iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-091796

Ensembl Protein ID

ENSPANP00000018144.1

UniProt Accession

A0A096NYI1; A0A096NYI1_PAPAN

Genbank Protein ID

ENSPANP00000018144

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHZZ01063516

Gene Name

CUL3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000016371.1	ENSPANT00000004878.1	ENSPANP00000018144.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	3.80e-228	759.2	15	648

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 2    lreavkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefi.kqvkkkveesedeqlLktynreWekfreqlkvlrkifay 89
           l++a+++i+r++++  ++eely+++y+++l+k+g+klY+ l+ev++e++ ++v+++v +s ++++L+t+n++W++++++++++r+i++y
   Q: 15   LKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLiNKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMY 103
           799*********************************************99*************************************** PP
   S: 90   ldrtyvkkskkvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrr.llsgvveslveLslnklaiykesFEakflea 175
           +dr+yv++ ++v++v++L+l ++r+++v++  i+++l ++ll++i++eRkge+vd+r  +++++++l+ L+l+ +++y+e+FEa+fle+
   Q: 104  MDRVYVQQ-NNVENVYNLGLIIFRDQVVRYgcIRDHLRQTLLDMIARERKGEVVDSRgAIRNACQMLMILGLEGRSVYEEDFEAPFLEM 191
           ********.**********************************************7649****************************** PP
   S: 176  tqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesll....aelvallrdkktedlsrmyk 260
           ++ef+++es++fl+en+ + Y+kkvear+nee er++++l++ste+++++vve+eli+kh+++++    ++lv++l++ ktedl++myk
   Q: 192  SAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVemenSGLVHMLKNGKTEDLGCMYK 280
           *****************************************************************99999******************* PP
   S: 261  LlsrvlngleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaaksp 349
           L+srv+ngl++++++++s+++eqgka++++e + k+p++y++ ll+lk+++++++ e+Fnnd+ F ++++ +fe+f+n n     ++sp
   Q: 281  LFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLN-----SRSP 364
           ********************************************************************************.....**** PP
   S: 350  EllAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMf 438
           E+l+ +iD++L+k++kglte+e+e++ldk++++f++++ekdvFe+yYk+hLa+RLl++ks+s+++E+++i+kLk+ecg++ftskLe+Mf
   Q: 365  EYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMF 453
           ***************************************************************************************** PP
   S: 439  qdlkvSedlnrqFkeekentees.esvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkael 526
           +d+++S++++++F+++ ++t  s  +v+l+v+vL++g+Wpt+s+t+k+++P+  ++++e+f++fYl khsgR+L++qh++g+a+l+a++
   Q: 454  RDMSISNTTMDEFRQHLQATGVSlGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATF 542
           *********************99889*************************************************************** PP
   S: 527  ..........................kkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvssk..kqvlkkep 587
                                     +++k++lqVstfQm++L++fnn+ek+++ee++++t++pe+eL r+lqsL+++k  ++vl+kep
   Q: 543  ygpvkkemkqedgsevgvggaqvtgsNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKptQRVLTKEP 631
           **************999999998888888************************************************************ PP
   S: 588  eskeieeedlfsvNqef 604
           +skeie++++f+vN++f
   Q: 632  KSKEIENGHIFTVNDQF 648
           ***************99 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MTMDEKYVNS IWDLLKNAIQ EIQRKNNSGL SFEELYRNAY TMVLHKHGEK LYTGLREVVT 60
EHLINKVRED VLNSLNNNFL QTLNQAWNDH QTAMVMIRDI LMYMDRVYVQ QNNVENVYNL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCAGGGGCA GCGCGCTCGC TCTCTTCTCG CGAGATCTGA GCTTCCCCGC CGCGGCCGCC 60
GGGCTCCCCC TCCCGTCCTC CCACCTCCCT CCCCCGACAT CTCTCACTCT CCGGCTCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0070062--C:extracellular exosome
GO:0000139--C:Golgi membrane
GO:0005634--C:nucleus
GO:0005827--C:polar microtubule
GO:0004842--F:ubiquitin-protein transferase activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0016477--P:cell migration
GO:0048208--P:COPII vesicle coating
GO:0040016--P:embryonic cleavage
GO:0044346--P:fibroblast apoptotic process
GO:0007369--P:gastrulation
GO:0007229--P:integrin-mediated signaling pathway
GO:0072576--P:liver morphogenesis
GO:0007080--P:mitotic metaphase plate congression
GO:0035024--P:negative regulation of Rho protein signal transduction
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0032467--P:positive regulation of cytokinesis
GO:0045842--P:positive regulation of mitotic metaphase/anaphase transition
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0017145--P:stem cell division
GO:0043149--P:stress fiber assembly
GO:0001831--P:trophectodermal cellular morphogenesis
GO:0071630--P:ubiquitin-dependent catabolism of misfolded proteins by nucleus-associated proteasome
GO:0016055--P:Wnt signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000335	Aegilops tauschii	46.78	0.00e+00	678.00
IUUC-Aml-002278	Ailuropoda melanoleuca	99.47	0.00e+00	1520.00
IUUC-Atr-002616	Amborella trichopoda	52.86	0.00e+00	766.00
IUUC-Apl-004172	Anas platyrhynchos	98.93	0.00e+00	1506.00
IUUC-Aca-004309	Anolis carolinensis	98.93	0.00e+00	1507.00
IUUC-Aly-005566	Arabidopsis lyrata	51.99	0.00e+00	762.00
IUUC-Ath-007587	Arabidopsis thaliana	52.39	0.00e+00	767.00
IUUC-Ago-007795	Ashbya gossypii	25.03	2.00e-47	184.00
IUUC-Acl-008317	Aspergillus clavatus	36.65	2.00e-142	499.00
IUUC-Afl-008727	Aspergillus flavus	36.31	2.00e-142	499.00
IUUC-Afu-008879	Aspergillus fumigatus	37.70	2.00e-130	459.00
IUUC-Ani-009393	Aspergillus nidulans	35.77	5.00e-133	468.00
IUUC-Ang-009626	Aspergillus niger	36.22	1.00e-138	487.00
IUUC-Aor-010207	Aspergillus oryzae	36.31	4.00e-142	498.00
IUUC-Ate-010305	Aspergillus terreus	36.94	4.00e-138	485.00
IUUC-Ame-011805	Astyanax mexicanus	96.54	0.00e+00	1471.00
IUUC-Bgr-012098	Blumeria graminis	35.68	2.00e-118	419.00
IUUC-Bta-013445	Bos taurus	99.07	0.00e+00	1509.00
IUUC-Bci-013612	Botrytis cinerea	36.39	1.00e-136	480.00
IUUC-Bdi-014269	Brachypodium distachyon	53.07	0.00e+00	739.00
IUUC-Bol-015350	Brassica oleracea	52.53	0.00e+00	766.00
IUUC-Bra-016763	Brassica rapa	52.66	0.00e+00	769.00
IUUC-Cel-018641	Caenorhabditis elegans	48.82	0.00e+00	720.00
IUUC-Cja-019175	Callithrix jacchus	99.20	0.00e+00	1511.00
IUUC-Cfa-020905	Canis familiaris	99.07	0.00e+00	1508.00
IUUC-Cpo-021293	Cavia porcellus	98.93	0.00e+00	1505.00
IUUC-Cre-022776	Chlamydomonas reinhardtii	48.28	0.00e+00	690.00
IUUC-Csa-023800	Chlorocebus sabaeus	99.33	0.00e+00	1513.00
IUUC-Cho-024839	Choloepus hoffmanni	97.96	0.00e+00	1340.00
IUUC-Cin-025201	Ciona intestinalis	71.08	0.00e+00	994.00
IUUC-Csv-026107	Ciona savignyi	70.92	0.00e+00	1084.00
IUUC-Cgl-026630	Colletotrichum gloeosporioides	35.21	4.00e-122	432.00
IUUC-Cne-027048	Cryptococcus neoformans	34.59	1.00e-115	410.00
IUUC-Cme-027254	Cyanidioschyzon merolae	31.02	1.00e-86	314.00
IUUC-Dre-028488	Danio rerio	96.94	0.00e+00	1480.00
IUUC-Dno-029784	Dasypus novemcinctus	99.07	0.00e+00	1508.00
IUUC-Dor-030682	Dipodomys ordii	91.74	0.00e+00	1353.00
IUUC-Dse-031326	Dothistroma septosporum	35.64	1.00e-126	447.00
IUUC-Dme-032112	Drosophila melanogaster	69.58	0.00e+00	1072.00
IUUC-Ete-032347	Echinops telfairi	82.29	0.00e+00	1185.00
IUUC-Eca-033560	Equus caballus	98.93	0.00e+00	1506.00
IUUC-Eeu-034502	Erinaceus europaeus	96.93	0.00e+00	1331.00
IUUC-Fca-035544	Felis catus	99.07	0.00e+00	1507.00
IUUC-Fal-036751	Ficedula albicollis	99.07	0.00e+00	1507.00
IUUC-Fox-037857	Fusarium oxysporum	36.70	2.00e-135	476.00
IUUC-Fso-038163	Fusarium solani	36.53	4.00e-139	488.00
IUUC-Gmo-038830	Gadus morhua	97.07	0.00e+00	1487.00
IUUC-Ggr-039999	Gaeumannomyces graminis	33.57	7.00e-125	441.00
IUUC-Gga-040329	Gallus gallus	98.93	0.00e+00	1508.00
IUUC-Gac-041510	Gasterosteus aculeatus	96.30	0.00e+00	1476.00
IUUC-Gma-043659	Glycine max	52.72	0.00e+00	738.00
IUUC-Ggo-044903	Gorilla gorilla	99.20	0.00e+00	1508.00
IUUC-Hsa-046000	Homo sapiens	99.33	0.00e+00	1513.00
IUUC-Hvu-047831	Hordeum vulgare	52.23	0.00e+00	695.00
IUUC-Itr-049067	Ictidomys tridecemlineatus	98.90	0.00e+00	934.00
IUUC-Kpa-049372	Komagataella pastoris	34.89	3.00e-113	402.00
IUUC-Lch-050458	Latimeria chalumnae	98.80	0.00e+00	1507.00
IUUC-Lpe-051396	Leersia perrieri	52.13	0.00e+00	747.00
IUUC-Loc-052186	Lepisosteus oculatus	98.27	0.00e+00	1503.00
IUUC-Lma-053030	Leptosphaeria maculans	38.31	3.00e-142	499.00
IUUC-Laf-053684	Loxodonta africana	99.07	0.00e+00	1507.00
IUUC-Mcc-055770	Macaca mulatta	99.33	0.00e+00	1513.00
IUUC-Meu-056852	Macropus eugenii	98.92	0.00e+00	758.00
IUUC-Mor-057273	Magnaporthe oryzae	34.42	4.00e-130	458.00
IUUC-Mpo-057403	Magnaporthe poae	33.80	9.00e-127	447.00
IUUC-Mtr-058317	Medicago truncatula	51.99	0.00e+00	747.00
IUUC-Mla-059055	Melampsora laricipopulina	37.55	9.00e-132	464.00
IUUC-Mga-060076	Meleagris gallopavo	97.34	0.00e+00	1475.00
IUUC-Mvi-060470	Microbotryum violaceum	33.56	9.00e-134	471.00
IUUC-Mmr-060976	Microcebus murinus	99.07	0.00e+00	1509.00
IUUC-Mdo-062741	Monodelphis domestica	99.07	0.00e+00	1509.00
IUUC-Mmu-063905	Mus musculus	98.80	0.00e+00	1504.00
IUUC-Mac-064718	Musa acuminata	51.13	0.00e+00	722.00
IUUC-Mpu-066356	Mustela putorius furo	99.07	0.00e+00	1507.00
IUUC-Mlu-067768	Myotis lucifugus	99.47	0.00e+00	1521.00
IUUC-Nfi-068285	Neosartorya fischeri	36.97	3.00e-144	505.00
IUUC-Ncr-068883	Neurospora crassa	36.20	1.00e-135	477.00
IUUC-Nle-069638	Nomascus leucogenys	99.33	0.00e+00	1512.00
IUUC-Opr-070333	Ochotona princeps	99.09	0.00e+00	1097.00
IUUC-Ont-071601	Oreochromis niloticus	97.47	0.00e+00	1523.00
IUUC-Oan-073281	Ornithorhynchus anatinus	98.73	0.00e+00	1288.00
IUUC-Ocu-074504	Oryctolagus cuniculus	99.07	0.00e+00	1508.00
IUUC-Oba-075332	Oryza barthii	52.55	0.00e+00	739.00
IUUC-Obr-076790	Oryza brachyantha	49.47	0.00e+00	708.00
IUUC-Ogl-077655	Oryza glaberrima	52.53	0.00e+00	749.00
IUUC-Ogu-078458	Oryza glumaepatula	52.55	0.00e+00	739.00
IUUC-Oin-079567	Oryza indica	52.40	0.00e+00	746.00
IUUC-Olo-080930	Oryza longistaminata	52.53	0.00e+00	749.00
IUUC-Ome-081353	Oryza meridionalis	52.53	0.00e+00	748.00
IUUC-Oni-082378	Oryza nivara	52.53	0.00e+00	749.00
IUUC-Opu-084055	Oryza punctata	52.53	0.00e+00	749.00
IUUC-Oru-084202	Oryza rufipogon	52.55	0.00e+00	739.00
IUUC-Osa-085290	Oryza sativa	52.53	0.00e+00	749.00
IUUC-Ola-087562	Oryzias latipes	97.20	0.00e+00	1488.00
IUUC-Olu-087866	Ostreococcus lucimarinus	37.53	3.00e-138	485.00
IUUC-Oga-088833	Otolemur garnettii	99.07	0.00e+00	1507.00
IUUC-Oar-089958	Ovis aries	99.07	0.00e+00	1507.00
IUUC-Ptr-091013	Pan troglodytes	99.33	0.00e+00	1513.00
IUUC-Psi-093564	Pelodiscus sinensis	97.34	0.00e+00	1473.00
IUUC-Pno-094939	Phaeosphaeria nodorum	37.99	3.00e-137	482.00
IUUC-Ppa-095920	Physcomitrella patens	52.33	0.00e+00	759.00
IUUC-Pfo-097498	Poecilia formosa	92.99	0.00e+00	1471.00
IUUC-Pab-098164	Pongo abelii	99.33	0.00e+00	1513.00
IUUC-Pop-099497	Populus trichocarpa	53.59	0.00e+00	782.00
IUUC-Pca-100702	Procavia capensis	90.81	0.00e+00	1335.00
IUUC-Ppe-101271	Prunus persica	52.66	0.00e+00	738.00
IUUC-Pva-103129	Pteropus vampyrus	98.93	0.00e+00	1508.00
IUUC-Pgr-103684	Puccinia graminis	36.33	9.00e-109	388.00
IUUC-Ptt-103961	Puccinia triticina	36.51	7.00e-108	385.00
IUUC-Pte-104325	Pyrenophora teres	37.62	3.00e-133	469.00
IUUC-Pyt-104746	Pyrenophora triticirepentis	36.65	2.00e-131	462.00
IUUC-Rno-105935	Rattus norvegicus	98.93	0.00e+00	1505.00
IUUC-Sce-106354	Saccharomyces cerevisiae	26.58	1.00e-52	201.00
IUUC-Sha-106569	Sarcophilus harrisii	98.40	0.00e+00	1371.00
IUUC-Sja-107676	Schizosaccharomyces japonicus	38.30	2.00e-152	532.00
IUUC-Spo-108135	Schizosaccharomyces pombe	37.67	1.00e-135	477.00
IUUC-Smo-109555	Selaginella moellendorffii	53.00	0.00e+00	781.00
IUUC-Sit-110763	Setaria italica	53.47	0.00e+00	755.00
IUUC-Sly-111090	Solanum lycopersicum	52.13	0.00e+00	758.00
IUUC-Stu-112351	Solanum tuberosum	52.26	0.00e+00	761.00
IUUC-Sar-113144	Sorex araneus	99.45	0.00e+00	1110.00
IUUC-Sbi-114690	Sorghum bicolor	52.67	0.00e+00	756.00
IUUC-Sre-115005	Sporisorium reilianum	37.78	3.00e-133	469.00
IUUC-Ssc-116053	Sus scrofa	98.74	0.00e+00	1132.00
IUUC-Tgu-116523	Taeniopygia guttata	99.07	0.00e+00	1507.00
IUUC-Tru-118189	Takifugu rubripes	93.48	0.00e+00	1398.00
IUUC-Tsy-118962	Tarsius syrichta	92.90	0.00e+00	1375.00
IUUC-Tni-120614	Tetraodon nigroviridis	57.10	0.00e+00	862.00
IUUC-Tca-121282	Theobroma cacao	53.05	0.00e+00	763.00
IUUC-Tre-122201	Trichoderma reesei	35.54	3.00e-131	462.00
IUUC-Tvi-122321	Trichoderma virens	36.14	3.00e-132	466.00
IUUC-Tae-124292	Triticum aestivum	52.40	0.00e+00	734.00
IUUC-Tur-126800	Triticum urartu	52.27	0.00e+00	733.00
IUUC-Tme-127053	Tuber melanosporum	40.21	5.00e-154	538.00
IUUC-Tbe-127427	Tupaia belangeri	84.32	0.00e+00	1150.00
IUUC-Ttr-128662	Tursiops truncatus	97.34	0.00e+00	1468.00
IUUC-Uma-129597	Ustilago maydis	38.13	7.00e-132	464.00
IUUC-Vda-129726	Verticillium dahliae	35.05	1.00e-131	463.00
IUUC-Vpa-130809	Vicugna pacos	99.20	0.00e+00	737.00
IUUC-Vvi-131630	Vitis vinifera	52.65	0.00e+00	748.00
IUUC-Xtr-131887	Xenopus tropicalis	98.01	0.00e+00	1492.00
IUUC-Xma-133517	Xiphophorus maculatus	97.34	0.00e+00	1490.00
IUUC-Yli-134576	Yarrowia lipolytica	33.50	2.00e-109	390.00
IUUC-Zma-135030	Zea mays	53.07	0.00e+00	763.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence