iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-044699

UUCD1 version

UUC-GoG-01074

Ensembl Protein ID

ENSGGOP00000004267.2

UniProt Accession

G3QNY6; G3QNY6_GORGO

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Gene Name

UCHL5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000004347.2	ENSGGOT00000004371.2	ENSGGOP00000004267.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	2.20e-90	303.9	1	292

Active Site

Position(s)	Description	Evidence
88	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
164	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 1    mnsqvkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktif 89
           m++++ ew+ +esdPg+ft+l++ fg+++  qvee++sL+pen++++ +pv+gl++lFk+++ +e +          +vv+++ ++tif
   Q: 1    MTGNAGEWCLMESDPGVFTELIKGFGCRGA-QVEEIWSLEPENFEKL-KPVHGLIFLFKWQPGEEPAG---------SVVQDSRLDTIF 78
           788999************************.****************.********************.........899********* PP
   S: 90   fakqvigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeaf 178
           fakqvi+N+Cat+A++svllnc+++ ++lG+tls++ke+++++++ +k+lal+n++v++++hns+ar+++++ +++++++    +++af
   Q: 79   FAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTSAK----EEDAF 163
           *****************************************************************************888....79*** PP
   S: 179  hfvsyvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid........ 259
           hfvsyv++ngrlyeldgl++ P+dlg+ ++++++ ++++ v+   +ri++++++eirfnl+aiv+dr++i+++++  l+ +        
   Q: 164  HFVSYVPVNGRLYELDGLREGPIDLGA-CNQDDWISAVRPVI--EKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQlaeeepmd 249
           **************************9.78999*********..******************************976666677888888 PP
   S: 260  .keLlkLlkdieseeekieaqlddekekrkkfkiddirRteny 301
             +  ++l++i+se++k+++ +++e++k k++ki++  +++ +
   Q: 250  tDQGNSMLSAIQSEVAKNQMLIEEEVQKLKRYKINANLKNKTS 292
           744569****************************987765544 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MTGNAGEWCL MESDPGVFTE LIKGFGCRGA QVEEIWSLEP ENFEKLKPVH GLIFLFKWQP 60
GEEPAGSVVQ DSRLDTIFFA KQVINNACAT QAIVSVLLNC THQDVHLGET LSEFKEFSQS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATCTGTGGC CGGCGGCAGC TGGTGCAGGG GGCACCTGAG AGCGAGAGGT GGATCGGGGC 60
GGTGTGTGGC CAGGGCCATG ACGGGCAATG CCGGGGAGTG GTGCCTCATG GAAAGCGACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005829--C:cytosol
GO:0031011--C:Ino80 complex
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0004866--F:endopeptidase inhibitor activity
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0048853--P:forebrain morphogenesis
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0016579--P:protein deubiquitination
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	42.34	2.00e-70	259.00
IUUC-Aml-001866	Ailuropoda melanoleuca	93.49	6.00e-171	592.00
IUUC-Atr-002966	Amborella trichopoda	43.32	2.00e-66	246.00
IUUC-Apl-003306	Anas platyrhynchos	78.27	4.00e-158	550.00
IUUC-Aca-004763	Anolis carolinensis	88.85	1.00e-161	561.00
IUUC-Aly-005581	Arabidopsis lyrata	43.64	2.00e-66	246.00
IUUC-Ath-007283	Arabidopsis thaliana	43.94	1.00e-69	256.00
IUUC-Ago-007999	Ashbya gossypii	37.71	7.00e-33	134.00
IUUC-Acl-008231	Aspergillus clavatus	43.57	6.00e-53	201.00
IUUC-Afl-008557	Aspergillus flavus	43.93	2.00e-54	206.00
IUUC-Afu-008988	Aspergillus fumigatus	45.00	9.00e-55	206.00
IUUC-Ani-009420	Aspergillus nidulans	42.53	1.00e-51	196.00
IUUC-Ang-009859	Aspergillus niger	40.82	9.00e-50	190.00
IUUC-Aor-010145	Aspergillus oryzae	43.93	2.00e-54	206.00
IUUC-Ate-010347	Aspergillus terreus	41.96	1.00e-53	203.00
IUUC-Ame-010791	Astyanax mexicanus	81.82	7.00e-163	566.00
IUUC-Bgr-012298	Blumeria graminis	41.81	4.00e-46	178.00
IUUC-Bta-013251	Bos taurus	92.51	3.00e-168	583.00
IUUC-Bci-013786	Botrytis cinerea	42.80	8.00e-55	207.00
IUUC-Bdi-014132	Brachypodium distachyon	49.25	2.00e-69	255.00
IUUC-Bol-015611	Brassica oleracea	45.29	2.00e-71	262.00
IUUC-Bra-017769	Brassica rapa	45.29	3.00e-71	261.00
IUUC-Cel-018604	Caenorhabditis elegans	47.69	2.00e-70	258.00
IUUC-Cja-019768	Callithrix jacchus	85.67	5.00e-166	576.00
IUUC-Cfa-020207	Canis familiaris	93.49	6.00e-171	592.00
IUUC-Cpo-021925	Cavia porcellus	89.25	1.00e-161	561.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	53.10	3.00e-66	244.00
IUUC-Csa-023958	Chlorocebus sabaeus	93.81	2.00e-169	588.00
IUUC-Cho-024928	Choloepus hoffmanni	100.00	1.00e-42	166.00
IUUC-Cin-025771	Ciona intestinalis	49.69	1.00e-85	309.00
IUUC-Csv-026149	Ciona savignyi	52.83	6.00e-88	317.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	44.50	2.00e-49	189.00
IUUC-Cne-026955	Cryptococcus neoformans	42.08	2.00e-48	185.00
IUUC-Cme-027104	Cyanidioschyzon merolae	32.49	2.00e-44	172.00
IUUC-Dre-027409	Danio rerio	80.91	9.00e-160	555.00
IUUC-Dno-028921	Dasypus novemcinctus	92.83	9.00e-170	588.00
IUUC-Dse-031170	Dothistroma septosporum	45.38	2.00e-55	209.00
IUUC-Dme-031677	Drosophila melanogaster	54.49	3.00e-100	358.00
IUUC-Ete-032707	Echinops telfairi	70.72	4.00e-101	360.00
IUUC-Eca-033776	Equus caballus	92.55	3.00e-154	537.00
IUUC-Eeu-035305	Erinaceus europaeus	78.72	3.00e-83	301.00
IUUC-Fca-035846	Felis catus	85.93	1.00e-165	575.00
IUUC-Fal-037597	Ficedula albicollis	88.65	3.00e-141	494.00
IUUC-Fox-037670	Fusarium oxysporum	50.21	7.00e-56	210.00
IUUC-Fso-038243	Fusarium solani	50.21	3.00e-55	208.00
IUUC-Gmo-038499	Gadus morhua	77.52	5.00e-144	503.00
IUUC-Ggr-039975	Gaeumannomyces graminis	41.06	1.00e-48	186.00
IUUC-Gga-040904	Gallus gallus	86.28	3.00e-168	583.00
IUUC-Gac-042058	Gasterosteus aculeatus	82.41	4.00e-153	533.00
IUUC-Gma-043030	Glycine max	43.95	1.00e-71	263.00
IUUC-Hsa-046227	Homo sapiens	94.14	4.00e-172	597.00
IUUC-Hvu-047359	Hordeum vulgare	51.05	8.00e-69	253.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	84.32	1.00e-164	572.00
IUUC-Lch-049829	Latimeria chalumnae	85.99	2.00e-157	547.00
IUUC-Lpe-050899	Leersia perrieri	53.28	2.00e-68	252.00
IUUC-Loc-052264	Lepisosteus oculatus	84.09	4.00e-155	540.00
IUUC-Lma-053110	Leptosphaeria maculans	45.65	2.00e-48	186.00
IUUC-Laf-053639	Loxodonta africana	93.49	6.00e-171	592.00
IUUC-Mcc-055506	Macaca mulatta	93.81	1.00e-169	588.00
IUUC-Mor-057001	Magnaporthe oryzae	46.41	2.00e-55	209.00
IUUC-Mpo-057608	Magnaporthe poae	41.03	2.00e-33	135.00
IUUC-Mtr-057731	Medicago truncatula	54.39	3.00e-75	275.00
IUUC-Mla-059016	Melampsora laricipopulina	43.28	1.00e-43	169.00
IUUC-Mga-060178	Meleagris gallopavo	86.23	4.00e-155	540.00
IUUC-Mvi-060353	Microbotryum violaceum	41.22	4.00e-50	191.00
IUUC-Mmr-060738	Microcebus murinus	93.49	4.00e-171	593.00
IUUC-Mdo-062266	Monodelphis domestica	97.55	2.00e-120	424.00
IUUC-Mmu-063619	Mus musculus	90.88	2.00e-167	581.00
IUUC-Mac-065301	Musa acuminata	45.28	5.00e-75	274.00
IUUC-Mpu-066058	Mustela putorius furo	93.16	2.00e-170	591.00
IUUC-Mlu-067292	Myotis lucifugus	91.86	1.00e-166	578.00
IUUC-Nfi-068275	Neosartorya fischeri	44.17	6.00e-54	204.00
IUUC-Ncr-068713	Neurospora crassa	42.54	1.00e-55	209.00
IUUC-Nle-069013	Nomascus leucogenys	93.49	4.00e-169	587.00
IUUC-Opr-070628	Ochotona princeps	81.44	1.00e-154	539.00
IUUC-Ont-072688	Oreochromis niloticus	83.17	7.00e-154	536.00
IUUC-Oan-073004	Ornithorhynchus anatinus	95.93	9.00e-142	495.00
IUUC-Ocu-074303	Oryctolagus cuniculus	93.16	1.00e-170	593.00
IUUC-Oba-075002	Oryza barthii	52.30	4.00e-70	257.00
IUUC-Obr-076392	Oryza brachyantha	52.30	1.00e-70	259.00
IUUC-Ogl-077271	Oryza glaberrima	52.30	4.00e-70	257.00
IUUC-Ogu-078493	Oryza glumaepatula	52.30	9.00e-71	259.00
IUUC-Oin-080084	Oryza indica	52.30	9.00e-71	259.00
IUUC-Olo-080803	Oryza longistaminata	52.30	1.00e-70	259.00
IUUC-Ome-081146	Oryza meridionalis	51.88	7.00e-70	257.00
IUUC-Oni-082146	Oryza nivara	52.30	9.00e-71	259.00
IUUC-Opu-083633	Oryza punctata	51.88	7.00e-70	257.00
IUUC-Oru-084789	Oryza rufipogon	52.30	9.00e-71	259.00
IUUC-Osa-086196	Oryza sativa	52.30	9.00e-71	259.00
IUUC-Ola-087126	Oryzias latipes	83.71	1.00e-150	525.00
IUUC-Olu-087665	Ostreococcus lucimarinus	40.49	5.00e-64	237.00
IUUC-Oga-089140	Otolemur garnettii	85.93	2.00e-166	578.00
IUUC-Oar-090296	Ovis aries	92.18	2.00e-168	584.00
IUUC-Ptr-090566	Pan troglodytes	94.14	4.00e-172	597.00
IUUC-Pan-092052	Papio anubis	93.81	2.00e-169	588.00
IUUC-Psi-093723	Pelodiscus sinensis	88.30	2.00e-147	514.00
IUUC-Pma-094568	Petromyzon marinus	65.25	5.00e-103	367.00
IUUC-Pno-095120	Phaeosphaeria nodorum	46.32	3.00e-50	191.00
IUUC-Ppa-095761	Physcomitrella patens	42.86	2.00e-70	258.00
IUUC-Pfo-096210	Poecilia formosa	83.06	1.00e-154	538.00
IUUC-Pab-098463	Pongo abelii	94.14	1.00e-171	595.00
IUUC-Pop-099109	Populus trichocarpa	43.79	1.00e-71	263.00
IUUC-Pca-100108	Procavia capensis	97.15	1.00e-142	499.00
IUUC-Ppe-101176	Prunus persica	46.55	8.00e-73	266.00
IUUC-Pva-102629	Pteropus vampyrus	95.80	4.00e-149	520.00
IUUC-Pgr-103419	Puccinia graminis	44.94	3.00e-56	211.00
IUUC-Pte-104207	Pyrenophora teres	44.97	2.00e-33	134.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	45.89	4.00e-56	211.00
IUUC-Rno-105579	Rattus norvegicus	81.07	3.00e-146	510.00
IUUC-Sha-106894	Sarcophilus harrisii	86.67	9.00e-138	482.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	43.61	2.00e-55	208.00
IUUC-Spo-108371	Schizosaccharomyces pombe	47.77	2.00e-56	212.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	42.47	6.00e-46	177.00
IUUC-Smo-109396	Selaginella moellendorffii	46.63	7.00e-75	273.00
IUUC-Sit-110630	Setaria italica	51.68	6.00e-72	264.00
IUUC-Sly-110972	Solanum lycopersicum	45.54	1.00e-67	249.00
IUUC-Stu-112185	Solanum tuberosum	46.25	8.00e-76	276.00
IUUC-Sar-113294	Sorex araneus	75.00	2.00e-146	511.00
IUUC-Sbi-113951	Sorghum bicolor	52.52	4.00e-72	264.00
IUUC-Ssc-115501	Sus scrofa	91.41	4.00e-157	546.00
IUUC-Tgu-117152	Taeniopygia guttata	88.30	3.00e-141	494.00
IUUC-Tru-118388	Takifugu rubripes	82.41	8.00e-154	536.00
IUUC-Tsy-119109	Tarsius syrichta	93.81	2.00e-171	594.00
IUUC-Tni-120048	Tetraodon nigroviridis	82.41	3.00e-154	537.00
IUUC-Tca-121750	Theobroma cacao	44.54	4.00e-75	274.00
IUUC-Tre-122130	Trichoderma reesei	44.87	9.00e-54	203.00
IUUC-Tvi-122284	Trichoderma virens	45.53	2.00e-51	196.00
IUUC-Tae-124082	Triticum aestivum	51.46	6.00e-69	254.00
IUUC-Tur-126366	Triticum urartu	45.65	9.00e-55	207.00
IUUC-Tme-127187	Tuber melanosporum	46.75	2.00e-57	216.00
IUUC-Tbe-127619	Tupaia belangeri	83.27	1.00e-127	449.00
IUUC-Ttr-128867	Tursiops truncatus	87.76	5.00e-124	437.00
IUUC-Vda-129912	Verticillium dahliae	42.61	7.00e-52	197.00
IUUC-Vpa-130552	Vicugna pacos	99.52	3.00e-126	444.00
IUUC-Vvi-130881	Vitis vinifera	46.15	5.00e-71	261.00
IUUC-Xtr-131934	Xenopus tropicalis	77.58	1.00e-155	541.00
IUUC-Xma-133312	Xiphophorus maculatus	83.06	2.00e-154	538.00
IUUC-Yli-134487	Yarrowia lipolytica	40.34	1.00e-48	186.00
IUUC-Zma-135639	Zea mays	45.45	5.00e-63	234.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence