iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-002214

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01068013

Gene Name

UBE3A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000007071.1	ENSAMET00000007775.1	ENSAMEP00000007461.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.80e-108	360.9	550	876

Active Site

Position(s)	Description	Evidence
845	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e+ k  ++ np+s+    e +  F+++G++lg+a++++ +ld+
   Q: 550  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWF-NPSSF----ETEGQFTLIGIVLGLAIYNNCILDV 633
           689******************************************998888876.88888....789********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.lgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl + +p ly+slk ++e+ e ++e+  + +tf++s++  +g+   ++Lk++G++ip+tneN++e+v+l+ 
   Q: 634  HFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEY-EGNVEDD-MMITFQISQTDlFGNPMMYDLKENGDKIPITNENRKEFVNLYS 720
           *************************************.7799986.99***9665444******************************* PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           +y+l++++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+++l+++t+y+ggyt+ds  i+ Fwe++++f++e+++ fLq
   Q: 721  DYILNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQ 809
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d +rlP+s+TCfn+L LPeYsske+lke+Ll Ai+++kgF++
   Q: 810  FTTGTDRAPVGGLGKLK---MIIAKNGPDtERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 876
           *****************...8888866666**************************************97 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

LSFLHESYTN LNHCAYCLNV CYRKRAAAKH LIERYYHQLT EGCGNEACTN EFCASCPTFL 60
RMDNNAAAIK ALELYKINAK LCDPHPSKKG ASSAYLENSK GAPNNSCSDI KMNKKEGQGA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTAAGCTTTT TACATGAGAG CTATACTAAT CTTAATCACT GTGCTTATTG TTTGAATGTT 60
TGCTACAGGA AGCGAGCAGC TGCAAAGCAT CTAATAGAAC GCTACTACCA CCAGTTAACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0003713--F:transcription coactivator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0030521--P:androgen receptor signaling pathway
GO:0001541--P:ovarian follicle development
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0060736--P:prostate gland growth
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0042752--P:regulation of circadian rhythm
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035037--P:sperm entry
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-003144	Amborella trichopoda	45.80	4.00e-96	345.00
IUUC-Apl-003742	Anas platyrhynchos	95.34	0.00e+00	1578.00
IUUC-Aca-004873	Anolis carolinensis	94.43	0.00e+00	1592.00
IUUC-Ame-011166	Astyanax mexicanus	86.70	0.00e+00	1458.00
IUUC-Bta-013286	Bos taurus	98.24	0.00e+00	1574.00
IUUC-Cja-019707	Callithrix jacchus	98.13	0.00e+00	1610.00
IUUC-Cfa-020154	Canis familiaris	99.30	0.00e+00	1618.00
IUUC-Cpo-021292	Cavia porcellus	96.96	0.00e+00	1604.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	49.06	2.00e-82	298.00
IUUC-Csa-023378	Chlorocebus sabaeus	98.01	0.00e+00	1612.00
IUUC-Cho-025059	Choloepus hoffmanni	94.16	0.00e+00	1525.00
IUUC-Cin-025643	Ciona intestinalis	44.80	0.00e+00	717.00
IUUC-Csv-026282	Ciona savignyi	44.98	0.00e+00	676.00
IUUC-Cme-027151	Cyanidioschyzon merolae	44.02	2.00e-101	363.00
IUUC-Dre-027901	Danio rerio	85.75	0.00e+00	1439.00
IUUC-Dno-029320	Dasypus novemcinctus	98.13	0.00e+00	1611.00
IUUC-Dor-030756	Dipodomys ordii	94.51	0.00e+00	744.00
IUUC-Dme-032035	Drosophila melanogaster	39.79	1.00e-168	587.00
IUUC-Eca-033843	Equus caballus	98.71	0.00e+00	1593.00
IUUC-Eeu-035109	Erinaceus europaeus	95.90	0.00e+00	1557.00
IUUC-Fca-036344	Felis catus	97.89	0.00e+00	1618.00
IUUC-Fal-036747	Ficedula albicollis	95.34	0.00e+00	1579.00
IUUC-Gmo-038840	Gadus morhua	63.36	0.00e+00	1103.00
IUUC-Gga-040399	Gallus gallus	95.22	0.00e+00	1578.00
IUUC-Gac-041933	Gasterosteus aculeatus	85.40	0.00e+00	1389.00
IUUC-Ggo-044804	Gorilla gorilla	98.24	0.00e+00	1613.00
IUUC-Hsa-045727	Homo sapiens	98.24	0.00e+00	1613.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	94.39	0.00e+00	1529.00
IUUC-Lch-050197	Latimeria chalumnae	91.35	0.00e+00	1535.00
IUUC-Loc-052743	Lepisosteus oculatus	89.86	0.00e+00	1518.00
IUUC-Lma-053245	Leptosphaeria maculans	33.87	4.00e-57	216.00
IUUC-Laf-053615	Loxodonta africana	97.08	0.00e+00	1608.00
IUUC-Mcc-054934	Macaca mulatta	98.01	0.00e+00	1612.00
IUUC-Meu-056061	Macropus eugenii	97.21	0.00e+00	1361.00
IUUC-Mga-059271	Meleagris gallopavo	94.32	0.00e+00	1598.00
IUUC-Mmr-061288	Microcebus murinus	97.78	0.00e+00	1610.00
IUUC-Mdo-062975	Monodelphis domestica	96.61	0.00e+00	1590.00
IUUC-Mmu-063674	Mus musculus	95.32	0.00e+00	1547.00
IUUC-Mpu-066568	Mustela putorius furo	99.65	0.00e+00	1644.00
IUUC-Mlu-067522	Myotis lucifugus	89.53	0.00e+00	1486.00
IUUC-Nle-069505	Nomascus leucogenys	98.24	0.00e+00	1613.00
IUUC-Opr-070570	Ochotona princeps	89.76	0.00e+00	1466.00
IUUC-Ont-071527	Oreochromis niloticus	86.10	0.00e+00	1464.00
IUUC-Oan-073446	Ornithorhynchus anatinus	90.99	0.00e+00	1039.00
IUUC-Ocu-074922	Oryctolagus cuniculus	95.93	0.00e+00	1602.00
IUUC-Ola-086996	Oryzias latipes	85.81	0.00e+00	1474.00
IUUC-Oga-088261	Otolemur garnettii	97.78	0.00e+00	1612.00
IUUC-Oar-090024	Ovis aries	98.24	0.00e+00	1574.00
IUUC-Ptr-090455	Pan troglodytes	98.24	0.00e+00	1613.00
IUUC-Pan-092509	Papio anubis	97.79	0.00e+00	1453.00
IUUC-Psi-092974	Pelodiscus sinensis	94.98	0.00e+00	1547.00
IUUC-Pma-094643	Petromyzon marinus	71.25	0.00e+00	1252.00
IUUC-Pno-094886	Phaeosphaeria nodorum	35.32	9.00e-58	219.00
IUUC-Pfo-096905	Poecilia formosa	85.73	0.00e+00	1458.00
IUUC-Pab-097840	Pongo abelii	95.90	0.00e+00	1569.00
IUUC-Pca-100869	Procavia capensis	96.73	0.00e+00	1595.00
IUUC-Pva-103040	Pteropus vampyrus	97.02	0.00e+00	667.00
IUUC-Rno-105453	Rattus norvegicus	95.32	0.00e+00	1548.00
IUUC-Sha-107651	Sarcophilus harrisii	96.61	0.00e+00	1590.00
IUUC-Smo-108858	Selaginella moellendorffii	49.88	2.00e-116	412.00
IUUC-Sar-113293	Sorex araneus	98.01	0.00e+00	1612.00
IUUC-Ssc-115979	Sus scrofa	98.71	0.00e+00	1624.00
IUUC-Tgu-116901	Taeniopygia guttata	95.34	0.00e+00	1579.00
IUUC-Tru-118368	Takifugu rubripes	86.30	0.00e+00	1456.00
IUUC-Tsy-119516	Tarsius syrichta	94.03	0.00e+00	1504.00
IUUC-Tni-120143	Tetraodon nigroviridis	85.73	0.00e+00	1448.00
IUUC-Tbe-127484	Tupaia belangeri	92.60	0.00e+00	1112.00
IUUC-Ttr-129078	Tursiops truncatus	98.24	0.00e+00	1592.00
IUUC-Vpa-130312	Vicugna pacos	90.66	0.00e+00	1371.00
IUUC-Xtr-132881	Xenopus tropicalis	92.28	0.00e+00	1544.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence