iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cin-025126

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

EAAA01001910

Gene Name

LOC100175038

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCING00000007996.3	ENSCINT00000016361.3	ENSCINP00000016361.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.00e-124	414.2	416	750

Active Site

Position(s)	Description	Evidence
720	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gE+gld+gG++re+l+ ls+e+ np++glf+ys +d +tlq+n ds + np+hl++F+f+Gr+lg+a+++g+++d 
   Q: 416  PKDLKKRLMVKFTGEDGLDYGGLAREWLYILSHEMLNPYYGLFQYSREDIYTLQINADSHI-NPDHLSYFHFVGRILGMAVYHGHYIDG 503
           689********************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++  fyk+llgk++sled+eevdp lyks+k+i++n   di+   ld tf+v+++++ge+ ++eLkp+G nipVt++Nk+eYvkl+v+
   Q: 504  GFTMLFYKQLLGKPISLEDMEEVDPALYKSMKWILQN---DINGV-LDHTFCVDQDSFGERVTHELKPNGVNIPVTEQNKREYVKLYVN 588
           ***********************************99...99998.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ ++++Gf+e+ip++ll+ F+e+elel+i G  +id+ d+kk+tk k+ +++ds+ ++wFw+++e+f++e+r++ LqFv
   Q: 589  WRFLRGIEAQFLSLSKGFYELIPQHLLRPFDERELELIIGGLGKIDLIDWKKHTKLKH-CSQDSNIVKWFWQAVESFDEEKRARVLQFV 676
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tgssr+Pl+Gf++l+       prlf+i+  d+++d lP+++TCfn+++LP+Y+s+++l ekL++A+e+t gF 
   Q: 677  TGSSRVPLQGFKALQgstgtqgPRLFTIQFvDNKTDCLPKAHTCFNRIDLPPYESYKKLLEKLTCAVENTCGFY 750
           ******************************89999*************************************96 PP

Organism

Ciona intestinalis

Protein Sequence
(Fasta)

VETPCLNNRG FSRLRSTIFC AKNICKRDFF RLPDPFAKIL VDGSGQCHAT GTCKATLDPK 60
WNQHYDLYVG KSDSITISVW NHRKVHKKHG AGFLGCIRIM SNAINRLKDT GYQRLDLCKQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGAGACCC CATGTTTAAA TAATCGTGGA TTTTCAAGAT TACGTAGTAC AAGTACATAA 60
TTTCGATACA TATCTCCCAA AACTCCCGCA TCGCTGCCGG TTCTATTCAA AACAAACGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001305	Ailuropoda melanoleuca	66.53	0.00e+00	1027.00
IUUC-Apl-003513	Anas platyrhynchos	67.16	0.00e+00	1032.00
IUUC-Aca-005358	Anolis carolinensis	65.42	0.00e+00	1031.00
IUUC-Ame-011320	Astyanax mexicanus	63.39	0.00e+00	999.00
IUUC-Bta-013399	Bos taurus	66.31	0.00e+00	1022.00
IUUC-Cja-019355	Callithrix jacchus	66.40	0.00e+00	1022.00
IUUC-Cfa-020568	Canis familiaris	61.65	0.00e+00	946.00
IUUC-Cpo-022200	Cavia porcellus	66.40	0.00e+00	1026.00
IUUC-Csa-024145	Chlorocebus sabaeus	63.31	0.00e+00	955.00
IUUC-Cho-024804	Choloepus hoffmanni	75.96	9.00e-146	509.00
IUUC-Csv-026339	Ciona savignyi	89.16	0.00e+00	1357.00
IUUC-Dre-027650	Danio rerio	63.93	0.00e+00	1025.00
IUUC-Dno-029534	Dasypus novemcinctus	65.40	0.00e+00	1027.00
IUUC-Dme-031740	Drosophila melanogaster	69.85	2.00e-169	588.00
IUUC-Ete-032715	Echinops telfairi	63.10	0.00e+00	956.00
IUUC-Eca-033580	Equus caballus	66.40	0.00e+00	1025.00
IUUC-Eeu-034945	Erinaceus europaeus	64.65	0.00e+00	945.00
IUUC-Fca-035905	Felis catus	63.17	0.00e+00	962.00
IUUC-Fal-037275	Ficedula albicollis	65.84	0.00e+00	1025.00
IUUC-Gmo-039486	Gadus morhua	64.84	0.00e+00	689.00
IUUC-Gga-040218	Gallus gallus	62.76	0.00e+00	957.00
IUUC-Gac-041295	Gasterosteus aculeatus	65.35	0.00e+00	1021.00
IUUC-Ggo-045408	Gorilla gorilla	57.22	0.00e+00	849.00
IUUC-Hsa-046726	Homo sapiens	66.18	0.00e+00	1027.00
IUUC-Itr-048042	Ictidomys tridecemlineatus	71.01	0.00e+00	760.00
IUUC-Lch-050026	Latimeria chalumnae	65.67	0.00e+00	1026.00
IUUC-Loc-051760	Lepisosteus oculatus	62.17	0.00e+00	994.00
IUUC-Laf-053753	Loxodonta africana	66.40	0.00e+00	1025.00
IUUC-Mcc-054815	Macaca mulatta	65.67	0.00e+00	1030.00
IUUC-Meu-056436	Macropus eugenii	48.70	0.00e+00	690.00
IUUC-Mga-059723	Meleagris gallopavo	64.12	0.00e+00	957.00
IUUC-Mvi-060395	Microbotryum violaceum	48.71	2.00e-144	504.00
IUUC-Mmr-060806	Microcebus murinus	66.36	0.00e+00	1024.00
IUUC-Mdo-062805	Monodelphis domestica	65.62	0.00e+00	1028.00
IUUC-Mmu-064034	Mus musculus	65.54	0.00e+00	1028.00
IUUC-Mpu-066762	Mustela putorius furo	66.05	0.00e+00	1027.00
IUUC-Mlu-066981	Myotis lucifugus	66.40	0.00e+00	1025.00
IUUC-Nle-069804	Nomascus leucogenys	66.18	0.00e+00	1028.00
IUUC-Opr-070591	Ochotona princeps	62.97	0.00e+00	953.00
IUUC-Ont-071239	Oreochromis niloticus	65.61	0.00e+00	1022.00
IUUC-Oan-072699	Ornithorhynchus anatinus	58.23	0.00e+00	903.00
IUUC-Ocu-074913	Oryctolagus cuniculus	65.54	0.00e+00	1028.00
IUUC-Ola-086597	Oryzias latipes	61.61	0.00e+00	951.00
IUUC-Oga-089116	Otolemur garnettii	65.07	0.00e+00	998.00
IUUC-Oar-089366	Ovis aries	66.22	0.00e+00	1022.00
IUUC-Ptr-091382	Pan troglodytes	66.18	0.00e+00	1027.00
IUUC-Pan-092479	Papio anubis	61.73	0.00e+00	946.00
IUUC-Psi-093298	Pelodiscus sinensis	66.09	0.00e+00	1019.00
IUUC-Pma-094354	Petromyzon marinus	61.19	0.00e+00	919.00
IUUC-Ppa-095250	Physcomitrella patens	44.97	4.00e-81	293.00
IUUC-Pfo-096071	Poecilia formosa	63.78	0.00e+00	1020.00
IUUC-Pab-098682	Pongo abelii	65.54	0.00e+00	1027.00
IUUC-Pca-100516	Procavia capensis	67.72	1.00e-140	492.00
IUUC-Pva-102754	Pteropus vampyrus	65.37	0.00e+00	990.00
IUUC-Pgr-103620	Puccinia graminis	47.90	5.00e-143	500.00
IUUC-Ptt-103806	Puccinia triticina	47.18	3.00e-120	424.00
IUUC-Rno-105396	Rattus norvegicus	64.11	0.00e+00	967.00
IUUC-Sha-107216	Sarcophilus harrisii	61.70	0.00e+00	954.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	39.60	6.00e-160	556.00
IUUC-Spo-108171	Schizosaccharomyces pombe	40.82	1.00e-163	568.00
IUUC-Sar-113122	Sorex araneus	57.62	0.00e+00	841.00
IUUC-Ssc-116413	Sus scrofa	63.06	0.00e+00	930.00
IUUC-Tgu-117112	Taeniopygia guttata	65.37	0.00e+00	1029.00
IUUC-Tru-118497	Takifugu rubripes	63.98	0.00e+00	996.00
IUUC-Tsy-119455	Tarsius syrichta	60.99	0.00e+00	893.00
IUUC-Tni-120781	Tetraodon nigroviridis	62.03	0.00e+00	828.00
IUUC-Tme-126897	Tuber melanosporum	37.97	4.00e-147	513.00
IUUC-Tbe-127371	Tupaia belangeri	59.02	0.00e+00	806.00
IUUC-Ttr-129305	Tursiops truncatus	61.76	0.00e+00	862.00
IUUC-Vpa-130591	Vicugna pacos	59.25	0.00e+00	874.00
IUUC-Xtr-132979	Xenopus tropicalis	54.44	0.00e+00	770.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence