iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-098530

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase RNF8; RING finger protein 8; RING-type E3 ubiquitin transferase RNF8

Genbank Nucleotide ID

ABGA01250403

Gene Name

RNF8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000016561.2	ENSPPYT00000019262.1	ENSPPYP00000018524.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.40e-07	32.0	380	418

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC e f +  ++l+C H f+  C++ w       ++++ CP+Cr
   Q: 380  CIICSEYFIE-AVTLNCAHSFCSYCINEW------MKRKIECPICR 418
           ********99.899***************......**********8 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MSAGWLLLED GCEVTVGRGF GVTYQLVSKI CPLMISRNHC VLKQNPEGQW TIMDNKSLNG 60
VWLNRARLEP LRVYSIHQGD YIQLGVPLEN KENAEYEYEV TEEDWETIYP CLSPKNDQVI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCGCCG GGTGGCTGCT GCTGGAAGAT GGGTGCGAGG TACGGGCGAT GGGGTCCTGT 60
GGAGCGGAGG GCAGGGGCTG GAGGGAGCCC TGGCTCCGGG GAGGGAGGAA GGTGTCTTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0779--Telomere
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000253--FHA_dom
IPR017335--RNF8
IPR008984--SMAD_FHA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50006--FHA_DOMAIN
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00498--FHA

SMART

SM00240--FHA
SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0000151--C:ubiquitin ligase complex
GO:0003682--F:chromatin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006302--P:double-strand break repair
GO:0070535--P:histone H2A K63-linked ubiquitination
GO:0034244--P:negative regulation of transcription elongation from RNA polymerase II promoter
GO:0045739--P:positive regulation of DNA repair
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002124	Ailuropoda melanoleuca	83.22	2.00e-174	605.00
IUUC-Apl-003664	Anas platyrhynchos	80.00	2.00e-39	154.00
IUUC-Aca-005036	Anolis carolinensis	56.92	9.00e-119	420.00
IUUC-Ani-009177	Aspergillus nidulans	34.65	7.00e-08	52.40
IUUC-Ame-011537	Astyanax mexicanus	41.77	1.00e-82	300.00
IUUC-Bta-013297	Bos taurus	83.37	2.00e-169	588.00
IUUC-Cel-018658	Caenorhabditis elegans	41.07	2.00e-07	51.20
IUUC-Cja-019201	Callithrix jacchus	91.72	0.00e+00	713.00
IUUC-Cfa-021041	Canis familiaris	83.77	0.00e+00	659.00
IUUC-Csa-024133	Chlorocebus sabaeus	96.32	0.00e+00	784.00
IUUC-Cho-024624	Choloepus hoffmanni	74.63	2.00e-133	468.00
IUUC-Dre-027918	Danio rerio	41.87	2.00e-76	279.00
IUUC-Dno-029774	Dasypus novemcinctus	84.50	0.00e+00	637.00
IUUC-Dor-030190	Dipodomys ordii	71.21	4.00e-146	511.00
IUUC-Ete-032301	Echinops telfairi	73.45	5.00e-135	474.00
IUUC-Eca-033607	Equus caballus	85.56	8.00e-173	599.00
IUUC-Eeu-034888	Erinaceus europaeus	82.06	7.00e-121	427.00
IUUC-Fca-036075	Felis catus	83.12	0.00e+00	652.00
IUUC-Fal-037569	Ficedula albicollis	61.12	2.00e-118	419.00
IUUC-Gmo-038588	Gadus morhua	39.57	2.00e-69	256.00
IUUC-Gga-040777	Gallus gallus	57.65	2.00e-115	409.00
IUUC-Gac-042463	Gasterosteus aculeatus	41.05	1.00e-59	223.00
IUUC-Ggo-045269	Gorilla gorilla	98.05	0.00e+00	807.00
IUUC-Hsa-046249	Homo sapiens	96.97	0.00e+00	780.00
IUUC-Itr-048314	Ictidomys tridecemlineatus	83.59	0.00e+00	647.00
IUUC-Lch-049805	Latimeria chalumnae	50.96	2.00e-111	396.00
IUUC-Loc-052377	Lepisosteus oculatus	48.48	2.00e-87	316.00
IUUC-Mcc-055344	Macaca mulatta	96.54	0.00e+00	791.00
IUUC-Meu-055950	Macropus eugenii	62.36	2.00e-122	432.00
IUUC-Mga-060049	Meleagris gallopavo	58.90	6.00e-117	414.00
IUUC-Mmr-061431	Microcebus murinus	84.97	7.00e-177	613.00
IUUC-Mdo-062016	Monodelphis domestica	66.74	1.00e-121	431.00
IUUC-Mmu-063235	Mus musculus	71.27	2.00e-166	578.00
IUUC-Mpu-066449	Mustela putorius furo	85.96	0.00e+00	683.00
IUUC-Mlu-067588	Myotis lucifugus	80.17	5.00e-169	587.00
IUUC-Nle-069192	Nomascus leucogenys	98.05	0.00e+00	805.00
IUUC-Opr-070300	Ochotona princeps	63.99	7.00e-132	463.00
IUUC-Ont-071998	Oreochromis niloticus	42.21	2.00e-63	236.00
IUUC-Oan-073610	Ornithorhynchus anatinus	65.65	4.00e-66	244.00
IUUC-Ocu-074603	Oryctolagus cuniculus	79.65	4.00e-175	607.00
IUUC-Ola-086681	Oryzias latipes	39.75	2.00e-68	253.00
IUUC-Oga-088183	Otolemur garnettii	85.25	0.00e+00	669.00
IUUC-Oar-090255	Ovis aries	83.48	2.00e-163	568.00
IUUC-Ptr-091029	Pan troglodytes	95.85	0.00e+00	773.00
IUUC-Pan-092241	Papio anubis	96.54	0.00e+00	790.00
IUUC-Psi-093506	Pelodiscus sinensis	63.12	2.00e-130	459.00
IUUC-Pma-094579	Petromyzon marinus	56.67	2.00e-26	113.00
IUUC-Pfo-097014	Poecilia formosa	41.83	2.00e-60	226.00
IUUC-Pca-100939	Procavia capensis	60.61	3.00e-127	448.00
IUUC-Pva-103148	Pteropus vampyrus	78.14	1.00e-172	598.00
IUUC-Rno-105338	Rattus norvegicus	72.35	7.00e-173	600.00
IUUC-Sce-106282	Saccharomyces cerevisiae	33.71	3.00e-06	46.20
IUUC-Sha-107187	Sarcophilus harrisii	65.93	2.00e-105	375.00
IUUC-Sja-107948	Schizosaccharomyces japonicus	22.34	3.00e-09	56.20
IUUC-Sar-113356	Sorex araneus	65.10	3.00e-128	451.00
IUUC-Ssc-116290	Sus scrofa	83.88	0.00e+00	688.00
IUUC-Tru-117910	Takifugu rubripes	40.65	5.00e-59	221.00
IUUC-Tsy-119329	Tarsius syrichta	79.24	1.00e-168	585.00
IUUC-Tni-120521	Tetraodon nigroviridis	38.91	5.00e-58	218.00
IUUC-Tme-126989	Tuber melanosporum	32.76	7.00e-07	48.90
IUUC-Ttr-128997	Tursiops truncatus	78.62	6.00e-178	616.00
IUUC-Vpa-130154	Vicugna pacos	82.03	0.00e+00	644.00
IUUC-Xtr-132805	Xenopus tropicalis	50.76	1.00e-102	366.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence