iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028187

UUCD1 version

UUC-DaR-01308

Ensembl Protein ID

ENSDARP00000097371.3

UniProt Accession

Q7ZV92; Q7ZV92_DANRE

Genbank Protein ID

AAH45954.1; AAI65225.1

Protein Name

PRP19/PSO4 homolog (S. cerevisiae); Prp19 protein

Genbank Nucleotide ID

BX530081; BC165225

Gene Name

prp19; prpf19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000015239.9	ENSDART00000106593.4	ENSDARP00000097371.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.70e-32	109.9	391	424
E3 activity/RING/U-box	4.40e-14	53.2	3	60
UBD/Beta-Prp	1.50e-52	179.6	233	462

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrt 32
           gH+++vt++af  ++ +l++G+ D ++k+WDlr+
   Q: 391  GHSGPVTAIAFseNGYYLATGAQDSSLKLWDLRK 424
           8**********976699**************986 PP

E3 activity/RING/U-box

   S: 6    flCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlvPnltlrr 63
           ++C+Is+e++++P+v+p s+++++r+ Iek++a++g  +P+++qpl+ee+l++ ++ + 
   Q: 3    LVCAISNEVPEHPCVSPvSNQVFERRLIEKYIAENGA-DPINGQPLSEEQLIDIKVSHP 60
           68**********************************9.**************9988765 PP

UBD/Beta-Prp

   S: 20   pdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdk 108
            d++ ++tg++d+ + v+d ++++ +++l+gh+++v++v ++p + +  ++s+D ti+vw++  g cv+++++he+ v+ ls++++gd+
   Q: 233  TDTNKVLTGGADKNVVVFDRREEQIVATLKGHTKKVSSVIYHPAQAVVFSASSDSTIRVWSVTGGNCVQVVRAHESAVTGLSLHATGDY 321
           68899************************************************************************************ PP
   S: 109  lvsGshdrtirvwdletgqclee.tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelv 196
           l+s s+d++    d++tg +l + t++    + +c+++hpdg ++ +G+ D+++++Wdlk  + +  + g h ++v+ ++f++ng +l+
   Q: 322  LLSSSEDQYWAFSDIQTGRVLTKvTDETAGCALTCAQFHPDGLIFGTGTGDSQIKIWDLKERTNVANFPG-HSGPVTAIAFSENGYYLA 409
           *********************997777777899************************************9.****************** PP
   S: 197  sgsldgtvklwdlqtgecvrtlng.htdnvksvrfspnderlvsgssDgsiri 248
           +g++d+++klwdl++ +  +t +   +  vks+ f++ +++l++g+sD  ++i
   Q: 410  TGAQDSSLKLWDLRKLKNFKTITLdNNYEVKSLVFDQSGTYLAVGGSDIRVYI 462
           **************888888777537799*******************88877 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MSLVCAISNE VPEHPCVSPV SNQVFERRLI EKYIAENGAD PINGQPLSEE QLIDIKVSHP 60
IRPKAPSATS IPAILKSLQD EWDAVMLHSF TLRQQLQTTR QELSHALYQH DAACRVIARL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGACCTCTCT GAACACATCT CAGTGGTGTT GCAGTGCGCG GCGCCGCCTG TCGAGAGAAC 60
ACGGGTTTCA TTTTTCGCTC TTGGAAGAGT CTGTATCCCA TCATGCACCG CTGTTTGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR013915--Pre-mRNA_splic_Prp19
IPR000772--Ricin_B_lectin
IPR003613--Ubox_domain
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50231--RICIN_B_LECTIN
PS51698--U_BOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08606--Prp19
PF04564--U-box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00504--Ubox
SM00320--WD40

Gene Ontology

GO:0000974--C:Prp19 complex
GO:0071006--C:U2-type catalytic step 1 spliceosome
GO:0004842--F:ubiquitin-protein transferase activity
GO:0000349--P:generation of catalytic spliceosome for first transesterification step
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator

KEGG

dre:321544

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000488	Aegilops tauschii	40.19	4.00e-97	350.00
IUUC-Aml-001230	Ailuropoda melanoleuca	83.00	0.00e+00	835.00
IUUC-Atr-002594	Amborella trichopoda	43.58	1.00e-116	413.00
IUUC-Apl-003686	Anas platyrhynchos	73.54	0.00e+00	629.00
IUUC-Aca-005272	Anolis carolinensis	85.74	0.00e+00	883.00
IUUC-Aly-005586	Arabidopsis lyrata	42.88	6.00e-116	411.00
IUUC-Ath-007696	Arabidopsis thaliana	42.77	8.00e-115	407.00
IUUC-Acl-008335	Aspergillus clavatus	37.32	3.00e-70	259.00
IUUC-Afl-008527	Aspergillus flavus	39.24	5.00e-75	275.00
IUUC-Afu-008957	Aspergillus fumigatus	38.99	4.00e-81	295.00
IUUC-Ani-009280	Aspergillus nidulans	38.37	4.00e-70	258.00
IUUC-Ang-009746	Aspergillus niger	37.97	6.00e-69	254.00
IUUC-Aor-009905	Aspergillus oryzae	39.03	1.00e-78	287.00
IUUC-Ate-010412	Aspergillus terreus	38.19	9.00e-66	244.00
IUUC-Ame-011561	Astyanax mexicanus	92.53	6.00e-119	420.00
IUUC-Bgr-012283	Blumeria graminis	33.12	1.00e-58	220.00
IUUC-Bta-013242	Bos taurus	85.35	0.00e+00	884.00
IUUC-Bci-013901	Botrytis cinerea	35.12	3.00e-68	252.00
IUUC-Bdi-014277	Brachypodium distachyon	44.62	2.00e-123	436.00
IUUC-Bol-016207	Brassica oleracea	44.66	2.00e-117	416.00
IUUC-Bra-017650	Brassica rapa	43.69	1.00e-115	410.00
IUUC-Cel-018271	Caenorhabditis elegans	52.27	4.00e-152	531.00
IUUC-Cja-019879	Callithrix jacchus	84.98	0.00e+00	876.00
IUUC-Cfa-020175	Canis familiaris	85.15	0.00e+00	881.00
IUUC-Cpo-022379	Cavia porcellus	85.54	0.00e+00	884.00
IUUC-Cre-022993	Chlamydomonas reinhardtii	40.86	1.00e-99	357.00
IUUC-Csa-023500	Chlorocebus sabaeus	85.35	0.00e+00	883.00
IUUC-Cho-025065	Choloepus hoffmanni	75.64	4.00e-124	437.00
IUUC-Cin-025699	Ciona intestinalis	66.67	7.00e-172	596.00
IUUC-Csv-026128	Ciona savignyi	65.96	0.00e+00	684.00
IUUC-Cgl-026507	Colletotrichum gloeosporioides	34.06	3.00e-66	246.00
IUUC-Cne-026860	Cryptococcus neoformans	36.79	2.00e-92	333.00
IUUC-Dno-029453	Dasypus novemcinctus	85.35	0.00e+00	882.00
IUUC-Dor-030150	Dipodomys ordii	84.10	3.00e-104	372.00
IUUC-Dse-031220	Dothistroma septosporum	32.56	5.00e-59	221.00
IUUC-Dme-031906	Drosophila melanogaster	66.73	0.00e+00	660.00
IUUC-Ete-033035	Echinops telfairi	84.58	9.00e-121	427.00
IUUC-Eca-033478	Equus caballus	85.15	0.00e+00	881.00
IUUC-Eeu-034974	Erinaceus europaeus	83.89	5.00e-174	604.00
IUUC-Fca-036194	Felis catus	84.69	0.00e+00	871.00
IUUC-Fal-037417	Ficedula albicollis	83.76	0.00e+00	874.00
IUUC-Fox-037922	Fusarium oxysporum	34.55	2.00e-65	243.00
IUUC-Fso-038256	Fusarium solani	35.19	3.00e-67	249.00
IUUC-Gmo-038713	Gadus morhua	94.26	0.00e+00	932.00
IUUC-Ggr-039854	Gaeumannomyces graminis	31.57	2.00e-50	193.00
IUUC-Gga-041143	Gallus gallus	83.76	0.00e+00	873.00
IUUC-Gac-042129	Gasterosteus aculeatus	93.27	0.00e+00	931.00
IUUC-Gma-044273	Glycine max	43.59	1.00e-116	413.00
IUUC-Ggo-045262	Gorilla gorilla	85.35	0.00e+00	883.00
IUUC-Hsa-046036	Homo sapiens	85.35	0.00e+00	883.00
IUUC-Hvu-047442	Hordeum vulgare	42.95	2.00e-65	242.00
IUUC-Itr-048169	Ictidomys tridecemlineatus	84.95	0.00e+00	869.00
IUUC-Lch-050105	Latimeria chalumnae	84.16	0.00e+00	868.00
IUUC-Lpe-050976	Leersia perrieri	43.95	7.00e-121	427.00
IUUC-Loc-052042	Lepisosteus oculatus	79.15	0.00e+00	677.00
IUUC-Lma-053143	Leptosphaeria maculans	34.39	2.00e-66	248.00
IUUC-Laf-053451	Loxodonta africana	82.38	0.00e+00	871.00
IUUC-Mcc-055786	Macaca mulatta	85.35	0.00e+00	883.00
IUUC-Meu-056161	Macropus eugenii	84.23	1.00e-123	436.00
IUUC-Mor-057215	Magnaporthe oryzae	32.87	1.00e-53	204.00
IUUC-Mpo-057419	Magnaporthe poae	31.37	1.00e-48	187.00
IUUC-Mtr-057756	Medicago truncatula	42.83	3.00e-112	399.00
IUUC-Mla-059085	Melampsora laricipopulina	38.55	6.00e-87	315.00
IUUC-Mga-060158	Meleagris gallopavo	79.00	0.00e+00	775.00
IUUC-Mvi-060441	Microbotryum violaceum	38.52	2.00e-80	293.00
IUUC-Mmr-061085	Microcebus murinus	85.35	0.00e+00	883.00
IUUC-Mdo-061804	Monodelphis domestica	85.35	0.00e+00	883.00
IUUC-Mmu-063608	Mus musculus	82.25	0.00e+00	870.00
IUUC-Mac-064972	Musa acuminata	44.98	6.00e-118	417.00
IUUC-Mpu-065700	Mustela putorius furo	85.15	0.00e+00	881.00
IUUC-Mlu-068223	Myotis lucifugus	82.50	0.00e+00	871.00
IUUC-Nfi-068504	Neosartorya fischeri	38.38	5.00e-80	291.00
IUUC-Ncr-068729	Neurospora crassa	35.19	7.00e-64	238.00
IUUC-Nle-069754	Nomascus leucogenys	85.35	0.00e+00	883.00
IUUC-Opr-070621	Ochotona princeps	82.33	0.00e+00	828.00
IUUC-Ont-071377	Oreochromis niloticus	93.66	0.00e+00	933.00
IUUC-Oan-073498	Ornithorhynchus anatinus	79.89	3.00e-81	295.00
IUUC-Ocu-074182	Oryctolagus cuniculus	81.94	0.00e+00	870.00
IUUC-Oba-075509	Oryza barthii	44.81	3.00e-122	432.00
IUUC-Obr-076480	Oryza brachyantha	45.19	2.00e-122	433.00
IUUC-Ogl-077052	Oryza glaberrima	44.81	4.00e-122	432.00
IUUC-Ogu-078919	Oryza glumaepatula	44.81	5.00e-122	431.00
IUUC-Oin-079357	Oryza indica	43.71	8.00e-115	407.00
IUUC-Olo-080376	Oryza longistaminata	43.44	1.00e-109	390.00
IUUC-Ome-081973	Oryza meridionalis	43.94	2.00e-109	389.00
IUUC-Oni-082849	Oryza nivara	44.81	2.00e-122	432.00
IUUC-Opu-083243	Oryza punctata	44.62	2.00e-121	429.00
IUUC-Oru-084613	Oryza rufipogon	44.15	4.00e-122	431.00
IUUC-Osa-085407	Oryza sativa	44.79	1.00e-121	430.00
IUUC-Ola-086566	Oryzias latipes	91.37	0.00e+00	914.00
IUUC-Olu-087757	Ostreococcus lucimarinus	38.29	2.00e-89	322.00
IUUC-Oga-089010	Otolemur garnettii	82.57	0.00e+00	838.00
IUUC-Oar-089638	Ovis aries	85.35	0.00e+00	884.00
IUUC-Ptr-091141	Pan troglodytes	85.35	0.00e+00	883.00
IUUC-Pan-092662	Papio anubis	85.35	0.00e+00	883.00
IUUC-Psi-093777	Pelodiscus sinensis	83.57	0.00e+00	709.00
IUUC-Pno-095115	Phaeosphaeria nodorum	36.08	3.00e-69	256.00
IUUC-Ppa-095841	Physcomitrella patens	45.95	2.00e-120	426.00
IUUC-Pfo-096390	Poecilia formosa	91.68	0.00e+00	923.00
IUUC-Pab-098250	Pongo abelii	84.91	0.00e+00	823.00
IUUC-Pop-099854	Populus trichocarpa	44.32	2.00e-118	419.00
IUUC-Pca-100553	Procavia capensis	84.75	0.00e+00	875.00
IUUC-Ppe-101383	Prunus persica	43.16	9.00e-112	397.00
IUUC-Pva-102189	Pteropus vampyrus	85.15	0.00e+00	882.00
IUUC-Pgr-103304	Puccinia graminis	37.22	2.00e-86	312.00
IUUC-Ptt-103984	Puccinia triticina	37.41	2.00e-90	327.00
IUUC-Pte-104385	Pyrenophora teres	34.81	4.00e-73	268.00
IUUC-Pyt-104697	Pyrenophora triticirepentis	34.60	6.00e-73	268.00
IUUC-Rno-105581	Rattus norvegicus	85.35	0.00e+00	882.00
IUUC-Sha-107071	Sarcophilus harrisii	81.78	0.00e+00	871.00
IUUC-Sja-107697	Schizosaccharomyces japonicus	30.19	3.00e-35	143.00
IUUC-Spo-108315	Schizosaccharomyces pombe	30.22	1.00e-41	164.00
IUUC-Ssl-108628	Sclerotinia sclerotiorum	34.46	2.00e-66	246.00
IUUC-Smo-109648	Selaginella moellendorffii	44.94	8.00e-120	424.00
IUUC-Sit-109873	Setaria italica	43.49	4.00e-121	429.00
IUUC-Sly-111673	Solanum lycopersicum	44.64	5.00e-113	401.00
IUUC-Stu-112125	Solanum tuberosum	45.11	7.00e-112	397.00
IUUC-Sbi-114696	Sorghum bicolor	41.68	1.00e-109	390.00
IUUC-Sre-115134	Sporisorium reilianum	31.97	2.00e-71	263.00
IUUC-Ssc-116260	Sus scrofa	85.15	0.00e+00	882.00
IUUC-Tgu-116533	Taeniopygia guttata	83.96	0.00e+00	875.00
IUUC-Tru-117800	Takifugu rubripes	92.48	0.00e+00	938.00
IUUC-Tsy-118980	Tarsius syrichta	80.45	0.00e+00	793.00
IUUC-Tni-120334	Tetraodon nigroviridis	90.69	0.00e+00	640.00
IUUC-Tca-121807	Theobroma cacao	43.57	7.00e-119	421.00
IUUC-Tre-121920	Trichoderma reesei	33.87	2.00e-64	239.00
IUUC-Tvi-122294	Trichoderma virens	33.53	3.00e-57	216.00
IUUC-Tae-125713	Triticum aestivum	44.64	3.00e-123	435.00
IUUC-Tur-126664	Triticum urartu	40.18	7.00e-113	401.00
IUUC-Tme-127026	Tuber melanosporum	36.13	1.00e-72	267.00
IUUC-Tbe-127582	Tupaia belangeri	83.89	5.00e-174	604.00
IUUC-Ttr-128313	Tursiops truncatus	85.15	0.00e+00	877.00
IUUC-Uma-129626	Ustilago maydis	33.70	4.00e-73	268.00
IUUC-Vda-129699	Verticillium dahliae	34.78	7.00e-68	251.00
IUUC-Vpa-130593	Vicugna pacos	85.49	0.00e+00	786.00
IUUC-Vvi-131668	Vitis vinifera	44.34	8.00e-120	424.00
IUUC-Xtr-132186	Xenopus tropicalis	80.68	0.00e+00	707.00
IUUC-Xma-133212	Xiphophorus maculatus	91.88	0.00e+00	920.00
IUUC-Yli-134607	Yarrowia lipolytica	55.30	4.00e-40	156.00
IUUC-Zma-135662	Zea mays	45.19	6.00e-123	434.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence