iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Atr-002644

Ensembl Protein ID

ERN17375

UniProt Accession

U5D564; U5D564_AMBTC

Genbank Protein ID

ERN17375.1

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

KI392350

Gene Name

AMTR_s00037p00181430

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AMTR_s00037p00181430	ERN17375	ERN17375

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	6.90e-109	365.2	8	514

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveaheesitele 101
           YDRQ+r+wGe++qe+l++a+++l+++g++G+E+lKnLvl+G+gsitv+D+++ve  +++++F+++ +++ +sKA++++++l+eln++v+++++ees+++l 
   Q: 8    YDRQLRIWGEQGQEALEKASICLLNCGPTGSETLKNLVLGGIGSITVIDGSKVEEGDMGNNFMVDLQSIAQSKAKCVCAFLQELNDSVRAKFVEESPEALI 108
           ***************************************************************************************************** PP
   S: 102  eeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctlketpn.........aaehtiew 189
           ++++ Ff++f++V++++  + + +k++++c+++++ li ++++Gl G vr++ik++ + + ++d   d++++++P+++lk++ +         ++++++++
   Q: 109  DTNPaFFQQFTLVIATQLLENSILKLDKICRQYNIMLIVARSYGLTGLVRISIKEHDVVDTKPDhflDDLRLNNPWPELKQFAEsidlyttdpVVHKHTPY 209
           **********************************************************************************99999999999******** PP
   S: 190  avlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfecdivtkskspfwv............... 274
           +v++ k++ee+a+++ ++ ++++eek+e+k++ ks++ s de+n++ea+e+++k   ++ i+    q+ ++ + +i  +s+ +fwv               
   Q: 210  VVILVKIVEEWASAHGGKFPSTREEKREFKELLKSKMISLDEDNYKEAMEASFKVSLPCGISPqLHQIVNDSSVEI-DSSSYNFWVlvaalkefieneggg 309
           ***************************************************************9*******77755.9*********************** PP
   S: 275  ............................................................sfcsnaealq...........vpekvekdeevvkasap... 301
                                                                       +fc+na++l              +  ++ +++++++++   
   Q: 310  epplegsipdmtslteyyislqkiyqskadadflaieqhvkgilkrigrdpdtilkttikNFCKNARKLMvcryrliedefNSPILTEVQKYLTDEDYsva 410
           **********************************************************************6666665555433777778888888888999 PP
   S: 302  ..lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiep.kldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknff 399
             +y+llra++rf ++++r pg ++ e+d+d   +l+t +a+ +  ++g+++  l++dli+e+++++ ++++t++a++gG+a+qE+iK+++++f pl  +f
   Q: 411  vgFYVLLRAVDRFTSNYNRFPGLFDGEMDED-TSRLKT-IAVGILNDMGCNGsSLSEDLISEMCRYGGAELHTVAAYIGGIASQEAIKLITKQFIPLTGTF 509
           99*****************************.888888.445566******************************************************** PP
   S: 400  lfdae 404
           +f+++
   Q: 510  IFNGI 514
           **986 PP

Organism

Amborella trichopoda

Functional Description
(View)

Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.

Protein Sequence
(Fasta)

MAEPKSKYDR QLRIWGEQGQ EALEKASICL LNCGPTGSET LKNLVLGGIG SITVIDGSKV 60
EEGDMGNNFM VDLQSIAQSK AKCVCAFLQE LNDSVRAKFV EESPEALIDT NPAFFQQFTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGAAC CGAAGAGCAA ATACGATCGT CAGCTCAGGT TCGCCTCCCC TCCCTCTTAC 60
TTTTTTTACT GAGTCATTCT CTATGCGCAC TATCACTAAC CAAGCATGTC GCTTCCCTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

KEGG

atr:18445714

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	69.20	0.00e+00	776.00
IUUC-Aml-002333	Ailuropoda melanoleuca	41.39	2.00e-123	435.00
IUUC-Apl-003446	Anas platyrhynchos	40.04	7.00e-113	399.00
IUUC-Aca-004450	Anolis carolinensis	39.58	7.00e-120	423.00
IUUC-Aly-005466	Arabidopsis lyrata	70.61	0.00e+00	811.00
IUUC-Ath-006692	Arabidopsis thaliana	71.56	0.00e+00	822.00
IUUC-Ago-007900	Ashbya gossypii	25.83	3.00e-35	141.00
IUUC-Acl-008333	Aspergillus clavatus	32.35	2.00e-68	252.00
IUUC-Afl-008529	Aspergillus flavus	33.45	3.00e-76	278.00
IUUC-Afu-009071	Aspergillus fumigatus	32.97	3.00e-70	258.00
IUUC-Ani-009443	Aspergillus nidulans	30.52	6.00e-63	234.00
IUUC-Ang-009669	Aspergillus niger	31.94	5.00e-72	264.00
IUUC-Aor-009914	Aspergillus oryzae	33.15	2.00e-74	271.00
IUUC-Ate-010450	Aspergillus terreus	33.52	3.00e-73	268.00
IUUC-Ame-011183	Astyanax mexicanus	38.79	4.00e-119	420.00
IUUC-Bgr-012111	Blumeria graminis	32.34	2.00e-63	235.00
IUUC-Bta-012583	Bos taurus	40.94	6.00e-124	436.00
IUUC-Bci-013892	Botrytis cinerea	31.23	2.00e-55	208.00
IUUC-Bdi-014592	Brachypodium distachyon	68.71	0.00e+00	771.00
IUUC-Bol-016399	Brassica oleracea	71.32	0.00e+00	817.00
IUUC-Bra-017506	Brassica rapa	69.33	0.00e+00	788.00
IUUC-Cel-018456	Caenorhabditis elegans	30.91	2.00e-71	261.00
IUUC-Cja-020007	Callithrix jacchus	40.93	7.00e-123	432.00
IUUC-Cfa-020324	Canis familiaris	41.54	5.00e-125	440.00
IUUC-Cpo-022248	Cavia porcellus	36.13	1.00e-64	239.00
IUUC-Csa-023149	Chlorocebus sabaeus	38.17	2.00e-95	341.00
IUUC-Cho-024537	Choloepus hoffmanni	34.35	2.00e-82	298.00
IUUC-Cin-025763	Ciona intestinalis	40.04	4.00e-111	394.00
IUUC-Csv-026113	Ciona savignyi	39.59	1.00e-105	375.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	30.04	9.00e-56	210.00
IUUC-Cne-026884	Cryptococcus neoformans	33.65	1.00e-72	266.00
IUUC-Cme-027210	Cyanidioschyzon merolae	22.59	1.00e-13	70.50
IUUC-Dre-028140	Danio rerio	40.30	7.00e-124	436.00
IUUC-Dno-030033	Dasypus novemcinctus	40.91	4.00e-106	377.00
IUUC-Dor-030513	Dipodomys ordii	51.82	2.00e-26	112.00
IUUC-Dse-031536	Dothistroma septosporum	32.43	7.00e-71	260.00
IUUC-Dme-031683	Drosophila melanogaster	38.39	4.00e-95	340.00
IUUC-Ete-032420	Echinops telfairi	37.96	5.00e-109	386.00
IUUC-Eca-033992	Equus caballus	38.95	2.00e-95	341.00
IUUC-Eeu-034713	Erinaceus europaeus	31.67	3.00e-34	138.00
IUUC-Fca-036548	Felis catus	40.90	3.00e-124	437.00
IUUC-Fal-037600	Ficedula albicollis	39.39	6.00e-114	403.00
IUUC-Fox-038037	Fusarium oxysporum	31.39	1.00e-63	236.00
IUUC-Fso-038387	Fusarium solani	32.19	7.00e-64	236.00
IUUC-Gmo-038562	Gadus morhua	39.05	4.00e-116	410.00
IUUC-Ggr-040005	Gaeumannomyces graminis	35.20	1.00e-55	209.00
IUUC-Gga-041129	Gallus gallus	40.15	7.00e-116	409.00
IUUC-Gac-042558	Gasterosteus aculeatus	39.77	5.00e-119	420.00
IUUC-Gma-043610	Glycine max	74.00	0.00e+00	822.00
IUUC-Ggo-045611	Gorilla gorilla	41.03	7.00e-122	429.00
IUUC-Hsa-046563	Homo sapiens	41.27	5.00e-123	433.00
IUUC-Hvu-047790	Hordeum vulgare	68.38	3.00e-162	563.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	40.94	1.00e-123	435.00
IUUC-Kpa-049309	Komagataella pastoris	35.65	1.00e-78	286.00
IUUC-Lch-050038	Latimeria chalumnae	39.59	7.00e-117	413.00
IUUC-Lpe-051535	Leersia perrieri	68.62	0.00e+00	701.00
IUUC-Loc-051917	Lepisosteus oculatus	38.10	4.00e-109	387.00
IUUC-Lma-053112	Leptosphaeria maculans	33.51	2.00e-75	275.00
IUUC-Laf-053690	Loxodonta africana	41.89	3.00e-125	441.00
IUUC-Mcc-055117	Macaca mulatta	40.26	1.00e-120	426.00
IUUC-Meu-056761	Macropus eugenii	33.58	6.00e-87	313.00
IUUC-Mor-057230	Magnaporthe oryzae	32.42	7.00e-64	236.00
IUUC-Mpo-057514	Magnaporthe poae	32.18	7.00e-63	233.00
IUUC-Mtr-058551	Medicago truncatula	69.94	0.00e+00	771.00
IUUC-Mla-059183	Melampsora laricipopulina	33.83	2.00e-85	308.00
IUUC-Mga-060144	Meleagris gallopavo	39.58	6.00e-113	399.00
IUUC-Mvi-060221	Microbotryum violaceum	33.40	6.00e-72	263.00
IUUC-Mmr-061325	Microcebus murinus	39.59	6.00e-120	423.00
IUUC-Mdo-062532	Monodelphis domestica	41.14	4.00e-122	430.00
IUUC-Mmu-063956	Mus musculus	40.75	4.00e-124	437.00
IUUC-Mac-064521	Musa acuminata	71.68	0.00e+00	810.00
IUUC-Mpu-066716	Mustela putorius furo	40.95	6.00e-116	410.00
IUUC-Mlu-067459	Myotis lucifugus	41.71	1.00e-125	442.00
IUUC-Nfi-068245	Neosartorya fischeri	32.48	2.00e-69	255.00
IUUC-Ncr-068910	Neurospora crassa	31.56	5.00e-65	240.00
IUUC-Nle-070034	Nomascus leucogenys	40.00	1.00e-118	418.00
IUUC-Opr-070552	Ochotona princeps	37.70	3.00e-96	344.00
IUUC-Ont-071426	Oreochromis niloticus	39.36	1.00e-121	428.00
IUUC-Oan-073389	Ornithorhynchus anatinus	39.46	3.00e-87	314.00
IUUC-Ocu-074911	Oryctolagus cuniculus	41.70	8.00e-126	442.00
IUUC-Oba-075437	Oryza barthii	71.98	0.00e+00	767.00
IUUC-Obr-076684	Oryza brachyantha	71.10	0.00e+00	725.00
IUUC-Ogl-077170	Oryza glaberrima	71.98	0.00e+00	767.00
IUUC-Ogu-078844	Oryza glumaepatula	70.62	0.00e+00	712.00
IUUC-Oin-079105	Oryza indica	71.79	0.00e+00	763.00
IUUC-Olo-080943	Oryza longistaminata	68.83	0.00e+00	689.00
IUUC-Oni-082891	Oryza nivara	69.48	0.00e+00	734.00
IUUC-Opu-083457	Oryza punctata	71.40	0.00e+00	758.00
IUUC-Oru-084960	Oryza rufipogon	68.75	0.00e+00	691.00
IUUC-Osa-085358	Oryza sativa	71.59	0.00e+00	760.00
IUUC-Ola-086420	Oryzias latipes	36.39	8.00e-75	272.00
IUUC-Olu-087625	Ostreococcus lucimarinus	29.07	5.00e-62	230.00
IUUC-Oga-088810	Otolemur garnettii	41.73	6.00e-125	439.00
IUUC-Oar-089196	Ovis aries	40.71	2.00e-122	431.00
IUUC-Ptr-090617	Pan troglodytes	41.27	2.00e-123	434.00
IUUC-Pan-092761	Papio anubis	41.32	9.00e-125	439.00
IUUC-Psi-093191	Pelodiscus sinensis	39.03	2.00e-115	407.00
IUUC-Pma-094380	Petromyzon marinus	39.72	6.00e-108	383.00
IUUC-Pno-095084	Phaeosphaeria nodorum	31.08	6.00e-60	225.00
IUUC-Ppa-095798	Physcomitrella patens	55.85	0.00e+00	646.00
IUUC-Pfo-096467	Poecilia formosa	38.97	6.00e-116	409.00
IUUC-Pab-098255	Pongo abelii	41.22	2.00e-102	364.00
IUUC-Pop-099722	Populus trichocarpa	76.67	0.00e+00	867.00
IUUC-Pca-100807	Procavia capensis	50.00	1.00e-51	196.00
IUUC-Ppe-101280	Prunus persica	77.06	0.00e+00	872.00
IUUC-Pva-102333	Pteropus vampyrus	40.19	6.00e-117	413.00
IUUC-Pgr-103401	Puccinia graminis	29.40	4.00e-73	268.00
IUUC-Ptt-103889	Puccinia triticina	28.40	8.00e-62	230.00
IUUC-Pte-104355	Pyrenophora teres	33.75	5.00e-72	264.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	35.01	9.00e-73	266.00
IUUC-Rno-105810	Rattus norvegicus	41.07	3.00e-123	434.00
IUUC-Sce-106397	Saccharomyces cerevisiae	26.04	9.00e-32	130.00
IUUC-Sha-106770	Sarcophilus harrisii	45.96	8.00e-70	255.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	32.25	5.00e-77	280.00
IUUC-Spo-108276	Schizosaccharomyces pombe	31.84	1.00e-79	288.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	31.45	1.00e-56	212.00
IUUC-Smo-109296	Selaginella moellendorffii	52.88	4.00e-168	583.00
IUUC-Sit-110157	Setaria italica	69.98	0.00e+00	804.00
IUUC-Sly-111105	Solanum lycopersicum	71.88	0.00e+00	832.00
IUUC-Stu-112469	Solanum tuberosum	72.63	0.00e+00	842.00
IUUC-Sar-113083	Sorex araneus	33.20	7.00e-84	303.00
IUUC-Sbi-113813	Sorghum bicolor	69.02	0.00e+00	799.00
IUUC-Sre-115058	Sporisorium reilianum	33.33	2.00e-62	232.00
IUUC-Tgu-116772	Taeniopygia guttata	40.61	1.00e-115	409.00
IUUC-Tru-118686	Takifugu rubripes	37.83	5.00e-118	417.00
IUUC-Tsy-119111	Tarsius syrichta	43.96	1.00e-62	232.00
IUUC-Tni-120231	Tetraodon nigroviridis	36.79	4.00e-104	370.00
IUUC-Tca-121491	Theobroma cacao	75.91	0.00e+00	822.00
IUUC-Tre-122103	Trichoderma reesei	31.55	7.00e-70	256.00
IUUC-Tvi-122672	Trichoderma virens	32.59	6.00e-67	247.00
IUUC-Tae-125316	Triticum aestivum	70.06	0.00e+00	783.00
IUUC-Tur-126487	Triticum urartu	68.67	0.00e+00	754.00
IUUC-Tme-127097	Tuber melanosporum	33.77	2.00e-74	271.00
IUUC-Ttr-128465	Tursiops truncatus	38.84	1.00e-110	392.00
IUUC-Uma-129645	Ustilago maydis	29.30	2.00e-67	249.00
IUUC-Vda-129989	Verticillium dahliae	27.62	2.00e-46	179.00
IUUC-Vpa-130529	Vicugna pacos	39.21	3.00e-113	400.00
IUUC-Vvi-131059	Vitis vinifera	78.59	0.00e+00	867.00
IUUC-Xtr-132002	Xenopus tropicalis	40.85	1.00e-122	432.00
IUUC-Xma-133930	Xiphophorus maculatus	39.46	1.00e-120	425.00
IUUC-Yli-134505	Yarrowia lipolytica	32.25	9.00e-80	289.00
IUUC-Zma-135895	Zea mays	68.33	0.00e+00	790.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence