iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-045436

UUCD1 version

UUC-GoG-00179

Ensembl Protein ID

ENSGGOP00000004088.2

UniProt Accession

G3QNH3; G3QNH3_GORGO

Protein Name

Uncharacterized protein

Gene Name

RFFL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000004166.2	ENSGGOT00000004188.2	ENSGGOP00000004088.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	100.00	0.00e+00	755.00	IUUC-Hsa-045798

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MWATCCNWFC LDGQPEEVPP PQGARMQAYS NPGYSSFPSP TGLEPSCKSC GAHFANTARK 60
QTCLDCKKNF CMTCSSQVGN GPRLCLLCQR FRATAFQREE LMKMKVKDLR DYLSLHDIST 120

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Nucleotide Sequence
(Fasta)

TTCCTGGGGC CGCCCGTGAG GATGTCGCGA CCGCCCCCGG GTGCCCCTCA GCCCCACAGA 60
CGCCGCCGCG GCGGAGTCCG CAGCCTCCCT GCCTGAGGCG TCCGCGGCCG GGATCCGGCC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001370--BIR_rpt
IPR003034--SAP_dom
IPR011011--Znf_FYVE_PHD
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0010008--C:endosome membrane
GO:0005886--C:plasma membrane
GO:0002947--C:tumor necrosis factor receptor superfamily complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:2001271--P:negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1901797--P:negative regulation of signal transduction by p53 class mediator
GO:0010804--P:negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

ggo:101131929

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001630	Ailuropoda melanoleuca	90.63	0.00e+00	637.00
IUUC-Apl-004124	Anas platyrhynchos	66.30	1.00e-125	442.00
IUUC-Aly-005548	Arabidopsis lyrata	47.06	1.00e-08	55.50
IUUC-Ame-011616	Astyanax mexicanus	59.67	8.00e-105	373.00
IUUC-Bta-012374	Bos taurus	85.95	0.00e+00	633.00
IUUC-Cja-019780	Callithrix jacchus	95.33	0.00e+00	688.00
IUUC-Cfa-021252	Canis familiaris	92.56	0.00e+00	647.00
IUUC-Cpo-022047	Cavia porcellus	91.46	0.00e+00	661.00
IUUC-Csa-023161	Chlorocebus sabaeus	98.35	0.00e+00	743.00
IUUC-Cho-024316	Choloepus hoffmanni	91.75	3.00e-157	547.00
IUUC-Cne-026858	Cryptococcus neoformans	25.15	7.00e-07	48.50
IUUC-Dre-028596	Danio rerio	55.92	3.00e-109	387.00
IUUC-Dno-029333	Dasypus novemcinctus	92.84	0.00e+00	670.00
IUUC-Ete-033163	Echinops telfairi	83.75	4.00e-166	577.00
IUUC-Eca-033994	Equus caballus	92.56	0.00e+00	679.00
IUUC-Eeu-035162	Erinaceus europaeus	86.67	3.00e-131	460.00
IUUC-Fca-036418	Felis catus	91.46	0.00e+00	694.00
IUUC-Fal-037427	Ficedula albicollis	65.40	1.00e-133	469.00
IUUC-Gga-041053	Gallus gallus	67.49	5.00e-132	463.00
IUUC-Hsa-045798	Homo sapiens	100.00	0.00e+00	755.00
IUUC-Itr-048077	Ictidomys tridecemlineatus	92.01	0.00e+00	649.00
IUUC-Lch-050639	Latimeria chalumnae	62.53	4.00e-126	444.00
IUUC-Laf-053355	Loxodonta africana	89.89	0.00e+00	629.00
IUUC-Mcc-055222	Macaca mulatta	97.80	0.00e+00	687.00
IUUC-Meu-056692	Macropus eugenii	77.96	1.00e-159	555.00
IUUC-Mga-059298	Meleagris gallopavo	66.39	6.00e-131	460.00
IUUC-Mmr-061792	Microcebus murinus	90.08	0.00e+00	641.00
IUUC-Mdo-062986	Monodelphis domestica	81.54	9.00e-171	592.00
IUUC-Mmu-063356	Mus musculus	89.53	0.00e+00	650.00
IUUC-Mpu-066273	Mustela putorius furo	91.74	0.00e+00	694.00
IUUC-Mlu-066953	Myotis lucifugus	91.46	0.00e+00	681.00
IUUC-Nle-070075	Nomascus leucogenys	98.62	0.00e+00	748.00
IUUC-Opr-070838	Ochotona princeps	89.53	0.00e+00	643.00
IUUC-Ont-071967	Oreochromis niloticus	50.96	7.00e-92	330.00
IUUC-Ocu-074807	Oryctolagus cuniculus	90.91	0.00e+00	681.00
IUUC-Obr-076159	Oryza brachyantha	41.07	4.00e-08	50.40
IUUC-Ola-086903	Oryzias latipes	48.40	6.00e-86	310.00
IUUC-Oga-088536	Otolemur garnettii	90.63	0.00e+00	630.00
IUUC-Oar-089838	Ovis aries	86.50	5.00e-179	620.00
IUUC-Ptr-090962	Pan troglodytes	99.72	0.00e+00	755.00
IUUC-Pan-092853	Papio anubis	97.80	0.00e+00	740.00
IUUC-Psi-093164	Pelodiscus sinensis	65.48	3.00e-127	447.00
IUUC-Pma-094104	Petromyzon marinus	44.65	3.00e-57	215.00
IUUC-Pno-094968	Phaeosphaeria nodorum	36.73	2.00e-08	56.20
IUUC-Pab-098304	Pongo abelii	99.17	0.00e+00	749.00
IUUC-Pca-100316	Procavia capensis	89.81	2.00e-178	617.00
IUUC-Ppe-101490	Prunus persica	37.80	1.00e-09	57.80
IUUC-Pva-102612	Pteropus vampyrus	77.96	1.00e-158	551.00
IUUC-Rno-105449	Rattus norvegicus	90.36	0.00e+00	649.00
IUUC-Sha-107578	Sarcophilus harrisii	80.44	4.00e-158	550.00
IUUC-Sar-113638	Sorex araneus	86.23	6.00e-176	609.00
IUUC-Ssc-116401	Sus scrofa	90.63	0.00e+00	685.00
IUUC-Tru-118765	Takifugu rubripes	49.59	1.00e-82	300.00
IUUC-Tsy-118850	Tarsius syrichta	90.43	1.00e-154	538.00
IUUC-Tbe-128086	Tupaia belangeri	85.12	0.00e+00	629.00
IUUC-Ttr-128249	Tursiops truncatus	69.42	3.00e-139	487.00
IUUC-Vpa-130816	Vicugna pacos	87.21	5.00e-41	160.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence