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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105634
UUCD1 version UUC-RaN-00453
Ensembl Protein ID ENSRNOP00000068785.1
UniProt Accession Q6J2U6; Q4G096; RN114_RAT
Genbank Protein ID AAT28739.1; AAH98633.1
Protein Name E3 ubiquitin-protein ligase RNF114; RING finger protein 114; RING-type E3 ubiquitin transferase RNF114; Zinc finger protein 313
Genbank Nucleotide ID AY603473; BC098633
Gene Name Rnf114; Zfp313; Znf313
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000060821.1 ENSRNOT00000086459.1 ENSRNOP00000068785.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/U-box 1.50e-08 34.9 25 73
E3 activity/RING/RING 1.20e-06 29.3 30 69
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 3    peeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplt 51
           ++ f Cp+ le+++ Pv +p+G+++  ++++++l+ ++  c v+r+ l+
   Q: 25   LSRFTCPVCLEVFEKPVQVPCGHVFCSACLQECLKPKKPVCGVCRSALA 73
           678******************************************9986 PP
   

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cle f++ p+ +pCgHvf+  Clq       ++ k+  C +Cr
   Q: 30   CPVCLEVFEK-PVQVPCGHVFCSACLQEC-----LKPKKPVCGVCR 69
           **********.999************555.....499999*****8 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle's G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis.
 E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle's G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis.
Protein Sequence
(Fasta)
MAAAQPESRD GAAQSAKPAS ETDPLSRFTC PVCLEVFEKP VQVPCGHVFC SACLQECLKP 60
KKPVCGVCRS ALAPGVRAAE LERQIESIET SCHGCRKDFV LSKIRAHVAS CSKYQSYIME 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105634|E3,U-box;E3,RING|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGCGCGACGC TCCTCAGCGG CAAGATGGCG GCGGCGCAGC CGGAGTCCCG CGACGGAGCC 60
GCGCAGTCGG CGAAGCCGGC GTCCGAAACT GACCCTCTCA GCCGCTTTAC GTGTCCCGTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105634|E3,U-box;E3,RING|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0744--Spermatogenesis
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR008598--Di19_Zn_binding_dom
IPR034734--ZF_C2HC_RNF
IPR027370--Znf-RING_LisH
IPR013087--Znf_C2H2_type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS51803--ZF_C2HC_RNF
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF05605--zf-Di19
PF13445--zf-RING_UBOX
SMART

SM00184--RING
SM00355--ZnF_C2H2
Gene Ontology

GO:0005829--C:cytosol
GO:0005622--C:intracellular
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0030154--P:cell differentiation
GO:0007275--P:multicellular organism development
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0007283--P:spermatogenesis
KEGG rno:362277
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002315 Ailuropoda melanoleuca 89.43 5.00e-123 432.00
IUUC-Apl-004036 Anas platyrhynchos 75.69 1.00e-81 295.00
IUUC-Aca-004569 Anolis carolinensis 71.43 3.00e-98 350.00
IUUC-Bta-013345 Bos taurus 88.60 4.00e-122 429.00
IUUC-Cja-019919 Callithrix jacchus 88.99 1.00e-121 428.00
IUUC-Cfa-021164 Canis familiaris 89.87 4.00e-123 433.00
IUUC-Cpo-022051 Cavia porcellus 78.60 1.00e-109 388.00
IUUC-Csa-023956 Chlorocebus sabaeus 92.27 4.00e-115 407.00
IUUC-Dre-027499 Danio rerio 52.48 4.00e-66 244.00
IUUC-Dno-029437 Dasypus novemcinctus 87.77 5.00e-119 419.00
IUUC-Dor-030428 Dipodomys ordii 73.57 2.00e-98 351.00
IUUC-Ete-032855 Echinops telfairi 72.05 1.00e-86 312.00
IUUC-Eca-034236 Equus caballus 91.71 1.00e-99 354.00
IUUC-Eeu-034875 Erinaceus europaeus 92.55 1.00e-104 372.00
IUUC-Fca-036017 Felis catus 92.45 5.00e-119 419.00
IUUC-Fal-037133 Ficedula albicollis 75.69 1.00e-83 302.00
IUUC-Gga-040752 Gallus gallus 72.27 8.00e-95 339.00
IUUC-Ggo-044654 Gorilla gorilla 91.60 4.00e-71 259.00
IUUC-Hsa-046280 Homo sapiens 92.27 3.00e-115 407.00
IUUC-Itr-048594 Ictidomys tridecemlineatus 90.32 1.00e-99 355.00
IUUC-Lch-050028 Latimeria chalumnae 60.48 1.00e-78 285.00
IUUC-Loc-051797 Lepisosteus oculatus 57.56 1.00e-69 255.00
IUUC-Laf-054248 Loxodonta africana 91.16 2.00e-99 353.00
IUUC-Mcc-054724 Macaca mulatta 92.27 4.00e-115 407.00
IUUC-Meu-056464 Macropus eugenii 58.56 4.00e-50 190.00
IUUC-Mga-059403 Meleagris gallopavo 75.94 4.00e-61 226.00
IUUC-Mmr-061582 Microcebus murinus 92.82 3.00e-101 360.00
IUUC-Mdo-062106 Monodelphis domestica 77.73 1.00e-97 348.00
IUUC-Mmu-064176 Mus musculus 96.94 2.00e-123 434.00
IUUC-Mpu-066083 Mustela putorius furo 89.43 2.00e-123 434.00
IUUC-Mlu-067060 Myotis lucifugus 89.86 1.00e-112 398.00
IUUC-Nle-069353 Nomascus leucogenys 92.75 9.00e-106 375.00
IUUC-Opr-070916 Ochotona princeps 87.67 5.00e-121 426.00
IUUC-Ont-072284 Oreochromis niloticus 57.08 3.00e-73 267.00
IUUC-Oan-072858 Ornithorhynchus anatinus 76.24 9.00e-83 298.00
IUUC-Ocu-074471 Oryctolagus cuniculus 93.07 3.00e-114 404.00
IUUC-Oin-079762 Oryza indica 52.17 2.00e-09 57.00
IUUC-Ola-087569 Oryzias latipes 54.59 1.00e-72 265.00
IUUC-Oga-089164 Otolemur garnettii 91.00 1.00e-116 412.00
IUUC-Oar-089436 Ovis aries 88.60 6.00e-123 432.00
IUUC-Ptr-090945 Pan troglodytes 92.27 3.00e-115 407.00
IUUC-Pan-092765 Papio anubis 92.27 4.00e-115 407.00
IUUC-Psi-093593 Pelodiscus sinensis 75.18 3.00e-63 233.00
IUUC-Pfo-096157 Poecilia formosa 53.36 1.00e-70 259.00
IUUC-Pab-098509 Pongo abelii 91.87 8.00e-116 409.00
IUUC-Pca-100293 Procavia capensis 86.14 3.00e-103 367.00
IUUC-Pva-102556 Pteropus vampyrus 87.22 3.00e-119 420.00
IUUC-Sha-107052 Sarcophilus harrisii 78.37 2.00e-91 328.00
IUUC-Sja-107944 Schizosaccharomyces japonicus 37.88 3.00e-08 52.00
IUUC-Sar-113680 Sorex araneus 90.61 2.00e-89 320.00
IUUC-Ssc-115451 Sus scrofa 91.16 3.00e-100 356.00
IUUC-Tgu-116515 Taeniopygia guttata 74.86 2.00e-82 298.00
IUUC-Tru-117712 Takifugu rubripes 56.88 5.00e-74 270.00
IUUC-Tsy-119419 Tarsius syrichta 91.71 4.00e-100 356.00
IUUC-Tni-119774 Tetraodon nigroviridis 58.26 2.00e-73 268.00
IUUC-Tbe-127924 Tupaia belangeri 86.28 1.00e-112 398.00
IUUC-Ttr-128721 Tursiops truncatus 88.11 1.00e-121 428.00
IUUC-Vpa-130175 Vicugna pacos 64.35 9.00e-79 286.00
IUUC-Xtr-131851 Xenopus tropicalis 57.28 1.00e-73 268.00
Created Date 25-Jun-2017

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