iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Dme-031683

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

AE014296

Gene Name

APP-BP1; anon-WO0140519.225; APPBP1; dAPP-BP1; dAPPBP1; DmelCG7828; CG7828; Dmel_CG7828

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
FBgn0261112	FBtr0076208	FBpp0075938

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	3.10e-89	300.1	18	515

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveaheesit 98
           YDRQirlwGe++q  l+ a v+lv+++++GcE++K Lvl G+g +tv D++tv+ ++l+++F+++ +  gksKA ++++ l+elnpdvn++ + es +
   Q: 18   YDRQIRLWGEHGQTLLEAATVCLVNVTAVGCETAKGLVLPGIGGFTVADGSTVKEEDLGNNFFLDSSYLGKSKALACMQLLQELNPDVNGDYVDESAD 115
           ************************************************************************************************** PP
   S: 99   eleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctlketpn..aaehtiewa 190
            l  + + Ff+ fd+V++ + n+++ + +++++++++vpli +++lG+lG++r  i+++ + + ++d    +++++ Pf  l+e+    ++++ ++w 
   Q: 116  FLLANRPnFFDSFDLVIASNLNEQTLLLLAERLWELNVPLIYCRSLGMLGTIRLQIREHCIVEAHPDnrqFDLRLEHPFDALREHLDgtEVTSKVPWL 213
           *****99******************************************************************************76669999999*9 PP
   S: 191  vlfnklleeeagee..evlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfecdivtkskspfwv........... 274
            ++ k+l+ +++++   ++ + +++ek + k+ +++e  ++deen+eeai+++++af   + ++  k ++++++c++++k+++ fw+           
   Q: 214  LVLHKYLNVWQKQQadGTQTPRNYKEKNQLKETIREE-MKADEENYEEAIKAVNTAFGAGQVPKsLKAIFEDDACEQLNKKSNVFWImakalkhfvih 310
           9999999988766511455566666666666666555.5669****************9999999********************************* PP
   S: 275  ................................................................................sfcsnaealqvpekvekd 292
                                                                                                          +++
   Q: 311  eneghlplpgvlpdmtantdsyialqhiyrqqalqdadqvyhkcqeylkqlalpadsidersvrlickeaaglavirgtrI--------------AEE 394
           *****************************9999999999999999999999999999999999866655555555555532..............222 PP
   S: 293  eevvkasap.............lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvg 377
            e++++  p               ++lra erf ++ g  pge+ +e+d   + +++++++    ++lg+ + ++dd+++ei++++ ++++ ++a++g
   Q: 395  YEKSSRLLPlvednelqgnltaYNFALRAYERFLSECGNIPGECIVEQDIGRLKSIAAKML----SDLGMHATISDDVLHEICRYGGAELHAVSAFIG 488
           222222222333333334444589***************************8777777777....9******************************** PP
   S: 378  GlaaqEviKvvsgkfeplknfflfdae 404
           G aaqEviK+++++++p++n+f+++a+
   Q: 489  GCAAQEVIKIITKQYKPIDNTFIYNAI 515
           ************************986 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MSSPAPKSPE LSDKSKKYDR QIRLWGEHGQ TLLEAATVCL VNVTAVGCET AKGLVLPGIG 60
GFTVADGSTV KEEDLGNNFF LDSSYLGKSK ALACMQLLQE LNPDVNGDYV DESADFLLAN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGACTTTCA CTTTTTAATT TCTCAACTGT TTATACATTT TATTTGTAAA GACTGATTGC 60
TTGTACGTAG ATGTAGTTTA ATGCAATAAA ATTAAATGAA ATGTAATACG TAATAGTCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

KEGG

dme:Dmel_CG7828

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	37.57	4.00e-99	354.00
IUUC-Aml-002333	Ailuropoda melanoleuca	44.49	1.00e-132	465.00
IUUC-Atr-002644	Amborella trichopoda	38.39	1.00e-90	326.00
IUUC-Apl-003446	Anas platyrhynchos	44.11	1.00e-125	442.00
IUUC-Aca-004450	Anolis carolinensis	42.99	4.00e-133	467.00
IUUC-Aly-005466	Arabidopsis lyrata	36.98	7.00e-105	373.00
IUUC-Ath-006692	Arabidopsis thaliana	37.17	7.00e-106	377.00
IUUC-Ago-007900	Ashbya gossypii	27.00	9.00e-30	124.00
IUUC-Acl-008333	Aspergillus clavatus	32.62	9.00e-75	273.00
IUUC-Afl-008529	Aspergillus flavus	35.83	2.00e-80	292.00
IUUC-Afu-009071	Aspergillus fumigatus	34.48	1.00e-77	283.00
IUUC-Ani-009443	Aspergillus nidulans	33.63	2.00e-71	262.00
IUUC-Ang-009669	Aspergillus niger	33.57	3.00e-78	285.00
IUUC-Aor-009914	Aspergillus oryzae	35.68	5.00e-78	284.00
IUUC-Ate-010450	Aspergillus terreus	34.77	2.00e-80	292.00
IUUC-Ame-011183	Astyanax mexicanus	42.24	2.00e-129	454.00
IUUC-Bgr-012111	Blumeria graminis	32.71	4.00e-62	231.00
IUUC-Bta-012583	Bos taurus	44.65	5.00e-135	473.00
IUUC-Bci-013892	Botrytis cinerea	34.20	3.00e-68	251.00
IUUC-Bdi-014592	Brachypodium distachyon	37.52	3.00e-98	351.00
IUUC-Bol-016399	Brassica oleracea	36.81	3.00e-102	365.00
IUUC-Bra-017506	Brassica rapa	36.07	6.00e-99	353.00
IUUC-Cel-018456	Caenorhabditis elegans	33.76	2.00e-84	305.00
IUUC-Cja-020007	Callithrix jacchus	44.22	1.00e-132	465.00
IUUC-Cfa-020324	Canis familiaris	44.70	3.00e-134	471.00
IUUC-Cpo-022248	Cavia porcellus	34.72	6.00e-75	273.00
IUUC-Csa-023149	Chlorocebus sabaeus	41.39	1.00e-103	369.00
IUUC-Cho-024537	Choloepus hoffmanni	37.55	2.00e-89	322.00
IUUC-Cin-025763	Ciona intestinalis	41.12	1.00e-116	412.00
IUUC-Csv-026113	Ciona savignyi	40.85	8.00e-115	406.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	33.10	5.00e-64	238.00
IUUC-Cne-026884	Cryptococcus neoformans	32.03	4.00e-66	244.00
IUUC-Cme-027210	Cyanidioschyzon merolae	25.63	2.00e-14	73.60
IUUC-Dre-028140	Danio rerio	42.99	2.00e-129	455.00
IUUC-Dno-030033	Dasypus novemcinctus	43.71	3.00e-111	394.00
IUUC-Dor-030513	Dipodomys ordii	58.82	1.00e-30	126.00
IUUC-Dse-031536	Dothistroma septosporum	32.63	3.00e-73	268.00
IUUC-Ete-032420	Echinops telfairi	39.62	2.00e-110	392.00
IUUC-Eca-033992	Equus caballus	41.81	5.00e-102	363.00
IUUC-Eeu-034713	Erinaceus europaeus	35.52	2.00e-41	162.00
IUUC-Fca-036548	Felis catus	44.09	3.00e-131	461.00
IUUC-Fal-037600	Ficedula albicollis	44.57	3.00e-125	441.00
IUUC-Fox-038037	Fusarium oxysporum	35.11	1.00e-72	266.00
IUUC-Fso-038387	Fusarium solani	36.73	2.00e-77	282.00
IUUC-Gmo-038562	Gadus morhua	42.99	3.00e-130	457.00
IUUC-Ggr-040005	Gaeumannomyces graminis	33.27	3.00e-65	242.00
IUUC-Gga-041129	Gallus gallus	43.71	2.00e-128	451.00
IUUC-Gac-042558	Gasterosteus aculeatus	42.27	6.00e-128	450.00
IUUC-Gma-043221	Glycine max	38.46	1.00e-98	352.00
IUUC-Ggo-045611	Gorilla gorilla	44.03	4.00e-131	460.00
IUUC-Hsa-046563	Homo sapiens	44.47	3.00e-133	468.00
IUUC-Hvu-047790	Hordeum vulgare	34.88	3.00e-62	231.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	44.47	2.00e-133	468.00
IUUC-Kpa-049309	Komagataella pastoris	37.09	3.00e-84	305.00
IUUC-Lch-050038	Latimeria chalumnae	42.91	2.00e-128	452.00
IUUC-Lpe-051535	Leersia perrieri	36.25	1.00e-82	299.00
IUUC-Loc-051917	Lepisosteus oculatus	41.14	8.00e-115	406.00
IUUC-Lma-053112	Leptosphaeria maculans	33.45	2.00e-77	282.00
IUUC-Laf-053690	Loxodonta africana	44.28	1.00e-133	469.00
IUUC-Mcc-055117	Macaca mulatta	43.39	6.00e-129	453.00
IUUC-Meu-056761	Macropus eugenii	37.57	2.00e-98	352.00
IUUC-Mor-057230	Magnaporthe oryzae	34.32	8.00e-71	260.00
IUUC-Mpo-057514	Magnaporthe poae	33.08	3.00e-62	232.00
IUUC-Mtr-058551	Medicago truncatula	36.90	5.00e-96	344.00
IUUC-Mla-059183	Melampsora laricipopulina	35.05	1.00e-82	300.00
IUUC-Mga-060144	Meleagris gallopavo	43.13	6.00e-125	440.00
IUUC-Mvi-060221	Microbotryum violaceum	34.95	5.00e-63	234.00
IUUC-Mmr-061325	Microcebus murinus	43.66	7.00e-130	456.00
IUUC-Mdo-062532	Monodelphis domestica	45.22	1.00e-135	476.00
IUUC-Mmu-063956	Mus musculus	45.03	5.00e-135	473.00
IUUC-Mac-064521	Musa acuminata	39.24	6.00e-102	363.00
IUUC-Mpu-066716	Mustela putorius furo	43.95	5.00e-122	430.00
IUUC-Mlu-067459	Myotis lucifugus	43.93	7.00e-133	466.00
IUUC-Nfi-068245	Neosartorya fischeri	34.65	1.00e-76	280.00
IUUC-Ncr-068910	Neurospora crassa	35.47	5.00e-70	258.00
IUUC-Nle-070034	Nomascus leucogenys	42.70	2.00e-125	441.00
IUUC-Opr-070552	Ochotona princeps	40.44	1.00e-100	359.00
IUUC-Ont-071426	Oreochromis niloticus	42.62	4.00e-131	461.00
IUUC-Oan-073389	Ornithorhynchus anatinus	42.04	5.00e-98	350.00
IUUC-Ocu-074911	Oryctolagus cuniculus	44.47	2.00e-134	471.00
IUUC-Oba-075437	Oryza barthii	38.71	1.00e-91	329.00
IUUC-Obr-076684	Oryza brachyantha	37.24	2.00e-83	302.00
IUUC-Ogl-077170	Oryza glaberrima	38.71	1.00e-91	329.00
IUUC-Ogu-078844	Oryza glumaepatula	38.03	3.00e-84	305.00
IUUC-Oin-079105	Oryza indica	38.71	2.00e-91	328.00
IUUC-Olo-080943	Oryza longistaminata	35.00	3.00e-76	278.00
IUUC-Oni-082891	Oryza nivara	35.48	2.00e-83	301.00
IUUC-Opu-083457	Oryza punctata	38.71	4.00e-90	324.00
IUUC-Oru-084960	Oryza rufipogon	34.58	2.00e-76	278.00
IUUC-Osa-085358	Oryza sativa	37.90	3.00e-91	328.00
IUUC-Ola-086420	Oryzias latipes	39.47	9.00e-82	296.00
IUUC-Olu-087625	Ostreococcus lucimarinus	29.46	3.00e-53	202.00
IUUC-Oga-088810	Otolemur garnettii	44.51	3.00e-134	471.00
IUUC-Oar-089196	Ovis aries	44.59	2.00e-133	468.00
IUUC-Ptr-090617	Pan troglodytes	44.47	2.00e-133	468.00
IUUC-Pan-092761	Papio anubis	44.65	5.00e-134	470.00
IUUC-Psi-093191	Pelodiscus sinensis	43.16	8.00e-129	452.00
IUUC-Pma-094380	Petromyzon marinus	46.26	6.00e-125	440.00
IUUC-Pno-095084	Phaeosphaeria nodorum	32.71	2.00e-73	270.00
IUUC-Ppa-095798	Physcomitrella patens	38.50	5.00e-103	367.00
IUUC-Pfo-096467	Poecilia formosa	44.22	3.00e-132	464.00
IUUC-Pab-098255	Pongo abelii	43.69	1.00e-107	382.00
IUUC-Pop-099722	Populus trichocarpa	39.13	2.00e-104	371.00
IUUC-Pca-100807	Procavia capensis	53.59	4.00e-54	204.00
IUUC-Ppe-101280	Prunus persica	39.89	6.00e-106	377.00
IUUC-Pva-102333	Pteropus vampyrus	42.35	6.00e-123	433.00
IUUC-Pgr-103401	Puccinia graminis	31.41	6.00e-66	244.00
IUUC-Ptt-103889	Puccinia triticina	27.85	1.00e-48	187.00
IUUC-Pte-104355	Pyrenophora teres	32.73	4.00e-77	281.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	33.81	8.00e-78	283.00
IUUC-Rno-105810	Rattus norvegicus	44.65	1.00e-132	466.00
IUUC-Sha-106770	Sarcophilus harrisii	50.55	9.00e-77	279.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	34.42	6.00e-75	274.00
IUUC-Spo-108276	Schizosaccharomyces pombe	32.51	4.00e-77	281.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	35.43	1.00e-72	266.00
IUUC-Smo-109296	Selaginella moellendorffii	38.07	5.00e-101	360.00
IUUC-Sit-110157	Setaria italica	38.84	2.00e-105	375.00
IUUC-Sly-111105	Solanum lycopersicum	38.26	5.00e-103	367.00
IUUC-Stu-112469	Solanum tuberosum	37.52	3.00e-102	365.00
IUUC-Sar-113083	Sorex araneus	35.70	7.00e-94	337.00
IUUC-Sbi-113813	Sorghum bicolor	38.09	2.00e-104	372.00
IUUC-Sre-115058	Sporisorium reilianum	33.11	2.00e-56	213.00
IUUC-Tgu-116772	Taeniopygia guttata	44.53	7.00e-126	443.00
IUUC-Tru-118686	Takifugu rubripes	41.68	4.00e-129	454.00
IUUC-Tsy-119111	Tarsius syrichta	44.04	8.00e-61	227.00
IUUC-Tni-120231	Tetraodon nigroviridis	39.15	5.00e-114	404.00
IUUC-Tca-121491	Theobroma cacao	38.27	9.00e-99	353.00
IUUC-Tre-122103	Trichoderma reesei	37.20	1.00e-74	273.00
IUUC-Tvi-122672	Trichoderma virens	37.53	1.00e-57	216.00
IUUC-Tae-125316	Triticum aestivum	38.12	2.00e-100	358.00
IUUC-Tur-126487	Triticum urartu	37.12	3.00e-95	341.00
IUUC-Tme-127097	Tuber melanosporum	35.40	3.00e-85	308.00
IUUC-Ttr-128465	Tursiops truncatus	42.53	1.00e-121	429.00
IUUC-Uma-129645	Ustilago maydis	32.38	2.00e-64	239.00
IUUC-Vda-129989	Verticillium dahliae	32.32	4.00e-59	221.00
IUUC-Vpa-130529	Vicugna pacos	44.01	3.00e-126	444.00
IUUC-Vvi-131059	Vitis vinifera	39.40	2.00e-102	365.00
IUUC-Xtr-132002	Xenopus tropicalis	45.95	6.00e-138	483.00
IUUC-Xma-133930	Xiphophorus maculatus	44.65	7.00e-133	466.00
IUUC-Yli-134505	Yarrowia lipolytica	32.88	3.00e-73	268.00
IUUC-Zma-135619	Zea mays	37.07	9.00e-100	356.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence