iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004450

UUCD1 version

UUC-AnC-00945

Ensembl Protein ID

ENSACAP00000002499.3

UniProt Accession

H9G6E9; H9G6E9_ANOCA

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Gene Name

NAE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000002445.3	ENSACAT00000002564.3	ENSACAP00000002499.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.30e-119	400.1	54	566

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
           YDRQ+rlwG+++qe+l+sa+v++++a+++G+E+lKnLvl Gvgs+t+vD+ +v+ +++++ F+++++++g+++A++a e l+eln  v+
   Q: 54   YDRQLRLWGDHGQEALESAHVCVINATATGTEILKNLVLPGVGSFTIVDGCQVTGEDVGNSFFLQRSNIGQNRAQCATELLQELNNEVS 142
           ***************************************************************************************** PP
   S: 90   veaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfc 174
           + ++ee++++l +++  Ff++f+vV++++ ++++ ++++++++n+++pl+ ++t+Gl+G++r+iik++ + +s++d   d++++++Pf+
   Q: 143  GHFVEEDPDKLLDNDAsFFCRFNVVIATQLPESTLLRLAEVLWNYDIPLLVCRTYGLIGYMRIIIKEHSVVESHPDnalDDLRLDNPFP 231
           ***************9************************************************************************* PP
   S: 175  tlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafakt 248
           +lke+++         +++++i+w+v+++k+le ++ e++++ +++++eke++++ +++++ +      edeenfeeai+++++a   t
   Q: 232  ELKEHIQsfdldhmekKEHSHIPWIVIVSKYLEIWYNENSGQMPKNYKEKEAFREMIRQGILKnengglEDEENFEEAIKNVNTAVMAT 320
           *****88888888888***********************************************9************************* PP
   S: 249  tins.ikqllksfecdivtkskspfwv.............................................................. 274
            i+  i++++++++c++++++++pfw+                                                              
   Q: 321  KIPVcIEDIFNDDHCNNLSQQTPPFWIlaravkefvakegqgnlpvrgiipdmiadsskfiklqniyrekakkdadavanyaakllqsv 409
           ***************************************************************************************** PP
   S: 275  .............sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..a 332
                         +csn++ l+v             +++k+e+++++++p     lyl+lra++rf k +gr+pg+ +++++dd+  +
   Q: 410  gkapesisqkelkLLCSNSAFLRVVrcrslseeygvNTANKEEIISHMDNPdsemvLYLMLRAVDRFFKHHGRYPGVYNYQVEDDIgkL 498
           *************9999999999666666666777766666666666666666677*****************************8888 PP
   S: 333  vdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
            +++++++    +++g++  ++dd+i+e++++++++ + t+a++gG+ aqE++K+++++f+ ++n+++++++
   Q: 499  KSCLNSFL----QEYGLPVTVKDDYIHEFCRYGAAEPHITAAFLGGVGAQEAVKIITKQFVIFNNTYIYNGM 566
           88888888....*********************************************************987 PP

Organism

Anolis carolinensis

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

MFKLRTLSSG ERSQCAGALR TPPPRRRGPA LKAGKMAAAQ PTQSGKISLK EQRYDRQLRL 60
WGDHGQEALE SAHVCVINAT ATGTEILKNL VLPGVGSFTI VDGCQVTGED VGNSFFLQRS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCGGATTAA AAAGTTTGAG GACCCCTGCT CCTAAGTATA GCGACGTTGA CAGATCTGAA 60
AGCTCTCACA TAAGCCTGCT TTAAAGGGCT GCAAAATATG AACTCATTCT TCTTCACTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0033314--P:mitotic DNA replication checkpoint
GO:0051402--P:neuron apoptotic process
GO:0045116--P:protein neddylation
GO:0043523--P:regulation of neuron apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	41.24	8.00e-122	430.00
IUUC-Aml-002333	Ailuropoda melanoleuca	80.75	0.00e+00	926.00
IUUC-Atr-002644	Amborella trichopoda	39.58	7.00e-111	394.00
IUUC-Apl-003446	Anas platyrhynchos	81.50	0.00e+00	894.00
IUUC-Aly-006187	Arabidopsis lyrata	40.11	1.00e-122	432.00
IUUC-Ath-007600	Arabidopsis thaliana	39.69	7.00e-123	434.00
IUUC-Ago-007900	Ashbya gossypii	25.61	5.00e-38	151.00
IUUC-Acl-008333	Aspergillus clavatus	32.86	2.00e-76	280.00
IUUC-Afl-008529	Aspergillus flavus	33.75	8.00e-84	304.00
IUUC-Afu-009071	Aspergillus fumigatus	32.91	3.00e-77	282.00
IUUC-Ani-009443	Aspergillus nidulans	33.45	4.00e-76	278.00
IUUC-Ang-009669	Aspergillus niger	32.34	2.00e-80	293.00
IUUC-Aor-009914	Aspergillus oryzae	33.27	6.00e-81	294.00
IUUC-Ate-010450	Aspergillus terreus	32.92	3.00e-81	295.00
IUUC-Ame-011183	Astyanax mexicanus	69.20	0.00e+00	797.00
IUUC-Bgr-012111	Blumeria graminis	33.52	2.00e-63	236.00
IUUC-Bta-012583	Bos taurus	80.68	0.00e+00	921.00
IUUC-Bci-013892	Botrytis cinerea	32.35	1.00e-60	227.00
IUUC-Bdi-014592	Brachypodium distachyon	42.02	3.00e-124	438.00
IUUC-Bol-016399	Brassica oleracea	40.23	3.00e-123	435.00
IUUC-Bra-018084	Brassica rapa	37.92	4.00e-115	408.00
IUUC-Cel-018456	Caenorhabditis elegans	36.30	3.00e-93	335.00
IUUC-Cja-020007	Callithrix jacchus	80.41	0.00e+00	918.00
IUUC-Cfa-020324	Canis familiaris	80.86	0.00e+00	927.00
IUUC-Cpo-022248	Cavia porcellus	54.43	1.00e-151	529.00
IUUC-Csa-023149	Chlorocebus sabaeus	77.07	0.00e+00	776.00
IUUC-Cho-024537	Choloepus hoffmanni	71.37	0.00e+00	693.00
IUUC-Cin-025763	Ciona intestinalis	50.94	1.00e-158	552.00
IUUC-Csv-026113	Ciona savignyi	47.69	4.00e-146	511.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	31.87	2.00e-66	246.00
IUUC-Cne-026884	Cryptococcus neoformans	30.99	7.00e-76	278.00
IUUC-Cme-027210	Cyanidioschyzon merolae	27.98	3.00e-20	93.20
IUUC-Dre-028140	Danio rerio	73.38	0.00e+00	840.00
IUUC-Dno-030033	Dasypus novemcinctus	80.25	0.00e+00	807.00
IUUC-Dor-030513	Dipodomys ordii	57.83	3.00e-97	348.00
IUUC-Dse-031536	Dothistroma septosporum	32.15	1.00e-80	293.00
IUUC-Dme-031683	Drosophila melanogaster	43.09	8.00e-126	443.00
IUUC-Ete-032420	Echinops telfairi	70.35	0.00e+00	766.00
IUUC-Eca-033992	Equus caballus	80.18	0.00e+00	768.00
IUUC-Eeu-034713	Erinaceus europaeus	67.72	4.00e-101	361.00
IUUC-Fca-036548	Felis catus	79.36	0.00e+00	907.00
IUUC-Fal-037600	Ficedula albicollis	76.70	0.00e+00	854.00
IUUC-Fox-038037	Fusarium oxysporum	33.16	5.00e-73	268.00
IUUC-Fso-038387	Fusarium solani	34.34	1.00e-78	287.00
IUUC-Gmo-038562	Gadus morhua	68.37	0.00e+00	795.00
IUUC-Ggr-040005	Gaeumannomyces graminis	32.44	1.00e-72	267.00
IUUC-Gga-041129	Gallus gallus	82.18	0.00e+00	916.00
IUUC-Gac-042558	Gasterosteus aculeatus	70.45	0.00e+00	804.00
IUUC-Gma-043610	Glycine max	39.35	3.00e-118	418.00
IUUC-Ggo-045611	Gorilla gorilla	80.04	0.00e+00	916.00
IUUC-Hsa-046563	Homo sapiens	80.11	0.00e+00	916.00
IUUC-Hvu-047790	Hordeum vulgare	37.85	5.00e-76	278.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	81.05	0.00e+00	923.00
IUUC-Kpa-049309	Komagataella pastoris	34.54	5.00e-81	295.00
IUUC-Lch-050038	Latimeria chalumnae	73.57	0.00e+00	838.00
IUUC-Lpe-051535	Leersia perrieri	41.08	2.00e-109	389.00
IUUC-Loc-051917	Lepisosteus oculatus	68.33	0.00e+00	762.00
IUUC-Lma-053112	Leptosphaeria maculans	32.69	2.00e-80	293.00
IUUC-Laf-053690	Loxodonta africana	80.11	0.00e+00	917.00
IUUC-Mcc-055117	Macaca mulatta	78.58	0.00e+00	899.00
IUUC-Meu-056761	Macropus eugenii	68.89	0.00e+00	749.00
IUUC-Mor-057230	Magnaporthe oryzae	32.38	9.00e-74	270.00
IUUC-Mpo-057514	Magnaporthe poae	32.33	9.00e-70	257.00
IUUC-Mtr-058551	Medicago truncatula	38.93	1.00e-115	410.00
IUUC-Mla-059183	Melampsora laricipopulina	37.43	5.00e-102	364.00
IUUC-Mga-060144	Meleagris gallopavo	80.27	0.00e+00	887.00
IUUC-Mvi-060221	Microbotryum violaceum	34.74	1.00e-79	290.00
IUUC-Mmr-061325	Microcebus murinus	80.22	0.00e+00	910.00
IUUC-Mdo-062532	Monodelphis domestica	81.27	0.00e+00	927.00
IUUC-Mmu-063956	Mus musculus	80.49	0.00e+00	920.00
IUUC-Mac-064521	Musa acuminata	39.06	6.00e-116	410.00
IUUC-Mpu-066716	Mustela putorius furo	79.88	0.00e+00	868.00
IUUC-Mlu-067459	Myotis lucifugus	77.53	0.00e+00	904.00
IUUC-Nfi-068245	Neosartorya fischeri	33.63	4.00e-79	288.00
IUUC-Ncr-068910	Neurospora crassa	33.45	6.00e-75	275.00
IUUC-Nle-070034	Nomascus leucogenys	78.67	0.00e+00	885.00
IUUC-Opr-070552	Ochotona princeps	73.25	0.00e+00	749.00
IUUC-Ont-071426	Oreochromis niloticus	71.48	0.00e+00	823.00
IUUC-Oan-073389	Ornithorhynchus anatinus	78.83	0.00e+00	729.00
IUUC-Ocu-074911	Oryctolagus cuniculus	79.55	0.00e+00	914.00
IUUC-Oba-075437	Oryza barthii	41.63	3.00e-112	399.00
IUUC-Obr-076684	Oryza brachyantha	40.87	5.00e-107	381.00
IUUC-Ogl-077170	Oryza glaberrima	41.63	3.00e-112	399.00
IUUC-Ogu-078844	Oryza glumaepatula	41.52	1.00e-104	373.00
IUUC-Oin-079105	Oryza indica	41.44	1.00e-111	396.00
IUUC-Olo-080943	Oryza longistaminata	38.88	5.00e-100	358.00
IUUC-Oni-082891	Oryza nivara	38.59	4.00e-106	378.00
IUUC-Opu-083457	Oryza punctata	41.63	6.00e-112	397.00
IUUC-Oru-084960	Oryza rufipogon	38.88	3.00e-100	358.00
IUUC-Osa-085358	Oryza sativa	41.41	3.00e-112	398.00
IUUC-Ola-086420	Oryzias latipes	68.90	5.00e-164	570.00
IUUC-Olu-087625	Ostreococcus lucimarinus	29.43	9.00e-58	218.00
IUUC-Oga-088810	Otolemur garnettii	79.92	0.00e+00	916.00
IUUC-Oar-089196	Ovis aries	80.22	0.00e+00	918.00
IUUC-Ptr-090617	Pan troglodytes	80.30	0.00e+00	918.00
IUUC-Pan-092761	Papio anubis	80.49	0.00e+00	922.00
IUUC-Psi-093191	Pelodiscus sinensis	85.69	0.00e+00	941.00
IUUC-Pma-094380	Petromyzon marinus	59.43	0.00e+00	644.00
IUUC-Pno-095084	Phaeosphaeria nodorum	31.26	4.00e-67	249.00
IUUC-Ppa-095798	Physcomitrella patens	39.06	8.00e-120	423.00
IUUC-Pfo-096467	Poecilia formosa	71.46	0.00e+00	807.00
IUUC-Pab-098255	Pongo abelii	79.05	0.00e+00	759.00
IUUC-Pop-099722	Populus trichocarpa	40.00	1.00e-119	422.00
IUUC-Pca-100807	Procavia capensis	67.17	6.00e-101	360.00
IUUC-Ppe-101280	Prunus persica	37.83	3.00e-116	412.00
IUUC-Pva-102333	Pteropus vampyrus	76.87	0.00e+00	866.00
IUUC-Pgr-103401	Puccinia graminis	31.56	3.00e-85	309.00
IUUC-Ptt-103889	Puccinia triticina	27.92	5.00e-63	235.00
IUUC-Pte-104355	Pyrenophora teres	32.32	3.00e-81	295.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	32.44	1.00e-81	297.00
IUUC-Rno-105810	Rattus norvegicus	80.68	0.00e+00	918.00
IUUC-Sce-106397	Saccharomyces cerevisiae	27.09	4.00e-38	152.00
IUUC-Sha-106770	Sarcophilus harrisii	79.93	1.00e-137	481.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	31.83	1.00e-75	277.00
IUUC-Spo-108276	Schizosaccharomyces pombe	34.65	1.00e-82	300.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	31.62	2.00e-64	239.00
IUUC-Smo-109296	Selaginella moellendorffii	40.53	2.00e-118	419.00
IUUC-Sit-110157	Setaria italica	42.51	2.00e-129	455.00
IUUC-Sly-111105	Solanum lycopersicum	38.50	5.00e-119	421.00
IUUC-Stu-112469	Solanum tuberosum	38.13	9.00e-119	420.00
IUUC-Sar-113083	Sorex araneus	62.40	0.00e+00	659.00
IUUC-Sbi-113813	Sorghum bicolor	43.18	8.00e-130	457.00
IUUC-Sre-115058	Sporisorium reilianum	37.55	3.00e-80	292.00
IUUC-Tgu-116772	Taeniopygia guttata	77.04	0.00e+00	855.00
IUUC-Tru-118686	Takifugu rubripes	70.34	0.00e+00	818.00
IUUC-Tsy-119111	Tarsius syrichta	72.70	6.00e-122	430.00
IUUC-Tni-120231	Tetraodon nigroviridis	65.22	0.00e+00	734.00
IUUC-Tca-121491	Theobroma cacao	38.83	3.00e-115	408.00
IUUC-Tre-122103	Trichoderma reesei	35.83	5.00e-83	301.00
IUUC-Tvi-122672	Trichoderma virens	34.93	1.00e-74	273.00
IUUC-Tae-125679	Triticum aestivum	41.63	7.00e-124	437.00
IUUC-Tur-126487	Triticum urartu	40.30	1.00e-117	416.00
IUUC-Tme-127097	Tuber melanosporum	36.31	9.00e-93	333.00
IUUC-Ttr-128465	Tursiops truncatus	74.63	0.00e+00	845.00
IUUC-Uma-129645	Ustilago maydis	36.67	3.00e-79	289.00
IUUC-Vda-129989	Verticillium dahliae	29.89	6.00e-56	211.00
IUUC-Vpa-130529	Vicugna pacos	76.91	0.00e+00	874.00
IUUC-Vvi-131059	Vitis vinifera	39.16	1.00e-117	416.00
IUUC-Xtr-132002	Xenopus tropicalis	74.10	0.00e+00	859.00
IUUC-Xma-133930	Xiphophorus maculatus	71.67	0.00e+00	810.00
IUUC-Yli-134505	Yarrowia lipolytica	32.23	1.00e-82	300.00
IUUC-Zma-135895	Zea mays	42.97	9.00e-128	450.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence