iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067884

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Nitric oxide synthase-interacting protein

Genbank Nucleotide ID

AAPE02063727

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000030656.1	ENSMLUT00000025753.1	ENSMLUP00000017728.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	1.40e-15	57.1	40	79

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk 41
           v ++ +C +sl++ +dPvv+p+G+ y+r++I +++ +++k
   Q: 40   VKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKK 79
           567789*****************************98887 PP

Organism

Myotis lucifugus

Functional Description
(View)

Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.

Protein Sequence
(Fasta)

MTRHGKNCTA GAVYTYHEKK KDTAASGYGT QNIRLSRDAV KDFDCCCLSL QPCHDPVVTP 60
DGYLYEREAI LEYILHQKKE IARQLKAYEK QRGARREERK ELQRAATQDQ VRGFLEKEAA 120

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Nucleotide Sequence
(Fasta)

ATGACGCGGC ACGGCAAGAA CTGTACGGCG GGGGCCGTCT ACACCTACCA CGAGAAGAAG 60
AAGGACACAG GTACTGGGTG GGAGGGGACA GATGCGTCTC GAAGCCACCG TCTCGCTTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR016818--Nitric_oxide_synth-interacting
IPR031790--Znf-NOSIP
IPR013083--Znf_RING/FYVE/PHD

Pfam

PF15906--zf-NOSIP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0050999--P:regulation of nitric-oxide synthase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Acl-008175	Aspergillus clavatus	33.63	9.00e-06	44.70
IUUC-Afl-008440	Aspergillus flavus	33.33	1.00e-05	43.90
IUUC-Afu-009012	Aspergillus fumigatus	34.21	6.00e-06	45.10
IUUC-Ani-009153	Aspergillus nidulans	29.84	3.50e-02	32.70
IUUC-Ang-009556	Aspergillus niger	33.33	2.00e-05	43.50
IUUC-Aor-009892	Aspergillus oryzae	33.33	1.00e-05	43.90
IUUC-Cne-026827	Cryptococcus neoformans	36.36	1.00e-06	47.40
IUUC-Nfi-068440	Neosartorya fischeri	34.21	7.00e-06	45.10
IUUC-Olo-080545	Oryza longistaminata	31.42	4.00e-28	119.00
IUUC-Pno-094830	Phaeosphaeria nodorum	34.31	9.00e-09	54.30
IUUC-Tre-122037	Trichoderma reesei	36.36	3.00e-08	52.80

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence