• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064050
UUCD1 version UUC-MuM-01071
Ensembl Protein ID ENSMUSP00000104616.2
UniProt Accession P52479; Q3T9L4; Q3TNN5; Q3TZB8; Q3U5E0; Q6ZQG9; Q91VY7; UBP10_MOUSE
Genbank Protein ID BAA12220.1; BAC97893.1; BAE32139.1; BAE34291.1; BAE38053.1; BAE43006.1; EDL11620.1; AAH07134.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 10; Deubiquitinating enzyme 10; Ubiquitin thioesterase 10; Ubiquitin-specific-processing protease 10
Genbank Nucleotide ID D84096; AK129083; AK153675; AK157970; AK165156; AK172443; CH466525; BC007134
Gene Name Usp10; Kiaa0190; Ode-1; Uchrp
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000031826.20 ENSMUST00000144458.7 ENSMUSP00000123590.1
ENSMUSG00000031826.20 ENSMUST00000108988.8 ENSMUSP00000104616.2
ENSMUSG00000031826.20 ENSMUST00000134729.1 ENSMUSP00000134182.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 11439350
Classification
Family E-value Score Start End
DUB/USP 9.80e-67 226.6 410 788
Active Site
Position(s) Description Evidence
418 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
743 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw......kskkk.............avspr 71
           Gl N gN CY+N++LQ+L+++p++ +l++   +   +  +++ +++++++s+ +l++e++      k ++              a++p+
   Q: 410  GLINKGNWCYINATLQALVACPPMYHLMKF-IPLYSK-VQRPCTSTPMIDSFVRLMNEFTnmpvppKPRQAlgdkivrdirpgaAFEPT 496
           9***************************99.333333.334799***************7666654333337777888888888***** PP
   S: 72   ellkalkkeaeefs.gyeqqDaqEflaflldqleeelkk.............eknkpkeeeeeedkselsde................. 129
            +++ l  +++++s + +q+Da+E+l f+l++l+ee+ +                         ++  +sd                  
   Q: 497  YIYRLLTVIKSSLSeKGRQEDAEEYLGFILNGLHEEMLSlkkllspthekhsV-----------SNGPRSDLiedeeledtgkgsedew 574
           *9999999999966599********************5555344444333331...........3333333355556666677777766 PP
   S: 130  ......aeekkkkknk...........slisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeeele 201
                 +        k           ++i+ +F+g+++ +++ ++  ++s + + f++l+l++++++ +   ++qd+Les +++e+++
   Q: 575  eqvgpkN--------KtsitrqadfvqTPITGIFGGHIR-SVVYQQSSKESATLQLFFTLQLDIQSDKIR---TVQDALESLVARESVQ 651
           5555541........33344455577799*********9.688999999*******************99...**************** PP
   S: 202  genkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke...kkkYeLiavvvHs 287
           g    y++k k+++e++++++l+klP+vL+lhLkRf ++++++++ k+ k++++p  L++s+ + sp  k+k+   +++Y+L+avv+H+
   Q: 652  G----YTTKTKQEVEVSRRVTLEKLPPVLVLHLKRFVYEKTGGCQ-KLVKNIDYPVDLEISRELLSPGIKNKNfkcQRTYRLFAVVYHH 735
           8....99999****************************9998886.****************99998877777777************* PP
   S: 288  G.slssGHYvayvknekgk.WllfdDskVtevkeeevleetg.staYvlfYkr 337
           G s+ +GHY+++v +   + Wl++dD++V+++++ +v++  + +taY+l+Y+r
   Q: 736  GnSATGGHYTTDVFQIGLNgWLRIDDQTVKVINQYQVVKPPAdRTAYLLYYRR 788
           ***************87777*******************8779********98 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage.
 Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage.
Protein Sequence
(Fasta)
MALHNPQYIF GDFSPDEFNQ FFVTPRSSVE LPPYSGTLCS IQAEDELPDG QEHQRIEFGV 60
DEVIEPSEGL PPTPSYSISS TLNPQAPEFI LGCTTSKKIP EAVEKDETYS SIDQYPASAL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064050|DUB,USP|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATTTGGTCCT CAAGGGTACA GGAGGCAGGG CTCCGTTACC CGCTGAGTCA TCTCACTAGC 60
TCCTTCAACG TTTACTTTTA TGTTTTACAA AGAAAAAAAA AATCTTTTTT TCCCCAATGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064050|DUB,USP|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0967--Endosome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR009818--Ataxin-2_C
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF07145--PAM2
PF00443--UCH
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0004197--F:cysteine-type endopeptidase activity
GO:0044325--F:ion channel binding
GO:0002039--F:p53 binding
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006914--P:autophagy
GO:0006974--P:cellular response to DNA damage stimulus
GO:0071347--P:cellular response to interleukin-1
GO:0030330--P:DNA damage response, signal transduction by p53 class mediator
GO:0006281--P:DNA repair
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0016579--P:protein deubiquitination
GO:0010506--P:regulation of autophagy
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:22224
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000082 Aegilops tauschii 31.87 1.00e-46 181.00
IUUC-Aml-001584 Ailuropoda melanoleuca 80.58 0.00e+00 1186.00
IUUC-Atr-002927 Amborella trichopoda 35.73 4.00e-59 222.00
IUUC-Apl-003988 Anas platyrhynchos 73.71 0.00e+00 1077.00
IUUC-Aca-004461 Anolis carolinensis 85.63 7.00e-160 556.00
IUUC-Aly-006038 Arabidopsis lyrata 35.71 1.00e-54 207.00
IUUC-Ath-007328 Arabidopsis thaliana 35.46 6.00e-53 201.00
IUUC-Ago-007717 Ashbya gossypii 30.56 3.00e-46 180.00
IUUC-Acl-008188 Aspergillus clavatus 35.84 1.00e-62 234.00
IUUC-Afl-008456 Aspergillus flavus 37.67 4.00e-48 185.00
IUUC-Afu-009067 Aspergillus fumigatus 37.23 3.00e-66 246.00
IUUC-Ani-009483 Aspergillus nidulans 33.61 3.00e-61 230.00
IUUC-Ang-009639 Aspergillus niger 35.08 2.00e-59 224.00
IUUC-Aor-010040 Aspergillus oryzae 35.15 1.00e-60 228.00
IUUC-Ate-010310 Aspergillus terreus 34.38 5.00e-61 229.00
IUUC-Ame-011012 Astyanax mexicanus 74.20 2.00e-164 573.00
IUUC-Bgr-012311 Blumeria graminis 34.67 1.00e-44 175.00
IUUC-Bta-013299 Bos taurus 79.12 0.00e+00 1146.00
IUUC-Bci-013783 Botrytis cinerea 37.27 7.00e-58 219.00
IUUC-Bdi-015039 Brachypodium distachyon 33.25 4.00e-49 189.00
IUUC-Bol-015806 Brassica oleracea 36.73 5.00e-62 232.00
IUUC-Bra-017076 Brassica rapa 36.99 3.00e-62 233.00
IUUC-Cja-018715 Callithrix jacchus 81.97 0.00e+00 1251.00
IUUC-Cfa-020194 Canis familiaris 81.08 0.00e+00 1211.00
IUUC-Cpo-022272 Cavia porcellus 73.36 0.00e+00 1016.00
IUUC-Cre-022713 Chlamydomonas reinhardtii 34.78 1.00e-35 144.00
IUUC-Csa-023310 Chlorocebus sabaeus 82.72 0.00e+00 1256.00
IUUC-Cho-024966 Choloepus hoffmanni 70.00 0.00e+00 830.00
IUUC-Cin-025616 Ciona intestinalis 46.89 1.00e-103 370.00
IUUC-Csv-026043 Ciona savignyi 44.84 1.00e-96 347.00
IUUC-Cgl-026421 Colletotrichum gloeosporioides 33.87 3.00e-45 177.00
IUUC-Cne-026962 Cryptococcus neoformans 35.52 5.00e-50 193.00
IUUC-Cme-027113 Cyanidioschyzon merolae 30.91 2.00e-38 154.00
IUUC-Dre-028072 Danio rerio 77.42 0.00e+00 722.00
IUUC-Dno-029489 Dasypus novemcinctus 81.08 0.00e+00 1242.00
IUUC-Dor-031068 Dipodomys ordii 74.12 1.00e-141 497.00
IUUC-Dse-031553 Dothistroma septosporum 37.47 5.00e-57 216.00
IUUC-Dme-031759 Drosophila melanogaster 42.69 1.00e-84 308.00
IUUC-Ete-032549 Echinops telfairi 72.32 0.00e+00 807.00
IUUC-Eca-033380 Equus caballus 80.96 0.00e+00 1220.00
IUUC-Eeu-034818 Erinaceus europaeus 78.05 0.00e+00 1156.00
IUUC-Fca-035535 Felis catus 79.22 0.00e+00 1096.00
IUUC-Fal-036627 Ficedula albicollis 73.43 0.00e+00 1067.00
IUUC-Fox-037904 Fusarium oxysporum 36.87 5.00e-55 209.00
IUUC-Fso-038170 Fusarium solani 33.41 2.00e-52 201.00
IUUC-Gmo-039499 Gadus morhua 70.13 0.00e+00 666.00
IUUC-Ggr-040042 Gaeumannomyces graminis 37.27 1.00e-62 235.00
IUUC-Gga-040571 Gallus gallus 73.78 0.00e+00 1073.00
IUUC-Gac-041345 Gasterosteus aculeatus 75.00 0.00e+00 657.00
IUUC-Gma-044407 Glycine max 35.64 2.00e-58 219.00
IUUC-Ggo-044652 Gorilla gorilla 82.98 0.00e+00 1286.00
IUUC-Hsa-045864 Homo sapiens 83.23 0.00e+00 1292.00
IUUC-Hvu-047071 Hordeum vulgare 33.50 7.00e-53 201.00
IUUC-Itr-048216 Ictidomys tridecemlineatus 88.45 0.00e+00 1012.00
IUUC-Kpa-049132 Komagataella pastoris 30.49 6.00e-46 178.00
IUUC-Lch-050040 Latimeria chalumnae 67.77 0.00e+00 892.00
IUUC-Loc-052449 Lepisosteus oculatus 77.78 0.00e+00 706.00
IUUC-Lma-053248 Leptosphaeria maculans 36.00 1.00e-57 218.00
IUUC-Laf-054121 Loxodonta africana 81.08 0.00e+00 1212.00
IUUC-Mcc-055514 Macaca mulatta 82.85 0.00e+00 1256.00
IUUC-Meu-056873 Macropus eugenii 68.45 0.00e+00 773.00
IUUC-Mor-057243 Magnaporthe oryzae 33.76 1.00e-57 218.00
IUUC-Mpo-057439 Magnaporthe poae 36.68 2.00e-61 231.00
IUUC-Mtr-058457 Medicago truncatula 34.36 2.00e-57 216.00
IUUC-Mla-058929 Melampsora laricipopulina 31.65 2.00e-57 216.00
IUUC-Mga-060157 Meleagris gallopavo 72.35 0.00e+00 1066.00
IUUC-Mvi-060442 Microbotryum violaceum 34.10 2.00e-54 208.00
IUUC-Mmr-061062 Microcebus murinus 82.83 0.00e+00 1275.00
IUUC-Mdo-062798 Monodelphis domestica 75.94 0.00e+00 1134.00
IUUC-Mac-065202 Musa acuminata 34.69 9.00e-52 197.00
IUUC-Mpu-066554 Mustela putorius furo 80.98 0.00e+00 1179.00
IUUC-Mlu-068003 Myotis lucifugus 80.60 0.00e+00 1218.00
IUUC-Nfi-068612 Neosartorya fischeri 36.47 5.00e-63 236.00
IUUC-Ncr-068878 Neurospora crassa 35.40 3.00e-52 200.00
IUUC-Nle-069661 Nomascus leucogenys 83.23 0.00e+00 1274.00
IUUC-Opr-070944 Ochotona princeps 78.57 2.00e-160 559.00
IUUC-Ont-071266 Oreochromis niloticus 77.61 0.00e+00 690.00
IUUC-Oan-073442 Ornithorhynchus anatinus 75.73 0.00e+00 1045.00
IUUC-Ocu-073788 Oryctolagus cuniculus 75.00 0.00e+00 1051.00
IUUC-Oba-075085 Oryza barthii 34.17 4.00e-36 144.00
IUUC-Obr-076663 Oryza brachyantha 33.67 6.00e-45 175.00
IUUC-Ogl-076937 Oryza glaberrima 30.63 2.00e-47 184.00
IUUC-Ogu-078909 Oryza glumaepatula 30.75 3.00e-45 176.00
IUUC-Oin-079617 Oryza indica 32.51 2.00e-47 184.00
IUUC-Olo-081043 Oryza longistaminata 26.87 9.00e-26 111.00
IUUC-Ome-081646 Oryza meridionalis 25.26 3.00e-23 103.00
IUUC-Oni-082914 Oryza nivara 30.75 2.00e-45 177.00
IUUC-Oru-084878 Oryza rufipogon 30.75 2.00e-45 177.00
IUUC-Osa-085822 Oryza sativa 31.52 1.00e-49 191.00
IUUC-Ola-086931 Oryzias latipes 58.35 0.00e+00 781.00
IUUC-Oga-088443 Otolemur garnettii 82.85 0.00e+00 1278.00
IUUC-Oar-089325 Ovis aries 77.34 0.00e+00 1076.00
IUUC-Ptr-091584 Pan troglodytes 80.35 0.00e+00 1202.00
IUUC-Pan-092551 Papio anubis 80.98 0.00e+00 1231.00
IUUC-Psi-093366 Pelodiscus sinensis 69.20 0.00e+00 633.00
IUUC-Pno-095136 Phaeosphaeria nodorum 35.33 2.00e-52 201.00
IUUC-Ppa-095574 Physcomitrella patens 37.28 2.00e-59 223.00
IUUC-Pfo-097462 Poecilia formosa 71.54 0.00e+00 698.00
IUUC-Pab-098547 Pongo abelii 83.35 0.00e+00 1274.00
IUUC-Pop-099529 Populus trichocarpa 36.92 4.00e-62 232.00
IUUC-Pca-101066 Procavia capensis 72.68 0.00e+00 1075.00
IUUC-Ppe-102110 Prunus persica 36.39 3.00e-60 225.00
IUUC-Pva-103015 Pteropus vampyrus 75.12 0.00e+00 1116.00
IUUC-Ptt-103998 Puccinia triticina 32.01 7.00e-52 198.00
IUUC-Pte-104417 Pyrenophora teres 33.92 5.00e-55 209.00
IUUC-Pyt-104820 Pyrenophora triticirepentis 34.68 4.00e-55 210.00
IUUC-Rno-105533 Rattus norvegicus 92.70 0.00e+00 1443.00
IUUC-Sce-106160 Saccharomyces cerevisiae 27.63 3.00e-37 150.00
IUUC-Sha-106590 Sarcophilus harrisii 75.69 0.00e+00 1122.00
IUUC-Sja-107669 Schizosaccharomyces japonicus 34.93 9.00e-57 214.00
IUUC-Spo-108353 Schizosaccharomyces pombe 35.46 2.00e-63 236.00
IUUC-Ssl-108599 Sclerotinia sclerotiorum 36.39 2.00e-56 214.00
IUUC-Smo-108842 Selaginella moellendorffii 35.84 8.00e-38 150.00
IUUC-Sit-110781 Setaria italica 32.58 9.00e-56 211.00
IUUC-Sly-111797 Solanum lycopersicum 33.76 4.00e-54 206.00
IUUC-Stu-112188 Solanum tuberosum 34.85 5.00e-54 205.00
IUUC-Sbi-114862 Sorghum bicolor 33.61 2.00e-45 177.00
IUUC-Sre-115162 Sporisorium reilianum 35.22 8.00e-67 248.00
IUUC-Ssc-115505 Sus scrofa 91.26 1.00e-160 558.00
IUUC-Tgu-116535 Taeniopygia guttata 73.39 0.00e+00 1071.00
IUUC-Tru-117542 Takifugu rubripes 76.34 0.00e+00 716.00
IUUC-Tni-120200 Tetraodon nigroviridis 57.54 0.00e+00 817.00
IUUC-Tca-121548 Theobroma cacao 34.92 1.00e-43 171.00
IUUC-Tre-122124 Trichoderma reesei 33.95 5.00e-61 229.00
IUUC-Tvi-122457 Trichoderma virens 34.63 1.00e-54 207.00
IUUC-Tae-125646 Triticum aestivum 35.19 1.00e-55 211.00
IUUC-Tme-127180 Tuber melanosporum 40.16 7.00e-71 261.00
IUUC-Tbe-127530 Tupaia belangeri 68.65 0.00e+00 942.00
IUUC-Ttr-128549 Tursiops truncatus 73.31 0.00e+00 1061.00
IUUC-Uma-129381 Ustilago maydis 33.98 5.00e-65 243.00
IUUC-Vda-129889 Verticillium dahliae 32.11 3.00e-51 197.00
IUUC-Vpa-130100 Vicugna pacos 75.44 0.00e+00 1079.00
IUUC-Vvi-131366 Vitis vinifera 36.13 5.00e-64 238.00
IUUC-Xtr-132048 Xenopus tropicalis 60.87 0.00e+00 888.00
IUUC-Xma-133593 Xiphophorus maculatus 71.54 0.00e+00 693.00
IUUC-Yli-134338 Yarrowia lipolytica 31.17 5.00e-33 136.00
IUUC-Zma-135586 Zea mays 31.20 3.00e-49 189.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved