iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
miRTarBase	microRNA	miRNAMap	RAID2
Protein-protein Interaction
IID	PINA	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.10e-38	127.1	52	88
UBD/Beta-Prp	1.20e-78	264.6	8	325

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           H ++v++++f +d +++vsG+dD +ikvW++++ +++
   Q: 52   HDGPVRGICFhHDqPIFVSGGDDYKIKVWNYKQKRCI 88
           99*********888****************9998886 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfs 103
           ++++++++ + f+p +++++t+  +g i++wd+++  ll+++ +h+++v+ ++f++d++i+v+g++D+ ikvw++++  c+ tl gh d+++++ f+
   Q: 8    ESKSARVKGISFHPTRPWVLTSLHSGVIQLWDYRMCVLLEKFDEHDGPVRGICFHHDQPIFVSGGDDYKIKVWNYKQKRCIFTLLGHLDYIRTTFFH 104
           6788999****************************************************************************************** PP
   S: 104  psgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl............................ktgkll 172
            +  +++s+s+d+t+r+w+++++  +  +l+gh++ v+c+++hp+++l++s+slD+tvr+Wd+                            + + + 
   Q: 105  HKYPWIISASDDQTVRIWNWQSRNSIA-ILTGHNHYVMCAQFHPTEDLVASASLDQTVRVWDIsglrkkqmpgggapsrptggqqaelfgqPDAVVK 200
           *99************************.*************************************************************96666666 PP
   S: 173  rtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec..vrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssv 267
           + l+g h++ v++++f+++ + lvsgs+d++vk+w + +++   +++++gh +nv+sv f+pn ++++s s+D+sir+Wd+++++ l+++ ++n+++
   Q: 201  HVLEG-HDRGVNWVAFHHTNPILVSGSDDRQVKIWRYNETKAweLDSCRGHYNNVSSVIFHPNADLILSNSEDKSIRVWDMQKRTSLHVFRHENERF 296
           66676.********************************8877789**************************************************** PP
   S: 268  isvavlsfgdnvlvlgsedskvniwklkkne 298
           +  a+ +++ n++++g + +   ++k ++++
   Q: 297  WVLAA-HPSLNMFAAGHD-NGMVVFKIQRER 325
           *****.999999988866.577778887766 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

Protein Sequence
(Fasta)

MSLLIKFESK SARVKGISFH PTRPWVLTSL HSGVIQLWDY RMCVLLEKFD EHDGPVRGIC 60
FHHDQPIFVS GGDDYKIKVW NYKQKRCIFT LLGHLDYIRT TFFHHKYPWI ISASDDQTVR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACCTTCATT CACGCCGAGG AGCAGTTTTT GACTGGTTAC CGACTATAAA TCGGATATCA 60
TGTCGCTCCT TATCAAATTT GAATCAAAAT CCGCTAGGGT TAAAGGTAAA TATTTTGGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR016391--Coatomer_asu
IPR010714--Coatomer_asu_C
IPR006692--Coatomer_WD-assoc_reg
IPR020472--G-protein_beta_WD-40_rep
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF04053--Coatomer_WDAD
PF06957--COPI_C
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0006891--P:intra-Golgi vesicle-mediated transport
GO:0006886--P:intracellular protein transport
GO:0006890--P:retrograde vesicle-mediated transport, Golgi to ER

KEGG

cel:CELE_Y71F9AL.17

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000064	Aegilops tauschii	54.81	0.00e+00	943.00
IUUC-Aml-001758	Ailuropoda melanoleuca	58.26	0.00e+00	1468.00
IUUC-Atr-002493	Amborella trichopoda	55.77	0.00e+00	960.00
IUUC-Apl-003385	Anas platyrhynchos	52.99	0.00e+00	1147.00
IUUC-Aca-005154	Anolis carolinensis	75.36	8.00e-98	347.00
IUUC-Aly-006020	Arabidopsis lyrata	54.95	0.00e+00	952.00
IUUC-Ath-007058	Arabidopsis thaliana	54.95	0.00e+00	951.00
IUUC-Ago-007992	Ashbya gossypii	41.63	0.00e+00	922.00
IUUC-Acl-008027	Aspergillus clavatus	52.32	0.00e+00	907.00
IUUC-Afl-008644	Aspergillus flavus	52.26	0.00e+00	910.00
IUUC-Afu-008964	Aspergillus fumigatus	44.74	0.00e+00	1057.00
IUUC-Ani-009379	Aspergillus nidulans	51.91	0.00e+00	912.00
IUUC-Ang-009756	Aspergillus niger	45.88	0.00e+00	1061.00
IUUC-Aor-010174	Aspergillus oryzae	52.26	0.00e+00	910.00
IUUC-Ate-010302	Aspergillus terreus	44.00	0.00e+00	1057.00
IUUC-Ame-011229	Astyanax mexicanus	56.90	0.00e+00	1416.00
IUUC-Bgr-012300	Blumeria graminis	44.12	0.00e+00	998.00
IUUC-Bta-012524	Bos taurus	58.84	0.00e+00	1469.00
IUUC-Bci-013781	Botrytis cinerea	44.49	0.00e+00	1045.00
IUUC-Bdi-014549	Brachypodium distachyon	54.69	0.00e+00	940.00
IUUC-Bol-015925	Brassica oleracea	54.59	0.00e+00	947.00
IUUC-Bra-016978	Brassica rapa	54.71	0.00e+00	945.00
IUUC-Cja-019107	Callithrix jacchus	57.30	0.00e+00	1444.00
IUUC-Cfa-020675	Canis familiaris	57.99	0.00e+00	1442.00
IUUC-Cpo-021813	Cavia porcellus	58.68	0.00e+00	1477.00
IUUC-Cre-022969	Chlamydomonas reinhardtii	55.05	0.00e+00	951.00
IUUC-Csa-023523	Chlorocebus sabaeus	58.68	0.00e+00	1483.00
IUUC-Cho-024704	Choloepus hoffmanni	45.84	0.00e+00	677.00
IUUC-Cin-025572	Ciona intestinalis	60.17	0.00e+00	1073.00
IUUC-Csv-025864	Ciona savignyi	60.26	0.00e+00	1053.00
IUUC-Cgl-026510	Colletotrichum gloeosporioides	52.44	0.00e+00	914.00
IUUC-Cne-027053	Cryptococcus neoformans	55.34	0.00e+00	951.00
IUUC-Cme-027222	Cyanidioschyzon merolae	36.51	5.00e-128	451.00
IUUC-Dre-027421	Danio rerio	57.72	0.00e+00	1461.00
IUUC-Dno-029303	Dasypus novemcinctus	58.75	0.00e+00	1473.00
IUUC-Dor-030290	Dipodomys ordii	51.95	3.00e-167	581.00
IUUC-Dse-031543	Dothistroma septosporum	42.36	0.00e+00	986.00
IUUC-Dme-031945	Drosophila melanogaster	62.28	0.00e+00	1073.00
IUUC-Ete-032873	Echinops telfairi	55.57	0.00e+00	1277.00
IUUC-Eca-033773	Equus caballus	57.67	0.00e+00	1432.00
IUUC-Eeu-034874	Erinaceus europaeus	46.51	0.00e+00	751.00
IUUC-Fca-035739	Felis catus	57.68	0.00e+00	1457.00
IUUC-Fal-037263	Ficedula albicollis	53.58	0.00e+00	1321.00
IUUC-Fox-037738	Fusarium oxysporum	52.27	0.00e+00	914.00
IUUC-Fso-038153	Fusarium solani	44.41	0.00e+00	1038.00
IUUC-Gmo-039602	Gadus morhua	53.68	0.00e+00	1309.00
IUUC-Ggr-039931	Gaeumannomyces graminis	51.43	0.00e+00	897.00
IUUC-Gga-040590	Gallus gallus	57.11	0.00e+00	1467.00
IUUC-Gac-041318	Gasterosteus aculeatus	56.75	0.00e+00	1438.00
IUUC-Gma-043894	Glycine max	55.89	0.00e+00	955.00
IUUC-Ggo-045029	Gorilla gorilla	58.42	0.00e+00	1476.00
IUUC-Hsa-046078	Homo sapiens	58.50	0.00e+00	1478.00
IUUC-Hvu-047556	Hordeum vulgare	48.44	0.00e+00	1138.00
IUUC-Itr-048881	Ictidomys tridecemlineatus	52.25	0.00e+00	878.00
IUUC-Kpa-049256	Komagataella pastoris	47.69	0.00e+00	817.00
IUUC-Lch-049706	Latimeria chalumnae	56.79	0.00e+00	1437.00
IUUC-Lpe-051316	Leersia perrieri	55.17	0.00e+00	947.00
IUUC-Loc-051867	Lepisosteus oculatus	50.11	0.00e+00	834.00
IUUC-Lma-053138	Leptosphaeria maculans	51.50	0.00e+00	892.00
IUUC-Laf-053510	Loxodonta africana	58.78	0.00e+00	1474.00
IUUC-Mcc-055836	Macaca mulatta	58.32	0.00e+00	1474.00
IUUC-Meu-056238	Macropus eugenii	56.55	0.00e+00	777.00
IUUC-Mor-057172	Magnaporthe oryzae	44.64	0.00e+00	1032.00
IUUC-Mpo-057300	Magnaporthe poae	51.55	0.00e+00	901.00
IUUC-Mtr-058248	Medicago truncatula	56.42	0.00e+00	956.00
IUUC-Mla-059019	Melampsora laricipopulina	46.44	0.00e+00	1100.00
IUUC-Mga-059499	Meleagris gallopavo	56.86	0.00e+00	1460.00
IUUC-Mvi-060336	Microbotryum violaceum	53.88	0.00e+00	932.00
IUUC-Mmr-061102	Microcebus murinus	58.10	0.00e+00	1465.00
IUUC-Mdo-062594	Monodelphis domestica	58.60	0.00e+00	1492.00
IUUC-Mmu-063736	Mus musculus	58.26	0.00e+00	1469.00
IUUC-Mac-065219	Musa acuminata	53.96	0.00e+00	855.00
IUUC-Mpu-066701	Mustela putorius furo	56.47	0.00e+00	1453.00
IUUC-Mlu-067392	Myotis lucifugus	57.54	0.00e+00	1466.00
IUUC-Nfi-068270	Neosartorya fischeri	52.69	0.00e+00	916.00
IUUC-Ncr-068892	Neurospora crassa	52.32	0.00e+00	905.00
IUUC-Nle-069634	Nomascus leucogenys	65.06	0.00e+00	941.00
IUUC-Opr-070952	Ochotona princeps	47.96	0.00e+00	753.00
IUUC-Ont-072488	Oreochromis niloticus	57.03	0.00e+00	1432.00
IUUC-Ocu-074211	Oryctolagus cuniculus	58.60	0.00e+00	1475.00
IUUC-Oba-075761	Oryza barthii	55.53	0.00e+00	951.00
IUUC-Obr-076429	Oryza brachyantha	54.81	0.00e+00	942.00
IUUC-Ogl-077364	Oryza glaberrima	55.53	0.00e+00	951.00
IUUC-Ogu-078257	Oryza glumaepatula	55.53	0.00e+00	954.00
IUUC-Oin-080029	Oryza indica	56.00	0.00e+00	949.00
IUUC-Olo-080466	Oryza longistaminata	55.35	0.00e+00	943.00
IUUC-Ome-081993	Oryza meridionalis	57.39	0.00e+00	897.00
IUUC-Oni-082874	Oryza nivara	55.94	0.00e+00	951.00
IUUC-Opu-083885	Oryza punctata	55.41	0.00e+00	951.00
IUUC-Oru-084274	Oryza rufipogon	55.53	0.00e+00	952.00
IUUC-Osa-085565	Oryza sativa	55.53	0.00e+00	952.00
IUUC-Ola-086921	Oryzias latipes	57.26	0.00e+00	1420.00
IUUC-Olu-087639	Ostreococcus lucimarinus	48.66	0.00e+00	1170.00
IUUC-Oga-087991	Otolemur garnettii	55.81	0.00e+00	1373.00
IUUC-Oar-089590	Ovis aries	58.84	0.00e+00	1480.00
IUUC-Ptr-090808	Pan troglodytes	58.42	0.00e+00	1476.00
IUUC-Pan-092475	Papio anubis	58.39	0.00e+00	1471.00
IUUC-Psi-093044	Pelodiscus sinensis	56.06	0.00e+00	928.00
IUUC-Pno-094839	Phaeosphaeria nodorum	42.96	0.00e+00	961.00
IUUC-Ppa-095254	Physcomitrella patens	56.59	0.00e+00	972.00
IUUC-Pfo-097493	Poecilia formosa	57.70	0.00e+00	1421.00
IUUC-Pab-098497	Pongo abelii	58.76	0.00e+00	1484.00
IUUC-Pop-099992	Populus trichocarpa	55.78	0.00e+00	950.00
IUUC-Pca-100413	Procavia capensis	58.92	0.00e+00	680.00
IUUC-Ppe-101392	Prunus persica	48.45	0.00e+00	1153.00
IUUC-Pva-102126	Pteropus vampyrus	56.50	0.00e+00	1406.00
IUUC-Pgr-103376	Puccinia graminis	46.93	0.00e+00	1111.00
IUUC-Ptt-103978	Puccinia triticina	41.81	0.00e+00	897.00
IUUC-Pte-104126	Pyrenophora teres	42.87	0.00e+00	966.00
IUUC-Pyt-104778	Pyrenophora triticirepentis	41.47	4.00e-153	534.00
IUUC-Rno-105428	Rattus norvegicus	58.76	0.00e+00	1477.00
IUUC-Sce-106464	Saccharomyces cerevisiae	40.66	0.00e+00	893.00
IUUC-Sha-107301	Sarcophilus harrisii	58.41	0.00e+00	1457.00
IUUC-Sja-107961	Schizosaccharomyces japonicus	43.24	0.00e+00	1008.00
IUUC-Spo-108217	Schizosaccharomyces pombe	43.11	0.00e+00	1030.00
IUUC-Ssl-108643	Sclerotinia sclerotiorum	45.05	0.00e+00	1045.00
IUUC-Smo-109582	Selaginella moellendorffii	57.49	0.00e+00	996.00
IUUC-Sit-109697	Setaria italica	54.93	0.00e+00	948.00
IUUC-Sly-111447	Solanum lycopersicum	48.57	0.00e+00	1169.00
IUUC-Stu-112564	Solanum tuberosum	48.92	0.00e+00	1159.00
IUUC-Sar-113313	Sorex araneus	47.24	0.00e+00	752.00
IUUC-Sbi-114388	Sorghum bicolor	55.05	0.00e+00	952.00
IUUC-Sre-115209	Sporisorium reilianum	52.06	0.00e+00	916.00
IUUC-Ssc-115933	Sus scrofa	58.76	0.00e+00	1479.00
IUUC-Tgu-117109	Taeniopygia guttata	47.68	9.00e-121	425.00
IUUC-Tru-117772	Takifugu rubripes	55.90	0.00e+00	1399.00
IUUC-Tsy-119105	Tarsius syrichta	49.17	0.00e+00	1213.00
IUUC-Tni-120556	Tetraodon nigroviridis	44.85	0.00e+00	895.00
IUUC-Tca-121545	Theobroma cacao	55.85	0.00e+00	957.00
IUUC-Tre-121951	Trichoderma reesei	51.62	0.00e+00	908.00
IUUC-Tvi-122359	Trichoderma virens	53.02	0.00e+00	915.00
IUUC-Tae-123611	Triticum aestivum	54.81	0.00e+00	944.00
IUUC-Tur-126754	Triticum urartu	54.93	0.00e+00	946.00
IUUC-Tme-127170	Tuber melanosporum	45.88	0.00e+00	1077.00
IUUC-Tbe-127882	Tupaia belangeri	48.51	4.00e-154	538.00
IUUC-Ttr-128217	Tursiops truncatus	56.90	0.00e+00	1412.00
IUUC-Uma-129337	Ustilago maydis	51.94	0.00e+00	913.00
IUUC-Vda-129828	Verticillium dahliae	51.42	0.00e+00	882.00
IUUC-Vpa-130537	Vicugna pacos	57.94	0.00e+00	1452.00
IUUC-Vvi-130958	Vitis vinifera	56.25	0.00e+00	964.00
IUUC-Xtr-132857	Xenopus tropicalis	56.46	0.00e+00	1379.00
IUUC-Xma-133138	Xiphophorus maculatus	57.61	0.00e+00	1420.00
IUUC-Yli-134399	Yarrowia lipolytica	48.20	0.00e+00	804.00
IUUC-Zma-135612	Zea mays	54.21	0.00e+00	939.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence