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Tag Content
UUCD2 ID IUUC-Xtr-132742
UUCD1 version UUC-XeT-00995
Ensembl Protein ID ENSXETP00000039688.2
UniProt Accession Q6P8D9; UBC12_XENTR
Genbank Protein ID AAH61289.1
Protein Name NEDD8-conjugating enzyme Ubc12; NEDD8 carrier protein; NEDD8 protein ligase; Ubiquitin-conjugating enzyme E2 M
Genbank Nucleotide ID BC061289
Gene Name ube2m; ubc12
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSXETG00000018326.2 ENSXETT00000039688.2 ENSXETP00000039688.2
Status Unreviewed
Classification
Family E-Value Score Start End
E2/UBC 3.50e-40 137.1 33 165
Active Site
Position(s) Description Evidence
111 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00388,
ECO:0000255|PROSITE-ProRule:PRU10133}
Domain Profile

   E2/UBC
   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkee 89
           R++k+++el  + p+++ ++++d++dl +++++i+ p++  Y+gg+F +++++ + YP +PPkvk++t ++hPn++ +G+vCl+il+  
   Q: 33   RIQKDINEL--NLPKTCEIEFSDHDDLLNFKLVIC-PDEGFYKGGKFVFSFKVGQGYPHDPPKVKCETMVYHPNIDLEGNVCLNILR-- 116
           89******9..8999*******************9.**************************************************9.. PP
   S: 90   ekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           e+W+p+l+++s+++++q l+ epnpe+pln+eaae l++nr+ ++++v+
   Q: 117  EDWKPVLTINSIIYGLQYLFLEPNPEDPLNKEAAEVLQNNRRLFEQNVQ 165
           ***********************************************97 PP
   
Organism Xenopus tropicalis
Functional Description
(View)

Functional Description


     Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase rbx1, but not rbx2, suggests that the rbx1-ube2m complex neddylates specific target proteins, such as cul1, cul2, cul3 and cul4. Involved in cell proliferation (By similarity).
 Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase rbx1, but not rbx2, suggests that the rbx1-ube2m complex neddylates specific target proteins, such as cul1, cul2, cul3 and cul4. Involved in cell proliferation (By similarity).
Protein Sequence
(Fasta)
MIKLFSLKQQ KKEEESAGGT KGSSKKASAA QLRIQKDINE LNLPKTCEIE FSDHDDLLNF 60
KLVICPDEGF YKGGKFVFSF KVGQGYPHDP PKVKCETMVY HPNIDLEGNV CLNILREDWK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Xtr-132742|E2,E2/UBC|Xenopus tropicalis
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCCTGTCTCC CCCCGGCCTG TGTGTGGCGA GAGAGAGAAA AGGGACGGAG GGGAGGGAGG 60
CTGGGAGCTT CCCCCAGTGC GGGACATAGG GAGAGCAGGA GGGGGTTGAG GGAGGTGCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Xtr-132742|E2,E2/UBC|Xenopus tropicalis
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD
PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2
Pfam

PF00179--UQ_con
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0019788--F:NEDD8 transferase activity
GO:0018169--F:ribosomal S6-glutamic acid ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006464--P:cellular protein modification process
GO:0045116--P:protein neddylation
KEGG xtr:394553
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000196 Aegilops tauschii 56.82 6.00e-55 206.00
IUUC-Aml-002007 Ailuropoda melanoleuca 97.28 1.00e-83 300.00
IUUC-Atr-003170 Amborella trichopoda 60.11 1.00e-65 241.00
IUUC-Aca-005037 Anolis carolinensis 98.91 7.00e-106 375.00
IUUC-Aly-006219 Arabidopsis lyrata 61.08 2.00e-65 241.00
IUUC-Ath-006876 Arabidopsis thaliana 60.33 6.00e-65 239.00
IUUC-Ago-007910 Ashbya gossypii 45.27 3.00e-37 147.00
IUUC-Acl-008364 Aspergillus clavatus 59.87 2.00e-54 204.00
IUUC-Afl-008463 Aspergillus flavus 61.84 5.00e-56 209.00
IUUC-Afu-008803 Aspergillus fumigatus 59.87 2.00e-54 204.00
IUUC-Ani-009422 Aspergillus nidulans 62.50 5.00e-57 213.00
IUUC-Ang-009728 Aspergillus niger 61.76 8.00e-50 188.00
IUUC-Aor-009962 Aspergillus oryzae 61.84 5.00e-56 209.00
IUUC-Ate-010430 Aspergillus terreus 58.39 1.00e-50 192.00
IUUC-Ame-011382 Astyanax mexicanus 91.35 7.00e-98 348.00
IUUC-Bgr-012306 Blumeria graminis 56.52 9.00e-61 225.00
IUUC-Bta-012818 Bos taurus 97.81 2.00e-104 370.00
IUUC-Bci-013626 Botrytis cinerea 57.07 3.00e-61 227.00
IUUC-Bdi-014528 Brachypodium distachyon 62.64 1.00e-62 231.00
IUUC-Bol-016135 Brassica oleracea 60.22 3.00e-65 240.00
IUUC-Bra-017161 Brassica rapa 61.41 1.00e-61 228.00
IUUC-Cja-019213 Callithrix jacchus 95.21 4.00e-102 362.00
IUUC-Cfa-020242 Canis familiaris 96.76 1.00e-102 365.00
IUUC-Cpo-022405 Cavia porcellus 93.44 7.00e-98 348.00
IUUC-Cre-022865 Chlamydomonas reinhardtii 60.57 2.00e-55 207.00
IUUC-Csa-023269 Chlorocebus sabaeus 97.81 2.00e-104 370.00
IUUC-Cin-025333 Ciona intestinalis 75.41 4.00e-82 296.00
IUUC-Csv-025898 Ciona savignyi 62.04 1.00e-74 272.00
IUUC-Cgl-026477 Colletotrichum gloeosporioides 55.74 4.00e-56 210.00
IUUC-Cne-027097 Cryptococcus neoformans 60.99 5.00e-62 229.00
IUUC-Cme-027287 Cyanidioschyzon merolae 50.65 2.00e-20 92.00
IUUC-Dre-028514 Danio rerio 88.11 3.00e-90 323.00
IUUC-Dno-029678 Dasypus novemcinctus 90.16 5.00e-95 339.00
IUUC-Dor-030851 Dipodomys ordii 65.87 4.00e-55 206.00
IUUC-Dse-031265 Dothistroma septosporum 56.83 2.00e-62 231.00
IUUC-Dme-032076 Drosophila melanogaster 74.73 1.00e-79 288.00
IUUC-Ete-032350 Echinops telfairi 72.17 3.00e-43 166.00
IUUC-Eca-034075 Equus caballus 96.72 7.00e-103 365.00
IUUC-Fca-035654 Felis catus 97.28 1.00e-83 300.00
IUUC-Fal-037283 Ficedula albicollis 90.36 1.00e-42 163.00
IUUC-Fox-037877 Fusarium oxysporum 57.84 6.00e-58 216.00
IUUC-Fso-038428 Fusarium solani 57.84 2.00e-63 234.00
IUUC-Gmo-039402 Gadus morhua 90.27 2.00e-97 347.00
IUUC-Ggr-039731 Gaeumannomyces graminis 59.78 2.00e-57 214.00
IUUC-Gga-041122 Gallus gallus 90.96 4.00e-94 337.00
IUUC-Gma-043805 Glycine max 61.08 7.00e-65 239.00
IUUC-Ggo-044436 Gorilla gorilla 97.81 2.00e-104 370.00
IUUC-Hsa-046026 Homo sapiens 97.81 2.00e-104 370.00
IUUC-Hvu-047056 Hordeum vulgare 60.99 7.00e-63 232.00
IUUC-Itr-047889 Ictidomys tridecemlineatus 97.81 2.00e-104 370.00
IUUC-Kpa-049315 Komagataella pastoris 49.72 3.00e-49 187.00
IUUC-Lch-050360 Latimeria chalumnae 76.22 2.00e-59 221.00
IUUC-Lpe-050743 Leersia perrieri 61.02 3.00e-63 234.00
IUUC-Lma-053001 Leptosphaeria maculans 57.92 5.00e-58 216.00
IUUC-Laf-053463 Loxodonta africana 97.28 2.00e-83 300.00
IUUC-Mcc-054966 Macaca mulatta 98.72 2.00e-43 166.00
IUUC-Meu-056085 Macropus eugenii 97.95 6.00e-84 301.00
IUUC-Mor-057250 Magnaporthe oryzae 62.50 6.00e-56 209.00
IUUC-Mpo-057481 Magnaporthe poae 63.82 9.00e-56 209.00
IUUC-Mtr-058251 Medicago truncatula 60.11 1.00e-65 242.00
IUUC-Mla-059119 Melampsora laricipopulina 59.02 6.00e-60 223.00
IUUC-Mga-059881 Meleagris gallopavo 92.45 8.00e-57 211.00
IUUC-Mvi-060449 Microbotryum violaceum 58.66 8.00e-60 222.00
IUUC-Mmr-061511 Microcebus murinus 98.72 2.00e-43 166.00
IUUC-Mmu-063962 Mus musculus 97.81 2.00e-104 370.00
IUUC-Mac-064967 Musa acuminata 62.84 2.00e-68 251.00
IUUC-Mlu-066955 Myotis lucifugus 95.36 3.00e-84 303.00
IUUC-Nfi-068300 Neosartorya fischeri 59.87 2.00e-54 204.00
IUUC-Ncr-068944 Neurospora crassa 57.30 2.00e-57 214.00
IUUC-Nle-069051 Nomascus leucogenys 97.28 1.00e-83 300.00
IUUC-Opr-070635 Ochotona princeps 97.26 6.00e-83 298.00
IUUC-Ont-072348 Oreochromis niloticus 90.27 5.00e-97 346.00
IUUC-Ocu-074905 Oryctolagus cuniculus 97.81 2.00e-104 370.00
IUUC-Oba-075825 Oryza barthii 61.54 3.00e-67 247.00
IUUC-Obr-076067 Oryza brachyantha 60.99 6.00e-67 246.00
IUUC-Ogl-077594 Oryza glaberrima 61.54 3.00e-67 247.00
IUUC-Ogu-078073 Oryza glumaepatula 61.54 3.00e-67 247.00
IUUC-Oin-080060 Oryza indica 61.20 3.00e-64 238.00
IUUC-Olo-080314 Oryza longistaminata 61.54 1.00e-67 248.00
IUUC-Ome-081713 Oryza meridionalis 61.54 2.00e-67 248.00
IUUC-Oni-082426 Oryza nivara 61.54 3.00e-67 247.00
IUUC-Opu-083942 Oryza punctata 61.85 1.00e-63 234.00
IUUC-Oru-085104 Oryza rufipogon 61.54 3.00e-67 247.00
IUUC-Osa-086168 Oryza sativa 61.54 2.00e-67 247.00
IUUC-Olu-087854 Ostreococcus lucimarinus 57.30 1.00e-58 218.00
IUUC-Oga-088580 Otolemur garnettii 97.81 2.00e-104 370.00
IUUC-Oar-089623 Ovis aries 90.54 5.00e-76 275.00
IUUC-Ptr-091161 Pan troglodytes 88.52 5.00e-91 325.00
IUUC-Pan-092119 Papio anubis 97.28 1.00e-83 300.00
IUUC-Psi-093494 Pelodiscus sinensis 98.64 5.00e-85 305.00
IUUC-Pno-094972 Phaeosphaeria nodorum 56.02 6.00e-56 209.00
IUUC-Ppa-095187 Physcomitrella patens 68.31 2.00e-71 261.00
IUUC-Pfo-097205 Poecilia formosa 86.10 5.00e-88 316.00
IUUC-Pab-098434 Pongo abelii 97.81 2.00e-104 370.00
IUUC-Pop-099789 Populus trichocarpa 61.75 6.00e-66 243.00
IUUC-Pca-100300 Procavia capensis 97.26 7.00e-83 298.00
IUUC-Ppe-101143 Prunus persica 60.66 7.00e-66 242.00
IUUC-Pva-102143 Pteropus vampyrus 97.81 2.00e-104 370.00
IUUC-Pgr-103675 Puccinia graminis 59.78 9.00e-59 219.00
IUUC-Ptt-103997 Puccinia triticina 61.24 6.00e-60 223.00
IUUC-Pte-104042 Pyrenophora teres 57.92 1.00e-57 215.00
IUUC-Pyt-104616 Pyrenophora triticirepentis 61.90 9.00e-53 198.00
IUUC-Rno-105107 Rattus norvegicus 97.81 2.00e-104 370.00
IUUC-Sce-106385 Saccharomyces cerevisiae 43.21 2.00e-37 148.00
IUUC-Sha-106899 Sarcophilus harrisii 90.80 1.00e-85 308.00
IUUC-Sja-107789 Schizosaccharomyces japonicus 51.65 7.00e-52 196.00
IUUC-Spo-108143 Schizosaccharomyces pombe 49.73 3.00e-49 187.00
IUUC-Ssl-108427 Sclerotinia sclerotiorum 56.83 6.00e-60 223.00
IUUC-Smo-108673 Selaginella moellendorffii 65.22 7.00e-69 252.00
IUUC-Sit-109702 Setaria italica 64.29 1.00e-62 231.00
IUUC-Sly-111650 Solanum lycopersicum 63.39 2.00e-67 247.00
IUUC-Stu-112655 Solanum tuberosum 62.84 8.00e-68 249.00
IUUC-Sar-113632 Sorex araneus 97.27 2.00e-103 367.00
IUUC-Sbi-114357 Sorghum bicolor 64.84 1.00e-63 234.00
IUUC-Sre-114912 Sporisorium reilianum 63.16 3.00e-57 213.00
IUUC-Tsy-119639 Tarsius syrichta 76.51 7.00e-60 222.00
IUUC-Tni-119674 Tetraodon nigroviridis 77.84 7.00e-78 282.00
IUUC-Tca-121359 Theobroma cacao 62.84 5.00e-67 246.00
IUUC-Tre-122115 Trichoderma reesei 59.75 8.00e-57 212.00
IUUC-Tvi-122656 Trichoderma virens 59.75 5.00e-56 209.00
IUUC-Tae-124489 Triticum aestivum 60.99 7.00e-63 232.00
IUUC-Tur-126125 Triticum urartu 60.99 7.00e-63 233.00
IUUC-Tme-126950 Tuber melanosporum 61.78 6.00e-57 213.00
IUUC-Tbe-127874 Tupaia belangeri 71.58 5.00e-66 243.00
IUUC-Ttr-128213 Tursiops truncatus 96.27 8.00e-89 318.00
IUUC-Uma-129329 Ustilago maydis 62.99 5.00e-57 213.00
IUUC-Vda-129754 Verticillium dahliae 60.51 4.00e-56 210.00
IUUC-Vvi-131182 Vitis vinifera 62.30 5.00e-66 243.00
IUUC-Xma-133558 Xiphophorus maculatus 87.03 1.00e-89 321.00
IUUC-Yli-134467 Yarrowia lipolytica 56.04 4.00e-59 220.00
IUUC-Zma-135527 Zea mays 64.84 4.00e-63 233.00
Created Date 25-Jun-2017

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