iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052472

Ensembl Protein ID

ENSLOCP00000018265.1

UniProt Accession

W5NCA6; W5NCA6_LEPOC

Genbank Protein ID

ENSLOCP00000018265

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHAT01006321

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000014797.1	ENSLOCT00000018297.1	ENSLOCP00000018265.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.80e-122	407.2	3935	4269
UBD/Alpha-Helix/UBA	5.30e-08	32.9	1362	1399

Active Site

Position(s)	Description	Evidence
4237	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           ++++k+rl++ f+gEeg+d+gG+ re++  +s+e++np++ lf++s++d+ t+++np+s + np+hl++F+f+Gr+++ka++d+rll
   Q: 3935 PEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHC-NPNHLSYFKFVGRVVAKAVYDNRLL 4020
           6799*******************************************************86.99*********************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           ++ +++sfyk++lgk++ + d+e+ d ++y+ l +++en   d+++lg +ltfs++ +++g +++++Lkp+G+ni Vt+eNk+eYv+
   Q: 4021 ECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLEN---DVSTLGYELTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVH 4104
           *************************************99...********************************************* PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           lv++++++  i++q++af eGf+e+ip++l+s+Fte+elelli+G ++id++dlk++t+y++ y+++s +iqwFw++l++f++ +r+
   Q: 4105 LVCQMKMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKANTEYHK-YQSSSIQIQWFWRALRSFDQADRA 4190
           ************************************************************66.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           +fLqFvTg+s++Pl+Gfa+l+     ++f+i++ d+s+drlPs++TCfn+L+LP Y+s+e+l+++Ll+Ai+e+ +gF+l
   Q: 4191 KFLQFVTGTSKVPLQGFAALEgmngIQKFQIHRdDRSTDRLPSAHTCFNQLDLPAYESYEKLRHMLLLAIQECsEGFGL 4269
           *********************99998999999988899***************************************97 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ++++l+ql++MGF+re+a +aL++   + e A+eyLl++
   Q: 1362 NQQQLQQLMDMGFTREHAMEALLN-TSTMEQATEYLLTH 1399
           89**********************.7***********98 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MKVDRSKLKK TPTEAPADCR TLIDKLKACS DEQLLLELQQ IKTWNIGKCE LYHWVDLLDR 60
FDGILCDAGQ TVENMSWMLV CDRPENGQLK SLLLGVLNFT ALLIEYSFSR HLYSSIEHLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAAGTAG ACAGAAGCAA GTTAAAGAAG ACCCCCACAG AGGCGGTGAG TCTTTGATGT 60
CTTTCACTTT CCCTTTGCAC CTCTTTCTCT CCACCTCTTC TACAGCCCCT TTTACTGTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like
IPR004170--WWE-dom

PROSITE

PS50237--HECT
PS50030--UBA
PS50918--WWE

Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT
PF00627--UBA
PF02825--WWE

SMART

SM00119--HECTc
SM00165--UBA

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	46.95	2.00e-106	382.00
IUUC-Aml-001684	Ailuropoda melanoleuca	84.16	0.00e+00	3820.00
IUUC-Atr-003044	Amborella trichopoda	52.69	1.00e-125	446.00
IUUC-Apl-003729	Anas platyrhynchos	92.42	0.00e+00	688.00
IUUC-Aca-005263	Anolis carolinensis	84.39	0.00e+00	3813.00
IUUC-Aly-006083	Arabidopsis lyrata	51.55	8.00e-126	447.00
IUUC-Ath-007472	Arabidopsis thaliana	51.55	4.00e-126	447.00
IUUC-Ago-008005	Ashbya gossypii	47.61	2.00e-131	465.00
IUUC-Acl-008254	Aspergillus clavatus	47.33	8.00e-135	476.00
IUUC-Afl-008712	Aspergillus flavus	47.14	3.00e-136	479.00
IUUC-Afu-009022	Aspergillus fumigatus	46.95	4.00e-134	474.00
IUUC-Ani-009412	Aspergillus nidulans	47.52	5.00e-136	480.00
IUUC-Ang-009771	Aspergillus niger	46.95	4.00e-135	478.00
IUUC-Aor-010186	Aspergillus oryzae	46.45	3.00e-126	446.00
IUUC-Ate-010253	Aspergillus terreus	47.04	3.00e-135	478.00
IUUC-Ame-011067	Astyanax mexicanus	86.74	0.00e+00	3893.00
IUUC-Bgr-012043	Blumeria graminis	47.80	5.00e-140	494.00
IUUC-Bta-012813	Bos taurus	84.12	0.00e+00	3831.00
IUUC-Bci-013995	Botrytis cinerea	46.85	2.00e-138	488.00
IUUC-Bdi-014884	Brachypodium distachyon	51.99	7.00e-127	450.00
IUUC-Bol-016533	Brassica oleracea	58.33	6.00e-90	323.00
IUUC-Bra-016637	Brassica rapa	50.56	5.00e-123	437.00
IUUC-Cel-018179	Caenorhabditis elegans	62.30	0.00e+00	647.00
IUUC-Cja-018741	Callithrix jacchus	84.28	0.00e+00	3814.00
IUUC-Cfa-020083	Canis familiaris	84.86	0.00e+00	3855.00
IUUC-Cpo-021923	Cavia porcellus	83.48	0.00e+00	3793.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	49.19	2.00e-119	422.00
IUUC-Csa-023853	Chlorocebus sabaeus	84.00	0.00e+00	3828.00
IUUC-Cho-024718	Choloepus hoffmanni	98.40	0.00e+00	803.00
IUUC-Cin-025627	Ciona intestinalis	41.57	0.00e+00	1873.00
IUUC-Csv-025824	Ciona savignyi	47.07	0.00e+00	1411.00
IUUC-Cgl-026647	Colletotrichum gloeosporioides	44.88	7.00e-137	483.00
IUUC-Cne-027095	Cryptococcus neoformans	42.07	2.00e-104	375.00
IUUC-Cme-027267	Cyanidioschyzon merolae	50.48	5.00e-116	413.00
IUUC-Dre-028525	Danio rerio	87.86	0.00e+00	3847.00
IUUC-Dno-029680	Dasypus novemcinctus	83.39	0.00e+00	3759.00
IUUC-Dor-030902	Dipodomys ordii	84.52	0.00e+00	1075.00
IUUC-Dse-031197	Dothistroma septosporum	46.65	4.00e-138	488.00
IUUC-Dme-032122	Drosophila melanogaster	69.64	0.00e+00	790.00
IUUC-Ete-032690	Echinops telfairi	83.08	0.00e+00	842.00
IUUC-Eca-033915	Equus caballus	83.67	0.00e+00	3795.00
IUUC-Eeu-034963	Erinaceus europaeus	81.17	0.00e+00	2616.00
IUUC-Fca-035824	Felis catus	84.24	0.00e+00	3828.00
IUUC-Fox-037756	Fusarium oxysporum	47.43	6.00e-138	487.00
IUUC-Fso-038464	Fusarium solani	54.72	1.00e-137	486.00
IUUC-Gmo-039073	Gadus morhua	85.19	0.00e+00	3771.00
IUUC-Ggr-039946	Gaeumannomyces graminis	46.37	2.00e-135	478.00
IUUC-Gga-040309	Gallus gallus	97.73	0.00e+00	647.00
IUUC-Gac-042430	Gasterosteus aculeatus	85.74	0.00e+00	3858.00
IUUC-Gma-044247	Glycine max	52.22	1.00e-125	446.00
IUUC-Ggo-044785	Gorilla gorilla	84.05	0.00e+00	3796.00
IUUC-Hsa-046879	Homo sapiens	84.09	0.00e+00	3806.00
IUUC-Hvu-047697	Hordeum vulgare	51.99	3.00e-127	451.00
IUUC-Itr-048430	Ictidomys tridecemlineatus	94.71	0.00e+00	1068.00
IUUC-Kpa-049228	Komagataella pastoris	48.66	7.00e-140	493.00
IUUC-Lch-050252	Latimeria chalumnae	82.84	0.00e+00	3158.00
IUUC-Lpe-051550	Leersia perrieri	51.38	2.00e-127	452.00
IUUC-Lma-053159	Leptosphaeria maculans	46.49	2.00e-136	481.00
IUUC-Laf-054154	Loxodonta africana	83.48	0.00e+00	3782.00
IUUC-Mcc-055085	Macaca mulatta	84.79	0.00e+00	3830.00
IUUC-Meu-056727	Macropus eugenii	85.04	0.00e+00	1764.00
IUUC-Mor-057201	Magnaporthe oryzae	46.87	5.00e-136	480.00
IUUC-Mpo-057597	Magnaporthe poae	45.99	7.00e-134	473.00
IUUC-Mtr-058088	Medicago truncatula	52.93	8.00e-127	450.00
IUUC-Mla-058888	Melampsora laricipopulina	49.87	2.00e-117	415.00
IUUC-Mvi-060320	Microbotryum violaceum	49.53	1.00e-122	436.00
IUUC-Mmr-060820	Microcebus murinus	84.36	0.00e+00	3829.00
IUUC-Mdo-062930	Monodelphis domestica	84.09	0.00e+00	3794.00
IUUC-Mmu-063601	Mus musculus	83.84	0.00e+00	3712.00
IUUC-Mac-065557	Musa acuminata	52.09	6.00e-119	424.00
IUUC-Mpu-066653	Mustela putorius furo	82.44	0.00e+00	3689.00
IUUC-Mlu-067418	Myotis lucifugus	84.08	0.00e+00	3865.00
IUUC-Nfi-068278	Neosartorya fischeri	47.14	1.00e-134	476.00
IUUC-Ncr-068813	Neurospora crassa	47.52	2.00e-137	486.00
IUUC-Nle-069418	Nomascus leucogenys	83.92	0.00e+00	3786.00
IUUC-Opr-070187	Ochotona princeps	78.32	0.00e+00	845.00
IUUC-Ont-071300	Oreochromis niloticus	86.43	0.00e+00	3838.00
IUUC-Oan-073046	Ornithorhynchus anatinus	75.69	0.00e+00	4137.00
IUUC-Ocu-074178	Oryctolagus cuniculus	83.84	0.00e+00	3836.00
IUUC-Oba-075757	Oryza barthii	51.38	9.00e-128	453.00
IUUC-Obr-076553	Oryza brachyantha	51.38	8.00e-127	450.00
IUUC-Ogl-077520	Oryza glaberrima	51.38	1.00e-127	453.00
IUUC-Ogu-078278	Oryza glumaepatula	51.38	1.00e-127	453.00
IUUC-Oin-079767	Oryza indica	51.38	1.00e-127	452.00
IUUC-Olo-080380	Oryza longistaminata	50.91	6.00e-126	447.00
IUUC-Ome-081925	Oryza meridionalis	50.91	5.00e-126	447.00
IUUC-Oni-082619	Oryza nivara	51.38	9.00e-128	453.00
IUUC-Opu-083684	Oryza punctata	50.91	4.00e-126	447.00
IUUC-Oru-084501	Oryza rufipogon	51.38	1.00e-127	453.00
IUUC-Osa-086251	Oryza sativa	51.38	3.00e-126	446.00
IUUC-Ola-087437	Oryzias latipes	85.28	0.00e+00	2148.00
IUUC-Olu-087813	Ostreococcus lucimarinus	50.75	3.00e-114	405.00
IUUC-Oga-088903	Otolemur garnettii	83.80	0.00e+00	3788.00
IUUC-Oar-090210	Ovis aries	84.64	0.00e+00	3841.00
IUUC-Ptr-090502	Pan troglodytes	83.79	0.00e+00	2896.00
IUUC-Pan-092368	Papio anubis	83.64	0.00e+00	3848.00
IUUC-Pma-094246	Petromyzon marinus	72.30	0.00e+00	1261.00
IUUC-Pno-094871	Phaeosphaeria nodorum	52.44	3.00e-134	474.00
IUUC-Ppa-095657	Physcomitrella patens	51.58	2.00e-125	445.00
IUUC-Pfo-096232	Poecilia formosa	86.11	0.00e+00	3862.00
IUUC-Pab-098583	Pongo abelii	84.04	0.00e+00	3804.00
IUUC-Pop-099613	Populus trichocarpa	53.40	2.00e-128	455.00
IUUC-Pca-100310	Procavia capensis	71.75	0.00e+00	1445.00
IUUC-Ppe-102109	Prunus persica	52.69	5.00e-127	451.00
IUUC-Pva-102116	Pteropus vampyrus	83.84	0.00e+00	3834.00
IUUC-Pgr-103465	Puccinia graminis	44.53	4.00e-128	454.00
IUUC-Ptt-103813	Puccinia triticina	42.23	5.00e-116	414.00
IUUC-Pte-104018	Pyrenophora teres	52.06	7.00e-133	470.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	52.08	9.00e-133	469.00
IUUC-Rno-105889	Rattus norvegicus	77.54	0.00e+00	3350.00
IUUC-Sce-106449	Saccharomyces cerevisiae	44.75	1.00e-127	452.00
IUUC-Sha-106961	Sarcophilus harrisii	83.48	0.00e+00	3775.00
IUUC-Sja-107814	Schizosaccharomyces japonicus	45.98	2.00e-128	455.00
IUUC-Spo-108024	Schizosaccharomyces pombe	47.02	6.00e-131	463.00
IUUC-Smo-109428	Selaginella moellendorffii	51.32	1.00e-130	462.00
IUUC-Sit-110598	Setaria italica	52.46	2.00e-127	452.00
IUUC-Sly-111285	Solanum lycopersicum	53.40	6.00e-128	454.00
IUUC-Stu-112582	Solanum tuberosum	32.92	7.00e-57	215.00
IUUC-Sar-113291	Sorex araneus	78.84	0.00e+00	2326.00
IUUC-Sbi-114042	Sorghum bicolor	52.46	7.00e-128	453.00
IUUC-Sre-114958	Sporisorium reilianum	55.79	1.00e-137	483.00
IUUC-Ssc-115754	Sus scrofa	84.08	0.00e+00	3817.00
IUUC-Tru-118570	Takifugu rubripes	85.14	0.00e+00	3871.00
IUUC-Tsy-119159	Tarsius syrichta	86.64	0.00e+00	1739.00
IUUC-Tni-120836	Tetraodon nigroviridis	81.45	0.00e+00	2112.00
IUUC-Tca-121479	Theobroma cacao	51.29	2.00e-124	442.00
IUUC-Tre-121909	Trichoderma reesei	54.12	1.00e-134	476.00
IUUC-Tvi-122370	Trichoderma virens	53.88	1.00e-134	476.00
IUUC-Tae-125214	Triticum aestivum	51.04	2.00e-125	444.00
IUUC-Tme-127172	Tuber melanosporum	47.61	2.00e-138	488.00
IUUC-Tbe-127506	Tupaia belangeri	77.41	0.00e+00	1225.00
IUUC-Ttr-129253	Tursiops truncatus	74.87	0.00e+00	1824.00
IUUC-Uma-129355	Ustilago maydis	49.24	2.00e-138	486.00
IUUC-Vda-129886	Verticillium dahliae	48.28	2.00e-139	492.00
IUUC-Vpa-130708	Vicugna pacos	82.02	0.00e+00	3333.00
IUUC-Vvi-131170	Vitis vinifera	53.16	5.00e-128	452.00
IUUC-Xtr-132123	Xenopus tropicalis	81.95	0.00e+00	3684.00
IUUC-Xma-133869	Xiphophorus maculatus	85.96	0.00e+00	3875.00
IUUC-Yli-134657	Yarrowia lipolytica	46.07	3.00e-130	461.00
IUUC-Zma-135570	Zea mays	51.38	1.00e-127	452.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence