iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tae-125542

Ensembl Protein ID

TRIAE_CS42_2BL_TGACv1_131910_AA0433460.4

UniProt Accession

A0A1D5U4A0; A0A1D5U4A0_WHEAT

Protein Name

Eukaryotic translation initiation factor 3 subunit I

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
TRIAE_CS42_2BL_TGACv1_131910_AA0433460	TRIAE_CS42_2BL_TGACv1_131910_AA0433460.1	TRIAE_CS42_2BL_TGACv1_131910_AA0433460.1
TRIAE_CS42_2BL_TGACv1_131910_AA0433460	TRIAE_CS42_2BL_TGACv1_131910_AA0433460.4	TRIAE_CS42_2BL_TGACv1_131910_AA0433460.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.70e-25	89.2	50	87
UBD/Beta-Prp	1.30e-39	138.8	6	257

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvll 36
           gH++ v++++   ++t+l++Gs D t k+WD+ tg+ l
   Q: 50   GHNGAVWSCDVsrHSTRLITGSADQTAKLWDVQTGREL 87
           8**********9644*******************9876 PP

UBD/Beta-Prp

   S: 48   lsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdr 116
           ++ghe + t +k+++dg++l ++++D+t  vw  s+g+ + t++gh+  v+s+++s+ + +l++Gs+d+
   Q: 6    MKGHERPLTFLKYNRDGDLLFSCAKDHTPTVWYASNGDRLGTYRGHNGAVWSCDVSRHSTRLITGSADQ 74
           478999999999999999999999999999999999999999999999999999999889999999999 PP
   S: 117  tirvwdletgqclee.....................................................t 132
           t+++wd++tg +l +                                                     +
   Q: 75   TAKLWDVQTGRELFTfrfdaparsvdfaigdhlavittdsfmgktptaqvkriaediqdrteteesalV 143
           99999999999998899999999999999999999999999999999999999999999999999*9** PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl..tgghtdsvyslsfdsngkelvsgs 199
            sg +g +n +v+ p ++ +++++ D t+r+Wd++tgkll++   + gh++++ sls + +  ++++gs
   Q: 144  ISGITGRINRAVWGPGNRTIITAGEDATIRIWDSETGKLLKESdkEAGHQKAISSLSKSLDWSHFLTGS 212
           *******************************************99777********************* PP
   S: 200  ldgtvklwdlqtgecvrtlnghtdnvksvrfs.pnderlvsgssDg 244
           ld++ klwd +t + ++t+   + +v+ v++s   d+ ++ g++D 
   Q: 213  LDKSAKLWDARTLTLIKTYVTER-PVNAVDMSpILDNVVIGGGQDA 257
           ******************99754.5555555522366666666664 PP

Organism

Triticum aestivum

Functional Description
(View)

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

Protein Sequence
(Fasta)

MRPVLMKGHE RPLTFLKYNR DGDLLFSCAK DHTPTVWYAS NGDRLGTYRG HNGAVWSCDV 60
SRHSTRLITG SADQTAKLWD VQTGRELFTF RFDAPARSVD FAIGDHLAVI TTDSFMGKTP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTAGGTTTT CCCACACACA AGCACCCCTT GTCCACGCGC AGCTAGGGTT TTGCTCCGCC 60
GCAACCACAC CCCCACACTT CCCTAGCCCT ACACCTCCTG GCGGCGGCGG CGGCGGCGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0396--Initiation factor
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR027525--eIF3i
IPR020472--G-protein_beta_WD-40_rep
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0016282--C:eukaryotic 43S preinitiation complex
GO:0033290--C:eukaryotic 48S preinitiation complex
GO:0005852--C:eukaryotic translation initiation factor 3 complex
GO:0003743--F:translation initiation factor activity
GO:0001731--P:formation of translation preinitiation complex
GO:0006446--P:regulation of translational initiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-008000	Ashbya gossypii	41.57	3.00e-74	272.00
IUUC-Cme-027304	Cyanidioschyzon merolae	53.40	5.00e-91	328.00
IUUC-Ggr-040045	Gaeumannomyces graminis	46.15	2.00e-79	290.00
IUUC-Kpa-049325	Komagataella pastoris	44.98	2.00e-79	289.00
IUUC-Loc-052094	Lepisosteus oculatus	41.95	3.00e-74	272.00
IUUC-Oan-073660	Ornithorhynchus anatinus	44.59	3.00e-72	265.00
IUUC-Sja-107758	Schizosaccharomyces japonicus	43.43	1.00e-79	290.00
IUUC-Tca-121316	Theobroma cacao	82.01	9.00e-160	556.00
IUUC-Tur-126334	Triticum urartu	87.50	4.00e-164	570.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence