iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033611

UUCD1 version

UUC-EqC-00666

Ensembl Protein ID

ENSECAP00000016078.1

UniProt Accession

F7AMH4; F7AMH4_HORSE

Protein Name

Uncharacterized protein

Gene Name

ERCC8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000018335.1	ENSECAT00000019632.1	ENSECAP00000016078.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.90e-27	93.3	126	160
UBD/Beta-Prp	4.70e-43	147.6	2	220

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd..tllvsGsdDgtikvWDlrt 32
           gH  ++ ++++ +    +l+++s D  +k+WD+r+
   Q: 126  GHRQEILAVSWsPRyeYILATASADSRVKLWDVRR 160
           89*********94344668*************986 PP

UBD/Beta-Prp

   S: 26   atgsrdgtikvwdvttgkl.............lrslsgheaevtavkfspdgk.ilvtgseDrtikvwdlstgkcvhtlkghedsvlsl 100
           ++g+ dg i ++d+++ +                    h+  v +v++ p++  ++ ++s D+t+kvwd +t ++  +++  e++v+s 
   Q: 2    LSGGSDGVIVLYDLENSSRqpcytckavcsvgRNHPDVHKYSVETVQWYPHDTgMFTSSSFDKTLKVWDTNTLQTADVFN-FEETVYSH 89
           34455555555555554444444444433321111133333355555544433355555555555555555555555555.55555555 PP
   S: 101  sfsp..sg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltgghtdsvys 185
           ++sp  ++   +++G++   +++ dl++g+c++ +l+gh++ +  v+++p    +l+++s+D+ v+lWd+                   
   Q: 90   HMSPvaTKhCLVAVGTRGPKVQLCDLKSGSCSH-ILQGHRQEILAVSWSPRYeYILATASADSRVKLWDV------------------- 158
           555554332334455555555555555555555.555555555555555555455555555555555555................... PP
   S: 186  lsfdsngkelvsgsldgtvklwdlq................tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
                                   +                ++ +  + ++h+  v+ + f++++ +l++++ D   r+W++ +g+
   Q: 159  ------------------------RrasgclitldqhngkkSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDDRMRLWNSSNGE 220
           ........................54433333333333332222233334444555555555555555555555555555555444 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MLSGGSDGVI VLYDLENSSR QPCYTCKAVC SVGRNHPDVH KYSVETVQWY PHDTGMFTSS 60
SFDKTLKVWD TNTLQTADVF NFEETVYSHH MSPVATKHCL VAVGTRGPKV QLCDLKSGSC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTATGTTATC AGGTGGTTCA GATGGTGTGA TTGTACTTTA TGATCTTGAG AACTCCAGCA 60
GACAACCTTG TTACACATGT AAAGCAGTGT GTTCCGTTGG CAGGTGTGTA TTGAAAATGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0016363--C:nuclear matrix
GO:0000109--C:nucleotide-excision repair complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0006979--P:response to oxidative stress
GO:0009411--P:response to UV
GO:0010165--P:response to X-ray
GO:0006283--P:transcription-coupled nucleotide-excision repair

KEGG

ecb:100051199

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001170	Aegilops tauschii	31.89	3.00e-31	130.00
IUUC-Aml-002201	Ailuropoda melanoleuca	95.56	0.00e+00	680.00
IUUC-Atr-002784	Amborella trichopoda	42.53	6.00e-35	141.00
IUUC-Apl-003202	Anas platyrhynchos	81.71	6.00e-171	593.00
IUUC-Aca-004708	Anolis carolinensis	83.10	2.00e-150	525.00
IUUC-Aly-006144	Arabidopsis lyrata	39.66	4.00e-36	145.00
IUUC-Ath-006673	Arabidopsis thaliana	40.80	6.00e-37	148.00
IUUC-Acl-008195	Aspergillus clavatus	38.87	2.00e-38	152.00
IUUC-Afl-008406	Aspergillus flavus	36.36	1.00e-38	153.00
IUUC-Afu-008759	Aspergillus fumigatus	35.89	2.00e-35	143.00
IUUC-Ani-009380	Aspergillus nidulans	35.44	8.00e-37	147.00
IUUC-Ang-009820	Aspergillus niger	36.76	1.00e-38	154.00
IUUC-Aor-010092	Aspergillus oryzae	36.36	2.00e-38	153.00
IUUC-Ate-010491	Aspergillus terreus	35.57	5.00e-38	152.00
IUUC-Bta-012825	Bos taurus	95.58	0.00e+00	672.00
IUUC-Bci-013856	Botrytis cinerea	31.98	8.00e-49	187.00
IUUC-Bdi-014899	Brachypodium distachyon	34.65	4.00e-59	222.00
IUUC-Bol-015337	Brassica oleracea	41.38	2.00e-36	146.00
IUUC-Bra-018089	Brassica rapa	41.38	2.00e-36	147.00
IUUC-Cja-018725	Callithrix jacchus	94.97	0.00e+00	676.00
IUUC-Cfa-021162	Canis familiaris	96.75	0.00e+00	683.00
IUUC-Cpo-022190	Cavia porcellus	93.79	0.00e+00	674.00
IUUC-Cre-022960	Chlamydomonas reinhardtii	39.20	7.00e-34	138.00
IUUC-Csa-023610	Chlorocebus sabaeus	95.56	0.00e+00	683.00
IUUC-Cho-024689	Choloepus hoffmanni	94.38	0.00e+00	669.00
IUUC-Cin-025324	Ciona intestinalis	40.24	8.00e-74	270.00
IUUC-Csv-026059	Ciona savignyi	38.18	8.00e-67	247.00
IUUC-Cgl-026384	Colletotrichum gloeosporioides	33.78	3.00e-35	142.00
IUUC-Cme-027182	Cyanidioschyzon merolae	28.66	2.00e-13	70.90
IUUC-Dre-028696	Danio rerio	73.47	9.00e-151	526.00
IUUC-Dno-029102	Dasypus novemcinctus	96.15	0.00e+00	684.00
IUUC-Dor-030361	Dipodomys ordii	85.20	5.00e-153	533.00
IUUC-Dse-031167	Dothistroma septosporum	32.75	7.00e-40	158.00
IUUC-Ete-032856	Echinops telfairi	74.85	1.00e-147	516.00
IUUC-Eeu-034583	Erinaceus europaeus	69.53	2.00e-129	455.00
IUUC-Fca-036481	Felis catus	96.15	0.00e+00	679.00
IUUC-Fal-037327	Ficedula albicollis	79.41	2.00e-168	584.00
IUUC-Fox-037684	Fusarium oxysporum	30.79	2.00e-43	169.00
IUUC-Fso-038306	Fusarium solani	32.04	4.00e-49	188.00
IUUC-Gmo-039043	Gadus morhua	68.84	4.00e-139	487.00
IUUC-Ggr-039783	Gaeumannomyces graminis	30.63	1.00e-33	137.00
IUUC-Gga-041085	Gallus gallus	86.21	9.00e-153	532.00
IUUC-Gac-042328	Gasterosteus aculeatus	66.86	5.00e-130	457.00
IUUC-Gma-043004	Glycine max	33.61	1.00e-53	203.00
IUUC-Ggo-045627	Gorilla gorilla	85.17	2.00e-172	598.00
IUUC-Hsa-046028	Homo sapiens	95.56	0.00e+00	683.00
IUUC-Hvu-047678	Hordeum vulgare	32.59	2.00e-35	142.00
IUUC-Itr-048648	Ictidomys tridecemlineatus	96.45	0.00e+00	686.00
IUUC-Kpa-049386	Komagataella pastoris	29.09	7.00e-41	161.00
IUUC-Lch-050590	Latimeria chalumnae	81.03	4.00e-134	470.00
IUUC-Lpe-051725	Leersia perrieri	33.66	3.00e-34	139.00
IUUC-Loc-051788	Lepisosteus oculatus	75.00	4.00e-157	547.00
IUUC-Lma-053082	Leptosphaeria maculans	33.04	4.00e-49	188.00
IUUC-Laf-053809	Loxodonta africana	95.28	0.00e+00	678.00
IUUC-Mcc-054998	Macaca mulatta	95.52	5.00e-128	450.00
IUUC-Meu-055929	Macropus eugenii	85.88	2.00e-176	611.00
IUUC-Mor-057003	Magnaporthe oryzae	32.92	1.00e-43	170.00
IUUC-Mtr-057921	Medicago truncatula	33.80	5.00e-54	204.00
IUUC-Mga-059449	Meleagris gallopavo	66.47	1.00e-127	449.00
IUUC-Mmr-061609	Microcebus murinus	90.86	0.00e+00	632.00
IUUC-Mdo-062564	Monodelphis domestica	86.47	3.00e-179	620.00
IUUC-Mmu-063904	Mus musculus	90.27	0.00e+00	644.00
IUUC-Mac-064716	Musa acuminata	39.88	3.00e-34	139.00
IUUC-Mpu-066617	Mustela putorius furo	96.15	0.00e+00	680.00
IUUC-Mlu-067054	Myotis lucifugus	93.49	0.00e+00	667.00
IUUC-Nfi-068467	Neosartorya fischeri	36.84	6.00e-34	138.00
IUUC-Nle-069731	Nomascus leucogenys	95.56	0.00e+00	683.00
IUUC-Opr-070297	Ochotona princeps	61.88	7.00e-56	211.00
IUUC-Ont-072558	Oreochromis niloticus	70.35	1.00e-136	479.00
IUUC-Oan-072864	Ornithorhynchus anatinus	89.47	3.00e-27	112.00
IUUC-Ocu-074415	Oryctolagus cuniculus	95.27	0.00e+00	681.00
IUUC-Oba-075759	Oryza barthii	41.62	2.00e-38	153.00
IUUC-Obr-076387	Oryza brachyantha	41.62	8.00e-39	154.00
IUUC-Ogl-077924	Oryza glaberrima	42.50	2.00e-17	81.60
IUUC-Ogu-078186	Oryza glumaepatula	34.42	8.00e-58	217.00
IUUC-Oin-079389	Oryza indica	33.93	2.00e-41	162.00
IUUC-Olo-080916	Oryza longistaminata	29.41	9.00e-17	79.70
IUUC-Ome-081471	Oryza meridionalis	41.04	3.00e-38	152.00
IUUC-Oni-082449	Oryza nivara	41.62	3.00e-38	152.00
IUUC-Opu-083210	Oryza punctata	41.04	1.00e-38	154.00
IUUC-Oru-085159	Oryza rufipogon	41.62	1.00e-38	154.00
IUUC-Osa-085926	Oryza sativa	41.98	3.00e-28	117.00
IUUC-Ola-087084	Oryzias latipes	68.93	2.00e-141	494.00
IUUC-Olu-087853	Ostreococcus lucimarinus	29.27	6.00e-37	147.00
IUUC-Oga-089008	Otolemur garnettii	92.67	0.00e+00	662.00
IUUC-Oar-089259	Ovis aries	95.58	0.00e+00	674.00
IUUC-Ptr-091112	Pan troglodytes	95.56	0.00e+00	684.00
IUUC-Pan-092303	Papio anubis	94.53	2.00e-71	260.00
IUUC-Psi-093050	Pelodiscus sinensis	84.66	2.00e-177	615.00
IUUC-Pma-094259	Petromyzon marinus	59.54	3.00e-112	398.00
IUUC-Pno-094798	Phaeosphaeria nodorum	30.99	2.00e-45	176.00
IUUC-Ppa-095477	Physcomitrella patens	31.84	7.00e-47	181.00
IUUC-Pfo-096855	Poecilia formosa	68.12	5.00e-137	480.00
IUUC-Pab-098096	Pongo abelii	94.67	0.00e+00	677.00
IUUC-Pop-098800	Populus trichocarpa	29.26	5.00e-52	198.00
IUUC-Pca-100187	Procavia capensis	95.92	6.00e-84	304.00
IUUC-Ppe-101759	Prunus persica	40.23	4.00e-36	145.00
IUUC-Pva-102438	Pteropus vampyrus	96.60	1.00e-82	300.00
IUUC-Pte-104197	Pyrenophora teres	32.34	3.00e-45	176.00
IUUC-Pyt-104421	Pyrenophora triticirepentis	32.94	2.00e-44	173.00
IUUC-Rno-106087	Rattus norvegicus	91.15	0.00e+00	650.00
IUUC-Sce-106276	Saccharomyces cerevisiae	27.84	1.00e-12	67.80
IUUC-Sha-106831	Sarcophilus harrisii	83.24	9.00e-171	592.00
IUUC-Sja-107681	Schizosaccharomyces japonicus	35.71	5.00e-53	201.00
IUUC-Spo-108294	Schizosaccharomyces pombe	35.33	5.00e-59	221.00
IUUC-Ssl-108613	Sclerotinia sclerotiorum	32.24	2.00e-47	183.00
IUUC-Smo-109008	Selaginella moellendorffii	39.55	1.00e-65	243.00
IUUC-Sit-110300	Setaria italica	36.68	7.00e-36	144.00
IUUC-Sly-111441	Solanum lycopersicum	34.10	1.00e-49	190.00
IUUC-Stu-111995	Solanum tuberosum	31.78	1.00e-45	177.00
IUUC-Sar-113196	Sorex araneus	84.03	2.00e-129	455.00
IUUC-Sbi-113790	Sorghum bicolor	40.43	4.00e-38	152.00
IUUC-Ssc-115609	Sus scrofa	96.15	0.00e+00	685.00
IUUC-Tgu-116927	Taeniopygia guttata	79.47	2.00e-168	585.00
IUUC-Tru-118164	Takifugu rubripes	69.36	2.00e-144	505.00
IUUC-Tsy-119151	Tarsius syrichta	88.46	3.00e-180	624.00
IUUC-Tni-120896	Tetraodon nigroviridis	69.39	2.00e-135	475.00
IUUC-Tca-121592	Theobroma cacao	40.80	2.00e-36	146.00
IUUC-Tre-122023	Trichoderma reesei	35.00	6.00e-44	171.00
IUUC-Tvi-122507	Trichoderma virens	34.78	2.00e-44	173.00
IUUC-Tae-125276	Triticum aestivum	34.34	9.00e-55	207.00
IUUC-Tur-126092	Triticum urartu	31.08	4.00e-31	129.00
IUUC-Tbe-127422	Tupaia belangeri	75.31	1.00e-137	482.00
IUUC-Ttr-129097	Tursiops truncatus	94.38	0.00e+00	677.00
IUUC-Vda-130014	Verticillium dahliae	36.09	1.00e-45	177.00
IUUC-Vpa-130782	Vicugna pacos	96.76	0.00e+00	683.00
IUUC-Vvi-131494	Vitis vinifera	29.73	1.00e-48	187.00
IUUC-Xtr-132165	Xenopus tropicalis	79.17	2.00e-153	535.00
IUUC-Xma-133205	Xiphophorus maculatus	68.31	2.00e-140	491.00
IUUC-Yli-134614	Yarrowia lipolytica	34.94	2.00e-49	189.00
IUUC-Zma-135861	Zea mays	34.35	1.00e-54	206.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence