iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-087991

Ensembl Protein ID

ENSOGAP00000009480.2

UniProt Accession

H0X315; H0X315_OTOGA

Genbank Protein ID

ENSOGAP00000009480

Protein Name

Coatomer subunit alpha

Genbank Nucleotide ID

AAQR03118687

Gene Name

COPA

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000010585.2	ENSOGAT00000010594.2	ENSOGAP00000009480.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.00e-35	118.0	133	163
UBD/Beta-Prp	6.90e-69	232.3	3	324

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gH+  v c +f ++ +l+vs+s D t++vWD
   Q: 133  GHNHYVMCAQFhPSeDLVVSASLDQTVRVWD 163
           8***********666**************** PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           t +++++++++ + f+p++++++t+  +g i++wd+++ +l+ ++ +h+++v+ ++f+++++++v+g++D+ ik+w+ + g  + ++  
   Q: 3    TKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKLWEARVGRWLEIIAV 91
           67889999********************************************************************************* PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl............... 166
             d v ++ +s++  +++s+s+d+tirvw++++++c+  +l+gh++ v+c+++hp+++l+vs+slD+tvr+Wd+               
   Q: 92   YIDAVKTCFLSKEYPWILSASDDQTIRVWNWQSRTCVC-VLTGHNHYVMCAQFHPSEDLVVSASLDQTVRVWDIsglrkknlspgaves 179
           **************************************.************************************************** PP
   S: 167  ............ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec..vrtlnghtdnvksvrfspnderlvsgs 241
                        t+ ++++  +gh++ v++ +f+++++ +vsg++d++vk+w + +++   v+t++gh +nv++  f+p++e+++s s
   Q: 180  dvrgitgvdlfgTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAweVDTCRGHYNNVSCAVFHPRQELILSNS 268
           ************888888888777********************************888888*************************** PP
   S: 242  sDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkknep 299
           +D+sir+Wd+ +++ ++t+ + +++++  a+ +++ n +++g  d+   ++kl++++p
   Q: 269  EDKSIRVWDMSKRTGVQTFRRDHDRFWVLAA-HPNLNLFAAG-HDGGMIVFKLERERP 324
           *******************************.5554444444.589999999988765 PP

Organism

Otolemur garnettii

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

Protein Sequence
(Fasta)

MLTKFETKSA RVKGLSFHPK RPWILTSLHN GVIQLWDYRM CTLIDKFDEH DGPVRGIDFH 60
KQQPLFVSGG DDYKIKLWEA RVGRWLEIIA VYIDAVKTCF LSKEYPWILS ASDDQTIRVW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTAACCA AATTTGAGAC CAAGAGCGCG CGAGTCAAAG GTAGTGGAGA AGAAAAGAGG 60
GAACGTGGAG GCTTGATGTC GGGGCAAGGG CGACACAGGG GAAGAGAGAA TGGGCAGACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR016391--Coatomer_asu
IPR010714--Coatomer_asu_C
IPR006692--Coatomer_WD-assoc_reg
IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF04053--Coatomer_WDAD
PF06957--COPI_C
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0006886--P:intracellular protein transport
GO:0030157--P:pancreatic juice secretion
GO:0016192--P:vesicle-mediated transport

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000064	Aegilops tauschii	51.09	0.00e+00	1233.00
IUUC-Aml-001758	Ailuropoda melanoleuca	93.13	0.00e+00	2347.00
IUUC-Atr-002493	Amborella trichopoda	51.76	0.00e+00	1243.00
IUUC-Apl-003385	Anas platyrhynchos	91.65	0.00e+00	1964.00
IUUC-Aca-005154	Anolis carolinensis	86.96	4.00e-107	380.00
IUUC-Aly-006020	Arabidopsis lyrata	57.84	0.00e+00	1012.00
IUUC-Ath-007058	Arabidopsis thaliana	58.08	0.00e+00	1005.00
IUUC-Ago-007992	Ashbya gossypii	42.98	0.00e+00	969.00
IUUC-Acl-008027	Aspergillus clavatus	53.44	0.00e+00	932.00
IUUC-Afl-008644	Aspergillus flavus	46.70	0.00e+00	1120.00
IUUC-Afu-008964	Aspergillus fumigatus	47.28	0.00e+00	1122.00
IUUC-Ani-009379	Aspergillus nidulans	52.64	0.00e+00	931.00
IUUC-Ang-009756	Aspergillus niger	47.10	0.00e+00	1134.00
IUUC-Aor-010174	Aspergillus oryzae	46.70	0.00e+00	1119.00
IUUC-Ate-010302	Aspergillus terreus	47.07	0.00e+00	1152.00
IUUC-Ame-011229	Astyanax mexicanus	81.68	0.00e+00	2058.00
IUUC-Bgr-012300	Blumeria graminis	45.83	0.00e+00	1087.00
IUUC-Bta-012524	Bos taurus	93.57	0.00e+00	2331.00
IUUC-Bci-013781	Botrytis cinerea	46.53	0.00e+00	1114.00
IUUC-Bdi-014549	Brachypodium distachyon	51.90	0.00e+00	1263.00
IUUC-Bol-015925	Brassica oleracea	57.84	0.00e+00	999.00
IUUC-Bra-016978	Brassica rapa	57.54	0.00e+00	996.00
IUUC-Cel-018115	Caenorhabditis elegans	60.10	0.00e+00	1028.00
IUUC-Cja-019107	Callithrix jacchus	90.95	0.00e+00	2286.00
IUUC-Cfa-020675	Canis familiaris	92.93	0.00e+00	2311.00
IUUC-Cpo-021813	Cavia porcellus	93.73	0.00e+00	2355.00
IUUC-Cre-022969	Chlamydomonas reinhardtii	59.93	0.00e+00	1011.00
IUUC-Csa-023523	Chlorocebus sabaeus	94.06	0.00e+00	2369.00
IUUC-Cho-024704	Choloepus hoffmanni	85.92	0.00e+00	1228.00
IUUC-Cin-025572	Ciona intestinalis	68.98	0.00e+00	1758.00
IUUC-Csv-025864	Ciona savignyi	70.74	0.00e+00	1193.00
IUUC-Cgl-026510	Colletotrichum gloeosporioides	53.61	0.00e+00	948.00
IUUC-Cne-027053	Cryptococcus neoformans	49.84	0.00e+00	1170.00
IUUC-Cme-027222	Cyanidioschyzon merolae	38.39	5.00e-133	469.00
IUUC-Dre-027421	Danio rerio	81.69	0.00e+00	2098.00
IUUC-Dno-029303	Dasypus novemcinctus	93.89	0.00e+00	2363.00
IUUC-Dor-030290	Dipodomys ordii	97.17	0.00e+00	1113.00
IUUC-Dse-031543	Dothistroma septosporum	43.93	0.00e+00	1048.00
IUUC-Dme-031945	Drosophila melanogaster	65.65	0.00e+00	1602.00
IUUC-Ete-032873	Echinops telfairi	88.99	0.00e+00	2058.00
IUUC-Eca-033773	Equus caballus	91.30	0.00e+00	2275.00
IUUC-Eeu-034874	Erinaceus europaeus	80.21	0.00e+00	1401.00
IUUC-Fca-035739	Felis catus	92.46	0.00e+00	2261.00
IUUC-Fal-037263	Ficedula albicollis	82.91	0.00e+00	1993.00
IUUC-Fox-037738	Fusarium oxysporum	46.14	0.00e+00	1143.00
IUUC-Fso-038153	Fusarium solani	46.55	0.00e+00	1135.00
IUUC-Gmo-039602	Gadus morhua	77.99	0.00e+00	1927.00
IUUC-Ggr-039931	Gaeumannomyces graminis	52.59	0.00e+00	938.00
IUUC-Gga-040590	Gallus gallus	91.37	0.00e+00	2275.00
IUUC-Gac-041318	Gasterosteus aculeatus	81.84	0.00e+00	2084.00
IUUC-Gma-043567	Glycine max	51.66	0.00e+00	1235.00
IUUC-Ggo-045029	Gorilla gorilla	93.21	0.00e+00	2358.00
IUUC-Hsa-046078	Homo sapiens	93.21	0.00e+00	2357.00
IUUC-Hvu-047556	Hordeum vulgare	52.83	0.00e+00	1277.00
IUUC-Itr-048881	Ictidomys tridecemlineatus	92.87	0.00e+00	1647.00
IUUC-Kpa-049256	Komagataella pastoris	43.18	0.00e+00	1016.00
IUUC-Lch-049706	Latimeria chalumnae	88.44	0.00e+00	2188.00
IUUC-Lpe-051316	Leersia perrieri	58.90	0.00e+00	1018.00
IUUC-Loc-051867	Lepisosteus oculatus	67.17	0.00e+00	1126.00
IUUC-Lma-053138	Leptosphaeria maculans	52.69	0.00e+00	944.00
IUUC-Laf-053510	Loxodonta africana	92.92	0.00e+00	2341.00
IUUC-Mcc-055836	Macaca mulatta	92.64	0.00e+00	2342.00
IUUC-Meu-056238	Macropus eugenii	78.42	0.00e+00	1045.00
IUUC-Mor-057172	Magnaporthe oryzae	46.33	0.00e+00	1125.00
IUUC-Mpo-057300	Magnaporthe poae	45.68	0.00e+00	1107.00
IUUC-Mtr-058248	Medicago truncatula	52.02	0.00e+00	1260.00
IUUC-Mla-059019	Melampsora laricipopulina	50.08	0.00e+00	1207.00
IUUC-Mga-059499	Meleagris gallopavo	91.22	0.00e+00	2272.00
IUUC-Mvi-060336	Microbotryum violaceum	50.44	0.00e+00	1192.00
IUUC-Mmr-061102	Microcebus murinus	93.37	0.00e+00	2318.00
IUUC-Mdo-062594	Monodelphis domestica	92.51	0.00e+00	2367.00
IUUC-Mmu-063736	Mus musculus	92.72	0.00e+00	2337.00
IUUC-Mac-065398	Musa acuminata	49.27	0.00e+00	1149.00
IUUC-Mpu-066701	Mustela putorius furo	93.81	0.00e+00	2316.00
IUUC-Mlu-067392	Myotis lucifugus	91.87	0.00e+00	2311.00
IUUC-Nfi-068270	Neosartorya fischeri	53.80	0.00e+00	934.00
IUUC-Ncr-068892	Neurospora crassa	47.20	0.00e+00	1117.00
IUUC-Nle-069634	Nomascus leucogenys	90.21	0.00e+00	1239.00
IUUC-Opr-070952	Ochotona princeps	86.69	0.00e+00	1466.00
IUUC-Ont-072488	Oreochromis niloticus	83.31	0.00e+00	2089.00
IUUC-Ocu-074211	Oryctolagus cuniculus	93.97	0.00e+00	2360.00
IUUC-Oba-075761	Oryza barthii	58.78	0.00e+00	1016.00
IUUC-Obr-076429	Oryza brachyantha	58.78	0.00e+00	1017.00
IUUC-Ogl-077364	Oryza glaberrima	58.78	0.00e+00	1017.00
IUUC-Ogu-078257	Oryza glumaepatula	59.05	0.00e+00	1017.00
IUUC-Oin-080029	Oryza indica	59.17	0.00e+00	1015.00
IUUC-Olo-080466	Oryza longistaminata	58.89	0.00e+00	1005.00
IUUC-Ome-081668	Oryza meridionalis	57.71	0.00e+00	841.00
IUUC-Oni-082874	Oryza nivara	59.05	0.00e+00	1017.00
IUUC-Opu-083697	Oryza punctata	51.21	0.00e+00	1241.00
IUUC-Oru-084274	Oryza rufipogon	58.78	0.00e+00	1016.00
IUUC-Osa-085565	Oryza sativa	58.78	0.00e+00	1016.00
IUUC-Ola-086921	Oryzias latipes	81.92	0.00e+00	2065.00
IUUC-Olu-087639	Ostreococcus lucimarinus	53.25	0.00e+00	1272.00
IUUC-Oar-089590	Ovis aries	93.81	0.00e+00	2357.00
IUUC-Ptr-090808	Pan troglodytes	93.29	0.00e+00	2360.00
IUUC-Pan-092475	Papio anubis	93.57	0.00e+00	2355.00
IUUC-Psi-093044	Pelodiscus sinensis	74.24	0.00e+00	1557.00
IUUC-Pno-094839	Phaeosphaeria nodorum	45.39	0.00e+00	1038.00
IUUC-Ppa-095254	Physcomitrella patens	53.46	0.00e+00	1296.00
IUUC-Pfo-097493	Poecilia formosa	82.82	0.00e+00	2063.00
IUUC-Pab-098497	Pongo abelii	94.06	0.00e+00	2370.00
IUUC-Pop-099992	Populus trichocarpa	52.52	0.00e+00	1266.00
IUUC-Pca-100413	Procavia capensis	78.38	0.00e+00	873.00
IUUC-Ppe-101899	Prunus persica	51.81	0.00e+00	1235.00
IUUC-Pva-102126	Pteropus vampyrus	92.24	0.00e+00	2316.00
IUUC-Pgr-103376	Puccinia graminis	50.64	0.00e+00	1226.00
IUUC-Ptt-103978	Puccinia triticina	45.73	0.00e+00	1038.00
IUUC-Pte-104126	Pyrenophora teres	52.77	0.00e+00	900.00
IUUC-Pyt-104778	Pyrenophora triticirepentis	44.74	1.00e-170	593.00
IUUC-Rno-105428	Rattus norvegicus	93.40	0.00e+00	2345.00
IUUC-Sce-106464	Saccharomyces cerevisiae	41.95	0.00e+00	957.00
IUUC-Sha-107301	Sarcophilus harrisii	92.51	0.00e+00	2310.00
IUUC-Sja-107961	Schizosaccharomyces japonicus	44.01	0.00e+00	1026.00
IUUC-Spo-108217	Schizosaccharomyces pombe	44.67	0.00e+00	1056.00
IUUC-Ssl-108643	Sclerotinia sclerotiorum	46.65	0.00e+00	1122.00
IUUC-Smo-109582	Selaginella moellendorffii	61.80	0.00e+00	1066.00
IUUC-Sit-109697	Setaria italica	58.42	0.00e+00	1011.00
IUUC-Sly-111447	Solanum lycopersicum	52.01	0.00e+00	1266.00
IUUC-Stu-112564	Solanum tuberosum	51.77	0.00e+00	1266.00
IUUC-Sar-113313	Sorex araneus	86.74	0.00e+00	1459.00
IUUC-Sbi-114388	Sorghum bicolor	58.90	0.00e+00	1016.00
IUUC-Sre-115209	Sporisorium reilianum	54.15	0.00e+00	962.00
IUUC-Ssc-115933	Sus scrofa	93.73	0.00e+00	2355.00
IUUC-Tgu-117109	Taeniopygia guttata	75.10	0.00e+00	665.00
IUUC-Tru-117772	Takifugu rubripes	82.10	0.00e+00	2055.00
IUUC-Tsy-119105	Tarsius syrichta	79.30	0.00e+00	1961.00
IUUC-Tni-120556	Tetraodon nigroviridis	67.10	0.00e+00	1430.00
IUUC-Tca-121046	Theobroma cacao	51.56	0.00e+00	1272.00
IUUC-Tre-121951	Trichoderma reesei	53.64	0.00e+00	947.00
IUUC-Tvi-122359	Trichoderma virens	54.04	0.00e+00	951.00
IUUC-Tae-125732	Triticum aestivum	52.50	0.00e+00	1266.00
IUUC-Tur-126754	Triticum urartu	58.06	0.00e+00	1009.00
IUUC-Tme-127170	Tuber melanosporum	47.32	0.00e+00	1158.00
IUUC-Tbe-127882	Tupaia belangeri	96.79	0.00e+00	843.00
IUUC-Ttr-128217	Tursiops truncatus	90.86	0.00e+00	2275.00
IUUC-Uma-129337	Ustilago maydis	53.62	0.00e+00	959.00
IUUC-Vda-129828	Verticillium dahliae	46.02	0.00e+00	1112.00
IUUC-Vpa-130537	Vicugna pacos	92.48	0.00e+00	2306.00
IUUC-Vvi-130958	Vitis vinifera	58.78	0.00e+00	1016.00
IUUC-Xtr-132857	Xenopus tropicalis	85.02	0.00e+00	2131.00
IUUC-Xma-133138	Xiphophorus maculatus	82.57	0.00e+00	2058.00
IUUC-Yli-134399	Yarrowia lipolytica	48.39	0.00e+00	820.00
IUUC-Zma-135612	Zea mays	51.78	0.00e+00	1251.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence