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Tag Content
iUUCD ID IUUC-Ssl-108571
Ensembl Protein ID EDO03394
UniProt Accession A7EKM8; LIS1_SCLS1
Genbank Protein ID EDO03394.1
Protein Name Nuclear distribution protein PAC1; Lissencephaly-1 homolog; nudF homolog
Genbank Nucleotide ID CH476627
Gene Name pac1; lis1; SS1G_05875
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SS1G_05875 EDO03394 EDO03394
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.40e-48 159.8 200 247
UBD/Beta-Prp 2.00e-62 210.1 113 406
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.........sd.tllvsGsdDgtikvWDlrtgvllks 38
    gH sv++++f s+ +llvs+s+D+t+++WD++tg ++k+
   Q: 200 GHDHSVSAVRFipsgaagspSSgNLLVSASRDKTLRIWDVSTGYCVKT 247
    8******************8557********************99875 PP
   


   UBD/Beta-Prp

   S: 8    hhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk..ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfsp. 104
    +h + itcv+f+p s la+gs+d tik+wd++ g l +++gh+ +v +v+f + +l+++s+D tik+wd+s ++k ++tl gh++sv +++f p
   Q: 113 SHREAITCVAFHPVFSSLASGSEDCTIKIWDWELGELELTVKGHTRAVLDVDFGGPRGgtLLASCSSDLTIKLWDPSdQYKNIRTLPGHDHSVSAVRFIPs 213
    67789************************************************8544446**************887699******************999 PP
   S: 105 .......sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsng...... 192
    sg+ lvs+s+d+t+r+wd++tg+c++ t +gh ++v+ v+ + dg+ l s++ D+t r+Wd ++g+ tl g h++ +++ f +
   Q: 214 gaagspsSGNLLVSASRDKTLRIWDVSTGYCVK-TVRGHADWVRDVAPSYDGRWLLSAGVDQTARIWDASSGEPKATLLG-HENTIECCVFAPPAsyphla 312
    999999888************************.*********************************************9.*********88877788888 PP
   S: 193 ...............kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdl.rsgdllktlqlhnssvisva 271
    +++++g++d+++++wd +g+ ++tl+gh+++++ + f+p +++l+s+++D+++r+Wdl + g+++kt++ + +++s+
   Q: 313 amaglkkppaasssaEYIATGARDKSIRIWDA-RGTLIKTLIGHDNWIRALVFHPGGKYLLSVADDRTLRCWDLaQEGKCVKTISDAHGHFVSCM 406
    888888888888888****************9.7889************************************85689*********98777765 PP
   

Organism Sclerotinia sclerotiorum
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
Protein Sequence
(Fasta)
MSQLLTSRQA EELHKSMIAY LNSANLLHSA ATLREELDIG ESFDSATSKK YEGLLEKKWT 60
SVVRLQKKIM DLESRNAALQ SEIDNATPTS LSNRNTDPTA WLPKSPARHN LQSHREAITC 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Ssl-108571|E3,WD_repeat;UBD,Beta-Prp|Sclerotinia sclerotiorum
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAGCCAAC TTCTGACGTC GCGGCAGGCC GAGGAGCTGT GAGTTGAGCT TATCTTCATC 60
ACATTCTCTA GATGGCTAAT ATTACTCCGC AGGCACAAGT CTATGATAGC ATACCTTAAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Ssl-108571|E3,WD_repeat;UBD,Beta-Prp|Sclerotinia sclerotiorum
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005938--C:cell cortex
GO:0000776--C:kinetochore
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0000922--C:spindle pole
GO:0008017--F:microtubule binding
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0031023--P:microtubule organizing center organization
GO:0007067--P:mitotic nuclear division
GO:0007097--P:nuclear migration
GO:2000574--P:regulation of microtubule motor activity
GO:0000003--P:reproduction
GO:0047496--P:vesicle transport along microtubule

KEGG ssl:SS1G_05875
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 44.58 7.00e-99 351.00
IUUC-Apl-004024 Anas platyrhynchos 44.71 2.00e-102 363.00
IUUC-Aca-004564 Anolis carolinensis 44.23 7.00e-100 355.00
IUUC-Ago-007862 Ashbya gossypii 26.97 1.00e-36 145.00
IUUC-Acl-008360 Aspergillus clavatus 77.54 0.00e+00 655.00
IUUC-Afl-008502 Aspergillus flavus 64.78 3.00e-164 568.00
IUUC-Afu-008848 Aspergillus fumigatus 76.43 0.00e+00 689.00
IUUC-Ani-009173 Aspergillus nidulans 65.41 1.00e-169 587.00
IUUC-Ang-009873 Aspergillus niger 65.06 6.00e-167 577.00
IUUC-Aor-009973 Aspergillus oryzae 61.50 2.00e-157 546.00
IUUC-Ate-010523 Aspergillus terreus 62.67 3.00e-170 588.00
IUUC-Ame-010969 Astyanax mexicanus 45.57 6.00e-103 365.00
IUUC-Bgr-011972 Blumeria graminis 74.60 0.00e+00 704.00
IUUC-Bta-013106 Bos taurus 44.71 3.00e-102 362.00
IUUC-Bci-013615 Botrytis cinerea 95.55 0.00e+00 861.00
IUUC-Cel-018459 Caenorhabditis elegans 42.37 5.00e-92 328.00
IUUC-Cja-018755 Callithrix jacchus 44.36 2.00e-99 353.00
IUUC-Cfa-020749 Canis familiaris 44.71 3.00e-102 362.00
IUUC-Cpo-022371 Cavia porcellus 44.71 3.00e-102 362.00
IUUC-Csa-023524 Chlorocebus sabaeus 44.54 5.00e-85 305.00
IUUC-Cho-024764 Choloepus hoffmanni 43.21 3.00e-85 306.00
IUUC-Cin-025753 Ciona intestinalis 44.02 6.00e-94 335.00
IUUC-Csv-025817 Ciona savignyi 43.06 7.00e-98 348.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 77.88 0.00e+00 671.00
IUUC-Cne-027087 Cryptococcus neoformans 52.80 5.00e-115 405.00
IUUC-Dre-028314 Danio rerio 45.07 2.00e-102 363.00
IUUC-Dno-029050 Dasypus novemcinctus 44.71 3.00e-102 362.00
IUUC-Dor-030222 Dipodomys ordii 42.41 5.00e-94 335.00
IUUC-Dse-031164 Dothistroma septosporum 68.87 0.00e+00 636.00
IUUC-Dme-031745 Drosophila melanogaster 44.72 1.00e-94 337.00
IUUC-Ete-032508 Echinops telfairi 45.85 2.00e-69 253.00
IUUC-Eca-034288 Equus caballus 44.09 1.00e-97 347.00
IUUC-Eeu-034984 Erinaceus europaeus 42.17 6.00e-93 332.00
IUUC-Fca-036498 Felis catus 44.71 3.00e-102 362.00
IUUC-Fal-036920 Ficedula albicollis 44.71 2.00e-102 363.00
IUUC-Fox-037996 Fusarium oxysporum 70.41 0.00e+00 656.00
IUUC-Fso-038160 Fusarium solani 68.43 8.00e-180 620.00
IUUC-Gmo-038983 Gadus morhua 45.19 3.00e-103 366.00
IUUC-Ggr-040051 Gaeumannomyces graminis 68.03 0.00e+00 627.00
IUUC-Gga-040623 Gallus gallus 44.71 2.00e-102 363.00
IUUC-Gac-041613 Gasterosteus aculeatus 45.19 6.00e-103 365.00
IUUC-Ggo-045410 Gorilla gorilla 41.35 3.00e-83 299.00
IUUC-Hsa-046358 Homo sapiens 44.71 2.00e-102 363.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 44.71 3.00e-102 362.00
IUUC-Kpa-049351 Komagataella pastoris 29.91 9.00e-47 179.00
IUUC-Lch-049936 Latimeria chalumnae 44.95 5.00e-103 365.00
IUUC-Loc-052476 Lepisosteus oculatus 45.07 4.00e-99 352.00
IUUC-Lma-053170 Leptosphaeria maculans 80.52 0.00e+00 684.00
IUUC-Laf-053713 Loxodonta africana 43.88 5.00e-100 355.00
IUUC-Mcc-054628 Macaca mulatta 44.71 5.00e-102 362.00
IUUC-Meu-055927 Macropus eugenii 38.27 2.00e-50 190.00
IUUC-Mor-056962 Magnaporthe oryzae 70.78 0.00e+00 651.00
IUUC-Mpo-057583 Magnaporthe poae 67.35 9.00e-173 597.00
IUUC-Mla-058819 Melampsora laricipopulina 50.24 1.00e-115 407.00
IUUC-Mga-059945 Meleagris gallopavo 44.47 4.00e-102 362.00
IUUC-Mvi-060403 Microbotryum violaceum 53.28 1.00e-129 454.00
IUUC-Mmr-061289 Microcebus murinus 44.20 4.00e-99 352.00
IUUC-Mdo-061912 Monodelphis domestica 44.95 4.00e-102 362.00
IUUC-Mmu-063253 Mus musculus 44.71 3.00e-102 362.00
IUUC-Mpu-066638 Mustela putorius furo 44.71 3.00e-102 362.00
IUUC-Mlu-067267 Myotis lucifugus 43.86 2.00e-99 353.00
IUUC-Nfi-068571 Neosartorya fischeri 72.88 0.00e+00 634.00
IUUC-Ncr-068895 Neurospora crassa 75.51 0.00e+00 657.00
IUUC-Nle-069087 Nomascus leucogenys 43.91 9.00e-83 297.00
IUUC-Opr-070579 Ochotona princeps 44.71 3.00e-102 362.00
IUUC-Ont-072432 Oreochromis niloticus 44.95 4.00e-102 362.00
IUUC-Oan-073072 Ornithorhynchus anatinus 44.71 3.00e-102 362.00
IUUC-Ocu-074180 Oryctolagus cuniculus 44.71 3.00e-102 362.00
IUUC-Ola-086815 Oryzias latipes 44.95 2.00e-103 366.00
IUUC-Oga-088219 Otolemur garnettii 43.88 4.00e-100 355.00
IUUC-Oar-090394 Ovis aries 44.71 3.00e-102 362.00
IUUC-Ptr-091517 Pan troglodytes 44.71 3.00e-102 362.00
IUUC-Pan-092421 Papio anubis 44.71 5.00e-102 362.00
IUUC-Psi-093370 Pelodiscus sinensis 44.71 4.00e-102 362.00
IUUC-Pma-094319 Petromyzon marinus 45.01 2.00e-86 310.00
IUUC-Pno-094815 Phaeosphaeria nodorum 77.28 0.00e+00 685.00
IUUC-Pfo-097089 Poecilia formosa 45.91 7.00e-104 368.00
IUUC-Pab-098421 Pongo abelii 44.71 3.00e-102 362.00
IUUC-Pca-100120 Procavia capensis 37.18 1.00e-57 214.00
IUUC-Pva-102960 Pteropus vampyrus 44.47 8.00e-101 358.00
IUUC-Pgr-103538 Puccinia graminis 51.32 2.00e-119 419.00
IUUC-Ptt-103990 Puccinia triticina 43.08 2.00e-45 175.00
IUUC-Pte-104261 Pyrenophora teres 77.52 0.00e+00 691.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 77.75 0.00e+00 692.00
IUUC-Rno-105123 Rattus norvegicus 44.71 3.00e-102 362.00
IUUC-Sce-106208 Saccharomyces cerevisiae 26.99 4.00e-37 146.00
IUUC-Sha-107010 Sarcophilus harrisii 44.95 2.00e-102 363.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 36.52 1.00e-68 251.00
IUUC-Sar-113309 Sorex araneus 43.84 3.00e-96 343.00
IUUC-Sre-115003 Sporisorium reilianum 50.23 1.00e-122 431.00
IUUC-Ssc-116148 Sus scrofa 44.71 3.00e-102 362.00
IUUC-Tgu-117299 Taeniopygia guttata 44.47 1.00e-101 360.00
IUUC-Tru-117721 Takifugu rubripes 44.95 8.00e-103 364.00
IUUC-Tsy-119493 Tarsius syrichta 44.95 2.00e-101 360.00
IUUC-Tni-120355 Tetraodon nigroviridis 45.19 5.00e-102 362.00
IUUC-Tre-121977 Trichoderma reesei 68.14 1.00e-173 600.00
IUUC-Tvi-122661 Trichoderma virens 69.10 9.00e-174 600.00
IUUC-Tme-127031 Tuber melanosporum 68.62 1.00e-177 613.00
IUUC-Tbe-127492 Tupaia belangeri 38.95 7.00e-47 179.00
IUUC-Ttr-128929 Tursiops truncatus 44.71 6.00e-102 362.00
IUUC-Uma-129347 Ustilago maydis 50.44 1.00e-124 437.00
IUUC-Vda-129837 Verticillium dahliae 76.02 0.00e+00 644.00
IUUC-Vpa-130532 Vicugna pacos 39.51 2.00e-82 296.00
IUUC-Xtr-131985 Xenopus tropicalis 44.47 7.00e-102 361.00
IUUC-Xma-133314 Xiphophorus maculatus 45.67 1.00e-103 367.00
IUUC-Yli-134403 Yarrowia lipolytica 44.62 1.00e-96 344.00
Created Date 25-Jun-2017

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