius syrichta	59.26	1.00e-26	110.00
IUUC-Tni-119674	Tetraodon nigroviridis	36.32	2.00e-32	129.00
IUUC-Tca-121359	Theobroma cacao	45.25	1.00e-40	157.00
IUUC-Tre-122115	Trichoderma reesei	46.30	7.00e-39	150.00
IUUC-Tvi-122656	Trichoderma virens	47.56	3.00e-39	152.00
IUUC-Tae-124489	Triticum aestivum	42.39	1.00e-38	150.00
IUUC-Tur-126125	Triticum urartu	42.39	2.00e-38	150.00
IUUC-Tme-126950	Tuber melanosporum	48.15	4.00e-42	162.00
IUUC-Tbe-127874	Tupaia belangeri	51.55	3.00e-23	99.00
IUUC-Ttr-128213	Tursiops truncatus	46.05	1.00e-36	143.00
IUUC-Uma-129329	Ustilago maydis	48.39	1.00e-39	153.00
IUUC-Vda-129754	Verticillium dahliae	46.91	4.00e-40	155.00
IUUC-Vvi-131182	Vitis vinifera	45.81	5.00e-41	158.00
IUUC-Xtr-132742	Xenopus tropicalis	41.27	7.00e-40	154.00
IUUC-Xma-133558	Xiphophorus maculatus	40.11	1.00e-36	143.00
IUUC-Yli-134467	Yarrowia lipolytica	43.55	6.00e-45	171.00
IUUC-Zma-135527	Zea mays	46.71	9.00e-37	144.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence