iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000002524.6	ENSGALT00000003977.5	ENSGALP00000003968.5
ENSGALG00000002524.6	ENSGALT00000069385.2	ENSGALP00000047819.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	4.80e-100	335.6	7	323

Active Site

Position(s)	Description	Evidence
90	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
166	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 5    vkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakq 93
           + ew+ +esdPg+ft+l++ fg+++  qvee++sL+pen++++ +pv+gl++lFk+++ +e +          +vv+++ ++tiffakq
   Q: 7    AGEWCLMESDPGVFTELIKGFGCRGA-QVEEIWSLEPENFEKL-KPVHGLIFLFKWQPGEEPAG---------SVVQDSRLDTIFFAKQ 84
           679***********************.****************.********************.........899************* PP
   S: 94   vigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvs 182
           vi+N+Cat+A++svllnc ++ + lG+tls++ke+++++++ +k+lal+n++v++++hns+ar+++++ + + +++    +++afhfvs
   Q: 85   VINNACATQAIVSVLLNCAHQDIRLGETLSEFKEFSQSFDAAMKGLALSNSEVIRQVHNSFARQQMFEFDAKSSAK----EEDAFHFVS 169
           **********************************************************************888776....89******* PP
   S: 183  yvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid.........keL 262
           yv++ngrlyeldgl++ P+dlg+ ++++++ ++++ v+   +ri++++++eirfnl+aiv+dr++i+++r+  l+ +          + 
   Q: 170  YVPVNGRLYELDGLREGPIDLGS-CNQDDWISAVRPVI--EKRIQKYSEGEIRFNLMAIVSDRKMIYEQRIAELQRQlaeeepmetDQS 255
           **********************9.78999*********..******************************9776666778888887556 PP
   S: 263  lkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefg 333
            ++l+ i+se++k+++ +++e++k k++ki++irR++ny  fi++++k+la++++l  lve+      +++
   Q: 256  SNMLSSIQSEVAKYQMLIEEENQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKAK---EKQN 323
           78**********************************************************9942...2333 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MAGGSSAGEW CLMESDPGVF TELIKGFGCR GAQVEEIWSL EPENFEKLKP VHGLIFLFKW 60
QPGEEPAGSV VQDSRLDTIF FAKQVINNAC ATQAIVSVLL NCAHQDIRLG ETLSEFKEFS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCACTTCCT GCTCCCGCCC TGTCTCACCA TAGAGATGCC AGGTGCGGCG TGGGCCGCGG 60
GGCCTGCCGG GAAGCGAGCG GCGTGCCTCG GTCTTGCGGC GTAGCTGGTC GGTGGCACCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031011--C:Ino80 complex
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0004866--F:endopeptidase inhibitor activity
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0048853--P:forebrain morphogenesis
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0016579--P:protein deubiquitination
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	46.99	7.00e-84	303.00
IUUC-Aml-001866	Ailuropoda melanoleuca	95.18	2.00e-179	621.00
IUUC-Atr-002966	Amborella trichopoda	47.11	5.00e-81	294.00
IUUC-Apl-003306	Anas platyrhynchos	89.30	0.00e+00	628.00
IUUC-Aca-004763	Anolis carolinensis	96.19	0.00e+00	635.00
IUUC-Aly-005581	Arabidopsis lyrata	48.94	5.00e-80	290.00
IUUC-Ath-007283	Arabidopsis thaliana	48.63	4.00e-82	297.00
IUUC-Ago-007999	Ashbya gossypii	38.14	9.00e-34	137.00
IUUC-Acl-008231	Aspergillus clavatus	43.15	4.00e-53	201.00
IUUC-Afl-008557	Aspergillus flavus	37.79	6.00e-55	207.00
IUUC-Afu-008988	Aspergillus fumigatus	44.40	4.00e-54	204.00
IUUC-Ani-009420	Aspergillus nidulans	38.92	1.00e-53	202.00
IUUC-Ang-009859	Aspergillus niger	41.46	1.00e-49	189.00
IUUC-Aor-010145	Aspergillus oryzae	37.79	6.00e-55	207.00
IUUC-Ate-010347	Aspergillus terreus	41.96	2.00e-53	202.00
IUUC-Ame-010791	Astyanax mexicanus	90.03	0.00e+00	629.00
IUUC-Bgr-012298	Blumeria graminis	38.16	3.00e-50	191.00
IUUC-Bta-013251	Bos taurus	94.86	1.00e-177	615.00
IUUC-Bci-013786	Botrytis cinerea	37.46	8.00e-57	213.00
IUUC-Bdi-014132	Brachypodium distachyon	48.16	3.00e-81	295.00
IUUC-Bol-015611	Brassica oleracea	49.69	7.00e-85	306.00
IUUC-Bra-017769	Brassica rapa	49.69	7.00e-85	306.00
IUUC-Cel-018604	Caenorhabditis elegans	46.67	1.00e-83	302.00
IUUC-Cja-019768	Callithrix jacchus	86.14	4.00e-172	597.00
IUUC-Cfa-020207	Canis familiaris	95.18	2.00e-179	621.00
IUUC-Cpo-021925	Cavia porcellus	91.29	3.00e-170	590.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	46.11	7.00e-74	270.00
IUUC-Csa-023958	Chlorocebus sabaeus	93.63	4.00e-176	610.00
IUUC-Cho-024928	Choloepus hoffmanni	96.10	4.00e-41	161.00
IUUC-Cin-025771	Ciona intestinalis	54.32	9.00e-102	362.00
IUUC-Csv-026149	Ciona savignyi	57.86	7.00e-105	373.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	37.87	2.00e-51	195.00
IUUC-Cne-026955	Cryptococcus neoformans	36.86	8.00e-54	203.00
IUUC-Cme-027104	Cyanidioschyzon merolae	33.15	7.00e-50	190.00
IUUC-Dre-027409	Danio rerio	90.63	0.00e+00	628.00
IUUC-Dno-028921	Dasypus novemcinctus	94.86	1.00e-178	618.00
IUUC-Dse-031170	Dothistroma septosporum	37.24	7.00e-58	217.00
IUUC-Dme-031677	Drosophila melanogaster	61.13	6.00e-115	406.00
IUUC-Ete-032707	Echinops telfairi	66.04	2.00e-114	405.00
IUUC-Eca-033776	Equus caballus	95.14	4.00e-165	573.00
IUUC-Eeu-035305	Erinaceus europaeus	76.34	8.00e-80	290.00
IUUC-Fca-035846	Felis catus	87.10	4.00e-174	603.00
IUUC-Fal-037597	Ficedula albicollis	98.26	7.00e-163	565.00
IUUC-Fox-037670	Fusarium oxysporum	48.05	2.00e-53	202.00
IUUC-Fso-038243	Fusarium solani	48.05	8.00e-53	200.00
IUUC-Gmo-038499	Gadus morhua	85.71	3.00e-164	570.00
IUUC-Ggr-039975	Gaeumannomyces graminis	42.97	4.00e-49	188.00
IUUC-Gac-042058	Gasterosteus aculeatus	90.48	8.00e-174	602.00
IUUC-Gma-043030	Glycine max	49.26	7.00e-86	310.00
IUUC-Ggo-044699	Gorilla gorilla	88.52	2.00e-161	561.00
IUUC-Hsa-046227	Homo sapiens	94.53	2.00e-178	617.00
IUUC-Hvu-047359	Hordeum vulgare	47.42	1.00e-82	299.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	86.09	7.00e-174	602.00
IUUC-Lch-049829	Latimeria chalumnae	93.33	5.00e-177	612.00
IUUC-Lpe-050899	Leersia perrieri	48.26	5.00e-78	284.00
IUUC-Loc-052264	Lepisosteus oculatus	91.77	6.00e-175	605.00
IUUC-Lma-053110	Leptosphaeria maculans	38.08	1.00e-47	183.00
IUUC-Laf-053639	Loxodonta africana	95.18	2.00e-179	621.00
IUUC-Mcc-055506	Macaca mulatta	93.63	5.00e-176	610.00
IUUC-Mor-057001	Magnaporthe oryzae	44.13	4.00e-54	204.00
IUUC-Mpo-057608	Magnaporthe poae	40.64	4.00e-33	134.00
IUUC-Mtr-057731	Medicago truncatula	48.66	4.00e-85	307.00
IUUC-Mla-059016	Melampsora laricipopulina	43.28	4.00e-44	170.00
IUUC-Mga-060178	Meleagris gallopavo	99.67	2.00e-180	624.00
IUUC-Mvi-060353	Microbotryum violaceum	38.14	6.00e-55	207.00
IUUC-Mmr-060738	Microcebus murinus	94.53	2.00e-178	617.00
IUUC-Mdo-062266	Monodelphis domestica	96.08	9.00e-119	418.00
IUUC-Mmu-063619	Mus musculus	93.25	1.00e-176	611.00
IUUC-Mac-065301	Musa acuminata	52.05	3.00e-89	321.00
IUUC-Mpu-066058	Mustela putorius furo	95.50	6.00e-180	622.00
IUUC-Mlu-067292	Myotis lucifugus	94.21	4.00e-176	610.00
IUUC-Nfi-068275	Neosartorya fischeri	38.34	1.00e-55	209.00
IUUC-Ncr-068713	Neurospora crassa	39.12	5.00e-59	220.00
IUUC-Nle-069013	Nomascus leucogenys	93.89	2.00e-175	608.00
IUUC-Opr-070628	Ochotona princeps	83.58	2.00e-164	571.00
IUUC-Ont-072688	Oreochromis niloticus	90.54	4.00e-173	600.00
IUUC-Oan-073004	Ornithorhynchus anatinus	95.88	8.00e-140	488.00
IUUC-Ocu-074303	Oryctolagus cuniculus	95.81	5.00e-180	624.00
IUUC-Oba-075002	Oryza barthii	48.49	7.00e-82	296.00
IUUC-Obr-076392	Oryza brachyantha	49.21	7.00e-80	290.00
IUUC-Ogl-077271	Oryza glaberrima	48.49	7.00e-82	296.00
IUUC-Ogu-078493	Oryza glumaepatula	48.49	1.00e-82	299.00
IUUC-Oin-080084	Oryza indica	48.49	1.00e-82	299.00
IUUC-Olo-080803	Oryza longistaminata	48.19	3.00e-82	298.00
IUUC-Ome-081146	Oryza meridionalis	47.29	3.00e-81	294.00
IUUC-Oni-082146	Oryza nivara	48.49	1.00e-82	299.00
IUUC-Opu-083633	Oryza punctata	48.90	2.00e-78	285.00
IUUC-Oru-084789	Oryza rufipogon	48.49	1.00e-82	299.00
IUUC-Osa-086196	Oryza sativa	48.49	1.00e-82	299.00
IUUC-Ola-087126	Oryzias latipes	90.79	4.00e-169	586.00
IUUC-Olu-087665	Ostreococcus lucimarinus	42.71	3.00e-70	258.00
IUUC-Oga-089140	Otolemur garnettii	86.65	5.00e-173	599.00
IUUC-Oar-090296	Ovis aries	94.53	6.00e-178	615.00
IUUC-Ptr-090566	Pan troglodytes	94.53	2.00e-178	617.00
IUUC-Pan-092052	Papio anubis	93.63	6.00e-176	609.00
IUUC-Psi-093723	Pelodiscus sinensis	96.88	1.00e-167	581.00
IUUC-Pma-094568	Petromyzon marinus	60.76	1.00e-107	382.00
IUUC-Pno-095120	Phaeosphaeria nodorum	37.84	5.00e-49	187.00
IUUC-Ppa-095761	Physcomitrella patens	47.95	4.00e-85	307.00
IUUC-Pfo-096210	Poecilia formosa	89.84	2.00e-173	600.00
IUUC-Pab-098463	Pongo abelii	94.53	4.00e-178	617.00
IUUC-Pop-099423	Populus trichocarpa	49.55	3.00e-85	308.00
IUUC-Pca-100108	Procavia capensis	93.93	2.00e-138	484.00
IUUC-Ppe-101176	Prunus persica	50.00	3.00e-84	304.00
IUUC-Pva-102629	Pteropus vampyrus	91.92	2.00e-142	498.00
IUUC-Pgr-103419	Puccinia graminis	41.46	1.00e-57	216.00
IUUC-Pte-104207	Pyrenophora teres	43.79	3.00e-32	130.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	39.02	3.00e-56	211.00
IUUC-Rno-105579	Rattus norvegicus	83.28	1.00e-156	545.00
IUUC-Sha-106894	Sarcophilus harrisii	92.75	1.00e-153	535.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	38.87	2.00e-59	221.00
IUUC-Spo-108371	Schizosaccharomyces pombe	41.58	9.00e-61	226.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	38.77	1.00e-47	182.00
IUUC-Smo-109396	Selaginella moellendorffii	51.38	6.00e-89	320.00
IUUC-Sit-110630	Setaria italica	50.31	1.00e-86	312.00
IUUC-Sly-110972	Solanum lycopersicum	49.20	2.00e-80	292.00
IUUC-Stu-112185	Solanum tuberosum	49.10	2.00e-89	322.00
IUUC-Sar-113294	Sorex araneus	78.37	2.00e-158	551.00
IUUC-Sbi-113951	Sorghum bicolor	50.93	6.00e-87	313.00
IUUC-Ssc-115501	Sus scrofa	94.61	6.00e-169	586.00
IUUC-Tgu-117152	Taeniopygia guttata	97.92	7.00e-163	565.00
IUUC-Tru-118388	Takifugu rubripes	90.16	1.00e-173	601.00
IUUC-Tsy-119109	Tarsius syrichta	94.86	8.00e-179	619.00
IUUC-Tni-120048	Tetraodon nigroviridis	90.16	3.00e-174	603.00
IUUC-Tca-121750	Theobroma cacao	49.41	4.00e-89	320.00
IUUC-Tre-122130	Trichoderma reesei	39.00	7.00e-56	210.00
IUUC-Tvi-122284	Trichoderma virens	38.54	5.00e-52	197.00
IUUC-Tae-124082	Triticum aestivum	47.71	3.00e-82	298.00
IUUC-Tur-126366	Triticum urartu	43.67	6.00e-68	251.00
IUUC-Tme-127187	Tuber melanosporum	41.25	9.00e-60	223.00
IUUC-Tbe-127619	Tupaia belangeri	86.41	7.00e-139	486.00
IUUC-Ttr-128867	Tursiops truncatus	85.31	3.00e-121	427.00
IUUC-Vda-129912	Verticillium dahliae	38.05	5.00e-53	201.00
IUUC-Vpa-130552	Vicugna pacos	96.14	3.00e-121	427.00
IUUC-Vvi-130881	Vitis vinifera	50.74	3.00e-85	308.00
IUUC-Xtr-131934	Xenopus tropicalis	85.80	6.00e-174	602.00
IUUC-Xma-133312	Xiphophorus maculatus	89.52	5.00e-172	596.00
IUUC-Yli-134487	Yarrowia lipolytica	40.34	8.00e-48	183.00
IUUC-Zma-135462	Zea mays	44.00	1.00e-72	266.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence