iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003787

Ensembl Protein ID

ENSAPLP00000004086.1

UniProt Accession

U3IA15; U3IA15_ANAPL

Genbank Protein ID

ENSAPLP00000004086

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01128083

Gene Name

KDM2B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000004534.1	ENSAPLT00000004694.1	ENSAPLP00000004086.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	2.80e-14	52.7	560	625
E3 adaptor/Cullin RING/SCF/F-box	1.10e-06	28.5	880	969

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggede.....k.....slveCekCrewfHpaClkls.....veeelpnsekwiCpkCrsk 54
           +vClvCge+g+++     +     +l+eC++C+e++Hp+Clk +     v++elpn+  w+CpkC+++
   Q: 560  AVCLVCGEAGKEDtveeeEskfnlMLMECSICNEIIHPGCLKVKesdgvVNDELPNC--WECPKCNHA 625
           79*********9977766156889*********************************..*******85 PP

E3 adaptor/Cullin RING/SCF/F-box

   S: 55   srrtprqpprgpsaaakpkaglrseaaaapap.apaptptpeegpdaglldrlpeeilveilklldkeellraarvcrrwqelasqkal 142
            r tpr   r p + + pk+         p p +p p   p    d g  + ++ e+++ ++++l++++l+ + rvc++w++ + +k+l
   Q: 880  LRSTPRGITRPPPSLSPPKCIQMERHVIRPPPiSPPPDSLPL---DDGAAHVMQREVWMAVFSYLSHRDLCICMRVCKTWNRWCCDKRL 965
           4789******99999999986666566666551344444443...6677788889**************************5555599* PP
   S: 143  wktv 146
           w ++
   Q: 966  WTKI 969
           9986 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

DFTFEYVQRE ALRVPLIFRN KDGLGIKMPD PDFTVRDVKL LVGSRRIVDV MDVNTQKGVE 60
MSMSQFVRYY ETPEAQREKL YNVISLEFSH TKLENIVKRP NVVDLVDWVD NMWPQHLKER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATTTTACTT TTGAGTATGT GCAAAGAGAA GCTCTCAGAG TTCCCCTTAT CTTCAGAAAT 60
AAGGATGGAC TGGGAATTAA GTAAGTTACA ACCAAATCTT GATGATTAAT AAATGTATTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001810--F-box_dom
IPR003347--JmjC_dom
IPR032675--L_dom-like
IPR006553--Leu-rich_rpt_Cys-con_subtyp
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51184--JMJC
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF00646--F-box
PF02373--JmjC
PF16866--PHD_4
PF02008--zf-CXXC

SMART

SM00558--JmjC
SM00367--LRR_CC
SM00249--PHD

Gene Ontology

GO:0031519--C:PcG protein complex
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0048596--P:embryonic camera-type eye morphogenesis
GO:0021592--P:fourth ventricle development
GO:0035518--P:histone H2A monoubiquitination
GO:0070544--P:histone H3-K36 demethylation
GO:0021993--P:initiation of neural tube closure
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0021555--P:midbrain-hindbrain boundary morphogenesis
GO:2000178--P:negative regulation of neural precursor cell proliferation
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030307--P:positive regulation of cell growth
GO:1902459--P:positive regulation of stem cell population maintenance
GO:0007283--P:spermatogenesis
GO:0021678--P:third ventricle development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001358	Ailuropoda melanoleuca	83.52	0.00e+00	1950.00
IUUC-Aca-004247	Anolis carolinensis	80.65	0.00e+00	1796.00
IUUC-Afl-008579	Aspergillus flavus	41.55	5.00e-23	102.00
IUUC-Bta-013531	Bos taurus	83.73	0.00e+00	1957.00
IUUC-Cel-018303	Caenorhabditis elegans	45.34	3.00e-81	296.00
IUUC-Cja-018876	Callithrix jacchus	80.98	0.00e+00	1874.00
IUUC-Cfa-020857	Canis familiaris	83.98	0.00e+00	1951.00
IUUC-Cpo-021967	Cavia porcellus	81.69	0.00e+00	1825.00
IUUC-Csa-023210	Chlorocebus sabaeus	82.61	0.00e+00	1903.00
IUUC-Cme-027118	Cyanidioschyzon merolae	36.03	3.00e-49	189.00
IUUC-Dre-028272	Danio rerio	65.30	0.00e+00	1481.00
IUUC-Dno-030034	Dasypus novemcinctus	83.36	0.00e+00	1904.00
IUUC-Dor-030736	Dipodomys ordii	71.90	0.00e+00	820.00
IUUC-Dse-031402	Dothistroma septosporum	42.61	5.00e-61	229.00
IUUC-Eca-034255	Equus caballus	83.85	0.00e+00	1957.00
IUUC-Eeu-035038	Erinaceus europaeus	83.26	0.00e+00	1023.00
IUUC-Fca-035786	Felis catus	83.89	0.00e+00	1947.00
IUUC-Fal-037589	Ficedula albicollis	96.02	0.00e+00	2212.00
IUUC-Gmo-038781	Gadus morhua	63.88	3.00e-180	625.00
IUUC-Gga-041103	Gallus gallus	98.03	0.00e+00	1194.00
IUUC-Gac-041304	Gasterosteus aculeatus	62.00	0.00e+00	1457.00
IUUC-Ggo-044522	Gorilla gorilla	73.62	0.00e+00	1580.00
IUUC-Hsa-045877	Homo sapiens	84.16	0.00e+00	1937.00
IUUC-Itr-049003	Ictidomys tridecemlineatus	83.86	0.00e+00	1145.00
IUUC-Lch-049950	Latimeria chalumnae	84.47	0.00e+00	1974.00
IUUC-Loc-051972	Lepisosteus oculatus	70.35	0.00e+00	1038.00
IUUC-Lma-053190	Leptosphaeria maculans	44.15	7.00e-61	229.00
IUUC-Laf-053623	Loxodonta africana	82.96	0.00e+00	1879.00
IUUC-Mcc-054943	Macaca mulatta	83.04	0.00e+00	1925.00
IUUC-Meu-056259	Macropus eugenii	83.98	0.00e+00	1919.00
IUUC-Mga-059671	Meleagris gallopavo	94.51	0.00e+00	2229.00
IUUC-Mmr-061003	Microcebus murinus	83.39	0.00e+00	1934.00
IUUC-Mmu-063584	Mus musculus	82.78	0.00e+00	1912.00
IUUC-Mpu-066056	Mustela putorius furo	83.75	0.00e+00	1931.00
IUUC-Mlu-067850	Myotis lucifugus	83.85	0.00e+00	1970.00
IUUC-Nle-069837	Nomascus leucogenys	86.10	0.00e+00	1828.00
IUUC-Opr-070943	Ochotona princeps	80.24	0.00e+00	1795.00
IUUC-Ont-071663	Oreochromis niloticus	64.62	0.00e+00	1523.00
IUUC-Oan-072934	Ornithorhynchus anatinus	76.71	0.00e+00	1279.00
IUUC-Ocu-074706	Oryctolagus cuniculus	83.53	0.00e+00	1937.00
IUUC-Ola-086543	Oryzias latipes	62.80	0.00e+00	1483.00
IUUC-Oga-088671	Otolemur garnettii	77.50	0.00e+00	935.00
IUUC-Oar-089560	Ovis aries	79.49	0.00e+00	1886.00
IUUC-Ptr-090875	Pan troglodytes	84.08	0.00e+00	1956.00
IUUC-Pan-091788	Papio anubis	81.77	0.00e+00	1887.00
IUUC-Psi-093382	Pelodiscus sinensis	93.64	0.00e+00	2167.00
IUUC-Pma-094687	Petromyzon marinus	52.81	2.00e-95	343.00
IUUC-Pno-094984	Phaeosphaeria nodorum	45.28	6.00e-62	233.00
IUUC-Pfo-096272	Poecilia formosa	66.18	0.00e+00	1471.00
IUUC-Pab-097907	Pongo abelii	79.52	0.00e+00	1784.00
IUUC-Pca-100628	Procavia capensis	82.63	0.00e+00	962.00
IUUC-Pva-102956	Pteropus vampyrus	75.73	0.00e+00	928.00
IUUC-Ptt-103859	Puccinia triticina	45.49	2.00e-73	269.00
IUUC-Pte-104241	Pyrenophora teres	44.53	8.00e-61	229.00
IUUC-Pyt-104741	Pyrenophora triticirepentis	44.53	4.00e-60	226.00
IUUC-Rno-105722	Rattus norvegicus	82.16	0.00e+00	1600.00
IUUC-Sha-106626	Sarcophilus harrisii	79.17	0.00e+00	1788.00
IUUC-Ssc-115918	Sus scrofa	81.53	0.00e+00	1532.00
IUUC-Tgu-117229	Taeniopygia guttata	81.91	0.00e+00	1867.00
IUUC-Tru-118638	Takifugu rubripes	68.65	0.00e+00	935.00
IUUC-Tme-127054	Tuber melanosporum	41.57	2.00e-52	201.00
IUUC-Tbe-127654	Tupaia belangeri	69.83	0.00e+00	1477.00
IUUC-Ttr-128821	Tursiops truncatus	77.00	0.00e+00	1727.00
IUUC-Xtr-131823	Xenopus tropicalis	76.13	0.00e+00	1738.00
IUUC-Yli-134626	Yarrowia lipolytica	42.25	2.00e-54	206.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence