iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011081

Ensembl Protein ID

ENSAMXP00000017376.1

UniProt Accession

W5LC14; W5LC14_ASTMX

Genbank Protein ID

ENSAMXP00000017376

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

APWO01036752

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000016876.1	ENSAMXT00000017376.1	ENSAMXP00000017376.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.10e-135	450.0	544	876

Active Site

Position(s)	Description	Evidence
845	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 544  AQDLRRRLWIIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDT 631
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s++fyk++l+k+l l dle++dpe+y+sl +iken   +iee+gl++ fsv+++ilge++++eLkp+G +i+Vt+eNkeeY++lv+e
   Q: 632  GFSQPFYKRILNKPLGLGDLESIDPEFYNSLIWIKEN---NIEECGLEMFFSVDKDILGEITTQELKPDGGDIQVTEENKEEYIRLVAE 717
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfnev+p++ l++F+++ele+l+cG++eid+ d++++t y++ y + +++i wFw+ ++e+++e+r ++LqFv
   Q: 718  WRLSRGVEEQTQAFFEGFNEVLPQQYLQYFDAKELEVLLCGMQEIDLADWQRNTIYRH-YARGNKQIVWFWQLVKEMDNEKRMRLLQFV 805
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 806  TGTCRLPVGGFADLMgsngPQKFCIEKTGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 876
           *********************************************************************96 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MACSIPTPGP GNGFPMKAQL QIVVLSAKLK ENKKNWFGPS PYVEVAVDGQ SKKTEKCNNT 60
HSPKWKQPLT VKVLTQCRYV VLWKHDEGRE HHLPTQTEQD QLCSLRAPVM TLSTLMSNLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCTGCA GCATTCCCAC ACCAGGCCCT GGTAATGGCT TCCCAATGAA GGCACAGCTA 60
CAGATCGTTG GTATGTTGGC ACTGTTTGTT TATTTATGCC TCATTTGACT TCTTTCTACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0048920--P:posterior lateral line neuromast primordium migration

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cfa-020648	Canis familiaris	86.96	0.00e+00	1063.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	46.91	3.00e-152	532.00
IUUC-Eeu-034716	Erinaceus europaeus	85.59	0.00e+00	824.00
IUUC-Fca-035605	Felis catus	88.81	0.00e+00	1097.00
IUUC-Fox-037774	Fusarium oxysporum	47.34	3.00e-154	539.00
IUUC-Oga-088167	Otolemur garnettii	82.72	0.00e+00	1004.00
IUUC-Spo-108171	Schizosaccharomyces pombe	50.53	4.00e-160	558.00
IUUC-Sre-114929	Sporisorium reilianum	47.38	9.00e-154	537.00
IUUC-Tru-118658	Takifugu rubripes	64.12	0.00e+00	1145.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence