iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aml-001225

Ensembl Protein ID

ENSAMEP00000011256.1

UniProt Accession

G1LW05; G1LW05_AILME

Genbank Protein ID

ENSAMEP00000011256

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01131818

Gene Name

SLX4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000010700.1	ENSAMET00000011735.1	ENSAMEP00000011256.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	6.60e-06	26.5	510	578
UBD/ZnF/UBZ	3.60e-08	33.6	119	144

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvg.geeffahkivLaasSsvFyalf..lmelees.....ksklmveikdvqpevfrallkFlYtg 63
           +Dv+++ + g +  ahk vL a+++ ++     ++ +        + + +v ++dv+ e+ rall++lYt 
   Q: 510  SDVQFQMDsGDVLYAHKFVLYARCPLLMQYVdsEGFFA-AedgdlR-GQRVLLSDVSTEAARALLHYLYTA 578
           69**************************9994333333.1346757.99********************96 PP

UBD/ZnF/UBZ

   S: 2    lvCPvCqkm...vdqtdfeeHlDeCl 24
           ++C++Cqk    +++t++e+H+++Cl
   Q: 119  FFCQICQKNlsaMNVTRREQHVNRCL 144
           89***********************8 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

PLPEASPDSS SQPPPSCLTV VAPSPSKPRT AELVLQRMQQ FKRADPERLQ HASEACSLEV 60
TLEENAPEGP AEEMTAGNGS RPGLPATQSD AAVALALQQE FGQQRASAHE ANLEETGLFF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTCTGCCAG AGGCTTCTCC GGACAGCAGC TCCCAGCCCC CTCCTTCCTG TCTGACAGTG 60
GTGGCACCAA GTCCCTCCAA ACCCCGGACG GCAGAGTTGG TCCTACAGCG AATGCAGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR018574--Structure-sp_endonuc_su_Slx4

PROSITE

PS50097--BTB

Pfam

PF00651--BTB
PF09494--Slx4

SMART

SM00225--BTB

Gene Ontology

GO:0030054--C:cell junction
GO:0005829--C:cytosol
GO:0070522--C:ERCC4-ERCC1 complex
GO:0048476--C:Holliday junction resolvase complex
GO:0000790--C:nuclear chromatin
GO:0000784--C:nuclear chromosome, telomeric region
GO:0005654--C:nucleoplasm
GO:0033557--C:Slx1-Slx4 complex
GO:0048257--F:3'-flap endonuclease activity
GO:0017108--F:5'-flap endonuclease activity
GO:0008821--F:crossover junction endodeoxyribonuclease activity
GO:0008047--F:enzyme activator activity
GO:0010792--P:DNA double-strand break processing involved in repair via single-strand annealing
GO:0006260--P:DNA replication
GO:0000724--P:double-strand break repair via homologous recombination
GO:1904357--P:negative regulation of telomere maintenance via telomere lengthening
GO:0006289--P:nucleotide-excision repair
GO:1904431--P:positive regulation of t-circle formation
GO:0072429--P:response to intra-S DNA damage checkpoint signaling
GO:0090656--P:t-circle formation
GO:0061820--P:telomeric D-loop disassembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003261	Anas platyrhynchos	36.79	0.00e+00	698.00
IUUC-Aca-004455	Anolis carolinensis	71.93	2.00e-19	86.30
IUUC-Ame-010993	Astyanax mexicanus	37.84	1.00e-11	62.80
IUUC-Bta-013472	Bos taurus	61.64	0.00e+00	1351.00
IUUC-Cja-019406	Callithrix jacchus	60.15	0.00e+00	1342.00
IUUC-Cfa-020129	Canis familiaris	77.03	0.00e+00	1945.00
IUUC-Cpo-021944	Cavia porcellus	55.52	0.00e+00	1277.00
IUUC-Csa-023941	Chlorocebus sabaeus	55.41	6.00e-175	607.00
IUUC-Cho-024847	Choloepus hoffmanni	73.07	4.00e-130	459.00
IUUC-Cin-025405	Ciona intestinalis	40.38	8.00e-07	48.10
IUUC-Csv-025916	Ciona savignyi	33.90	3.00e-06	45.10
IUUC-Dre-027764	Danio rerio	34.44	5.00e-77	283.00
IUUC-Dno-030083	Dasypus novemcinctus	61.16	0.00e+00	763.00
IUUC-Dor-031129	Dipodomys ordii	52.04	0.00e+00	937.00
IUUC-Dse-031510	Dothistroma septosporum	33.33	6.60e-01	30.00
IUUC-Ete-032536	Echinops telfairi	45.40	3.00e-100	360.00
IUUC-Eca-033407	Equus caballus	73.14	0.00e+00	1613.00
IUUC-Eeu-034473	Erinaceus europaeus	47.95	1.00e-52	202.00
IUUC-Fca-035730	Felis catus	74.37	0.00e+00	1925.00
IUUC-Fal-036850	Ficedula albicollis	48.57	1.00e-143	504.00
IUUC-Gmo-038677	Gadus morhua	44.44	8.00e-34	138.00
IUUC-Gga-041088	Gallus gallus	47.28	1.00e-143	504.00
IUUC-Gac-041824	Gasterosteus aculeatus	49.28	2.00e-13	68.90
IUUC-Ggo-045642	Gorilla gorilla	61.29	0.00e+00	1312.00
IUUC-Hsa-047035	Homo sapiens	61.77	0.00e+00	1426.00
IUUC-Itr-049010	Ictidomys tridecemlineatus	60.48	0.00e+00	1382.00
IUUC-Lch-050364	Latimeria chalumnae	42.20	2.00e-82	301.00
IUUC-Loc-052423	Lepisosteus oculatus	42.27	2.00e-46	182.00
IUUC-Laf-053910	Loxodonta africana	60.04	0.00e+00	1389.00
IUUC-Mcc-055883	Macaca mulatta	61.26	0.00e+00	1434.00
IUUC-Meu-056224	Macropus eugenii	51.32	4.00e-89	323.00
IUUC-Mga-059880	Meleagris gallopavo	47.22	5.00e-146	512.00
IUUC-Mvi-060510	Microbotryum violaceum	36.36	1.00e-04	42.40
IUUC-Mmr-061715	Microcebus murinus	62.83	0.00e+00	1489.00
IUUC-Mdo-062426	Monodelphis domestica	44.76	0.00e+00	942.00
IUUC-Mmu-063947	Mus musculus	63.18	0.00e+00	823.00
IUUC-Mpu-066184	Mustela putorius furo	79.67	0.00e+00	2070.00
IUUC-Mlu-067533	Myotis lucifugus	71.27	0.00e+00	1729.00
IUUC-Nle-069204	Nomascus leucogenys	61.71	0.00e+00	1447.00
IUUC-Opr-070377	Ochotona princeps	65.96	0.00e+00	798.00
IUUC-Ont-072551	Oreochromis niloticus	34.35	2.00e-68	255.00
IUUC-Oan-073350	Ornithorhynchus anatinus	56.22	4.00e-96	345.00
IUUC-Ocu-074915	Oryctolagus cuniculus	64.09	0.00e+00	788.00
IUUC-Oba-075062	Oryza barthii	29.55	3.00e-08	52.80
IUUC-Ola-087360	Oryzias latipes	45.41	9.00e-34	136.00
IUUC-Oga-089106	Otolemur garnettii	59.54	0.00e+00	1215.00
IUUC-Oar-089289	Ovis aries	64.64	0.00e+00	946.00
IUUC-Ptr-091469	Pan troglodytes	61.59	0.00e+00	1406.00
IUUC-Pan-091841	Papio anubis	60.50	0.00e+00	1176.00
IUUC-Psi-093842	Pelodiscus sinensis	45.98	5.00e-133	469.00
IUUC-Pma-094732	Petromyzon marinus	61.54	1.00e-09	56.20
IUUC-Pno-095010	Phaeosphaeria nodorum	50.00	4.30e-02	32.30
IUUC-Pfo-097299	Poecilia formosa	40.18	6.00e-35	143.00
IUUC-Pab-098271	Pongo abelii	61.05	0.00e+00	1409.00
IUUC-Pca-100721	Procavia capensis	55.37	0.00e+00	785.00
IUUC-Pva-102276	Pteropus vampyrus	70.10	0.00e+00	1837.00
IUUC-Pyt-104755	Pyrenophora triticirepentis	46.15	3.50e-01	28.90
IUUC-Rno-105619	Rattus norvegicus	62.58	0.00e+00	824.00
IUUC-Sha-106722	Sarcophilus harrisii	45.14	0.00e+00	1001.00
IUUC-Sar-113673	Sorex araneus	49.84	1.00e-88	322.00
IUUC-Ssc-115383	Sus scrofa	65.16	0.00e+00	847.00
IUUC-Tgu-117243	Taeniopygia guttata	51.65	3.00e-94	338.00
IUUC-Tru-118092	Takifugu rubripes	59.74	1.00e-20	93.20
IUUC-Tsy-119362	Tarsius syrichta	56.62	7.00e-138	485.00
IUUC-Tni-120380	Tetraodon nigroviridis	75.00	4.00e-20	91.30
IUUC-Tbe-127404	Tupaia belangeri	49.03	0.00e+00	649.00
IUUC-Ttr-128317	Tursiops truncatus	67.83	0.00e+00	1520.00
IUUC-Uma-129640	Ustilago maydis	32.20	2.00e-03	37.00
IUUC-Xtr-132533	Xenopus tropicalis	41.21	6.00e-97	349.00
IUUC-Xma-134059	Xiphophorus maculatus	39.17	2.00e-36	148.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence